System and method for moving a probe to follow movements of tissue

An apparatus is described for moving a probe that engages moving living tissue such as a heart or an artery that is penetrated by the probe, which moves the probe in synchronism with the tissue to maintain the probe at a constant location with respect to the tissue. The apparatus includes a servo positioner which moves a servo member to maintain a constant distance from a sensed object while applying very little force to the sensed object, and a follower having a stirrup at one end resting on a surface of the living tissue and another end carrying a sensed object adjacent to the servo member. A probe holder has one end mounted on the servo member and another end which holds the probe

Respect the gap : from big to boutique data through "Laboring-Class Poets Online"

This thesis consists of two major components. The first is Laboring-Class Poets Online (LCPO), a database-driven website that provides information about the more than 2,000 British laboring-class poets who published between 1700 and 1900 and their writing, lives, and literary relationships. I developed LCPO to demonstrate the importance of laboring-class writing to social and literary history by enhancing access to the underlying dataset, which numerous scholars have contributed to over the past thirty years. LCPO transforms this unstructured document into a relational database and provides new interfaces for users to query, visualize, and explore this rich source of biographical and bibliographic information. In the second written section, I argue that current big data understandings and implementations of databases fail to adequately meet the needs of many humanities scholars. I introduce the concept of boutique data as an alternative framework that respects the ambiguous gaps in humanities datasets. Using LCPO as an example of a boutique data project, I contend that a boutique approach to data better accommodates complex understandings of space and time as continuously unfolding events.Keywords: eighteenth-century, laboring-class writing, geography, boutique data, digital humanities, chronology, British literature, big data, events, databases, nineteenth-centur

Concert recording 2018-02-18

[Track 1]. Cavatina Largo al factotum / Gioachino Rossini -- [Track 2]. Duettino / Eugene Bozza -- [Track 3]. Romance de barrio / Anibal Troilo arranged by Gonzalo Brusco -- [Track 4]. Danny boy / Traditional arranged by Ian McCubbin -- [Track 5]. Malevos / Noelia Escalzo -- [Track 6]. Muppets theme / Jim Henson Sam Pottle

Checklists and illustrative financial statements for state and local governmental units : a financial reporting practice aid, June 2007 edition

https://egrove.olemiss.edu/aicpa_indev/1941/thumbnail.jp

Time-periodic phases in populations of nonlinearly coupled oscillators with bimodal frequency distributions

The mean field Kuramoto model describing the synchronization of a population of phase oscillators with a bimodal frequency distribution is analyzed (by the method of multiple scales) near regions in its phase diagram corresponding to synchronization to phases with a time periodic order parameter. The richest behavior is found near the tricritical point were the incoherent, stationarily synchronized, ``traveling wave'' and ``standing wave'' phases coexist. The behavior near the tricritical point can be extrapolated to the rest of the phase diagram. Direct Brownian simulation of the model confirms our findings.Comment: Revtex,16 pag.,10 fig., submitted to Physica

Concert recording 2016-11-16

[Tracks 1-3]. Concerto in E minor / Antonio Vivaldi -- [Tracks 4-5]. Sonata in F minor / Georg Philipp Telemann -- [Tracks 6-7]. Three etudes / José Siqueira -- [Track 8]. Andante e rondo ongarese / Carl Maria v. Weber -- [Track 9]. Monolog for bassoon / Isang Yun -- [Track 10]. Malevos / Noelia Escalzo

Noble gas films on a decagonal AlNiCo quasicrystal

Thermodynamic properties of Ne, Ar, Kr, and Xe adsorbed on an Al-Ni-Co quasicrystalline surface (QC) are studied with Grand Canonical Monte Carlo by employing Lennard-Jones interactions with parameter values derived from experiments and traditional combining rules. In all the gas/QC systems, a layer-by-layer film growth is observed at low temperature. The monolayers have regular epitaxial fivefold arrangements which evolve toward sixfold close-packed structures as the pressure is increased. The final states can contain either considerable or negligible amounts of defects. In the latter case, there occurs a structural transition from five to sixfold symmetry which can be described by introducing an order parameter, whose evolution characterizes the transition to be continuous or discontinuous as in the case of Xe/QC (first-order transition with associated latent heat). By simulating fictitious noble gases, we find that the existence of the transition is correlated with the size mismatch between adsorbate and substrate's characteristic lengths. A simple rule is proposed to predict the phenomenon.Comment: 19 pages. 8 figures. (color figures can be seen at http://alpha.mems.duke.edu/wahyu/ or http://www.iop.org/EJ/abstract/0953-8984/19/1/016007/

Flagellin‐induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108697/1/eji3053-sup-0001-SupMat.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/108697/2/eji3053.pd

Feasibility of home-based exercise training during adjuvant treatment for metastatic castrate-resistant prostate cancer patients treated with an androgen receptor pathway inhibitor (EXACT)

BackgroundExercise is an effective adjuvant therapy that can alleviate treatment-related toxicities for men with prostate cancer (PC). However, the feasibility of delivering exercise training to men with advanced disease and the wider impact on clinical outcomes remain unknown. The purpose of the EXACT trial was to determine the feasibility and effects of home-based exercise training in men with metastatic castrate-resistant prostate cancer (mCRPC). MethodsPatients with mCRPC receiving ADT + an androgen receptor pathway inhibitor (ARPI) were prescribed 12 weeks of home-based, remotely monitored, moderate intensity, aerobic and resistance exercise. Feasibility was assessed using recruitment, retention and adherence rates. Safety and adverse events were monitored throughout, with functional and patient-reported outcomes captured at baseline, post-intervention and at 3-month follow-up. ResultsFrom the 117 screened, 49 were deemed eligible and approached, with 30 patients providing informed consent (61% recruitment rate). Of those who consented, 28 patients completed baseline assessments, with 24 patients completing the intervention and 22 completing follow-up (retention rates: 86% and 79% respectively). Task completion was excellent throughout, with no intervention-related adverse events recorded. Self-reported adherence to the overall intervention was 82%. Exercise training decreased mean body mass (−1.5%), improved functional fitness (> 10%) and improved several patient-reported outcomes including clinically meaningful changes in fatigue (p = 0.042), FACT-G (p = 0.054) and FACT-P (p = 0.083), all with moderate effect sizes. ConclusionHome-based exercise training, with weekly remote monitoring, was feasible and safe for men with mCRPC being treated with an ARPI. Given that treatment-related toxicities accumulate throughout the course of treatment, and as a result, negatively impact functional fitness and health-related quality of life (HRQoL), it was positive that exercise training improved or prevented a decline in these clinically important variables and could better equip patients for future treatment. Collectively, these preliminary feasibility findings support the need for a definitive, larger RCT, which downstream may lead to the inclusion of home-based exercise training as part of adjuvant care for mCRPC