189 research outputs found
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STARS Report: Benchmarking Our Progress on Sustainability
UMass Amherst is ranked in the top 10 research universities nationwide for its commitment to innovation and leadership in sustainability. The campus received a gold rating from the Association for the Advancement of Sustainability in Higher Education (AASHE)’s Sustainability Tracking Assessment Rating System (STARS). Only 16 U.S. universities have received this distinction as of January 2012. The STARS rating recognizes the multifaceted accomplishments and initiatives on campus, ranging from curriculum and education to energy use, food services, and campus planning. This executive summary of UMass Amherst’s standing using the national standards set by AASHE demonstrates the breadth and scope of UMass strengths and indicates potential areas of growth
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Modeling Effectiveness of Low Impact Development on Runoff Volume in the Tan Brook Watershed
The Tan Brook is a heavily channelized stream that runs through an urbanized watershed in Amherst, MA. It poses a stormwater management problem for the University of Massachusetts Amherst due to flooding of soccer fields and erosion of a drainage ditch. The purpose of this study was to estimate reductions in runoff volume to the Tan Brook based on the hypothetical implementation of permeable pavements in various combinations of parking lots, driveways, roadways, and sidewalks, which cover 26% of the watershed area. A spreadsheet model-based approach utilized the Watershed Treatment Model to estimate runoff volume. The percent imperviousness of various land uses was altered to model permeable pavements. Total replacement of parking lots, roadways, sidewalks, and driveways were found to reduce runoff by 18%, 15%, 12%, and 3%, respectively. Recommendations were made to begin replacing parking lots on the UMass Amherst campus and Town of Amherst property
Exploring Stakeholders’ Perceptions of Urban Growth Scenarios for Metropolitan Boston (USA): The Relationship Between Urban Trees and Perceived Density
Achieving multiple goals rather than trading one goal off for another is the essence of sustainability. Visualizing alternative futures in a participatory planning process helps disentangle complex planning issues particularly when stakeholders may perceive key goals as imposing potential tradeoffs, such as increased housing for a growing population and availability of green space. This study explored the effects of using visualization and scenarios as planning tools in a workshop with stakeholders in the Boston Metro Area, Massachusetts (USA), in achieving multiple benefits of sustainable future growth of the region. We applied mixed methods sequential explanatory design and a survey instrument with a landscape preference survey designed to garner stakeholders\u27 preference and acceptability of perceived urban density versus urban greening in four future growth scenarios reflecting multiple goals in sustainability. The results of the landscape preference survey demonstrated that increasing tree canopy appears to ameliorate the low ratings of high-rise buildings for the region\u27s urban development. In addition, the scenario planning process, especially the use of small group discussions, represented an effective tool in facilitating stakeholders\u27 discussion about achieving the multiple benefits of the three goals of sustainability: Environment, Economy, Equity. This study provided theoretical and applied insights for planners in the use of visualization and scenario planning methodologies to engage stakeholders in the participatory planning process. It revealed the potential for a policy decision shift among stakeholders in the Boston region, namely that higher density urban development would likely be more acceptable to them when combined with a simultaneous increase in tree canopy cover. Through practices like these, stakeholders are more likely to consider policies and designs that embrace a variety of goals for their community’s future instead of simplistically placing one goal in opposition to another or trading them off against each other
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Scenario Planning for the Boston Metropolitan Region: Exploring Environmental and Social Implications of Alternative Futures
The Boston Metropolitan Area Urban Long-term Ecological Research Area (BMA-ULTRA-EX) Project is an interdisciplinary project that is studying the effects of socio-economic and biophysical drivers on urban ecosystems. The Boston region is experiencing low-density urban sprawl (suburbanization) on the rural-urban fringes of the metropolitan area that is creating environmental impacts to natural resources. At the same time, central cities such as Boston are seeing disinvestment in some low-income neighborhoods causing property abandonment, along with limited infill development (densification) near the commercial core and transit hubs. These competing socio-economic forces of suburbanization, densification, and disinvestment have environmental implications for urban ecosystems, including urban forest canopy, water quantity and quality, and biodiversity. Landscape planning initiatives to address these issues will require a pro-active approach to concentrating development on currently built lands and in the suburban fringe to protect forests, farms and other natural resources, while greening and enhancing ecosystem services in the current high-density urban core.
It is within this landscape planning setting that the research team used a stakeholder- driven process to develop a set of four planning scenarios to explore the future of the region. This paper will describe the planning process with stakeholders to develop these plans, along with the preliminary analyses. It will conclude with insights for other landscape planners engaged in scenario planning
What Does It Take to Achieve Equitable Urban Tree Canopy Distribution? A Boston Case Study.
Considerable attention has been paid to the benefits that urban trees provide and recent research has focused on how the distribution of trees in the urban landscape is affected by socioeconomic processes like social stratification, as indicated by associations with income, race, ethnicity, and education. These studies have found marked disparity in urban canopy cover, with primarily low income and minority neighborhoods commonly being underserved. However, few studies have investigated the potential to overcome urban canopy inequities through urban planning and reforestation. This question becomes even more important as many U.S. cities pledge to increase urban canopy cover as part of larger climate change mitigation strategies. Can today’s heavily developed U.S. cities use these tree planting initiatives to increase equity in urban canopy cover while still providing the infrastructure and housing necessary for expected population growth? This case study characterizes the socioeconomic drivers of the current urban canopy cover in Boston, Massachusetts, and further explores the possibility of distributing trees to increase equitable access to environmental justice and ecosystem services, while meeting housing and infrastructure needs. Results suggest that even when tree planting initiatives focus specifically on increasing canopy cover for environmental justice communities, equitable distribution of urban trees is difficult to achieve. Our findings indicate that difficulties arise not only from the expected policy and funding aspects, but also from ecological ones, including the physical availability of tree planting sites in environmental justice communities
Nutritional significance of a winter-flowering succulent for opportunistic avian nectarivores
The winter-flowering succulent Aloe marlothii provides nectar for many opportunistic
avian nectarivores in southern African savannas. We assessed the importance of A. marlothii
nectar sugar for opportunistic nectarivores by analysing temporal changes in stable
carbon isotope ratios (d13C) in the tissues of birds in Suikerbosrand Nature Reserve,
South Africa. The blood of the 11 most common non-granivorous opportunistic nectarivores
at our site was enriched in 13C by 3.4 ± 1.5& during the flowering period of
A. marlothii, reflecting the enriched crassulacean acid metabolism (CAM) isotopic
signature of nectar ()12.6 ± 0.5&). This relatively small contribution of A. marlothii
nectar to assimilated carbon in whole blood contrasted with that of exhaled CO2 in African
Red-eyed Bulbuls Pycnonotus nigricans and Cape White-eyes Zosterops capensis. In
both these species, the d13C of breath samples was significantly enriched compared with
blood and feathers, and closely resembled that of the nectar, revealing combustion of
ingested nectar rather than assimilation. Although our analysis was complicated by the
presence of C4 grasses, whose d13C values are similar to those of CAM photosynthesizers,
when considered with previously published feeding observations our data reveal that
opportunistic nectarivores feeding on A. marlothii nectar obtain a relatively small fraction
of their assimilated carbon, but most of their metabolized carbon, from this seasonally
available carbohydrate food resource. Because the d13C values of insects associated with
C3 plants also became enriched during the flowering season, some insect-eating opportunistic
nectarivores may have assimilated A. marlothii carbon indirectly from insects. This
study highlights the importance of understanding isotopic routing when assessing the
nutritional significance of specific dietary items to consumer communities.The National Research Foundation of
South Africahttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1474-919X/ab201
Climate variability, oceanography, bowhead whale distribution, and Iñupiat subsistence whaling near Barrow, Alaska
Author Posting. © Arctic Institute of North America, 2010. This article is posted here by permission of Arctic Institute of North America for personal use, not for redistribution. The definitive version was published in Arctic 63 (2010): 179-194.The annual migration of bowhead whales (Balaena mysticetus) past Barrow, Alaska, has provided subsistence hunting to Iñupiat for centuries. Bowheads recurrently feed on aggregations of zooplankton prey near Barrow in autumn. The mechanisms that form these aggregations, and the associations between whales and oceanography, were investigated using field sampling, retrospective analysis, and traditional knowledge interviews. Oceanographic and aerial surveys were conducted near Barrow during August and September in 2005 and 2006. Multiple water masses were observed, and close coupling between water mass type and biological characteristics was noted. Short-term variability in hydrography was associated with changes in wind speed and direction that profoundly affected plankton taxonomic composition. Aggregations of ca. 50–100 bowhead whales were observed in early September of both years at locations consistent with traditional knowledge. Retrospective analyses of records for 1984–2004 also showed that annual aggregations of whales near Barrow were associated with wind speed and direction. Euphausiids and copepods appear to be upwelled onto the Beaufort Sea shelf during Eor SEwinds. A favorable feeding environment is produced when these plankton are retained and concentrated on the shelf by the prevailing westward Beaufort Sea shelf currents that converge with the Alaska Coastal Current flowing to the northeast along the eastern edge of Barrow Canyon.This work was supported by NSF Grants OPPPP-0436131 to C. Ashjian (S. Braund Subcontract), OPPPP-0436110 to R. Campbell, OPPPP-0436127 to W. Maslowski, OPPPP-0436009 to C. Nicolson and J. Kruse, OPPPP-043166 to S. Okkonen, and OPPPP-0435956 to Y. Spitz, E. Sherr, and B. Sherr
Rationale and study design of the MINERVA study: Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction-UK multicentre collaboration
Introduction The purpose of this study is to assess the ability of two new ECG markers (Regional Repolarisation Instability Index (R2I2) and Peak Electrical Restitution Slope) to predict sudden cardiac death (SCD) or ventricular arrhythmia (VA) events in patients with ischaemic cardiomyopathy undergoing implantation of an implantable cardioverter defibrillator for primary prevention indication. Methods and analysis Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction is a prospective, open label, single blinded, multicentre observational study to establish the efficacy of two ECG biomarkers in predicting VA risk. 440 participants with ischaemic cardiomyopathy undergoing routine first time implantable cardioverter-defibrillator (ICD) implantation for primary prevention indication are currently being recruited. An electrophysiological (EP) study is performed using a non-invasive programmed electrical stimulation protocol via the implanted device. All participants will undergo the EP study hence no randomisation is required. Participants will be followed up over a minimum of 18 months and up to 3 years. The first patient was recruited in August 2016 and the study will be completed at the final participant follow-up visit. The primary endpoint is ventricular fibrillation or sustained ventricular tachycardia >200 beats/min as recorded by the ICD. The secondary endpoint is SCD. Analysis of the ECG data obtained during the EP study will be performed by the core lab where blinding of patient health status and endpoints will be maintained. Ethics and dissemination Ethical approval has been granted by Research Ethics Committees Northern Ireland (reference no. 16/NI/0069). The results will inform the design of a definitive Randomised Controlled Trial (RCT). Dissemination will include peer reviewed journal articles reporting the qualitative and quantitative results, as well as presentations at conferences and lay summaries
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Low dose Btk inhibitors selectively block platelet activation by CLEC-2
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2 in human platelets. Activation is also blocked in patients with X-linked agammaglobulinaemia (XLA) caused by a deficiency or absence of Btk. In contrast, the response to GPVI is delayed in the presence of low concentrations of ibrutinib or in patients with XLA, and tyrosine
phosphorylation of Syk is preserved. A similar set of results is seen with the second-generation inhibitor, acalabrutinib. The differential effect of Btk inhibition in CLEC-2 relative to GPVI signalling is explained by the positive feedback role involving Btk itself, as well as ADP and thromboxane A2 mediated activation of P2Y12 and TP receptors, respectively. This feedback role is not seen in mouse platelets and, consistent with this, CLEC-2-mediated activation is blocked by high but not by low concentrations of ibrutinib. Nevertheless, thrombosis was absent in 8 out of 13 mice treated with ibrutinib. These results show that Btk
inhibitors selectively block activation of human platelets by CLEC-2 relative to GPVI suggesting that they can be used at ‘low dose’ in patients to target CLEC-2 in thrombo-inflammatory disease
Therapy interventions for children with neurodisability : a qualitative scoping study of current practice and perceived research needs.
Background: Therapy interventions emerged four times in the top 10 research priorities in a James Lind Alliance research prioritisation exercise for children with neurodisabilities (Morris C, Simkiss D, Busk M, Morris M, Allard A, Denness J, et al. Setting research priorities to improve the health of children and young people with neurodisability: a British Academy of Childhood Disability-James Lind Alliance Research Priority Setting Partnership. BMJ Open 2015;5:e006233). The National Institute for Health Research (NIHR) commissioned this study as part of an information-gathering exercise in response to this. Objectives: The objectives were to (1) describe the current practice, approaches and schools of thought in relation to physiotherapy, occupational therapy and speech and language therapy for children with neurodisability; (2) explore clinical decision-making; (3) investigate views on outcomes and their measurement, particularly participation as an outcome, that is, the child’s ability to have the opportunity to be involved in life situations and activities (e.g. communication, mobility, interpersonal interactions, self-care, learning and applying knowledge); (4) seek views on the aspects of therapy interventions that have an impact on outcomes; and (5) elicit stakeholder views on research needs and priorities. Design, setting and participants: More than 70 professionals (therapists, service leads, paediatricians and education staff) and 25 parents participated in a qualitative interview (either individually or as part of a focus group). Results: Professional thinking and models of service delivery are in a state of flux and development. There is a move towards goals-focused, family-centred approaches. Work tends to be highly individualised, with few protocols. Parents are certain of the value of therapies, although they may experience difficulties with provision and may seek (additional) private provision. Therapy interventions are conceived as three components: the therapist, the procedures/equipment, etc., and the wider therapeutic environment. They are believed to be highly complex and poorly understood. Although participation is widely endorsed as a core intervention objective of therapy interventions, its suitability, or appropriateness, as an outcome measure was questioned. Other child and/or parent outcomes were identified as more or equally important. Notions of intermediate outcomes – in terms of body structure/function, and the achievement of activities – were regarded as important and not counter to participation-focused approaches. Among therapists, research on intervention effectiveness was (cautiously) welcomed. A number of methodological challenges were identified. A portfolio of study designs – quantitative and qualitative, experimental and observational – was called for, and which included economic evaluation and clear pathways to impact. Limitations: The study was not successful in recruiting children and young people. Further work is required to elucidate the views of this key stakeholder group. Conclusions: Therapy interventions are poorly understood. There was strong support, tempered a little by concerns among some about the feasibility of demonstrating impact, for investment in research
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