Decays of metastable vacua in SQCD

The decay rates of metastable SQCD vacua in ISS-type models, both towards supersymmetric vacua as well as towards other nonsupersymmetric configurations arising in theories with elementary spectators, are estimated numerically in the semiclassical approximation by computing the corresponding multifield bounce configurations. The scaling of the bounce action with respect to the most relevant dimensionless couplings and ratios of scales is analyzed. In the case of the decays towards the susy vacua generated by nonperturbative effects, the results confirm previous analytical estimations of this scaling, obtained by assuming a triangular potential barrier. The decay rates towards susy vacua generated by R-symmetry breaking interactions turn out to be more than sufficiently suppressed for the phenomenologically relevant parameter range, and their behavior in this regime differs from analytic estimations valid for parametrically small scale ratios. It is also shown that in models with spectator fields, even though the decays towards vacua involving nonzero spectator VEVs don't have a strong parametric dependence on the scale ratios, the ISS vacuum can still be made long-lived in the presence of R-symmetry breaking interactions.Comment: 22 pages, 7 figure

The Ursinus Weekly, December 3, 1962

Fourteen Ursinus seniors named to Who\u27s Who in American Colleges • 25th annual Messiah performance scheduled for Thursday evening • Sophomore dance set for Saturday • A report from the president of the men\u27s student government • Computers to be topic of Math Club meeting • Lord & lady, permanent officers named at Friday\u27s senior ball • Russia subject of recent Y lecturer • Relevance of the parish church topic of theologian tomorrow • Curriculum changes discussed • Pre-medicals hear kidney lecture • Editorial: Toward a better Messiah • Alumni snatches • Letters to the editor • Constant activity a way of life with Dr. Maurice Armstrong • Eastern Baptist downs UC cagers 72-59 in season\u27s opener Saturday • Women cagers set schedule • Intramural story • Gymnasium hours set for winter season • Women\u27s swim team faces full schedulehttps://digitalcommons.ursinus.edu/weekly/1282/thumbnail.jp

Children's Medicines in Tanzania: A National Survey of Administration Practices and Preferences.

The dearth of age-appropriate formulations of many medicines for children poses a major challenge to pediatric therapeutic practice, adherence, and health care delivery worldwide. We provide information on current administration practices of pediatric medicines and describe key stakeholder preferences for new formulation characteristics. We surveyed children aged 6-12 years, parents/caregivers over age 18 with children under age 12, and healthcare workers in 10 regions of Tanzania to determine current pediatric medicine prescription and administration practices as well as preferences for new formulations. Analyses were stratified by setting, pediatric age group, parent/caregiver education, and healthcare worker cadre. Complete data were available for 206 children, 202 parents/caregivers, and 202 healthcare workers. Swallowing oral solid dosage forms whole or crushing/dissolving them and mixing with water were the two most frequently reported methods of administration. Children frequently reported disliking medication taste, and many had vomited doses. Healthcare workers reported medicine availability most significantly influences prescribing practices. Most parents/caregivers and children prefer sweet-tasting medicine. Parents/caregivers and healthcare workers prefer oral liquid dosage forms for young children, and had similar thresholds for the maximum number of oral solid dosage forms children at different ages can take. There are many impediments to acceptable and accurate administration of medicines to children. Current practices are associated with poor tolerability and the potential for under- or over-dosing. Children, parents/caregivers, and healthcare workers in Tanzania have clear preferences for tastes and formulations, which should inform the development, manufacturing, and marketing of pediatric medications for resource-limited settings

Alteration of Electroencephalographic Responses to Castration in Cats by Administration of Opioids

The aim of this study was to investigate the effect of opioids on electroencephalogram (EEG) indices of nociception in cats undergoing castration. Cats were randomly assigned to receive one of the four treatments (n=8); 0.2 mg/kg morphine, 0.005 mg/ kg fentanyl, 0.01 mg/kg buprenorphine or 0.2 mg/kg butorphanol, administered subcutaneously (SC) at the time of pre-anesthetic medication. Anesthesia was induced with intravenous propofol and maintained with halothane in oxygen. EEG was recorded continuously in a three electrode montage. Median frequency (F50), total power (PTOT) and 95% spectral edge frequency (F95) derived from the EEG power spectra recorded prior to skin incision (baseline) were compared with those recorded during the ligation of the spermatic cords of both testicles. During the ligation of testicle 1, the mean F50 of cats that received buprenorphine and butorphanol was significantly (p0.05). These results indicate that opioid analgesics, acting at different opioid receptors with variable affinity, produce changes in the EEG responses that reflect their anti-nociceptive efficacy. This study demonstrates the usefulness of the EEG as a valid tool for evaluating analgesic efficacy in cats, as shown in other species of animals in previous studies

Amplification and next generation sequencing of near full-length human enteroviruses for identification and characterisation from clinical samples

© 2018, The Author(s). More than 100 different enterovirus (EV) genotypes infect humans and contribute to substantial morbidity. However, current methods for characterisation of full-length genomes are based on Sanger sequencing of short genomic regions, which are labour-intensive and do not enable comprehensive characterisation of viral populations. Here, we describe a simple and sensitive protocol for the amplification and sequencing of near full-length genomes of human EV species using next generation sequencing. EV genomes were amplified from 89% of samples tested, with Ct values ranging between 15.7 and 39.3. These samples included 7 EV-A genotypes (CVA2, 5–7, 10, 16 and EV71), 19 EV-B genotypes (CVA9, CVB1-6, ECHO3, 4, 6, 7, 9, 11, 16, 18, 25, 29, 30, and EV69), 3 EV-C genotypes (CVA19 and PV2, 3) and 1 EV-D genotype (EV70). We characterised 70 EVs from 58 clinical stool samples and eight reference strains, with a minimum of 100X depth. We found evidence of co-infection in four clinical specimens, each containing two distinct EV genotypes (CVB3/ECHO7, CVB3/ECHO18 and ECHO9/30). Characterisation of the complete genome provided conclusive genotyping of EVs, which can be applied to investigate the intra-host virus evolution of EVs, and allows further identification and investigation of EV outbreaks

The Ursinus Weekly, January 7, 1963

Burst water pipes in 724 lead to semi-evacuation • Speaker from GE will discuss US in space race • PSEA features talks by grad, student teachers • Ed Myers selected representative to National Committee for Youth • College laments death of director Douthett • Psychiatry topic of pre-med meeting • Dolman attends forum on education problems • New heating & power plant now in service • Cub & Key, men\u27s honorary, now accepting applications • Curtain Club version of Antigone scheduled for second semester • Dr. Vorrath concludes discussion of changes in Spanish courses • Schweiker talks on GOP future • Leber open house a Christmas highlight • Chessmen compete in national event • Lynne Maloney, Miss Penna. \u2761, wed last month • Editorial: Unjust, unfair, unwise • Letters to the editor • Snyder to train Civil Defense people • Wrestlers open season Saturday by smashing scared Fords 31-3 • Ursinus gridmen named to MAC all-star teams • Netmen downed by Haverford 72-56 • Intramural story • Ursinus women\u27s club honors Marion Spanglerhttps://digitalcommons.ursinus.edu/weekly/1284/thumbnail.jp

The Ursinus Weekly, October 30, 1961

Loyalty kick-off dinner features famous co-eds • Ursinus College treats Homecoming visitors to decorations, dinners, sports, and a dance: Haverford foe for Homecoming tilt; Campus readied • Six fraternity queens grace Homecoming scene • Work abroad plan offered by ASIS • Pfahler film festival shows Henry V, LaStrada • Placenta subject for Dr. Rathmell in pre-med talk • Senator Smith sees moral force as Khrushchev\u27s chief enemy • A-Phi-O welcomes thirteen pledges • Princeton\u27s Homrighausen visits here tomorrow • Dr. Parsons publishes Norris journal excerpt • Editorial: Censorship here • U.S. government offers junior Summer work • Social Security interview Friday in U.C. Library • Ursinus in the past • U.C. man is drag champ • The Late George Apley Curtain Club Fall choice • MSGA imposes fines for firebox tampering • Ursinus booters beat Muhlenberg, 2-1; Lose to Swarthmore Wenesday, 4-1 • Field hockey girls beat Stroudsburg • Leber-South unbeaten, unscored upon; Leads touch football teams • Wagner wrecks Bear hopes for a \u2761 winning campaign • Sophomore Scholl mainstay at end; Solid defensively, slick offensively • Dean\u27s listhttps://digitalcommons.ursinus.edu/weekly/1302/thumbnail.jp

A microscopic theory of gauge mediation

We construct models of indirect gauge mediation where the dynamics responsible for breaking supersymmetry simultaneously generates a weakly coupled subsector of messengers. This provides a microscopic realization of messenger gauge mediation where the messenger and hidden sector fields are unified into a single sector. The UV theory is SQCD with massless and massive quarks plus singlets, and at low energies it flows to a weakly coupled quiver gauge theory. One node provides the primary source of supersymmetry breaking, which is then transmitted to the node giving rise to the messenger fields. These models break R-symmetry spontaneously, produce realistic gaugino and sfermion masses, and give a heavy gravitino.Comment: 24 pages, 2 figures, accepted to JHEP for publicatio

The Ursinus Weekly, March 5, 1962

Chest drive starts with $2500 goal • Democrats name Dr. Zucker for State Senate candidacy • Pre-med students hear veterinarian • Two one-act plays to aid Chest fund • Rabbi\u27s visit here religious emphasis feature last week • Betsy Friend, Walt Trout chairmen of two-week U.C. charity appeal • Dr. Helfferich\u27s talk encourages support of drive: Freeland\u27s steps site of after lunch address • GOP alliance talk delivered by Neitz • NYU retailing school visited by two co-eds • Elected Ugliest men on campus • English Club to discuss writers Malamud, Bellow • Jean is cover girl for three newspapers • Editorial: Campus Chest; Making peace • Ursinus in the past • Letters to the editor • Old German fraternities resemble the stereotype • Staverosky\u27s art work on display in local bank • Local Protectory\u27s history and work outlined for U.C. • Wrestlers lose to Drexel, 15 to 11; Disappoint Ursinus fans in MACs • Cagers joust Juniata, 61-59 to finish with three wins • Badminton players unbeaten in three • Collegeville retains lead in Phoenix court league • Individuals star in intramurals • Bryn Mawr\u27s swimmers succumb to Ursinus, 36-30 • Rotary Club hears Dr. Miller\u27s letter • Graduate grantshttps://digitalcommons.ursinus.edu/weekly/1313/thumbnail.jp

A Longitudinal Cline Characterizes the Genetic Structure of Human Populations in the Tibetan Plateau

Indigenous populations of the Tibetan plateau have attracted much attention for their good performance at extreme high altitude. Most genetic studies of Tibetan adaptations have used genetic variation data at the genome scale, while genetic inferences about their de- mography and population structure are largely based on uniparental markers. To provide genome-wide information on population structure, we analyzed new and published data of 338 individuals from indigenous populations across the plateau in conjunction with world- wide genetic variation data. We found a clear signal of genetic stratification across the east- west axis within Tibetan samples. Samples from more eastern locations tend to have higher genetic affinity with lowland East Asians, which can be explained by more gene flow from lowland East Asia onto the plateau. Our findings corroborate a previous report of admixture signals in Tibetans, which were based on a subset of the samples analyzed here, but add evidence for isolation by distance in a broader geospatial context