2,431 research outputs found

    Early and late effects of objecthood and spatial frequency on event-related potentials and gamma band activity

    Get PDF
    Background: The visual system may process spatial frequency information in a low-to-high, coarse-to-fine sequence. In particular, low and high spatial frequency information may be processed via different pathways during object recognition, with LSF information projected rapidly to frontal areas and HSF processed later in visual ventral areas. In an electroencephalographic study, we examined the time course of information processing for images filtered to contain different ranges of spatial frequencies. Participants viewed either high spatial frequency (HSF), low spatial frequency (LSF), or unfiltered, broadband (BB) images of objects or non-object textures, classifying them as showing either man-made or natural objects, or non-objects. Event-related potentials (ERPs) and evoked and total gamma band activity (eGBA and tGBA) recorded using the electroencephalogram were compared for object and non-object images across the different spatial frequency ranges. Results: The visual P1 showed independent modulations by object and spatial frequency, while for the N1 these factors interacted. The P1 showed more positive amplitudes for objects than non-objects, and more positive amplitudes for BB than for HSF images, which in turn evoked more positive amplitudes than LSF images. The peak-to-peak N1 showed that the N1 was much reduced for BB non-objects relative to all other images, while HSF and LSF non-objects still elicited as negative an N1 as objects. In contrast, eGBA was influenced by spatial frequency and not objecthood, while tGBA showed a stronger response to objects than non-objects. Conclusions: Different pathways are involved in the processing of low and high spatial frequencies during object recognition, as reflected in interactions between objecthood and spatial frequency in the visual N1 component. Total gamma band seems to be related to a late, probably high-level representational process

    Induction of tumours in intact and partially hepatectomized rats with ethyl methanesulphonate.

    Get PDF
    SINCE the suggestion was made that replicating liver cells may be especially sensitive to chemical carcinogens (Pound, 1968), much evidence has accumulated which supports this idea. As an instance of this, certain carcinogenic alkylating agents, dimethylnitrosamine (DMN) and nitrosomethylurea (NMU), which do not usually induce liver cancer by a single treatment, are hepatocarcinogens if given during the period of restorative hyper-plasia following partial hepatectomy (Craddock, 1971; Craddock and Frei, 1974). These results suggest that repli-cation of alkylated DNA is an initial event in carcinogenesis. Another methy-lating agent, methyl methanesulphonate (MMS), on the other hand, was not found to be a hepatocarcinogen, even when given after partial hepatectomy (Craddock, 1973a). Evidence suggests that this difference may be due to a difference in the nature of the reaction products formed in DNA. It appears likely that 06-alkylguanine rather than 7-alkylgua-nine is relevant in carcinogenesis (Love-less, 1969). DMN and NMU give rise to both these methylated bases, whereas no 06-methylguanine was detectable in rat liver after treatment with MMS (Craddock, 1973b). A small amount was measured after treatment of DNA with MMS in vitro (Lawley and Shah, 1972), and in mice treated with MMS in vivo (Frei and Lawley, 1976). In the case of ethy

    Initial error analysis for the LHC collimation insertion

    Get PDF
    The two cleaning insertions in the LHC, for betatron and momentum collimation, are optimized for an ideal lattice and collimator jaw setup. We have studied a collimation beam line with randomly generated jaw misalignments and quadrupole field and alignment errors, the resultant distortion of the reference orbit being corrected with the help of monitors placed near critical collimators. Different closed orbit errors and beam shapes are considered at the entrance. We report the level of errors for which no corrections are needed and the level for which corrections are not possible

    Numerical Optimization of Collimator Jaw Orientations and Locations in the LHC

    Get PDF
    The collimation system of LHC will consist of flat collimator jaws distributed along the IR7 lattice with the aim of limiting the maximum combined amplitudes of secondary halo particles (born along the edges of the primary collimators). The code DJ (Distribution of Jaws) computes this amplitude using a quasi-analytic algorithm (no tracking), by which the maximum initial angles are found, corresponding to trajectories escaping all secondary jaws. We report the latest version of DJ, which contains the following enhancements: (1) the orientation of each pair of jaws is a free variable (instead of using only vertical, horizontal, or 45 degrees skew jaws); (2) the minimizing method used is "simulated annealing", which, for our case of a discontinuous function of up to 32 variables, always finds a global minimum. Different initial jaw distributions lead to different final ones, but they all give essentially the same maximum halo amplitude; this seems to depend only on the number of jaws and the lattice parameters, particularly the tune-split. We discuss lattice characteristics found favorable for collimation

    Optimization of Collimator Jaw Locations for the LHC

    Get PDF
    A highly effective collimation scheme is required in the LHC to limit heating of the vacuum chamber and superconducting magnets by protons either uncaptured at injection or scattered from the collision points. The proposed system would consist of one set of primary collimators followed by three sets of secondary collimators downstream to clean up protons scattered from the primaries. Each set of collimators would consist of four pairs of jaws - horizontal, vertical, and 45 o and 135 o skew. A study is reported of the optimization of the longitudinal positions of these jaws with the aim of minimizing the maximum betatron amplitudes of protons surviving the collimation system. This is performed using an analytical representation of the action of the jaws and is confirmed by tracking. Significant improvement can be obtained by omitting inactive jaws and adding skew jaws

    Topological Order in Projected Wave Functions and Effective Theories of Quantum Antiferromagnets

    Full text link
    We study the topological order in RVB state derived from Gutzwiller projection of BCS-like mean field state. We propose to construct the topological excitation on the projected RVB state through Gutzwiller projection of mean field state with inserted Z2Z_{2} flux tube. We prove that all projected RVB states derived from bipartite effective theories, no matter the gauge structure in the mean field ansatz, are positive definite in the sense of the Marshall sign rule, which provides a universal origin for the absence of topological order in such RVB state.Comment: 5 pages, 1 figure
    • 

    corecore