El desarrollo de la expresión escrita en la Universidades de Madrid: los trabajos fin de grado en los estudios de ADE

Ante la preocupación generalizada de la sociedad acerca de las carencias de los jóvenes en cuanto a la expresión escrita, el presente artículo tiene como objetivo analizar si esta competencia se desarrolla y se evalúa en la Universidad. La comunidad académica no puede permanecer ajena a este problema, por lo que es importante que incluya dentro de sus planes de estudio la mejora de esta competencia. El desarrollo de la expresión escrita se incluye entre las competencias generales instrumentales para el aprendizaje y la formación. Se considera, por tanto, una competencia necesaria para cualquier tipo de estudio y cualquier perfil profesional. En particular, en los estudios de ADE, la adquisición de la expresión escrita no se circunscribe a ninguna asignatura en concreto, sino que puede desarrollarse en varias de ellas a lo largo de la titulación. No obstante, el Trabajo de Fin de Grado es una de las asignaturas en la que mejor puede enmarcarse la consecución de esta habilidad. Por este motivo, se realiza un análisis sobre el diseño, la organización, el contenido y la evaluación del Trabajo de Fin de Grado en todas las universidades de la Comunidad de Madrid, tanto públicas como privadas, en las que se imparte el Grado en Administración y Dirección de Empresas. El estudio se ha elaborado a partir de la información de los planes de estudio y de las guías docentes de la asignatura, disponibles en las páginas web de las universidades

Propuesta de una investigación participativa para la asignatura ¿Administración de la empresa familiar?: utilización del análisis comparativo y la entrevista en profundidad

En este estudio se expone una de las actividades llevadas a cabo en la asignatura “Administración de la Empresa Familiar”. Esta práctica se realiza utilizando distintas metodologías docentes afines al Espacio Europeo de Educación Superior: la lección magistral, el estudio de casos y el aprendizaje cooperativo, combinando además estos métodos con un análisis comparativo entre empresas y la técnica de la entrevista en profundidad. El objetivo perseguido es acercar al estudiante a la realidad empresarial que le rodea, en el que el 85 1 por ciento de las empresas son familiares. Se pretende que el estudiante comparta experiencias y se integre durante unas horas en una empresa familiar para que conozca su funcionamiento y pueda aplicar, en la práctica, lo que en teoría se explica en el aula. Además, se intenta que la búsqueda de información sobre la empresa elegida, el contacto que el estudiante mantenga en la entrevista así como la elaboración del informe que el estudiante tendrá que elaborar después, despierte en el alumno el interés por la investigación

Effect of high hydrostatic pressure challenge on biogenic amines, microbiota, and sensory profile in traditional poultry- and pork-based semidried fermented sausage

Research Areas: Food Science & TechnologyThe processing of traditional poultry- and pork-based semidried fermented smoked sausages needs to bemodernized to improve product quality and further extend its shelf life. The aim of the present study was to applydifferent combinations of high pressure (300 to 600 MPa) and time (154 to 1,800 s) on the sausages using an experimentaldesign based on response surface methodology. The chemical, microbial, and sensory characteristics of sausages treatedwith high-pressure processing (HPP) were investigated. HPP application to semidried fermented sausages resulted incolor changes, which could be dependent on the ingredients, formulation, and smoking conditions used. Nevertheless,none of the HPP treatments applied resulted in detectable changes in sensory properties, as tested in a triangle test andconfirmed by the analysis of focus groups assessment. Significant differences were detected for lactic acid bacteria (LAB)counts from 344 MPa and 1,530 s onward, with a marked decrease for the combination of 600 MPa and 960 s (P<0.05).Coagulase-negativestaphylococcishowed higher tolerance to the increase in pressure than LAB. HPP induced a microbialreduction onEnterobacteriaceae, molds, and yeasts, minimizing the production of the main biogenic amines. However,the polyamines (spermine and spermidine) increased since their metabolic use by microorganisms did not occur. Giventhe reduction of the main spoilage microbial indicators with no detectable sensory changes observed with the binomialcondition of 600 MPa and 960 s, this was chosen as the optimal combination to be further applied.info:eu-repo/semantics/publishedVersio

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Design, synthesis and antimalarial evaluation of novel thiazole derivatives

As part of our medicinal chemistry program’s ongoing search for compounds with antimalarial activity, we prepared a series of thiazole analogs and conducted a SAR study analyzing their in vitro activities against the chloroquine-sensitive Plasmodium falciparum 3D7 strain. The results indicate that modifications of the N-aryl amide group linked to the thiazole ring are the most significant in terms of in vitro antimalarial activity, leading to compounds with high antimalarial potency and low cytotoxicity in HepG2 cell lines. Furthermore, the observed SAR implies that non-bulky, electron-withdrawing groups are preferred at ortho position on the phenyl ring, whereas small atoms such as H or F are preferred at para position. Finally, replacement of the phenyl ring by a pyridine affords a compound with similar potency, but with potentially better physicochemical properties which could constitute a new line of research for further studies.M.C., A.C.C., J.A.M., N.R. and J.F.S.-C. thank the Ministerio de Ciencia e Innovación of Spain (research grant CTQ2011-27560) and the Consellería d’Educació, Investigació, Cultura i Esport de la Generalitat Valenciana (research grant PROMETEO/2013/027) for financial support

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage

Emerging artemisinin resistance in Plasmodium falciparum malaria has the potential to become a global public health crisis. In Southeast Asia, this phenomenon clinically manifests in the form of delayed parasite clearance following artemisinin treatment. Reduced artemisinin susceptibility is limited to the early ring stage window, which is sufficient to allow parasites to survive the short half-life of artemisinin exposure. A screen of known clinically-implemented antimalarial drugs was performed to identify a drug capable of enhancing the killing activity of artemisinins during this critical resistance window. As a result, lumefantrine was found to increase the killing activity of artemisinin against an artemisinin-resistant clinical isolate harboring the C580Y kelch13 mutation. Isobologram analysis revealed synergism during the early ring stage resistance window, when lumefantrine was combined with artemether, an artemisinin derivative clinically partnered with lumefantrine. These findings suggest that lumefantrine should be clinically explored as a partner drug in artemisinin-based combination therapies to control emerging artemisinin resistance

Acoustic Evidence of Shallow Gas Occurrences in the Offshore Sinú Fold Belt, Colombian Caribbean Sea

High-resolution seismic analysis and bathymetry data, used in the Offshore Sinú Fold Belt (OSFB), have revealed seabed and sub-surface anomalies, which were probably caused by the presence of shallow gas within the sedimentary records. Shallow gas is widely detected by the frequent presence of anomalous acoustic reflections including acoustic blanking, enhanced reflections, acoustic plumes, pockmarks, and dome structures. More than 30 anomalies that occur within a subsurface depth of ~65 m were acoustically detected within an area of 1000 km2 on the continental shelf and upper continental slope, in water depths ranging from −20 to −1300 m. Moreover, a map with the spatial distribution of the gas occurrences is shown. A close relationship between the locally elevated seabed (dome structures), pockmarks, and acoustic blanking was found. Most of the active pockmarks may be closely related to the submarine path of the Uramita Fault, indicating that the gas occurrences are controlled by active faulting. The shallow gas occurrence was confirmed by the generation of authigenic carbonate and the occurrence of chemosymbiotic biological communities sampled in the area. Although there is an admixture of biogenic gas, it is believed that many of the features observed relate to thermogenic gas. The identification of these anomalies represents a useful basis for an assessment of marine geohazards and can serve as a hydrocarbon exploration tool