Axions and saxions from the primordial supersymmetric plasma and extra radiation signatures

We calculate the rate for thermal production of axions and saxions via scattering of quarks, gluons, squarks, and gluinos in the primordial supersymmetric plasma. Systematic field theoretical methods such as hard thermal loop resummation are applied to obtain a finite result in a gauge-invariant way that is consistent to leading order in the strong gauge coupling. We calculate the thermally produced yield and the decoupling temperature for both axions and saxions. For the generic case in which saxion decays into axions are possible, the emitted axions can constitute extra radiation already prior to big bang nucleosynthesis and well thereafter. We update associated limits imposed by recent studies of the primordial helium-4 abundance and by precision cosmology of the cosmic microwave background and large scale structure. We show that the trend towards extra radiation seen in those studies can be explained by late decays of thermal saxions into axions and that upcoming Planck results will probe supersymmetric axion models with unprecedented sensitivity.Comment: 16 pages, 7 figures; v2: references added, minor clarifying additions, matches published versio

On the APM power spectrum and the CMB anisotropy: Evidence for a phase transition during inflation?

Adams et al. (1997b) have noted that according to our current understanding of the unification of fundamental interactions, there should have been phase transitions associated with spontaneous symmetry breaking {\em during} the inflationary era. This may have resulted in the breaking of scale-invariance of the primordial density perturbation for brief periods. A possible such feature was identified in the power spectrum of galaxy clustering in the APM survey at the scale $k \sim 0.1 h$ Mpc^{-1} and it was shown that the secondary acoustic peaks in the power spectrum of the CMB anisotropy should consequently be suppressed. We demonstrate that this prediction is confirmed by the recent Boomerang and Maxima observations, which favour a step-like spectral feature in the range $k \sim (0.06-0.6)h$ Mpc^{-1}, independently of the similar previous indication from the APM data. Such a spectral break enables an excellent fit to both APM and CMB data with a baryon density consistent with the BBN value. It also allows the possibility of a matter-dominated universe with zero cosmological constant, which we show can now account for even the evolution of the abundance of rich clusters.Comment: 11 pages (LaTeX, mn.sty) incl. 9 eps figs; small changes to match version accepted for publication in MNRA

Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry

AIMS: Calmodulinopathy due to mutations in any of the three CALM genes (CALM1-3) causes life-threatening arrhythmia syndromes, especially in young individuals. The International Calmodulinopathy Registry (ICalmR) aims to define and link the increasing complexity of the clinical presentation to the underlying molecular mechanisms. METHODS AND RESULTS: The ICalmR is an international, collaborative, observational study, assembling and analysing clinical and genetic data on CALM-positive patients. The ICalmR has enrolled 140 subjects (median age 10.8 years [interquartile range 5-19]), 97 index cases and 43 family members. CALM-LQTS and CALM-CPVT are the prevalent phenotypes. Primary neurological manifestations, unrelated to post-anoxic sequelae, manifested in 20 patients. Calmodulinopathy remains associated with a high arrhythmic event rate (symptomatic patients, n = 103, 74%). However, compared with the original 2019 cohort, there was a reduced frequency and severity of all cardiac events (61% vs. 85%; P = .001) and sudden death (9% vs. 27%; P = .008). Data on therapy do not allow definitive recommendations. Cardiac structural abnormalities, either cardiomyopathy or congenital heart defects, are present in 30% of patients, mainly CALM-LQTS, and lethal cases of heart failure have occurred. The number of familial cases and of families with strikingly different phenotypes is increasing. CONCLUSION: Calmodulinopathy has pleiotropic presentations, from channelopathy to syndromic forms. Clinical severity ranges from the early onset of life-threatening arrhythmias to the absence of symptoms, and the percentage of milder and familial forms is increasing. There are no hard data to guide therapy, and current management includes pharmacological and surgical antiadrenergic interventions with sodium channel blockers often accompanied by an implantable cardioverter-defibrillator

Reanalysis of a 10-year record (2004-2013) of seasonal mass balances at Langenferner/Vedretta Lunga, Ortler Alps, Italy

Records of glacier mass balance represent important data in climate science and their uncertainties affect calculations of sea level rise and other societally relevant environmental projections. In order to reduce and quantify uncertainties in mass balance series obtained by direct glaciological measurements, we present a detailed reanalysis workflow which was applied to the 10-year record (2004 to 2013) of seasonal mass balance of Langenferner, a small glacier in the European Eastern Alps. The approach involves a methodological homogenization of available point values and the creation of pseudo-observations of point mass balance for years and locations without measurements by the application of a process-based model constrained by snow line observations. We examine the uncertainties related to the extrapolation of point data using a variety of methods and consequently present a more rigorous uncertainty assessment than is usually reported in the literature. Results reveal that the reanalyzed balance record considerably differs from the original one mainly for the first half of the observation period. For annual balances these misfits reach the order of &gt; 300 kg m-2 and could primarily be attributed to a lack of measurements in the upper glacier part and to the use of outdated glacier outlines. For winter balances respective differences are smaller (up to 233 kg m-2) and they originate primarily from methodological inhomogeneities in the original series. Remaining random uncertainties in the reanalyzed series are mainly determined by the extrapolation of point data to the glacier scale and are on the order of ±79 kg m-2 for annual and ±52 kg m-2 for winter balances with values for single years/seasons reaching ±136 kg m-2. A comparison of the glaciological results to those obtained by the geodetic method for the period 2005 to 2013 based on airborne laser-scanning data reveals that no significant bias of the reanalyzed record is detectable.</p