3,572 research outputs found

    Insetos que atacam o camu-camuzeiro (Myrciaria dubia (H.B.K.) Mc Vaugh Myrtaceae) em cultivos paraenses.

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    Human Adipose Tissue As A Reservoir For Memory Cd4(+) T Cells And Hiv

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    Objective: The objective of this study is to determine whether adipose tissue functions as a reservoir for HIV-1. Design: We examined memory CD4(+) T cells and HIV DNA in adipose tissue-stromal vascular fraction (AT-SVF) of five patients [four antiretroviral therapy (ART)-treated and one untreated]. To determine whether adipocytes stimulate CD4(+) T cells and regulate HIV production, primary human adipose cells were cocultured with HIV-infected CD4(+) T cells. Methods: AT-SVF T cells were studied by flow cytometry, and AT-SVF HIV DNA (Gag and Env) was examined by nested PCR and sequence analyses. CD4(+) T-cell activation and HIV production were measured by flow cytometry and ELISA. Results: AT-SVF CD3(+) T cells were activated (\u3e60% CD69(+)) memory CD4(+) and CD8(+) T cells in uninfected and HIV-infected persons, but the AT-SVF CD4(+)/CD8(+) ratio was lower in HIV patients. HIV DNA(Gag and Env) was detected in AT-SVF of all five patients examined by nested PCR, comparably to other tissues [peripheral blood mononuclear cell (PBMC), lymph node or thymus]. In coculture experiments, adipocytes increased CD4(+) T-cell activation and HIV production approximately two to three-fold in synergy with gamma-chain cytokines interleukin (IL)-2, IL7 or IL15. These effects were mitigated by neutralizing antibodies against IL6 and integrin-alpha 1 beta 1. Adipocytes also enhanced T-cell viability. Conclusion: Adipose tissues of ART-treated patients harbour activated memory CD4(+) T cells and HIV DNA. Adipocytes promote CD4(+) T-cell activation and HIV production in concert with intrinsic adipose factors. Adipose tissue may be an important reservoir for HIV. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved

    Regeneration of Raney®-Nickel Catalyst for the Synthesis of High-Value Amino-Ester Renewable Monomers

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    Aiming to synthesize high-value renewable monomers for the preparation of renewable specialty polyamides, we designed a new protocol. Amino-esters, produced via the hydrogenation of unsaturated nitrile-esters, are alternative monomers for the production of these polymers. A high monomer yield can be obtained using a Raney®-nickel catalyst despite the drawback of fast deactivation. The hydrogenation of 10-cyano-9-decenoate (UNE11) was tentatively reactivated by three different regeneration procedures: solvent wash, regeneration under hydrogen, and regeneration under sonication. Among these procedures, the in-pot catalyst regeneration (H2 30 bar, 150 °C) demonstrated complete activity recovery and full recycling

    The one dimensional Kondo lattice model at partial band filling

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    The Kondo lattice model introduced in 1977 describes a lattice of localized magnetic moments interacting with a sea of conduction electrons. It is one of the most important canonical models in the study of a class of rare earth compounds, called heavy fermion systems, and as such has been studied intensively by a wide variety of techniques for more than a quarter of a century. This review focuses on the one dimensional case at partial band filling, in which the number of conduction electrons is less than the number of localized moments. The theoretical understanding, based on the bosonized solution, of the conventional Kondo lattice model is presented in great detail. This review divides naturally into two parts, the first relating to the description of the formalism, and the second to its application. After an all-inclusive description of the bosonization technique, the bosonized form of the Kondo lattice hamiltonian is constructed in detail. Next the double-exchange ordering, Kondo singlet formation, the RKKY interaction and spin polaron formation are described comprehensively. An in-depth analysis of the phase diagram follows, with special emphasis on the destruction of the ferromagnetic phase by spin-flip disorder scattering, and of recent numerical results. The results are shown to hold for both antiferromagnetic and ferromagnetic Kondo lattice. The general exposition is pedagogic in tone.Comment: Review, 258 pages, 19 figure

    List coloring in the absence of a linear forest.

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    The k-Coloring problem is to decide whether a graph can be colored with at most k colors such that no two adjacent vertices receive the same color. The Listk-Coloring problem requires in addition that every vertex u must receive a color from some given set L(u)⊆{1,…,k}. Let Pn denote the path on n vertices, and G+H and rH the disjoint union of two graphs G and H and r copies of H, respectively. For any two fixed integers k and r, we show that Listk-Coloring can be solved in polynomial time for graphs with no induced rP1+P5, hereby extending the result of Hoàng, Kamiński, Lozin, Sawada and Shu for graphs with no induced P5. Our result is tight; we prove that for any graph H that is a supergraph of P1+P5 with at least 5 edges, already List 5-Coloring is NP-complete for graphs with no induced H

    Detailed spectral and morphological analysis of the shell type SNR RCW 86

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    Aims: We aim for an understanding of the morphological and spectral properties of the supernova remnant RCW~86 and for insights into the production mechanism leading to the RCW~86 very high-energy gamma-ray emission. Methods: We analyzed High Energy Spectroscopic System data that had increased sensitivity compared to the observations presented in the RCW~86 H.E.S.S. discovery publication. Studies of the morphological correlation between the 0.5-1~keV X-ray band, the 2-5~keV X-ray band, radio, and gamma-ray emissions have been performed as well as broadband modeling of the spectral energy distribution with two different emission models. Results:We present the first conclusive evidence that the TeV gamma-ray emission region is shell-like based on our morphological studies. The comparison with 2-5~keV X-ray data reveals a correlation with the 0.4-50~TeV gamma-ray emission.The spectrum of RCW~86 is best described by a power law with an exponential cutoff at Ecut=(3.5±1.2stat)E_{cut}=(3.5\pm 1.2_{stat}) TeV and a spectral index of Γ\Gamma~1.6±0.21.6\pm 0.2. A static leptonic one-zone model adequately describes the measured spectral energy distribution of RCW~86, with the resultant total kinetic energy of the electrons above 1 GeV being equivalent to \sim0.1\% of the initial kinetic energy of a Type I a supernova explosion. When using a hadronic model, a magnetic field of BB~100μ\muG is needed to represent the measured data. Although this is comparable to formerly published estimates, a standard E2^{-2} spectrum for the proton distribution cannot describe the gamma-ray data. Instead, a spectral index of Γp\Gamma_p~1.7 would be required, which implies that ~7×1049/ncm37\times 10^{49}/n_{cm^{-3}}erg has been transferred into high-energy protons with the effective density ncm3=n/1n_{cm^{-3}}=n/ 1 cm^-3. This is about 10\% of the kinetic energy of a typical Type Ia supernova under the assumption of a density of 1~cm^-3.Comment: accepted for publication by A&

    The exceptionally powerful TeV gamma-ray emitters in the Large Magellanic Cloud

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    The Large Magellanic Cloud, a satellite galaxy of the Milky Way, has been observed with the High Energy Stereoscopic System (H.E.S.S.) above an energy of 100 billion electron volts for a deep exposure of 210 hours. Three sources of different types were detected: the pulsar wind nebula of the most energetic pulsar known N 157B, the radio-loud supernova remnant N 132D and the largest non-thermal X-ray shell - the superbubble 30 Dor C. The unique object SN 1987A is, surprisingly, not detected, which constrains the theoretical framework of particle acceleration in very young supernova remnants. These detections reveal the most energetic tip of a gamma-ray source population in an external galaxy, and provide via 30 Dor C the unambiguous detection of gamma-ray emission from a superbubble.Comment: Published in Science Magazine (Jan. 23, 2015). This ArXiv version has the supplementary online material incorporated as an appendix to the main pape
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