t-books: merging traditional storybooks with electronics

In this paper, we describe the design process and a first pilot study of t-books, a toolkit consisting of an electronic platform, a book with slots on it and a set of picture cards that children place on the book to interact and explore the narrative. t-books was motivated by the wish to offer children an environment where they can play with the language elements, while engaging as story authors. In this process children can enlarge their vocabulary, experiment different storylines, simultaneously learning to create meaningful sequences that evolve to a narrative. At the same time children can build their own story world by choosing among a diversity of different characters, settings and actions according to their needs and preferences, thus generating a simulation environment within the story universe, where alternative scenarios, and what-if questions can be posed and tested. A first insight of children’s interaction with t-books was very promising showing that children were highly motivated to create and share their own stories.Fundação para a Ciência e a Tecnologia (FCT) - PTDC/CPE-CED/110417/2009 Doctoral Grant: SFRH / BD / 62531 / 2009

A tangible platform for mixing and remixing narratives

In this article we will present a study on the social network Proedi, which included the analysis of the content of a discussion forum entitled "Technology vs Methodology", formal in its constitution, which involves a group of future teachers of a master's degree in Teaching at the University of Minho. The objective of the review was to evaluate the presence of teaching, one of the components of the Community of Inquiry Model of [1], on the basis of an analysis grid containing the categories and keywords that have been adapted by the authors of the original model. The results obtained show that the teaching presence detected in that forum resulted from the engagement and willingness to learn of the group added to the e-moderator that, throughout the discussion, was always questioning the members and instilling a critical reflection on the topic under consideration.(undefined

ABORDAGEM CLÍNICA NA SÍNDROME DE MIRIZZI: ANÁLISE RETROSPETIVA

Introduction: The Mirizzi syndrome consists of the obstruction either of the common hepatic duct or the choledocus, secondary to the impact of calculus in the cystic duct or in the gallbladder infundibulum. According to the Csendes classification, Mirizzi syndrome is divided into five types that involve different surgical procedures. Materials and methods: After a literature review, fifteen patients with Mirizzi Syndrome are retrospectively described between 2008 and 2018 at the Unidade Saude da Guarda (ULSG). The clinical records were reviewed. Clinical data, gender, clinical condition, test results, operative procedures and type of Mirizzi syndrome (according to Csendes) were examined. Results: Of the 15 patients, 11 (73,3%) were women and 4 (26,7%) men. All of them (100%) showed abdominal pain, 14 (93,3%) nausea and vomit, 10 (66,7%) symptoms of cholangitis / acute cholecystitis, 5 (33%) recurrent jaundice, 4 (26,6%) choluria and weight loss and 2 (13,3%) itch. Every cases of Mirizzi syndrome was diagnosed intraoperatively and requiring conversion to laparotomy. Were identified 5(33,3%) cases with type III, 4 (26,6%) with type I, 3 (20%) with type II, 2 (13,3%) with type IV and 1 (6,7%) with type V. In 5 (33,3%) patients was treated with cholecystectomy and bilio-digestive anastomosis on Roux-en-Y, 3 (20%) by total cholecystectomy with Kher drain, 2 (13,3%) by total cholecystectomy, partial and partial with Kher drain, and finally 1 (6,6%) by cholecystectomy with Kher drain with suture of the gastric orifice. Conclusion: The treatment of Mirizzi Syndrome is a diagnosis and surgical challenge. Despite the era of laparoscopic cholecystectomy, the laparotomic treatment of Mirizzi syndrome should be the standard procedure.Introdução: A Síndrome de Mirizzi resulta da compressão extrínseca do canal hepático comum (CHC) e/ou colédoco pela impactação de cálculos no canal cístico ou no infundíbulo da vesícula biliar. Segundo a classificação de Csendes, dividide-se em 5 tipos que implicam diferentes técnicas cirúrgicas. Materiais e Métodos: Após uma breve revisão bibliográfica, descrevem-se retrospetivamente quinze doentes diagnosticados com Síndrome de Mirizzi, entre 2008 e 2018, na Unidade Local de Saúde da Guarda (ULSG). A análise dos respectivos processos clínicos permitiu recolher dados relativamente ao género, quadro clínico, resultados de exames complementares de diagnóstico, momento do diagnóstico, tipo de síndrome de Mirizzi (segundo Csendes) e tratamento cirúrgico. Resultados: Dos 15 doentes, 11 (73,3%) eram mulheres e 4 (26,7%) homens. Todos os doentes (100%) apresentaram dor abdominal, 14 (93,3%) náuseas e vómitos, 10 (66,7%) sintomas de colangite/colecistite aguda, 5 (33%) icterícia recorrente, 4 (26,6%) colúria e emagrecimento e 2 (13,3%) prurido. O diagnóstico foi estabelecido, em todos os casos, intra-operatoriamente com necessidade de conversão para laparotomia, sendo: 5 (33,3%) do tipo III, 4 (26,6%) do tipo I, 3 (20%) do tipo II, 2 (13,3%) do tipo IV e 1 (6,7%) do tipo V. Foi realizada em 5 (33,3%) doentes colecistectomia com anastomose bilio-digestiva em Y de Roux, em 3 (20%) colecistectomia total com dreno de Kehr, em 2 (13,3%) colecistectomia total, parcial e parcial com dreno de Kehr e por fim, em 1 (6,6%) colecistectomia com dreno de Kehr com sutura de orifício gástrico. Conclusões: O tratamento da Síndrome de Mirizzi é um desafio diagnóstico e cirúrgico. Apesar da era da colecistectomia laparoscópica, a via laparotómica deve ser a via de abordagem de eleição para o tratamento cirúrgico desta entidade

Intenção de Rotatividade e Percepção de Suporte Organizacional em um Órgão Público Federal

Este estudo testou a influência do suporte organizacional percebido na intenção de rotatividade de servidores públicos efetivos de um Órgão da Administração Pública Federal. Um total de 112 servidores preencheu um questionário composto por medidas validadas no Brasil. Os resultados descritivos revelaram que os servidores têm um alto desejo de deixar a organização e avaliam negativamente o suporte organizacional voltado à ascensão, promoção e salários e o suporte organizacional voltado à gestão do desempenho. Os resultados da regressão múltipla hierárquica indicaram que quanto menor é a percepção de suporte organizacional, maior é a intenção de rotatividade. Além disso, idade e tempo na organização também influenciaram a intenção de rotatividade. Os resultados estimulam a discussão sobre práticas e políticas de recursos humanos e valorização no serviço público.Revista do Serviço Público - RSP, v. 67, n.2, 147-172Gestão de PessoasSaúdeISSN eletrônico: 2357-8017ISSN impresso: 0034-924

Magnetoliposomes based on magnetite nanoparticles

In this work, magnetic nanoparticles of magnetite were prepared by soft chemical methods, using different surfactants as templating media. These nanoparticles were either covered with a lipid bilayer, forming dry magnetoliposomes, or entrapped in liposomes - aqueous magnetoliposomes.FCT, FEDER, COMPETE/QREN/EU for financial support to CFUM (Strategic Project PEst-C/FIS/UI0607/2011) and to the research project PTDC/QUI/81238/2006 (FCOMP-01-0124-FEDER-007467)

Fluorescence studies on new potential antitumoral 1,3-diarylurea derivatives in the thieno[3,2-b]pyridine series encapsulated in magnetoliposomes

Magnetic nanoparticles of magnetite and of nickel core with silica shell were prepared and either covered with a lipid bilayer or entrapped in liposomes, forming magnetoliposomes. New potential antitumoral 1,3-diarylurea derivatives of thieno[3,2-b]pyridines were then encapsulated in liposomes and magnetoliposomes and their photophysical behavior was investigated.Fundação para a Ciência e a Tecnologia (FCT), FEDER, COMPETE/QREN/EU for financial support to CFUM (PEst-C/FIS/UI0607/2011) and CQ/UM (PEst-C/QUI/UI0686/2011) and to research projects PTDC/QUI/81238/2006 (FCOMP-01-0124-FEDER-007467), PTDC/QUIQUI/111060/2009 (FCOMP-01-0124-FEDER-015603)

Surface crystallization of ionic liquid crystals

The evidence for surface crystallization in ionic liquids is scarce. The existing reports seem to be contradictory as for its driving forces, since in the two compounds investigated in the literature, the contribution of coloumbic and van der Waals forces is very different. In this work 1-dodecyl-3- methylimidazolium tetrafluoroborate was studied and its surface crystallization characterized by surface tension, ellipsometry and optical microscopy. The results obtained seem to reconcile previous observations, and it was further shown, using the same techniques, that this phenomenon is prevalent in other ionic liquids. MD simulation results illustrate the different possibilities of organization, providing reasonable models to rationalize the experimental observations.This work was developed with the scope of the project CICECO – Aveiro Institute of Materials, UID/CTM/50011/2019, Associate Laboratory LSRE-LCM, UID/EQU/50020/2019, and of Instituto de Telecomunicaço˜es/IT (UID/EEA/50008/2013) – funded by national funds through FCT/MCTES (PIDDAC). M. A. R. M. acknowledges financial support from NORTE-01-0145-FEDER- 000006 – funded by NORTE2020 through PT2020 and ERDF, and P. J. C. acknowledges the FCT for the contract IF/00758/2015. A. R. Bastos from UA is acknowledged for help in the ellipsometry measurements. M. C. C. aknowledges FAPESP (2012/05027-1) and CNPq (310272/2017) for financial support.info:eu-repo/semantics/publishedVersio

Predictors of Psychological Well-Being during Behavioral Obesity Treatment in Women

This study examined the association of autonomy-related variables, including exercise motivation, with psychological well-being and quality of life, during obesity treatment. Middle-aged overweight/obese women (n = 239) participated in a 1-year behavioral program and completed questionnaires measuring need support, general self-determination, and exercise and treatment motivation. General and obesity-specific health-related quality of life (HRQOL), self-esteem, depression, and anxiety were also assessed. Results showed positive correlations of self-determination and perceived need support with HRQOL and self-esteem, and negative associations with depression and anxiety (P < .001). Treatment autonomous motivation correlated positively with physical (P = .004) and weight-related HRQOL (P < .001), and negatively with depression (P = .025) and anxiety (P = .001). Exercise autonomous motivation was positively correlated with physical HRQOL (P < .001), mental HRQOL (P = .003), weight-related HRQOL (P < .001), and self-esteem (P = .003), and negatively with anxiety (P = .016). Findings confirm that self-determination theory's predictions apply to this population and setting, showing that self-determination, perceived need support, and autonomous self-regulation positively predict HRQOL and psychological well-being

2,4,5-Triaminopyrimidines as blue fluorescent probes for cell viability monitoring: synthesis, photophysical properties, and microscopy applications

Monitoring cell viability is critical in cell biology, pathology, and drug discovery. Most cell viability assays are cell-destructive, time-consuming, expensive, and/or hazardous. Herein, we present a series of newly synthesized 2,4,5-triaminopyrimidine derivatives able to discriminate between live and dead cells. To our knowledge, these compounds are the first fluorescent nucleobase analogues (FNAs) with cell viability monitoring potential. These new fluorescent molecules are synthesized using highly efficient and cost- effective methods and feature unprecedented photophysical properties (longer absorption and emission wavelengths, environment-sensitive emission, and unprecedented brightness within FNAs). Using a live– dead Saccharomyces cerevisiae cell and theoretical assays, the fluorescent 2,4,5-triaminopyrimidine derivatives were found to specifically accumulate inside dead cells by interacting with dsDNA grooves, thus paving the way for the emergence of novel and safe fluorescent cell viability markers emitting in the blue region. As the majority of commercially available viability dyes emit in the green to red region of the visible spectrum, these novel markers might be useful to meet the needs of blue markers for co-staining combinations