2,152 research outputs found
Prostate cancer radiotherapy: potential applications of metal nanoparticles for imaging and therapy
Prostate cancer (CaP) is the most commonly diagnosed cancer in males. There have been dramatic technical advances in radiotherapy delivery, enabling higher doses of radiotherapy to primary cancer, involved lymph nodes and oligometastases with acceptable normal tissue toxicity. Despite this, many patients relapse following primary radical therapy, and novel treatment approaches are required. Metal nanoparticles are agents that promise to improve diagnostic imaging and image-guided radiotherapy and to selectively enhance radiotherapy effectiveness in CaP. We summarize current radiotherapy treatment approaches for CaP and consider pre-clinical and clinical evidence for metal nanoparticles in this condition
P05.24. An integrative approach to improving quality of life for underserved women with advanced cancer at the end of life
Validity of the activPAL3 activity monitor in people moderately affected by Multiple Sclerosis
Background: Walking is the primary form of physical activity performed by people with Multiple Sclerosis (MS), therefore it is important to ensure the validity of tools employed to measure walking activity. The aim of this study was to assess the criterion validity of the activPAL3 activity monitor during overground walking in people with MS.\ud
Methods: Validity of the activPAL3 accelerometer was compared to video observation in 20 people moderately affected by MS. Participants walked 20-30m twice along a straight quiet corridor at a comfortable speed.\ud
Results: Inter-rater reliability of video observations was excellent (all intraclass correlations > 0.99). The mean difference (activPAL3- mean of raters) was -4.70 ± 9.09, -4.55 s ± 10.76 and 1.11 s ± 1.11 for steps taken, walking duration and upright duration respectively. These differences represented 8.7, 10.0 and 1.8% of the mean for each measure respectively. The activPAL3 tended to underestimate steps taken and walking duration in those who walked at cadences of ≤ 38 steps/minute by 60% and 47% respectively.\ud
Discussion: The activPAL3 is valid for measuring walking activity in people moderately affected by MS. It is accurate for upright duration regardless of cadence. In participants with slow walking cadences, outcomes of steps taken and walking duration should be interpreted with caution
What e-patients want from the doctor-patient relationship: content analysis of posts on discussion boards.
People with long-term conditions are encouraged to take control and ownership of managing their condition. Interactions between health care staff and patients become partnerships with sharing of expertise. This has changed the doctor-patient relationship and the division of roles and responsibilities that traditionally existed, but what each party expects from the other may not always be clear. Information that people with long-term conditions share on Internet discussion boards can provide useful insights into their expectations of health care staff. This paper reports on a small study about the expectations that people with a long-term condition (diabetes) have of their doctors using information gleaned from Internet discussion boards
Working group written presentation: Trapped radiation effects
The results of the Trapped Radiation Effects Panel for the Space Environmental Effects on Materials Workshop are presented. The needs of the space community for new data regarding effects of the space environment on materials, including electronics are listed. A series of questions asked of each of the panels at the workshop are addressed. Areas of research which should be pursued to satisfy the requirements for better knowledge of the environment and better understanding of the effects of the energetic charged particle environment on new materials and advanced electronics technology are suggested
emiT: an apparatus to test time reversal invariance in polarized neutron decay
We describe an apparatus used to measure the triple-correlation term (\D
\hat{\sigma}_n\cdot p_e\times p_\nu) in the beta-decay of polarized neutrons.
The \D-coefficient is sensitive to possible violations of time reversal
invariance. The detector has an octagonal symmetry that optimizes
electron-proton coincidence rates and reduces systematic effects. A beam of
longitudinally polarized cold neutrons passes through the detector chamber,
where a small fraction beta-decay. The final-state protons are accelerated and
focused onto arrays of cooled semiconductor diodes, while the coincident
electrons are detected using panels of plastic scintillator. Details regarding
the design and performance of the proton detectors, beta detectors and the
electronics used in the data collection system are presented. The neutron beam
characteristics, the spin-transport magnetic fields, and polarization
measurements are also described.Comment: 15 pages, 13 figure
Search for a T-odd, P-even Triple Correlation in Neutron Decay
Background: Time-reversal-invariance violation, or equivalently CP violation,
may explain the observed cosmological baryon asymmetry as well as signal
physics beyond the Standard Model. In the decay of polarized neutrons, the
triple correlation D\cdot(p_{e}\timesp_{\nu}) is a parity-even,
time-reversal- odd observable that is uniquely sensitive to the relative phase
of the axial-vector amplitude with respect to the vector amplitude. The triple
correlation is also sensitive to possible contributions from scalar and tensor
amplitudes. Final-state effects also contribute to D at the level of 1e-5 and
can be calculated with a precision of 1% or better. Purpose: We have improved
the sensitivity to T-odd, P-even interactions in nuclear beta decay. Methods:
We measured proton-electron coincidences from decays of longitudinally
polarized neutrons with a highly symmetric detector array designed to cancel
the time-reversal-even, parity-odd Standard-Model contributions to polarized
neutron decay. Over 300 million proton-electron coincidence events were used to
extract D and study systematic effects in a blind analysis. Results: We find D
= [-0.94\pm1.89(stat)\pm0.97(sys)]e-4. Conclusions: This is the most sensitive
measurement of D in nuclear beta decay. Our result can be interpreted as a
measurement of the phase of the ratio of the axial-vector and vector coupling
constants (CA/CV= |{\lambda}|exp(i{\phi}_AV)) with {\phi}_AV = 180.012{\deg}
\pm0.028{\deg} (68% confidence level) or to constrain time-reversal violating
scalar and tensor interactions that arise in certain extensions to the Standard
Model such as leptoquarks. This paper presents details of the experiment,
analysis, and systematic- error corrections.Comment: 21 pages, 22 figure
Silicon-based molecular electronics
Molecular electronics on silicon has distinct advantages over its metallic
counterpart. We describe a theoretical formalism for transport through
semiconductor-molecule heterostructures, combining a semi-empirical treatment
of the bulk silicon bandstructure with a first-principles description of the
molecular chemistry and its bonding with silicon. Using this method, we
demonstrate that the presence of a semiconducting band-edge can lead to a novel
molecular resonant tunneling diode (RTD) that shows negative differential
resistance (NDR) when the molecular levels are driven by an STM potential into
the semiconducting band-gap. The peaks appear for positive bias on a p-doped
and negative for an n-doped substrate. Charging in these devices is compromised
by the RTD action, allowing possible identification of several molecular
highest occupied (HOMO) and lowest unoccupied (LUMO) levels. Recent experiments
by Hersam et al. [1] support our theoretical predictions.Comment: Author list is reverse alphabetical. All authors contributed equally.
Email: rakshit/liangg/ ghosha/[email protected]
Measuring organisational readiness for patient engagement (MORE) : an international online Delphi consensus study
Date of Acceptance: 28/01/2015. © 2015 Oostendorp et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise statedWidespread implementation of patient engagement by organisations and clinical teams is not a reality yet. The aim of this study is to develop a measure of organisational readiness for patient engagement designed to monitor and facilitate a healthcare organisation’s willingness and ability to effectively implement patient engagement in healthcarePeer reviewedFinal Published versio
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