Effets Antihypertensifs Des Extraits Aqueux Et Éthanolique Des Graines Fermentées De Parkia Biglobosa (Mimosaceae) Chez Les Rats

High blood pressure is a major cardiovascular risk factor in the occurrence of stroke, heart failure, kidney failure, and coronary heart disease. They are regarded as the leading causes of death worldwide. The aim of this study was to provide a scientific and pharmacological basis for the traditional use of Parkia biglobosa in the traditional treatment of arterial hypertension. Here, we first looked for certain mineral elements in the fermented seeds of P. biglobosa "soumara". Subsequently, we evaluated the hypotensive and antihypertensive effects of the aqueous and ethanolic extracts from these fermented seeds of P. biglobosa in normotensive and hypertensive rats. The cardiovascular parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR). The results showed that "soumara" is rich in calcium, potassium and magnesium, but low in sodium. Also, plant extracts at doses between 1000 and 2000 mg / kg bw induced a dose-dependent decrease in cardiovascular parameters in healthy rats. The treatment of rats made hypertensive with adrenaline by the ethanolic extract at a dose of 1500 mg / kg bw induced a dose-dependent decrease in cardiovascular parameters until normalization. The aqueous and ethanolic extracts of “soumara” acted in the same way as Nifédipine®, which is a calcium channel blocker

Antibacterial Activity of 04 Medicinal Plant on the IN VITRO Growth of Multi-Resistant Strains Involved in Diarrhea in the Department of Kouto (Ivory Coast)

This work aims at evaluating in vitro the antibacterial effects of aqueous and hydroethanolic extracts of leaf macerates, Manilkara multinervis, Waltheria indica root bark, Securrinega virosa, and Anogeissus leiocarpa stem bark. These four medicinal plants are traditionally used to treat diarrhea in the canton of North-Niéné (Department of Kouto, Côte d'Ivoire). The antibacterial activities of the various extracts from these plants were carried out on multi-resistant strains (Escherichia coli BLSE, Shigella flexneri BLSE, Staphylococcus aureus meti-R). The methodology consisted of extracting the drugs with a 70% hydroalcoholic solvent and distilled water. Agar diffusion and dilution methods were used for susceptibility testing and determination of CMI and CMB parameters. Agar diffusion and dilution methods were used. By the diffusion method, all four plants were found to be active on at least one of the bacteria tested. The ethanolic extract of M. Multinervis was the most active by inducing a diameter of 15 mm on the growth of S. aureus meti-R. As for the dilution method, the ethanolic extracts of W. indica and M. Multinervis showed bactericidal effects on both S. aureus at 6.25 mg/mL and 3.125 mg/mLrespectively as well as on all other 100 mg/mL germs. Only M. Multinervis recorded the highest activity. This important activity was demonstrated on S. aureus meti-R with a minimum bactericidal concentration of 3.125 mg/mL. These results confirm the traditional use of these plants in the management of diarrheal diseases in the Department of Kouto

Antibacterial Activity of 04 Medicinal Plant on the IN VITRO Growth of Multi-Resistant Strains Involved in Diarrhea in the Department of Kouto (Ivory Coast)

This work aims at evaluating in vitro the antibacterial effects of aqueous and hydroethanolic extracts of leaf macerates, Manilkara multinervis, Waltheria indica root bark, Securrinega virosa, and Anogeissus leiocarpa stem bark. These four medicinal plants are traditionally used to treat diarrhea in the canton of North-Niéné (Department of Kouto, Côte d'Ivoire). The antibacterial activities of the various extracts from these plants were carried out on multi-resistant strains (Escherichia coli BLSE, Shigella flexneri BLSE, Staphylococcus aureus meti-R). The methodology consisted of extracting the drugs with a 70% hydroalcoholic solvent and distilled water. Agar diffusion and dilution methods were used for susceptibility testing and determination of CMI and CMB parameters. Agar diffusion and dilution methods were used. By the diffusion method, all four plants were found to be active on at least one of the bacteria tested. The ethanolic extract of M. Multinervis was the most active by inducing a diameter of 15 mm on the growth of S. aureus meti-R. As for the dilution method, the ethanolic extracts of W. indica and M. Multinervis showed bactericidal effects on both S. aureus at 6.25 mg/mL and 3.125 mg/mLrespectively as well as on all other 100 mg/mL germs. Only M. Multinervis recorded the highest activity. This important activity was demonstrated on S. aureus meti-R with a minimum bactericidal concentration of 3.125 mg/mL. These results confirm the traditional use of these plants in the management of diarrheal diseases in the Department of Kouto

Prise En Charge Des Victimes Du Conflit Armé Du Nord Mali Dans Les Hôpitaux De Niamey

Objectives: The aims of this study was to evaluate the management of lesions in victims of the malian conflict patients admitted to Niamey hospitals. Methods: A retrospective study was conducted in Niamey hospitals from January 1st, 2012 to December, 31th, 2013. Data collected included âge, sex, means of transport, topography of trauma, treatment and outcome. Results: The sample included fifty one (51) patients. All patients were male; the mean age was 29,5 years ± 9 years, ranging from 17-71 years. The age between 26 and 35 were most affected in 47% of cases (24 patients), soldiers represented 72.54% (37 patients); and civils 27.45% (14 patients). 74.50% of our patients (38) were been transported in Niamey by aircraft. The trauma concerned the members in 54.90% (28 cases), canio facial in 17.60% (9 cases), abdomen in 11.80% (6 cases). We observed only one polytrauma. 66.66% (34) of patients were injured by firearms, 29.41% (15) by accidents of roads, 3,93% by burn (2 patients). The lesions found were bone in 41.17% (21 patients), skin-muscle in 35.29% (18 patients), visceral in 9.80% (5 patients). Five patients died (9.80%). Conclusion: the internationalization of conflicts requires a reorganization of the care by involving all the nearness health structures in order to ensure adequate care and neutrality

Integration of maternal postpartum services in maternal and child health services in Kaya health district (Burkina Faso): an intervention time trend analysis

Background: The Missed Opportunities in Maternal and Infant Health (MOMI) project aimed at reducing maternal and newborn mortality and morbidity within the year after childbirth in four sub-Saharan African countries. MOMI interventions including the integration of maternal and infant services in the postpartum (PP) period at day 6–10, week 6–8, and month 9 were implemented from September 2013 to December 2015. We hereby assess the effect of integrating maternal postpartum care (PPC) in infant immunization services in Kaya health district in Burkina Faso. Methods: We apply a longitudinal mixed method on monthly monitoring data collected from 12 months before the project start to the end. Outcome indicators were: attendance of PPC at day 6–10 and week 6–8, provision of PP family planning counselling, and management of PP morbidity in mother and infant. We tested the significance level of changes in the different indicators by performing an interrupted time series analysis with Newey–West standard errors and one lag. Additional data were extracted at the individual level which allowed to link infant immunization with maternal PPC from September 2013 to August 2014 in the health facilities’ (HF) PP and immunization registers. We also conducted a review of documents that allowed for a qualitative evaluation of the effects. Results: Show an increasing trend of all monitored indicators during the interventions, particularly at day 6–10 when PPC increased from 61% in 2013 to 81% in 2015 and especially in rural areas (p \u3c 0.05). We found large improvements in the detection and management of PP maternal hemorrhage, sepsis and newborn fever or low temperature. However, the intervention was less successful in raising PPC at week 6–8 and later due to the existence of structural barriers, caused for instance by the lack of collaboration among health workers and high turnover in the staff of HF. Conclusion: The overall package of community and facility interventions contributed to improve integrated PPC at day 6–10, particularly the role of community health workers. While the integration of maternal and child health services seems to be a valid concept, it needs to be rethought within the primary health care syste

(E)-Ethyl 2-cyano-3-[5-nitro-2-(pyrrolidin-1-yl)phen­yl]acrylate

The title compound, C16H17N3O4, was prepared by the reaction of 5-nitro-2-(pyrrolidin-1-yl)benzaldehyde and ethyl cyano­acetate. The mol­ecular structure adopts an E conformation with respect to the C=C double bond. The five-membered ring has a half-chair conformation, with puckering parameters Q(2)= 0.399 (2) Å and ϕ = 93.1 (3)°. In the crystal, inversion dimers , linked by pairs of C—H⋯O inter­actions, are further connected through C—H⋯N hydrogen bonds. Weak slipped π-π inter­actions occur between symmetry-related benzene rings [centroid–centroid distance = 3.785 (1)Å]

SUPERFICIAL ANTICANDIDOSIC ACTIVITY OF LEAVES OF COMBRETUM RACEMOSUM P. BEAUV. (COMBRETACEAE) EXTRACTS

This preliminary work consists in evaluating the superficial anticandidic activity of the leaves of Combretum racemosum P. Beauv in humans. To this end, we first demonstrated bioactive compounds of five (5) crude extracts (aqueous and hydro-organic 70%) from C. racemosum. Then, and finally, we have separately evaluated the superficial anticandidic activity of these extracts on Candida albicans, a species of genus Candida, mostly encountered in superficial human candidiasis. C. albicans was found to be sensitive to the five extracts tested. This partly justifies the use of C. racemosum in traditional medical practice against superficial microbial diseases. For these extracts, the Inhibitory Minimum Concentrations (MIC) recorded ranged from 7.8125 mg/mL to 62.550 mg/mL; While Fungicide Minimum Concentrations (CMF) range from 31.25 ± 0.00 mg/mL to 62.550 mg/mL. Concentrations for Fifty Percent Inhibition (IC50) range from 0.930 mg/mL to 3.861 mg/mL. The hydroethanolic macerated extract 70% (Eeth 70%) is the most active fraction on C. albicans (CMF = 7.8125 ± 0.00 mg/mL, IC50 = 0.941 ± 0.009 mg/mL) compared to the total of the five crude extracts tested. The preliminary phytochemical screening of the five crude extracts revealed the presence of alkaloids, saponins, terpenoids steroids and tannins (catechics and gallics) at various levels of concentration in our study. Eeth 70%, the most active extract in our work, contains in medium concentrations the same active ingredients cited above.  Finally, we note that the hydroethanolic macerated extract 70% is the most active fractions in this work. It may, however, subject to toxicological studies, be used in the treatment of theskin, the cutaneous appendages and the mucous membranes in humans. Keywords: Combretum racemosum, phytochemical screening, superficial anticandidi

Factors associated with intrapartum stillbirth in a tertiary teaching hospital in Burkina Faso

IntroductionIntrapartum stillbirth is an indicator of health and community development.ObjectiveTo identify the risk factors associated with intrapartum stillbirth in a tertiary teaching hospital in Burkina Faso.Patients and methodsA case-control study conducted from January 1 to August 30, 2019. Cases were defined as patients admitted to Yalgado Ouedraogo teaching hospital (YOTH) with a live fetus of at least 28 weeks’ gestation and who gave birth to an intrapartum stillborn, a fetus delivered without any signs of life in the first minute postpartum. Controls were defined as patients who delivered a live newborn. Study controls were gradually recruited and matched to cases. For each case, two controls were recruited and matched according to criteria such as delivery route and day of delivery. Data were cleaned in Epidata and exported to Stata for analysis. Variables with a p < 0.05 significance level in the multivariable regression were retained. Odds ratio (OR) and 95% confidence intervals are reported.ResultsEighty-three intrapartum stillbirths were documented among a total of 4,122 deliveries, a stillbirth rate of 20.1 per 1,000 births. There was a statistically significant association between intrapartum stillbirth and prior caesarean section (p = 0.045), multiparity (p = 0.03), the receipt of antenatal care (ANC) by a nurse (p = 0.005) and the disuse of the partogram (p = 0.004). We did not find a significant association between the number of ANC consultations performed (p = 0.3), whether membranes were ruptured at admission (p = 0.6), the duration of labor (p = 0.6) and intrapartum fetal death. Multivariate analysis showed that patient referral to another heath facility (OR: 3.33; 95% IC: 1.56, 7.10), no obstetric ultrasound performed (OR: 3.16; 95% IC: 2.11, 4.73), birth weight less than 2,500 g (OR: 7.49; 95% IC: 6.40, 8.76) were significantly associated with intrapartum stillbirth.ConclusionSpecific interventions must be taken to identify these risk factors of intrapartum stillbirth in order to ensure better and appropriate management

Concordance of vaccination status and associated factors with incomplete vaccination: a household survey in the health district of Segou, Mali, 2019

Introduction: the region of Segou recorded 36.8% of children were incompletely vaccinated in 2018. In 2019, the district of Segou was one of the districts with the lowest vaccination coverage in the region, with 85.1% coverage for the three doses of the pentavalent vaccine and 85.4% for the measles vaccine. This study was initiated to better understand this low vaccination coverage, in the absence of specific studies on vaccination coverage in the district of Segou. Methods: a prospective cross-sectional study was conducted from May to August 2020 with 30 clusters. We performed Kappa coefficient, bivariate, and multiple logistic regression analysis. Results: findings showed that 18.46% (101/547) [15.44-21.93] of children were incompletely vaccinated. Mothers correctly reported the vaccination status of their children in 67.30% of cases (Kappa coefficient). Uneducated (OR[IC95%]=2.13[1.30-3.50]), living in rural area (OR[IC95%]=2.07[1.23-3.47]), lack of knowledge of Expanded Program on Immunization (EPI) target diseases (OR[IC95%]=2.37[1.52-3.68]), lack of knowledge of vaccination schedule (OR[IC95%]=3.33[1.90-5.81]) and lack of knowledge of the importance of vaccination (OR[IC95%]=3.6[2.35-6.32]) were associated with incomplete vaccination. In multivariate analysis, uneducated (ORa[IC95%>]=1.68[1.004-2.810]) and lack of knowledge of the importance of vaccination were associated with incomplete vaccination (ORa[IC95%]=3.40[2.049-5.649]). Conclusion: findings showed a good concordance of the vaccination status. Living in a rural area, no education, lack of the knowledge of EPI target diseases, lack of the knowledge of vaccination schedule and lack of knowledge of the importance of vaccination were associated with incomplete vaccination

Improving postpartum care delivery and uptake by implementing context-specific interventions in four countries in Africa: a realist evaluation of the Missed Opportunities in Maternal and Infant Health (MOMI) project

Postpartum care (PPC) has remained relatively neglected in many interventions designed to improve maternal and neonatal health in sub-Saharan Africa. The Missed Opportunities in Maternal and Infant Health project developed and implemented a context-specific package of health system strengthening and demand generation in four African countries, aiming to improve access and quality of PPC. A realist evaluation was conducted to enable nuanced understanding of the influence of different contextual factors on both the implementation and impacts of the interventions. Mixed methods were used to collect data and test hypothesised context–mechanism–outcome configurations: 16 case studies (including interviews, observations, monitoring data on key healthcare processes and outcomes), monitoring data for all study health facilities and communities, document analysis and participatory evaluation workshops. After evaluation in individual countries, a cross-country analysis was conducted that led to the development of four middle-range theories. Community health workers (CHWs) were key assets in shifting demand for PPC by ‘bridging’ communities and facilities. Because they were chosen from the community they served, they gained trust from the community and an intrinsic sense of responsibility. Furthermore, if a critical mass of women seek postpartum healthcare as a result of the CHWs bridging function, a ‘buzz’ for change is created, leading eventually to the acceptability and perceived value of attending for PPC that outweighs the costs of attending the health facility. On the supply side, rigid vertical hierarchies and defined roles for health facility workers (HFWs) impede integration of maternal and infant health services. Additionally, HFWs fear being judged negatively which overrides the self-efficacy that could potentially be gained from PPC training. Instead the main driver of HFWs’ motivation to provide comprehensive PPC is dependent on accountability systems for delivering PPC created by other programmes. The realist evaluation offers insights into some of the contextual factors that can be pivotal in enabling the community-level and service-level interventions to be effective