1,627 research outputs found
Drainage of a nanoconfined simple fluid: rate effects on squeeze-out dynamics
We investigate the effect of loading rate on drainage in molecularly thin
films of a simple fluid made of quasi-spherical molecules
(octamethylcyclotetrasiloxane, OMCTS). We find that (i) rapidly confined OMCTS
retains its tendency to organize into layers parallel to the confining
surfaces, and (ii) flow resistance in such layered films can be described by
bulklike viscous forces if one accounts for the existence of one monolayer
immobilized on each surfaces. The latter result is fully consistent with the
recent work of Becker and Mugele, who reached a similar conclusion by analyzing
the dynamics of squeeze-out fronts in OMCTS [T. Becker and F. Mugele, Phys.
Rev. Lett. {\bf 91} 166104(2003)]. Furthermore, we show that the confinement
rate controls the nature of the thinning transitions: layer-by-layer expulsion
of molecules in metastable, slowly confined films proceeds by a
nucleation/growth mechanism, whereas deeply and rapidly quenched films are
unstable and undergo thinning transitions akin to spinodal decomposition
Multinational evaluation of the measurement invariance of the level of personality functioning scale–brief form 2.0: comparison of student and community samples across seven countries
DSM-5’s Level of Personality Functioning Scale (LPFS) was introduced as a dimensional rating of impairments in self- and interpersonal functioning, and the LPFS – Brief Form (LPFS-BF) was the first published corresponding self-report. The updated LPFS-BF 2.0 has been translated into several languages and international research supports many of the instrument’s psychometric properties; however, its measurement invariance has only been evaluated across a few countries. This study expands previous studies as an introductory step in a global evaluation of the LPFS-BF 2.0’s measurement invariance. Archival data (N = 5,618, 57% female) from seven countries (Canada, Chile, Denmark, Germany, Italy, United Arab Emirates, United States of America) were used for this study. Participants were recruited from both community (n = 4,677) and student (n = 941) populations. After confirming adequate model fit separately in the community and student samples, we evaluated a series of increasingly stringent model comparisons to test three aspects of measurement invariance (configural, metric, scalar) and then examined latent mean differences across countries. Full scalar invariance was supported in the community sample and partial scalar invariance was supported in the student sample. Evaluation of latent mean differences revealed multiple significant differences. Overall, the LPFS-BF 2.0 appears to assess self- and interpersonal functioning impairment similarly across the included countries. Findings are discussed through the lenses of the cultures from which participants were recruited, as well as in the context of alternative explanations. Limitations, plans for future research, and implications for both research and clinical practice are offered
Diffusion in pores and its dependence on boundary conditions
We study the influence of the boundary conditions at the solid liquid
interface on diffusion in a confined fluid. Using an hydrodynamic approach, we
compute numerical estimates for the diffusion of a particle confined between
two planes. Partial slip is shown to significantly influence the diffusion
coefficient near a wall. Analytical expressions are derived in the low and high
confinement limits, and are in good agreement with numerical results. These
calculations indicate that diffusion of tagged particles could be used as a
sensitive probe of the solid-liquid boundary conditions.Comment: soumis \`a J.Phys. Cond. Matt. special issue on "Diffusion in
Liquids, Polymers, Biophysics and Chemical Dynamics
One-dimensional Topological Edge States of Bismuth Bilayers
The hallmark of a time-reversal symmetry protected topologically insulating
state of matter in two-dimensions (2D) is the existence of chiral edge modes
propagating along the perimeter of the system. To date, evidence for such
electronic modes has come from experiments on semiconducting heterostructures
in the topological phase which showed approximately quantized values of the
overall conductance as well as edge-dominated current flow. However, there have
not been any spectroscopic measurements to demonstrate the one-dimensional (1D)
nature of the edge modes. Among the first systems predicted to be a 2D
topological insulator are bilayers of bismuth (Bi) and there have been recent
experimental indications of possible topological boundary states at their
edges. However, the experiments on such bilayers suffered from irregular
structure of their edges or the coupling of the edge states to substrate's bulk
states. Here we report scanning tunneling microscopy (STM) experiments which
show that a subset of the predicted Bi-bilayers' edge states are decoupled from
states of Bi substrate and provide direct spectroscopic evidence of their 1D
nature. Moreover, by visualizing the quantum interference of edge mode
quasi-particles in confined geometries, we demonstrate their remarkable
coherent propagation along the edge with scattering properties that are
consistent with strong suppression of backscattering as predicted for the
propagating topological edge states.Comment: 15 pages, 5 figures, and supplementary materia
Lattice Boltzmann simulations in microfluidics: probing the no-slip boundary condition in hydrophobic, rough, and surface nanobubble laden microchannels
In this contribution we review recent efforts on investigations of the effect
of (apparent) boundary slip by utilizing lattice Boltzmann simulations. We
demonstrate the applicability of the method to treat fundamental questions in
microfluidics by investigating fluid flow in hydrophobic and rough
microchannels as well as over surfaces covered by nano- or microscale gas
bubbles.Comment: 11 pages, 6 figure
Pirfenidone in idiopathic pulmonary fibrosis:expert panel discussion on the management of drug-related adverse events
Pirfenidone is currently the only approved therapy for idiopathic pulmonary fibrosis, following studies demonstrating that treatment reduces the decline in lung function and improves progression-free survival. Although generally well tolerated, a minority of patients discontinue therapy due to gastrointestinal and skin-related adverse events (AEs). This review summarizes recommendations based on existing guidelines, research evidence, and consensus opinions of expert authors, with the aim of providing practicing physicians with the specific clinical information needed to educate the patient and better manage pirfenidone-related AEs with continued pirfenidone treatment. The main recommendations to help prevent and/or mitigate gastrointestinal and skin-related AEs include taking pirfenidone during (or after) a meal, avoiding sun exposure, wearing protective clothing, and applying a broad-spectrum sunscreen with high ultraviolet (UV) A and UVB protection. These measures can help optimize AE management, which is key to maintaining patients on an optimal treatment dose.Correction in: Advances in Therapy, Volume 31, Issue 5, pp 575-576 , doi: 10.1007/s12325-014-0118-8</p
Optical conductivity signatures of open Dirac nodal lines
We investigate the optical conductivity and far-infrared magneto-optical
response of BaNiS, a simple square-lattice semimetal characterized by Dirac
nodal lines that disperse exclusively along the out-of-plane direction. With
the magnetic field aligned along the nodal line the in-plane Landau level
spectra show a nearly behavior, the hallmark of a conical-band
dispersion with a small spin-orbit coupling gap. The optical conductivity
exhibits an unusual temperature-independent isosbestic line, ending at a Van
Hove singularity. First-principles calculations unambiguously assign the
isosbestic line to transitions across Dirac nodal states. Our work suggests a
universal topology of the electronic structure of Dirac nodal lines
β blockers and mortality after myocardial infarction in patients without heart failure: multicentre prospective cohort study
Objective: To assess the association between early and prolonged β blocker treatment and mortality after acute myocardial infarction. Design: Multicentre prospective cohort study. Setting: Nationwide French registry of Acute ST- and non-ST-elevation Myocardial Infarction (FAST-MI) (at 223 centres) at the end of 2005. Participants: 2679 consecutive patients with acute myocardial infarction and without heart failure or left ventricular dysfunction. Main outcome measures: Mortality was assessed at 30 days in relation to early use of β blockers (≤48 hours of admission), at one year in relation to discharge prescription, and at five years in relation to one year use. Results: β blockers were used early in 77% (2050/2679) of patients, were prescribed at discharge in 80% (1783/2217), and were still being used in 89% (1230/1383) of those alive at one year. Thirty day mortality was lower in patients taking early β blockers (adjusted hazard ratio 0.46, 95% confidence interval 0.26 to 0.82), whereas the hazard ratio for one year mortality associated with β blockers at discharge was 0.77 (0.46 to 1.30). Persistence of β blockers at one year was not associated with lower five year mortality (hazard ratio 1.19, 0.65 to 2.18). In contrast, five year mortality was lower in patients continuing statins at one year (hazard ratio 0.42, 0.25 to 0.72) compared with those discontinuing statins. Propensity score and sensitivity analyses showed consistent results. Conclusions: Early β blocker use was associated with reduced 30 day mortality in patients with acute myocardial infarction, and discontinuation of β blockers at one year was not associated with higher five year mortality. These findings question the utility of prolonged β blocker treatment after acute myocardial infarction in patients without heart failure or left ventricular dysfunction. Trial registration: Clinical trials NCT00673036
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