A Fast Frequency Sweep – Green’s Function Based Analysis of Substrate Integrated Waveguide

In this paper, a fast frequency sweep technique is applied to the analysis of Substrate Integrated Waveguides performed with a Green’s function technique. The well-known Asymptotic Waveform Evaluation technique is used to extract the Padè approximation of the frequency response of Substrate Integrated Waveguides devices. The analysis is extended to a large frequency range by adopting the Complex Frequency Hopping algorithm. It is shown that, with this technique, CPU time can be reduced of almost one order of magnitude with respect to a point by point computation

Optical Force/Tactile Sensors for Robotic Applications

Nowadays, robotic systems use tactile sensing as a key enabling technology to implement complex tasks. For example, manipulation and grasping problems strongly depend on the physical and geometrical characteristics of the objects; in fact, objects may be deformable or change their shape when in contact with the robot or the environment. For this reason, often, robots end effectors are equipped with sensorized fingers which can estimate the objects' features, forces, and contact locations. This is useful in a safe and efficient physical Human-Robot Interaction (pHRI) to perform cooperation and co-manipulation tasks while limiting damage from accidental impacts

Il rilievo fotogrammetrico del Castello di Maredolce a Palermo

Le tecniche di rilievo fotogrammetrico stanno trovando un sempre più largo impiego nel campo dei BB.CC. Esse, infatti, consentono una rappresentazione dei manufatti con un'elevata cura del dettaglio geometrico mediante la restituzione vettoriale ed una elevata definizione degli aspetti materici degli oggetti attraverso la realizzazione dei fotopiani, che forniscono informazioni sia metriche che qualitative dell'oggetto. Tali tecniche, pertanto, costituiscono un fondamentale strumento di supporto alle attività di diagnostica e restauro dei monumenti antichi. Il presente articolo illustra la metodologia, le fasi operative e gli strumenti impiegati per il rilievo fotogrammetrico di un edificio complesso: il Castello di Maredolce a Palermo. Nel caso in esame la geometria dell'edificio, i dislivelli del suolo e la presenza di elementi fisici generanti ombre sull'edificio hanno sensibilmente condizionato le operazioni di rilievo, consentendo di affrontare e risolvere una vasta compagine di problematiche che il rilievo di un edificio storico, sito in un contesto oggi urbanizzato, comporta. Lo scritto, in particolare, descrive il workflow seguito e le procedure impiegate sino alla modellazione 3D image-based. Quest'ultima è stata implementata a partire dal blocco fotogrammetrico georiferito ottenuto dall'orientamento dei fotogrammi. I fotopiani del castello prodotti sono stati utilizzati come texture fotorealistica del modello fotogrammetrico tridimensionale.The techniques related to the photogrammetric survey are even more widely used in the field of Cultural Heritage In fact, they allow a representation of artifacts with a high attention to the geometric detail by a vector restitution and a high definition of the textural aspects of objects: they based on the creation of photo-plans, which provide information both metrics and qualitative about the object. These techniques, therefore, are an essential tool supporting diagnostics and restoration of ancient monuments. This article discusses the methodology, the operational phases and the instruments used for the photogrammetric survey of a building complex: the Castle of Maredolce in Palermo. In this case the geometry of the building, the uneven ground and the pres ence of physical elements creating shadows on the building have significantly affected the operations of relief: they have allowed to address and solve a wide range of issues deriving from the survey of historic buildings that are located in a urban context today. This paper, in particular, describes the workflow and the procedures used until the 3D image-based modeling. The latter was implemented from the georeferenced photogrammetric block obtained by the orientation of the frames. The photo-plans of the castle have been used as photo-realistic texture of the photogrammetric three-dimensional model

A Fully Coupled Immersed Finite Element Method for Fluid Structure Interaction via the Deal.II Library

We present the implementation of a solution scheme for fluid-structure interaction problems via the finite element software library deal.II. The solution scheme is an immersed finite element method in which two independent discretizations are used for the fluid and immersed deformable body. In this type of formulation the support of the equations of motion of the fluid is extended to cover the union of the solid and fluid domains. The equations of motion over the extended solution domain govern the flow of a fluid under the action of a body force field. This body force field informs the fluid of the presence of the immersed solid. The velocity field of the immersed solid is the restriction over the immersed domain of the velocity field in the extended equations of motion. The focus of this paper is to show how the determination of the motion of the immersed domain is carried out in practice. We show that our implementation is general, that is, it is not dependent on a specific choice of the finite element spaces over the immersed solid and the extended fluid domains. We present some preliminary results concerning the accuracy of the proposed method

Exploring the links between cancer and placenta development

The development of metastatic cancer is a multistage process, which often requires decades to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors generate genetically heterogeneous cell populations. However, despite heterogeneity most solid cancers have stereotypical behaviours, including invasiveness and suppression of immune responses that can be unleashed with immunotherapy targeting lymphocyte checkpoints. The mechanisms leading to the acquisition of stereotypical properties remain poorly understood. Reactivation of embryonic development processes in cells with unstable genomes might contribute to tumour expansion and metastasis formation. However, it is unclear whether these events are linked to immune response modulation. Tumours and embryos have non-self-components and need to avoid immune responses in their microenvironment. In mammalian embryos, neo-antigens are of paternal origin, while in tumour cells DNA mismatch repair and replication defects generate them. Inactivation of the maternal immune response towards the embryo, which occurs at the placental-maternal interface, is key to ensuring embryonic development. This regulation is accomplished by the trophoblast, which mimics several malignant cell features, including the ability to invade normal tissues and to avoid host immune responses, often adopting the same cancer immunoediting strategies. A better understanding as to whether and how genotoxic stress promotes cancer development through reactivation of programmes occurring during early stages of mammalian placentation could help to clarify resistance to drugs targeting immune checkpoint and DNA damage responses and to develop new therapeutic strategies to eradicate cancer

Entangling quantum and classical states of light

Entanglement between quantum and classical objects is of special interest in the context of fundamental studies of quantum mechanics and potential applications to quantum information processing. In quantum optics, single photons are treated as light quanta while coherent states are considered the most classical among all pure states. Recently, entanglement between a single photon and a coherent state in a free-traveling field was identified to be a useful resource for optical quantum information processing. However, it was pointed out to be extremely difficult to generate such states since it requires a clean cross-Kerr nonlinear interaction. Here, we devise and experimentally demonstrate a scheme to generate such hybrid entanglement by implementing a coherent superposition of two distinct quantum operations. The generated states clearly show entanglement between the two different types of states. Our work opens a way to generate hybrid entanglement of a larger size and to develop efficient quantum information processing using such a new type of qubits.Comment: 9 pages, 4 figure

Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation

Current research into original therapies to treat intestinal inflammation is focusing on no-drug therapies. KLD is a mixture of krill oil (KO), probiotic Lactobacillus reuteri (LR), and vitamin D (VitD3). The aim of this study was to assess in vitro and in vivo the potential cooperative effects of KLD in reducing gut inflammation. Colorectal adenocarcinoma cell lines, CACO2 and HT29, and C57BL/6 mice were used for in vitro and in vivo analyses, respectively. Cells were exposed to cytomix (interferon gamma + tumour necrosis factor alpha (TNF-a)) to induce inflammation or co-exposed to cytomix and KO, LR and VitD3 alone or to cytomix and KLD. Animals were treated for 7 days with dextran sodium sulphate (DSS) to induce colitis or with DSS and KLD. In vitro assays: F-actin expression was analysed by immunofluorescence; scratch test and trans-epithelial electric resistance test were performed to measure wound healing; adhesion/invasion assays of adhesive and invasive Escherichia coli (AIEC) bacteria were made; mRNA expression of TNF-α, interleukin (IL)-8 and vitamin D receptor (VDR) was detected by quantitative PCR. In vivo assays: body weight, clinical score, histological score and large intestine weight and length were estimated; mRNA expression of TNF-α, IL-1ß, IL-6, IL-10 by quantitative PCR; VDR expression was detected by quantitative PCR and immunohistochemistry. In vitro: KLD restores epithelial cell-cell adhesion and mucosal healing during inflammation, while decreases the adhesiveness and invasiveness of AIEC bacteria and TNF-α and IL-8 mRNA expression and increases VDR expression. In vivo: KLD significantly improves body weight, clinical score, histological score and large intestine length of mice with DSS-induced colitis and reduces TNF-α, IL-1ß and IL-6 mRNA levels, while increases IL-10 mRNA and VDR levels. KLD has significant effects on the intestinal mucosa, strongly decreasing inflammation, increasing epithelial restitution and reducing pathogenicity of harmful commensal bacteria

Stress growth and relaxation of dendritically branched macromolecules in shear and uniaxial extension

We present unique nonlinear rheological data of well-defined symmetric Cayley-tree poly(methyl methacrylates) in shear and uniaxial extension. Earlier work has shown that their linear viscoelasticity is governed by the hierarchical relaxation of different generations, whereas the segments between branch points are responsible for their substantial strain hardening as compared to linear homopolymers of the same total molar mass at the same value of imposed stretch rate. Here, we extend that work in order to obtain further experimental evidence that will help understanding the molecular origin of the remarkable properties of these highly branched macromolecules. In particular, we address three questions pertinent to the specific molecular structure: (i) is steady state attainable during uniaxial extension? (ii) what is the respective transient response in simple shear? and (iii) how does stress relax upon cessation of extension or shear? To accomplish our goal we utilize state-of-the-art instrumentation, i.e., filament stretching rheometry (FSR) and cone-partitioned plate (CPP) shear rheometry for polymers with 3 and 4 generations, and complement it with state-of-the-art modeling predictions using the Branch-on-Branch (BoB) algorithm. The data indicates that the extensional viscosity reaches a steady state value, whose dependence on extension rate is identical to that of entangled linear and other branched polymer melts. Nonlinear shear is characterized by transient stress overshoots and the validity of the Cox-Merz rule. Remarkably, nonlinear stress relaxation is much broader and slower in extension compared to shear. It is also slower at higher generation, and rate-independent for rates below the Rouse rate of the outer segment. For extension, the relaxation time is longer than that of the linear stress relaxation, suggesting a strong ‘elastic memory’ of the material. These results are 2 described by BoB semi-quantitatively, both in linear and nonlinear shear and extensional regimes. Given the fact that the segments between branch points are less than 3 entanglements long, this is a very promising outcome that gives confidence in using BoB for understanding the key features. Moreover, the response of the segments between generations controls the rheology of the Cayley trees. Their substantial stretching in uniaxial extension appears responsible for strain hardening, whereas coupling of stretches of different parts of the polymer appears to be the origin of the slower subsequent relaxation of extensional stress. Concerning the latter effect, for which predictions are not available, it is hoped that the present experimental findings and proposed framework of analysis will motivate further developments in the direction of molecular constitutive models for branched and hyperbranched polymers