863 research outputs found
An Adult with Episodic Abnormal Limb Posturing
info:eu-repo/semantics/publishedVersio
Comemoração Solene do Nascimento de Martins Sarmento. Discurso de homenagem a M. Sarmento, pronunciado pelo Prf. Dr. Francisco Miranda da Costa Lobo, Presidente do "Instituto" e director do Observatório Astronómico da Universidade de Coimbra.
43 Jan.-Dez. 1933, p. 76-80
Acanthospermum australe é hospedeiro alternativo de Thanatephorus cucumeris, agente causal da mela do feijoeiro.
Acanthospermum australe, a frequently weed infesting bean crops in the State of Goiás, Brazil, was found infected by T. cucumeris under natural field conditions. Plants were severely affected and may be an important reservoir of inoculum for infection of cultivated crops. Pathogenicity of T. cucumeris in both A. australe and Phaseolus vulgaris was confirmed by Koch´s postulates.Notas fitopatológicas
Photoallergic reaction to cyamemazine.
A 50-year-old man presented with a scaly erythema of the face, upper chest, forearms, and dorsum of the hands. He has been treated with cyamemazine for 6 months. Photopatch tests were performed and the patient was diagnosed with photoallergic reaction to cyamemazine. The drug was discontinued and a course of oral steroids was prescribed. The patient was advised to avoid light exposure. There has been no evidence of recurrence during a six-month follow-up period. Photoallergic reactions are much less frequent than phototoxic disorders. It is well known that several drugs including neuroleptics of the phenothiazine family may produce a skin eruption on light-exposed areas by dose-dependent (phototoxic) or photoallergic mechanisms. It is believed that photopatch testing, which is the clinical investigation of choice for suspected photoallergic reactions, is significantly underused in Europe and probably world-wide
MELANOMA? OBSERVE MAIS PERTO
Pigmented skin lesions are sometimes misdiagnosed due to clinical similarities between melanocytic and non-melanocytic lesions. We report the case of a patient with a pigmented lesion that clinically resembles melanoma. With dermoscopy, observed features, namely leaf-like areas, allowed us to make the diagnosis of pigmented basal cell carcinoma. This case represents a clinical setting in which clinical examination alone could lead to a misdiagnosis, but with the use of dermoscopy an accurate diagnosis was possible.Lesões cutâneas pigmentadas por vezes são mal diagnosticadas devido às semelhanças entre as lesões melanocíticas e não-melanocíticas. Relatamos o caso de um doente com uma lesão pigmentada, clinicamente sugestiva de melanoma. Quando analisada com dermatoscopia, é possível observar características, nomeadamente áreas “leaf-like”, que nos permitem fazer o diagnóstico de carcinoma basocelular pigmentado. Este caso representa uma situação clínica em que o exame clinico isoladamente pode levar a um diagnóstico incorreto, mas que com o apoio da dermatoscopia foi feito corretamente
Epidemiologia da mela e produtividade do feijoeiro-comum tratado com fungicidas.
O efeito dos fungicidas azoxistrobina, carbendazim, mancozebe, tebuconazole, hidróxido de fenilestanho, piraclostrobina, trifloxistrobina + ciproconazol, trifloxistrobina + propiconazol e clorotalonil no progresso da mela e na produtividade do feijoeiro foi avaliado em campo e casa de vegetação. No campo, três experimentos foram conduzidos nas estações chuvosas de 2004/05, 2005/06 e 2006/07, em blocos ao acaso com quatro repetições.Na safra 2004/05 foi realizada apenas uma aplicação, aos 45 dias após o plantio (DAP); em 2005/06 foram realizadas duas aplicações aos 30 e 45 DAP e em 2006/07 foram realizadas três aplicações, aos 30, 45 e 60 DAP. A avaliação da severidade da doença foi feita semanalmente, atribuindo-se notas de 1 (sem sintomas) a 9 (acima de 90% da área foliar destruída) e taxas de progresso da doença foram calculadas após o ajuste das curvas de progresso ao modelo logístico. Os resultados mostraram que uma única aplicação de qualquer dos produtos, aos 45 DAP, foi ineficiente para o controle da taxa de progresso da mela (taxa média, r = 0,2348). A eficiência do controle aumentou com o incremento do número de aplicações e aplicações mais precoces, iniciando-se aos 30 DAP (médias de r = 0,1988 e 0,1671 em 2005/06 e 2006/07, respectivamente). Com três aplicações,as menores severidades de doença foram observadas com hydróxido de fenil estanho, trifloxistrobina + propiconazol e trifloxistrobina + cyproconazol. Em casa de vegetação, o efeito protetor e curativo dos fungicidas foi estudado com aplicação dos produtos em pré ou pós-inoculação de folíolos, através da avaliação do diâmetro das lesões. Todos os fungicidas apresentaram tanto efeito protetor quanto curativo, mas os melhores resultados foram observados em aplicação preventiva. Foi encontrada alta correlação negativa entre intensidade da mela e a produção do feijoeiro e o ganho em produtividade com uso de fungicidas chegou a 304 %
Estuarine ecological risk based on hepatic histopathological indices from laboratory and in situ tested fish
Juvenile Senegalese soles were exposed through 28-day laboratory and field (in situ) bioassays to sediments
from three sites of the Sado estuary (W Portugal): a reference and two contaminated by metallic
and organic contaminants. Fish were surveyed for ten hepatic histopathological alterations divided by
four distinct reaction patterns and integrated through the estimation of individual histopathological condition
indices. Fish exposed to contaminated sediments sustained more damage, with especial respect to
regressive changes like necrosis. However, differences were observed between laboratory- and fieldexposed
animals, with the latest, for instance, exhibiting more pronounced fatty degeneration and hepatocellular
eosinophilic alteration. Also, some lesions in fish exposed to the reference sediment indicate
that in both assays unaccounted variables produced experimental background noise, such as hyaline
degeneration in laboratory-exposed fish. Still, the field assays yielded results that were found to better
reflect the overall levels of contaminants and physico-chemical characteristics of the tested sediments.info:eu-repo/semantics/publishedVersio
Evaluation of the potential of the common cockle (cerastoderma edule l.) for the ecological risk assessment of estuarine sediments: Bioaccumulation and biomarkers
Common cockles (Cerastoderma edule, L.
1758, Bivalvia: Cardiidae) were subjected to a laboratory
assay with sediments collected from distinct sites of the
Sado Estuary (Portugal). Cockles were obtained from a
mariculture site of the Sado Estuary and exposed through
28-day, semi-static, assays to sediments collected from
three sites of the estuary. Sediments from these sites
revealed different physico-chemical properties and levels
of metals and organic contaminants, ranging from unimpacted (the reference site) to moderately impacted, when
compared to available sediment quality guidelines. Cockles
were surveyed for bioaccumulation of trace elements (Ni,
Cu, Zn, As, Cd and Pb) and organic contaminants (PAHs,
PCBs and DDTs). Two sets of potential biomarkers were
employed to assess toxicity: whole-body metallothionein
(MT) induction and digestive gland histopathology. The
bioaccumulation factor and the biota-to-soil accumulation
factor were estimated as ecological indices of exposure to
metals and organic compounds. From the results it is
inferred that C. edule responds to sediment-bound contamination and might, therefore, be suitable for biomonitoring.
The species was found capable to regulate and eliminate
both types of contaminants. Still, the sediment contamination levels do not account for all the variation in bioaccumulation and MT levels, which may result from the
moderate metal concentrations found in sediments, the
species’ intrinsic resistance to pollution and from yet
unexplained xenobiotic interaction effects.info:eu-repo/semantics/publishedVersio
Genotoxic damage in Solea senegalensis exposed to sediments from the Sado Estuary (Portugal): effects of metallic and organic contaminants
Juvenile Solea senegalensis (Senegalese sole) were exposed to freshly collected sediments from three sites
of the Sado Estuary (West-Portuguese coast) in 28-day laboratory assays in order to assess the ecological
risk from sediment contaminants, by measuring two genotoxicity biomarkers in peripheral blood: the
percentage of Erythrocyte Nuclear Abnormalities (ENA) by use of an adaptation of the micronucleus test,
and the percentage of DNA strand-breakage (DNA-SB) with the Comet assay. Sediments were surveyed for
metallic (Cr, Ni, Cu, Zn, As, Cd and Pb) and organic (PAHs (polycyclic aromatic hydrocarbons), PCBs (polychlorinated biphenyls) and DDTs (dichloro-diphenyl-trichloroethane)) contaminants. Sediments from site
A (farthest from hotspots of contamination) were found to be the least contaminated and weaker inducers
of genotoxic damage, whereas sediments from sites B (urban influence) and C (affected by industrial effluents and agricultural runoffs) were responsible for a very significant increase in both ENA and DNA-SB,
site B being most contaminated with metals and site C mainly with organic pollutants, especially PAHs
and PCBs . Analysis of genotoxic effects showed a strong correlation between the concentrations of PAHs
and PCBs and both biomarkers at sampling times T14 and T28, while the amounts of Cu, As, Cd and Pb
were less strongly correlated, and at T28 only, with ENA and DNA-SB. These results show that organic
contaminants in sediment are stronger and faster acting genotoxic stressors. The results also suggest that
metals may have an inhibitory effect on genotoxicity when interacting with organic contaminants, at least
during early exposure. ENA and DNA-SB do not show a linear relationship, but a strong correlation exists
between the overall increase in genotoxicity caused by exposure to sediment, confirming that they are
different, and possibly non-linked effects that respond similarly to exposure. Although the Comet assay
showed enhanced sensitivity, the two analyses are complementary and suitable for the biomonitoring of
sediment contaminants in a benthic species like S. senegalensis.info:eu-repo/semantics/publishedVersio
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