La dépression post-natale : les facteurs socio-environnementaux

Au cours des semaines et des mois qui suivent la naissance, de 10 % à 20 % des mères présentent des symptômes dépressifs modérés ou graves. Cet état de détresse psychologique influe sur l'interaction de la mère avec son nourrisson et peut modifier à plus long terme le développement de l'enfant. Les études récentes associent de plus en plus ces symptômes aux stresseurs psycho-sociaux et environnementaux. Une meilleure compréhension de l'effet du stress et du soutien social sur la santé mentale des mères s'avère essentielle à la mise en place d'interventions de promotion et de prévention pertinentes et efficaces.In the weeks and months that follow the birth of a child, between 10 and 20 per cent of mothers experience serious or moderate symptoms of depression. This state of psychological distress affects the mother-infant interaction, and can modify the child's development in the longer term. Recent studies increasingly link these symptoms to environmental and psychosocial stress factors. The setting up of relevant and efficient prevention and promotion programs requires a better understanding of the effect of stress and social support on the mental health of mothers

L’« inexpressivité » masculine : des mythes et des faits

Cet article examine la thèse couramment admise selon laquelle les hommes expriment moins leurs émotions que les femmes. Les données de recherche montrent peu de différences à cet effet entre les garçons et les filles avant l'adolescence et la vie adulte où, par ailleurs, les hommes apparaissent moins expressifs que les femmes, sauf pour les émotions reliées aux conduites agressives. Cette expressivité moins grande s'observe toutefois dans le cadre d'interactions intimes, alors que les contextes sociaux où la compétition et le statut social sont en jeu semblent plus propices à l'expression d'émotions chez les hommes. Nous proposons que davantage d'études soient menées à ce sujet, en tenant compte des contextes sociaux d'expression émotive engendrés par la division sexuelle du travail.This article examines the common admission that men express their emotions less than do women. Research data shows little difference between the behaviours of boys and girls before adolescence. During adulthood, however, evidence points to men being less expressive than women except in situations involving aggressive behaviour. Men's diminished expressiveness is apparent in a context of intimate interaction. But in situations where they compete for social status, men seem more likely to express emotions. The authors suggest that more studies take into account the social contexts of emotional expressiveness generated by division of labor based on sex

Correction to: Eight years after an international workshop on myotonic dystrophy patient registries: Case study of a global collaboration for a rare disease (Orphanet Journal of Rare Diseases (2018) 13 (155) DOI: 10.1186/s13023-018-0889-0)

The original version of this article [1] unfortunately included an error to an author\u27s name. Author Jordi Díaz-Manera was erroneously presented as Jorge Alberto Diaz Manera. The correct author name has been included in the author list of this Correction article. For citation purposes the author\u27s given name is Jordi and family name Diaz-Manera. Therefore, the correct citation of the author\u27s details is: Diaz-Manera J

Researching complex interventions in health: the state of the art

CITATION: Craig, P., et al. 2016. Researching complex interventions in health : the state of the art. BMC Health Services Research, 16:101, doi:10.1186/s12913-016-1274-0.The original publication is available at https://bmchealthservres.biomedcentral.comENGLISH SUMMARY : Keynote presentationsPublishers' Versio

Eight years after an international workshop on myotonic dystrophy patient registries: case study of a global collaboration for a rare disease.

Background Myotonic Dystrophy is the most common form of muscular dystrophy in adults, affecting an estimated 10 per 100,000 people. It is a multisystemic disorder affecting multiple generations with increasing severity. There are currently no licenced therapies to reverse, slow down or cure its symptoms. In 2009 TREAT-NMD (a global alliance with the mission of improving trial readiness for neuromuscular diseases) and the Marigold Foundation held a workshop of key opinion leaders to agree a minimal dataset for patient registries in myotonic dystrophy. Eight years after this workshop, we surveyed 22 registries collecting information on myotonic dystrophy patients to assess the proliferation and utility the dataset agreed in 2009. These registries represent over 10,000 myotonic dystrophy patients worldwide (Europe, North America, Asia and Oceania). Results The registries use a variety of data collection methods (e.g. online patient surveys or clinician led) and have a variety of budgets (from being run by volunteers to annual budgets over €200,000). All registries collect at least some of the originally agreed data items, and a number of additional items have been suggested in particular items on cognitive impact. Conclusions The community should consider how to maximise this collective resource in future therapeutic programmes

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely