Multiple Glaciations of the Cordon del Plata, Mendoza, Argentina [Glaciaciones multiples del Cordon del Plata, Mendoza, Argentina]

Evidence exists for four glaciations in the Río Blanco basin west of Mendoza, Argentina. Morphology, superposition of tills, soil-profile development, loess thickness, and boulder weathering have been the techniques most useful in mapping the tills. Glaciers of Vallecitos (= Wisconsinan) age extended to 2600 m and left distinctive moraines. Tills of two preVallecitos glacier advances cover the floor of the valley from 2600 m to below 2100 m, and remnants of one of the tills extend nearly to the junction with Río Mendoza (1400 m) 13 km below the lowest Vallecitos moraines. These deposits were considered to be mudflows rather than tills by Polanski; however, the quartz sand grains examined with SEM have surface textures characteristic of glacial abrasion. The sediments, thus, are more likely glacial than mudflow deposits. One still older till caps ridges as much as 200 m above the present valley floor. Vallecitos glaciers did not smooth the walls of the wide valleys through which they flowed; the valleys had been enlarged by the larger ice tongues during one or more of the earlier glaciations. Frost shattering of the rhyolite and quartzite has altered much of the distinctive glacial valley shape, and talus lies between the valley walls and Vallecitos lateral moraines. Holocene glaciations seem to be in phase with those of the Northern Hemisphere, and the Vallecitos glaciation coincided with oxygen isotope stage 2 and the Wisconsin of North America. The next older glaciation may correlate with oxygen isotope stage 6 and the Illinoian glaciation of North America. A till that underlies it is difficult to correlate and is clearly much older, but postdates the last major uplift of the range. It may represent isotope stage 12, and the period that followed it was more moist than other interglacial ages in this area. The oldest, Los Mesones, may correlate with Mercer\u27s Greatest Glaciation of Patagonia, 1.0 to 1.2 m.y. ago. Although it is beyond the established oxygen isotope stages, a long cold period is present on the curves at this time, and it coincides with one of the glaciations of the Nebraskan-Kansan complex of North America. Resumen: Existe en la cuenca del río Blanco, al oeste de Mendoza, Argentina, evidencia por cuatro glaciaciones. Los métodos más útiles en la identificación y el trazar un mapa de los depósitos son la morfología, la superposición de los tils, el desarrollo de los perfiles de los suelos, el espesor del loess, y la meteorización de los rodados. Glaciares de la etapa Vallecitoense (= Wisconsinan/Würm) extendieron a 2600 in donde depositaron morrenas distinctivas. Los tils de los avanzes glaciales pre-Vallecitos llenan la parte baja del valle entre 2600 m y 2100 m, y remanantes de uno de ellos extiende casi a la unión de los ríos Blanco y Mendoza, 13 km más bajo que las morrenas Vallecitoenses más bajas. Estos acarreos eran considerado por Polanski como depositos de corrientes de barro más bien que til; sin embargo, las superficies de los granos de cuarzo en tamaño de arena son fracturados para que puedan ser transportados por un glaciar. Por esto, es más probable que son los acarreos depósitos de glaciares que los de corrientes de barro. Un til más antiguo cubre caballetes que están a 200 m más altos que los arroyos actuales. Los glaciares Vallecitoense no erosionaron lisos las muredes de los valles en que se deslizaron. Durante glaciaciones anteriores, lenguas de hielo más grandes que las de la última etapa han erosionado los valles. La forma distinta glaciaria se ha alterado por el astillar por congelamiento de los cuarcitas y riolitas de las pendientes, y taludes están entre los muredes y las morrenas. Las glaciaciones Holocénicas parecen en fase con elias del hemisferio del norte, y la glaciación Vallecitoense coincidió con la etapa 2 de los isótopos de oxígeno y de la glaciación Wisconsinense norteamericana. El til de la glaciación más antigua, la Río Blancoense, se correlacione con la etapa 6 de los isótopos de oxígeno y la glaciación Illinoianense de norteamerica. Hay dificultades en el correlacionar del til que está debajo de éste, el til Angosturaense. Claramente tiene más edad, pero depositó después de la ültima elevación del cordón. Se correlacione con la etapa 12. El suelo ahora enterrado que se desarrolló en la superficie de este til tiene rasgos semejantes a los de los suelos de áreas algos húmedas; en contraste, los suelos calcáreos indican que dos otros períodos interglaciales fueron más secos. El til de edad más grande de esta cuenca, Los Mesones, se correlacione con la Glaciacion Más Grande de Patagonia, descrito por Mercer, que occurrió hace 1.0 a 1.2 × 106 años. Aunque es más antigua que las etapas establecidas de isótopos de oxígeno, existe en las curvas un período largo y frío por este tiempo. También, coincide con una de las glaciaciones de complejo Nebraskan-Kansan de norteamerica

Effect of Nitrogen on Agronomic Yield, Spad Units and Nitrate Content in Roselle (Hibiscus Sabdariffal.) in Dry Weather

This study was conducted in polyethylene bags of 4 kg capacity with plants of Jamaica from seeds collected from an accession on the coast of Oaxaca, which were planted under the ecological conditions of Teotitlán de Flores Magón, and evaluated under completely randomized design, where treatments were four levels of nitrogen: 0, 50, 100 and 150 kg ha-1 and four repetitions (4x4) = 16 experimental units. The variables evaluated were: both agronomic yields: chalice and seed, harvest index, SPAD units and nitrate content in leaf. The results indicate that higher yields ofseed and chalice, biomass, nitrate content in leaf and SPAD units were achieved with the application of 100 kg ha-1 of nitrogen with 50.39, 196.80, 620.4 g plant-1, 85.00 mg kg-1 and 29.10 units, respectively. The content of nitrates and its relationship with SPAD units, adjusted to an increasing linear model for the four levels of nitrogen studied. From this study it can be concluded that the application of 100 kg N ha-1, positively affect the culture of Jamaica under dry weather conditions way

Lethal Concentration of Carbonate OF Ca as a Function of the Osmotic Potential of the Solution in Sunflower (Heliantusannuus L.)

In order to know the effect of CaCO3 in solution, sunflower seedlings cv. Victoria, an experiment was completely randomized, where five concentrations of calcium carbonate were evaluated to determine the lethal concentration (LC50), pH and EC of the solution under laboratory conditions in the Universidad Tecnologica de Tehuacan, to simulate of excess Ca++ in the soils or nutrient solution. The results indicate, the LC50 was 62.8 mg CaCO3 L-1, so maximum values for pH, EC and calcium absorption, They were achieved at concentrations of 120 and 160 mg L-1 of CaCO3. This work can be concluded, Sunflower can absorb the high levels of calcium and used as an alternative, for remediation of agricultural soils affected hard water and Ca++ salts

Quality indicators for patients with traumatic brain injury in European intensive care units

Background: The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and to study its potential for quality measur

Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe

Purpose: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers. Methods: This is a prospective observational multicenter study conducted across 18 countries in Europe and Israel. Admission characteristics, clinical data, and outcome were described at patient- and center levels. Between-center variation in the total ICU population was quantified with the median odds ratio (MOR), with correction for case-mix and random variation between centers. Results: A total of 2138 patients were admitted to the ICU, with median age of 49 years; 36% of which were mild TBI (Glasgow Coma Scale; GCS 13–15). Within, 72 h 636 (30%) were discharged and 128 (6%) died. Early deaths and long-stay patients (> 72 h) had more severe injuries based on the GCS and neuroimaging characteristics, compared with short-stay patients. Long-stay patients received more monitoring and were treated at higher intensity, and experienced worse 6-month outcome compared to short-stay patients. Between-center variations were prominent in the proportion of short-stay patients (MOR = 2.3, p < 0.001), use of intracranial pressure (ICP) monitoring (MOR = 2.5, p < 0.001) and aggressive treatme

Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury

Objective: We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. Study Design and Setting: We performed logistic regression (LR), lasso regression, and ridge regression with key baseline predictors in the IMPACT-II database (15 studies, n = 11,022). ML algorithms included support vector machines, random forests, gradient boosting machines, and artificial neural networks and were trained using the same predictors. To assess generalizability of predictions, we performed internal, internal-external, and external validation on the recent CENTER-TBI study (patients with Glasgow Coma Scale <13, n = 1,554). Both calibration (calibration slope/intercept) and discrimination (area under the curve) was quantified. Results: In the IMPACT-II database, 3,332/11,022 (30%) died and 5,233(48%) had unfavorable outcome (Glasgow Outcome Scale less than 4). In the CENTER-TBI study, 348/1,554(29%) died and 651(54%) had unfavorable outcome. Discrimination and calibration varied widely between the studies and less so between the studied algorithms. The mean area under the curve was 0.82 for mortality and 0.77 for unfavorable outcomes in the CENTER-TBI study. Conclusion: ML algorithms may not outperform traditional regression approaches in a low-dimensional setting for outcome prediction after moderate or severe traumatic brain injury. Similar to regression-based prediction models, ML algorithms should be rigorously validated to ensure applicability to new populations

Variation in Structure and Process of Care in Traumatic Brain Injury: Provider Profiles of European Neurotrauma Centers Participating in the CENTER-TBI Study.

INTRODUCTION: The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for optimal care for TBI patients. The first step in CER is to map the existing variation. The aim of current study is to quantify variation in general structural and process characteristics among centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. METHODS: We designed a set of 11 provider profiling questionnaires with 321 questions about various aspects of TBI care, chosen based on literature and expert opinion. After pilot testing, questionnaires were disseminated to 71 centers from 20 countries participating in the CENTER-TBI study. Reliability of questionnaires was estimated by calculating a concordance rate among 5% duplicate questions. RESULTS: All 71 centers completed the questionnaires. Median concordance rate among duplicate questions was 0.85. The majority of centers were academic hospitals (n = 65, 92%), designated as a level I trauma center (n = 48, 68%) and situated in an urban location (n = 70, 99%). The availability of facilities for neuro-trauma care varied across centers; e.g. 40 (57%) had a dedicated neuro-intensive care unit (ICU), 36 (51%) had an in-hospital rehabilitation unit and the organization of the ICU was closed in 64% (n = 45) of the centers. In addition, we found wide variation in processes of care, such as the ICU admission policy and intracranial pressure monitoring policy among centers. CONCLUSION: Even among high-volume, specialized neurotrauma centers there is substantial variation in structures and processes of TBI care. This variation provides an opportunity to study effectiveness of specific aspects of TBI care and to identify best practices with CER approaches

Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study

Background: Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. Methods: Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subj

Informed consent procedures in patients with an acute inability to provide informed consent

Purpose: Enrolling traumatic brain injury (TBI) patients with an inability to provide informed consent in research is challenging. Alternatives to patient consent are not sufficiently embedded in European and national legislation, which allows procedural variation and bias. We aimed to quantify variations in informed consent policy and practice. Methods: Variation was explored in the CENTER-TBI study. Policies were reported by using a questionnaire and national legislation. Data on used informed consent procedures were available for 4498 patients from 57 centres across 17 European countries. Results: Variation in the use of informed consent procedur

Tracheal intubation in traumatic brain injury

Background: We aimed to study the associations between pre- and in-hospital tracheal intubation and outcomes in traumatic brain injury (TBI), and whether the association varied according to injury severity. Methods: Data from the international prospective pan-European cohort study, Collaborative European NeuroTrauma Effectiveness Research for TBI (CENTER-TBI), were used (n=4509). For prehospital intubation, we excluded self-presenters. For in-hospital intubation, patients whose tracheas were intubated on-scene were excluded. The association between intubation and outcome was analysed with ordinal regression with adjustment for the International Mission for Prognosis and Analysis of Clinical Trials in TBI variables and extracranial injury. We assessed whether the effect of intubation varied by injury severity by testing the added value of an interaction term with likelihood ratio tests. Results: In the prehospital analysis, 890/3736 (24%) patients had their tracheas intubated at scene. In the in-hospital analysis, 460/2930 (16%) patients had their tracheas intubated in the emergency department. There was no adjusted overall effect on functional outcome of prehospital intubation (odds ratio=1.01; 95% confidence interval, 0.79–1.28; P=0.96), and the adjusted overall effect of in-hospital intubation was not significant (odds ratio=0.86; 95% confidence interval, 0.65–1.13; P=0.28). However, prehospital intubation was associated with better functional outcome in patients with higher thorax and abdominal Abbreviated Injury Scale scores (P=0.009 and P=0.02, respectively), whereas in-hospital intubation was associated with better outcome in patients with lower Glasgow Coma Scale scores (P=0.01): in-hospital intubation was associated with better functional outcome in patients with Glasgow Coma Scale scores of 10 or lower. Conclusion: The benefits and harms of tracheal intubation should be carefully evaluated in patients with TBI to optimise benefit. This study suggests that extracranial injury should influence the decision in the prehospital setting, and level of consciousness in the in-hospital setting. Clinical trial registration: NCT02210221