Variational determination of multi-qubit geometrical entanglement in NISQ computers

Current noise levels in physical realizations of qubits and quantum operations limit the applicability of conventional methods to characterize entanglement. In this adverse scenario, we follow a quantum variational approach to estimate the geometric measure of entanglement of multiqubit pure states. The algorithm requires only single-qubit gates and measurements, so it is well suited for NISQ devices. This is demonstrated by successfully implementing the method on IBM Quantum devices for Greenberger-Horne-Zeilinger states of $3$, $4$, and $5$ qubits. Numerical simulations with random states show the robustness and accuracy of the method. The scalability of the protocol is numerically demonstrated via matrix product states techniques up to $25$ qubits

Exercises using a touchscreen tablet application improved functional ability more than an exercise program prescribed on paper in people after surgical carpal tunnel release: a randomised trial

Question: In people who have undergone surgical carpal tunnel release, do sensorimotor-based exercises performed on the touchscreen of a tablet device improve outcomes more than a conventional home exercise program prescribed on paper? Design: Randomised, parallel-group trial with concealed allocation, assessor blinding, and intention-to-treat analysis. Participants: Fifty participants within 10 days of surgical carpal tunnel release. Intervention: Each participant was prescribed a 4-week home exercise program. Participants in the experimental group received the ReHand tablet application, which administered and monitored exercises via the touchscreen. The control group was prescribed a home exercise program on paper, as is usual practice in the public hospital system. Outcome measures: The primary outcome was functional ability of the hand, reported using the shortened form of the Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire. Secondary outcomes were grip strength, pain intensity measured on a 10-cm visual analogue scale, and dexterity measured with the Nine-Hole Peg Test. Outcomes were measured by a blinded assessor at baseline and at the end of the 4-week intervention period. Results: At Week 4, functional ability improved significantly more in the experimental group than the control group (MD –21, 95% CI –33 to –9) on the QuickDASH score (0 to 100). Although the mean estimates of effect on the secondary outcome also all favoured the experimental group, none reached statistical significance: grip strength (MD 5.6 kg, 95% CI –0.5 to 11.7), pain (MD –1.4 cm, 95% CI –2.9 to 0.1), and dexterity (MD –1.3 seconds, 95% CI –3.7 to 1.1). Conclusion: Use of the ReHand tablet application for early rehabilitation after carpal tunnel release is more effective in the recovery of functional ability than a conventional home exercise program. It remains unclear whether there are any benefits in grip strength, pain or dexterity. Trial registration: ACTRN12618001887268

Cobertura financiera de la banca de desarrollo para el sector rural de México: FIRA y Financiera Rural

En México, el financiamiento al sector rural se sustenta en los Fideicomisos Instituidos en Relación a la Agricultura y en la Finan - ciera Rural, instituciones que conforman la banca de desarrollo para este sector y cuyo propósito esencial es el fomento productivo. Este trabajo analiza la cobertura financiera de la banca de desarrollo en el sector rural en sus dimensiones de amplitud, profundidad, alcance y permanencia. Por la investigación se concluye que la banca de desarrollo del sector rural ha priorizado su sostenibilidad financiera, concentrándose en la amplitud y con pocos logros en alcance y profundidad, lo cual refleja un limitado desempeño como institución de fomento

Quality of Work Life and Mental Health in Primary Care Physicians

AbstractThe aim of this study was to find the relationship between the perception of Quality of Work Life (QWL) and the mental health of primary care physicians of a public health institution in Guadalajara, Mexico. The study was analytical and was carried out with a universe of 818 doctors from 92 health units and the probability sample of 154 people. In all of them, CVT-GOHISALO and Goldberg GHQ-28 questionnaires were applied in order to measure their perception of QWL and the risk of mental illness respectively. Both instruments were selected because of their high reliability. We measured the satisfaction of the people interviewed for each one of the seven dimensions of CVT-GOHISALO and related to the points assigned to GHQ-28 case or not to consider the case of mental illness. The percentages of dissatisfaction with the QWL were greater than 12% in all dimensions of the instrument, being the highest value of 20.5% dissatisfaction for the job satisfaction dimension. In the classification of the case or not according to the GHQ-28, 22% were considered cases and 78% non-cases. We sought correspondence of satisfaction with the QWL by dimensions and non-case of Goldberg's, as well as dissatisfaction with the QWL and Goldberg's case, finding a clear link between being satisfied and having mental health. All dimensions have a correspondence that goes from 79.7% to 82.3% between satisfaction and non-case, being in all the statistical significance value less than 0.05 For primary care physicians in the studied institution, there is a clear relationship between being satisfied with the QWL and present less risk of mental illness. It is alarming that the medical staff presents high rates of dissatisfaction with the QWL and risk of mental illness. It is necessary to provide preventive programs among health care workers in order to improve their QWL and mental health

Vortices and domain walls in a Chern-Simons theory with magnetic moment interaction

We study the structure and properties of vortices in a recently proposed Abelian Maxwell-Chern-Simons model in $2 +1$ dimensions. The model which is described by gauge field interacting with a complex scalar field, includes two parity and time violating terms: the Chern-Simons and the anomalous magnetic terms. Self-dual relativistic vortices are discussed in detail. We also find one dimensional soliton solutions of the domain wall type. The vortices are correctly described by the domain wall solutions in the large flux limit.Comment: To be published in Phys RevD 23 pages, RevTex, 5 figure

Induction of neural crest stem cells from Bardet–Biedl syndrome patient derived hiPSCs

Neural crest cells arise in the embryo from the neural plate border and migrate throughout the body, giving rise to many different tissue types such as bones and cartilage of the face, smooth muscles, neurons, and melanocytes. While studied extensively in animal models, neural crest development and disease have been poorly described in humans due to the challenges in accessing embryonic tissues. In recent years, patient-derived human induced pluripotent stem cells (hiPSCs) have become easier to generate, and several streamlined protocols have enabled robust differentiation of hiPSCs to the neural crest lineage. Thus, a unique opportunity is offered for modeling neurocristopathies using patient specific stem cell lines. In this work, we make use of hiPSCs derived from patients affected by the Bardet–Biedl Syndrome (BBS) ciliopathy. BBS patients often exhibit subclinical craniofacial dysmorphisms that are likely to be associated with the neural crest-derived facial skeleton. We focus on hiPSCs carrying variants in the BBS10 gene, which encodes a protein forming part of a chaperonin-like complex associated with the cilium. Here, we establish a pipeline for profiling hiPSCs during differentiation toward the neural crest stem cell fate. This can be used to characterize the differentiation properties of the neural crest-like cells. Two different BBS10 mutant lines showed a reduction in expression of the characteristic neural crest gene expression profile. Further analysis of both BBS10 mutant lines highlighted the inability of these mutant lines to differentiate toward a neural crest fate, which was also characterized by a decreased WNT and BMP response. Altogether, our study suggests a requirement for wild-type BBS10 in human neural crest development. In the long term, approaches such as the one we describe will allow direct comparison of disease-specific cell lines. This will provide valuable insights into the relationships between genetic background and heterogeneity in cellular models. The possibility of integrating laboratory data with clinical phenotypes will move us toward precision medicine approaches

Multicenter prospective clinical study to evaluate children short-term neurodevelopmental outcome in congenital heart disease (children NEURO-HEART) : study protocol

Altres ajuts: RETICS funded by the PN 2018-2021 (Spain).Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances in early diagnosis and postnatal management have increased survival in CHD children, worrying long-term outcomes, particularly neurodevelopmental disability, have emerged as a key prognostic factor in the counseling of these pregnancies. Eligible participants are women presenting at 20 to < 37 weeks of gestation carrying a fetus with CHD. Maternal/neonatal recordings are performed at regular intervals, from the fetal period to 24 months of age, and include: placental and fetal hemodynamics, fetal brain magnetic resonance imaging (MRI), functional echocardiography, cerebral oxymetry, electroencephalography and serum neurological and cardiac biomarkers. Neurodevelopmental assessment is planned at 12 months of age using the ages and stages questionnaire (ASQ) and at 24 months of age with the Bayley-III test. Target recruitment is at least 150 cases classified in three groups according to three main severe CHD groups: transposition of great arteries (TGA), Tetralogy of Fallot (TOF) and Left Ventricular Outflow Tract Obstruction (LVOTO). The results of NEURO-HEART study will provide the most comprehensive knowledge until date of children's neurologic prognosis in CHD and will have the potential for developing future clinical decisive tools and improving preventive strategies in CHD. , on 4th December 2016 (retrospectively registered)

Cross-Sectional Analysis of Late HAART Initiation in Latin America and the Caribbean: Late Testers and Late Presenters

Background: Starting HAART in a very advanced stage of disease is assumed to be the most prevalent form of initiation in HIV-infected subjects in developing countries. Data from Latin America and the Caribbean is still lacking. Our main objective was to determine the frequency, risk factors and trends in time for being late HAART initiator (LHI) in this region. Methodology: Cross-sectional analysis from 9817 HIV-infected treatment-naive patients initiating HAART at 6 sites (Argentina, Chile, Haiti, Honduras, Peru and Mexico) from October 1999 to July 2010. LHI had CD4$^+$ count $\leq$200cells/mm$^3$ prior to HAART. Late testers (LT) were those LHI who initiated HAART within 6 months of HIV diagnosis. Late presenters (LP) initiated after 6 months of diagnosis. Prevalence, risk factors and trends over time were analyzed. Principal Findings: Among subjects starting HAART (n = 9817) who had baseline CD4$^+$ available (n = 8515), 76% were LHI: Argentina (56%[95%CI:52–59]), Chile (80%[95%CI:77–82]), Haiti (76%[95%CI:74–77]), Honduras (91%[95%CI:87–94]), Mexico (79%[95%CI:75–83]), Peru (86%[95%CI:84–88]). The proportion of LHI statistically changed over time (except in Honduras) ($p\leq0.02$; Honduras p = 0.7), with a tendency towards lower rates in recent years. Males had increased risk of LHI in Chile, Haiti, Peru, and in the combined site analyses (CSA). Older patients were more likely LHI in Argentina and Peru (OR 1.21 per +10-year of age, 95%CI:1.02–1.45; OR 1.20, 95%CI:1.02–1.43; respectively), but not in CSA (OR 1.07, 95%CI:0.94–1.21). Higher education was associated with decreased risk for LHI in Chile (OR 0.92 per +1-year of education, 95%CI:0.87–0.98) (similar trends in Mexico, Peru, and CSA). LHI with date of HIV-diagnosis available, 55% were LT and 45% LP. Conclusion: LHI was highly prevalent in CCASAnet sites, mostly due to LT; the main risk factors associated were being male and older age. Earlier HIV-diagnosis and earlier treatment initiation are needed to maximize benefits from HAART in the region