12 research outputs found
Conceptual Framework for Appling Internet of Things in Production Systems for Sensing Enterprises
Sensing Enterprise is a new concept, which appears with the Internet of Things (IoT) application in industry. This
technology applied in production systems provides many benefits like better transparency or real time information. This
approach proposes a conceptual framework for IoT application in Production Systems. The aim of this framework is helping
enterprises to identify the main elements to apply IoT in Production Systems. To create this framework, a literature re-view
has been made and the main components of IoT in Sensing Enterprise in production proposals have been identify. Thus,
these elements and its relations have been the source for the conceptual framework proposed.Boza, A.; Cortés-Santamaría, B.; Alemany Díaz, MDM.; Cuenca, L. (2016). Conceptual Framework for Appling Internet of Things in Production Systems for Sensing Enterprises. Brazilian Journal of Operations and Production Management. 13(1):66-71. doi:10.14488/BJOPM.2016.v13.n1.a7S667113
Universidad y sociedad: comunicación e integración en empresas e instituciones públicas y organizaciones no lucrativas. Nuevos avances
Depto. de Teorías y Análisis de la ComunicaciónFac. de Ciencias de la InformaciónFALSEsubmitte
El grupu neandertal de la Cueva d'El Sidrón (Borines, Piloña).
Na monografía clásica de Puig y Larraz (1896: 250-252) amiéntense delles cavidaes del Conceyu de Piloña2 , pero non la Cueva d’El Sidrón (Fig. 1). Esta conocíase, ensin dulda, dende la Guerra Civil y el maquis al servir d’abellugu a persiguíos políticos, y guarda una alcordanza imborrable nuna de les sos múltiples entraes, yá qu’ellí ta enterrada Olvido Otero González (1908-1938). Per El Sidrón pasaron munches persones a lo llargo de los años, pero en 1994 prodúxose’l descubrimientu per parte d’unos espeleólogos xixoneses d’unos güesos humanos que dieron un importante xiru a la conocencia de los nuesos antepasaos neandertale
El grupu neandertal de la Cueva d' El Sidrón (Borines, Piloña)
El artículo está en la lengua asturianaPeer reviewe
El grupu neandertal de la Cueva d'El Sidrón (Borines, Piloña)
Na monografía clásica de Puig y Larraz (1896: 250-252) amiéntense delles cavidaes del Conceyu de Piloña, pero non la Cueva d’El Sidrón (Fig. 1). Esta conocíase, ensin dulda, dende la Guerra Civil y el maquis al servir d’abellugu a persiguíos políticos, y guarda una alcordanza imborrable nuna de les sos múltiples entraes, yá qu’ellí ta enterrada Olvido Otero González (1908-1938). Per El Sidrón pasaron munches persones a lo llargo de los años, pero en 1994 prodúxose’l descubrimientu per parte d’unos espeleólogos xixoneses d’unos güesos humanos que dieron un importante xiru a la conocencia de los nuesos antepasaos neandertales.Peer Reviewe
CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative
Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Herramienta software de ayuda en la detección de eventos inesperados en un sistema de producción
En
este
proyecto
final
de
carrera,
se
describe
la
realización
de
un
software
de
ayuda
para
la
identificación
de
eventos
no
esperados
en
una
cadena
de
producción.
El
usuario
podrá
crear
un
sistema
experto
(formado
por
una
serie
de
criterios)
que
detecte
cuando
haya
un
evento
inesperado
que
obligue
a
replanificar
y
también
podrá
ejecutar
este
sistema
manual
o
automáticamente.
Para
ello,
primero
se
estudia
los
conceptos
teóricos
de
este
ámbito,
para
poder
entender
mejor
el
contexto
en
el
que
trabajamos,
y
veremos
también
un
descripción
de
las
herramientas
utilizadas
para
la
creación
de
este
software.
Una
vez
los
conceptos
explicados,
se
pasará
la
implementación
del
programa.
Se
empezará
con
un
análisis
previo
del
software,
utilizando
métodos
vistos
durante
la
carrera.
Luego
veremos
que
uso
le
hemos
dado
a
las
herramientas
de
ayuda
para
la
creación
del
software.
Y
por
último,
una
descripción
detallada
de
la
interfaz
y
el
comportamiento
interno
del
software.Cortés Santamaría, B. (2013). Herramienta software de ayuda en la detección de eventos inesperados en un sistema de producción. http://hdl.handle.net/10251/32446.Archivo delegad
SARS-CoV-2 infection, vaccination, and antibody response trajectories in adults: a cohort study in Catalonia
Abstract
Background
Heterogeneity of the population in relation to infection, COVID-19 vaccination, and host characteristics is likely reflected in the underlying SARS-CoV-2 antibody responses.
Methods
We measured IgM, IgA, and IgG levels against SARS-CoV-2 spike and nucleocapsid antigens in 1076 adults of a cohort study in Catalonia between June and November 2020 and a second time between May and July 2021. Questionnaire data and electronic health records on vaccination and COVID-19 testing were available in both periods. Data on several lifestyle, health-related, and sociodemographic characteristics were also available.
Results
Antibody seroreversion occurred in 35.8% of the 64 participants non-vaccinated and infected almost a year ago and was related to asymptomatic infection, age above 60 years, and smoking. Moreover, the analysis on kinetics revealed that among all responses, IgG RBD, IgA RBD, and IgG S2 decreased less within 1 year after infection. Among vaccinated, 2.1% did not present antibodies at the time of testing and approximately 1% had breakthrough infections post-vaccination. In the post-vaccination era, IgM responses and those against nucleoprotein were much less prevalent. In previously infected individuals, vaccination boosted the immune response and there was a slight but statistically significant increase in responses after a 2nd compared to the 1st dose. Infected vaccinated participants had superior antibody levels across time compared to naïve-vaccinated people. mRNA vaccines and, particularly the Spikevax, induced higher antibodies after 1st and 2nd doses compared to Vaxzevria or Janssen COVID-19 vaccines. In multivariable regression analyses, antibody responses after vaccination were predicted by the type of vaccine, infection age, sex, smoking, and mental and cardiovascular diseases.
Conclusions
Our data support that infected people would benefit from vaccination. Results also indicate that hybrid immunity results in superior antibody responses and infection-naïve people would need a booster dose earlier than previously infected people. Mental diseases are associated with less efficient responses to vaccination