El narco, estado paralelo

El incremento de la violencia cobra cada vez más víctimas civiles y la importancia del narcotráfico y del problema sociopolítico que representa para México se vuelve, cada vez más, un tema de primer orden para el estado.ITESO, A.C

Benchmarks for flexible and rigid transcription factor-DNA docking

<p>Abstract</p> <p>Background</p> <p>Structural insight from transcription factor-DNA (TF-DNA) complexes is of paramount importance to our understanding of the affinity and specificity of TF-DNA interaction, and to the development of structure-based prediction of TF binding sites. Yet the majority of the TF-DNA complexes remain unsolved despite the considerable experimental efforts being made. Computational docking represents a promising alternative to bridge the gap. To facilitate the study of TF-DNA docking, carefully designed benchmarks are needed for performance evaluation and identification of the strengths and weaknesses of docking algorithms.</p> <p>Results</p> <p>We constructed two benchmarks for flexible and rigid TF-DNA docking respectively using a unified non-redundant set of 38 test cases. The test cases encompass diverse fold families and are classified into easy and hard groups with respect to the degrees of difficulty in TF-DNA docking. The major parameters used to classify expected docking difficulty in flexible docking are the conformational differences between bound and unbound TFs and the interaction strength between TFs and DNA. For rigid docking in which the starting structure is a bound TF conformation, only interaction strength is considered.</p> <p>Conclusions</p> <p>We believe these benchmarks are important for the development of better interaction potentials and TF-DNA docking algorithms, which bears important implications to structure-based prediction of transcription factor binding sites and drug design.</p

Why do grape-based fruit wines could be &#8220;super&#8221; magic?

In Europe, the global consumption of wine is decreasing and new alternatives of wine have been appearing on the market. The attractiveness of these products rely on the fact that they are inexpensive and easy to drink, with low alcohol content and obtained by mixing wines with fruit juices or flavoring wine. While fruit wines represent an ancient art [1], no studies have investigated the production of beverages that are obtained by the co-fermentation of grape and fruit. The formulation of new mixed-fruit wines could represent the basis for reducing post-harvest fruit losses and contribute to the economy of the existing wine industry. Moreover, throughout the selection of useful yeasts that drive the alcoholic fermentation, the final products could be enriched in novel active bio-functional compounds not found in traditional wines. The research activity has involved the setup of fermentation trials using grape must and fruit juices of strawberry, peach, cherry and kiwi. Must fermentations were carried out inoculating Saccharomyces cerevisiae and Torulaspora delbruekii species in four musts obtained by blending grape must (Chardonnay and Cabernet Sauvignon) and juices at 80:20 and 60:40 grape:fruit juice proportion. The aromatic profile was determined by GC-MS. S. cerevisiae was able to exhaust the available sugars in all trials. In particular, based on the proportion used, alcohol was 3-5% less in wines prepared with red grape and 6-7% (v/v) less in case of white grape. T. delbruekii showed a good fermentation performance as well, suggesting its potential use as starter yeast. Only negligible difference was found for the pH, while the total acidity was higher for mixed-fruit wines obtained with must from white grape and at the 60:40 proportion. In particular, the high level of citric acid detected (up to 8 g/L) in some products could exert a beneficial effect by protecting the wine components, bio-functional compounds included, against oxidation

La construcción de la sociedad: entre competencia y cooperación

En tiempos en los que la economía ha permeado todos los aspectos de la vida; en los que la histerización de la política hace que seamos cada vez más violentos, cerrados al diálogo y menos civilizados; en los que la competencia y la competitividad son los parámetros para medir el desempeño de las personas, es necesario dar un giro y pasar a una actitud de cooperación porque la competencia no trae lo mejor de nosotros mismos, sino lo peor. Sólo la cooperación genera confianza, y debe ser una tarea fundamental para instituciones como el ITESO y para las universidades en general. La“economistificación”, concepto propuesto por el filósofo Jean-Pierre Dupuy, señala que la lógica política ha sido remplazada por una lógica económica, lo que trae tres consecuencias principales: la economistificación no da cuenta de la capacidad que tenemos para hacer el mal, porque la técnica rebasó toda nuestra capacidad moral; da pie a la comercialización de la competencia, y medimos el desempeño en términos de competitividad; ocasiona la proliferación de la falta de civilidad en la sociedad, y la solución de conflictos es cada vez más violenta. Para responder a la pregunta de cómo salir de la economistificación conviene recordar las tres pasiones propuestas por Hobbes, la competencia, la desconfianza y la vanidad, y cambiarlas por tres pasiones positivas: la cooperación, la confianza y la benevolencia

Muerte de un lince ibérico. Establecimiento de la causa y la autoría

Las ciencias forenses se aplican desde hace poco tiempo como herramientas en las investigaciones de delitos contra el medio ambiente. En este trabajo se expone un caso pionero en cuanto a la utilización de estas técnicas en un caso de un delit o contra la fauna silvestre. La investigación se inicia tras la apari ción de un lince ibérico muerto en el interior de una finca, donde se encontraron también varios pollos supuestamente utilizados como cebos envenenados y otro cadáver, el de un zorro. El lince ib érico es uno de los mamíferos más amenazados del planeta. Se llevaron a cabo distintos análisis a partir de la necropsia de los cadáveres en el Centro de Análisis y Diagnóstico de la Fauna Silvestre (CAD), el laboratorio de referencia para la fauna silvestre pertene ciente a la Junta de Andalucía. Los resultados fuer on concluyentes, ambas muertes se produjeron como consecuencia de la ingestión de cebos envenenados con un plaguicida extremadamente tóxico, el aldicarb. También se encontró esta sustancia en los pollos recogidos en el interior de la finca. Con el fin de e stablecer la culpabilidad de los propietarios de la finca, que negaron tener nada que ver con las muertes y la colocación de los cebos, se utilizó una herramienta novedosa en este tipo de investigaciones, la genética forens e. En base a los resultados se co nsiguió establecer una relación de parentesco entre los pollos utilizados como cebos envenenados y los pollos propiedad reconocida de los sospechosos, que permitió demostrar que todos tenían el mismo origen. Gracias al trabajo conjunto y coordinado durante toda la investigación y el informe pericial elaborado por el laboratorio del CAD, la Consejería de Medio Ambiente y Organización del Territorio de la Junta de Andalucía consiguió una sentencia ejemplar contra los envenenador es.The application of forensic science as a research tool to resolve crimes against the environment is relatively rec ent. To our knowledge this is the first instance in which the forensic genetic have been used as a definitive evidence to find out guilty in crimes against the wildlife. Our research starts when an Iberian lynx was found dead into a farm; very close to sev eral chickens used as poisoned baits and a fox carcass. Iberian lynx is one of the most endangered mammals in the planet. A comprehensive investigation from the carcasses was performed in the Analysis and Diagnostic Center for Wildlife in Andalucia (CAD), the reference laboratory for wildlife of the Andalusian Government (Spain). The results determined that the deaths occurred as a result of ingestion o f baits poisoned with an extremely toxic pesticide, aldicarb. This substance was also found in chickens ga thered inside the farm. In order to establish the guilt of the owners of the farm, who refused to be related to the deaths and the placement of the b aits, an innovative tool was used in this kind of research, the forensic genetic. Based on the results we got, we established a relationship between the chickens used as poisoned baits and the chickens from the farmer, all of them had the same origin. Thanks to the coordinated actuation during the complete investigation and the official report by the CAD labor atory used in the trial, the Ministry of Environmental and Territorial Organization got an exemplary sentence against the poisoners

A data-driven linguistic characterization of hallucinated voices in clinical and non-clinical voice-hearers

Background: Auditory verbal hallucinations (AVHs) are heterogeneous regarding phenomenology and etiology. This has led to the proposal of AVHs subtypes. Distinguishing AVHs subtypes can inform AVHs neurocognitive models and also have implications for clinical practice. A scarcely studied source of heterogeneity relates to the AVHs linguistic characteristics. Therefore, in this study we investigate whether linguistic features distinguish AVHs subtypes, and whether linguistic AVH-subtypes are associated with phenomenology and voice-hearers' clinical status. Methods: Twenty-one clinical and nineteen non-clinical voice-hearers participated in this study. Participants were instructed to repeat verbatim their AVHs just after experiencing them. AVH-repetitions were audio-recorded and transcribed. AVHs phenomenology was assessed using the Auditory Hallucinations Rating Scale of the Psychotic Symptom Rating Scales. Hierarchical clustering analyses without a priori group dichotomization were performed using quantitative measures of sixteen linguistic features to distinguish sets of AVHs. Results: A two-AVHs-cluster solution best partitioned the data. AVHs-clusters significantly differed in linguistic features (p < .001); AVHs phenomenology (p < .001); and distribution of clinical voice-hearers (p < .001). The “expanded-AVHs” cluster was characterized by more determiners, more prepositions, longer utterances (all p < .01), and mainly contained non-clinical voice-hearers. The “compact-AVHs” cluster had fewer determiners and prepositions, shorter utterances (all p < .01), more negative content, higher degree of negativity (both p < .05), and predominantly came from clinical voice-hearers. Discussion: Two voice-speech clusters were recognized, differing in syntactic-grammatical complexity and negative phenomenology. Our results suggest clinical voice-hearers often hear negative, “compact-voices”, understandable under Broca's right hemisphere homologue and memory-based mechanisms. Conversely, non-clinical voice-hearers experience “expanded-voices”, better accounted by inner speech AVHs models

Neurodynamic evaluation of hearing aid features using EEG correlates of listening effort

In this study, we propose a novel estimate of listening effort using electroencephalographic data. This method is a translation of our past findings, gained from the evoked electroencephalographic activity, to the oscillatory EEG activity. To test this technique, electroencephalographic data from experienced hearing aid users with moderate hearing loss were recorded, wearing hearing aids. The investigated hearing aid settings were: a directional microphone combined with a noise reduction algorithm in a medium and a strong setting, the noise reduction setting turned off, and a setting using omnidirectional microphones without any noise reduction. The results suggest that the electroencephalographic estimate of listening effort seems to be a useful tool to map the exerted effort of the participants. In addition, the results indicate that a directional processing mode can reduce the listening effort in multitalker listening situations