Allergic Reactions to Metamizole: Immediate and Delayed Responses

[EN] Background: Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to metamizole. Methods: Patients with suspicion of hypersensitivity to metamizole were evaluated. We verified acetylsalicylic acid tolerance and classified patients as immediate or delayed responders if they showed symptoms less or more than 24 h after metamizole administration. Skin tests were performed and if negative, a basophil activation test (BAT) was performed on immediate responders. If it was negative, we performed a drug provocation test (DPT) with metamizole. Results: A total of 137 patients were included: 132 reacted within 24 h (single NSAID-induced urticaria/angioedema/ anaphylaxis; SNIUAA) and 5 after 24 h (single NSAID-induced delayed hypersensitivity reaction; SNIDHR). Most SNIUAA patients developed anaphylaxis (60.60%); for SNIDHR, maculopapular exanthema was the most frequent entity (60%). Skin testing was positive in 62.04% of all cases and BAT in 28% of the SNIUAA patients with negative skin tests. In 5.1% of the cases, DPT with metamizole was needed to establish the diagnosis. In 22.62% of the cases, diagnosis was established by consistent and unequivocal history of repeated allergic episodes in spite of a negative skin test and BAT. Conclusions: SNIUAA to metamizole is the most frequent type of selective NSAID hypersensitivity, with anaphylaxis being the most common clinical entity. It may occur within 1 h after drug intake. SNIDHR occurs in a very low percentage of cases. The low sensitivity of diagnostic tests may be due to incomplete characterization of the chemical structures of metamizole and its metabolites.The present study has been supported by the Institute of Health ‘Carlos III’ of the Ministry of Economy and Competitiveness [grants cofounded by European Regional Development Fund (ERDF), Red de Reacciones Adversas a Alergenos y Farmacos (RD12/0013/0001 and PI15/01317)] and by Consejeria de Salud de la Junta de Andalucía (PI-0463-2013).Blanca-López, N.; Pérez-Sanchez, N.; Agúndez, JA.; García-Martín, E.; Torres, MJ.; Cornejo-Garcia, JA.; Perkins, JR.... (2016). Allergic Reactions to Metamizole: Immediate and Delayed Responses. International Archives of Allergy and Immunology. 169(4):223-230. https://doi.org/10.1159/000444798S223230169

Omics technologies in allergy and asthma research: An EAACI position paper

Allergic diseases and asthma are heterogenous chronic inflammatory conditions with several distinct complex endotypes. Both environmental and genetic factors can influence the development and progression of allergy. Complex pathogenetic pathways observed in allergic disorders present a challenge in patient management and successful targeted treatment strategies. The increasing availability of high-throughput omics technologies, such as genomics, epigenomics, transcriptomics, proteomics, and metabolomics allows studying biochemical systems and pathophysiological processes underlying allergic responses. Additionally, omics techniques present clinical applicability by functional identification and validation of biomarkers. Therefore, finding molecules or patterns characteristic for distinct immune-inflammatory endotypes, can subsequently influence its development, progression, and treatment. There is a great potential to further increase the effectiveness of single omics approaches by integrating them with other omics, and nonomics data. Systems biology aims to simultaneously and longitudinally understand multiple layers of a complex and multifactorial disease, such as allergy, or asthma by integrating several, separated data sets and generating a complete molecular profile of the condition. With the use of sophisticated biostatistics and machine learning techniques, these approaches provide in-depth insight into individual biological systems and will allow efficient and customized healthcare approaches, called precision medicine. In this EAACI Position Paper, the Task Force “Omics technologies in allergic research” broadly reviewed current advances and applicability of omics techniques in allergic diseases and asthma research, with a focus on methodology and data analysis, aiming to provide researchers (basic and clinical) with a desk reference in the field. The potential of omics strategies in understanding disease pathophysiology and key tools to reach unmet needs in allergy precision medicine, such as successful patients’ stratification, accurate disease prognosis, and prediction of treatment efficacy and successful prevention measures are highlighted

Dairy product consumption and changes in cognitive performance: two-year analysis of the PREDIMED-Plus Cohort

Scope: Dairy consumption has been suggested to impact cognition; however, evidence is limited and inconsistent. This study aims to longitudinally assess the association between dairy consumption with cognitive changes in an older Spanish population at high cardiovascular disease risk. Methods and results: Four thousand six hundred sixty eight participants aged 55–75 years, completed a validated food frequency questionnaire at baseline and a neuropsychological battery of tests at baseline and 2-year follow-up. Multivariable linear regression models are used, scaled by 100 (i.e., the units of β correspond to 1 SD/100), to assess associations between baseline tertile daily consumption and 2-year changes in cognitive performance. Participants in the highest tertile of total milk and whole-fat milk consumption have a greater decline in global cognitive function (β: –4.71, 95% CI: –8.74 to –0.69, p-trend = 0.020 and β: –6.64, 95% CI: –10.81 to –2.47, p-trend = 0.002, respectively) compared to those in the lowest tertile. No associations are observed between low fat milk, yogurt, cheese or fermented dairy consumption, and changes in cognitive performance. Conclusion:Results suggest there are no clear prospective associations between consumption of most commonly consumed dairy products and cognition, although there may be an association with a greater rate of cognitive decline over a 2-year period in older adults at high cardiovascular disease risk for whole-fat milk

Genetic predictors of inflammation in the risk of occupational asthma in young apprentices.

International audienceBACKGROUND: The influence of genetic predictors of inflammation and atopy on occupational asthma in apprentices is not known. OBJECTIVES: To assess the influence of genetic polymorphisms of IL4RA, IL13, TNFA, IL1A, and IL5 on the decline of lung function and bronchial hyperresponsiveness in a prospective follow-up study of baker/pastry maker and hairdresser apprentices. METHODS: A total of 351 apprentices were included in the study. We performed skin testing, spirometry, fractional exhaled nitric oxide measurement, and methacholine hyperreactivity testing at the initial visit and during and at the end of the 18-month training period. Gene variants of IL4RA, IL13, TNFA, IL1A, and IL5 were determined in DNA from nasal lavage. RESULTS: IL13 R130Q/IL4RA S478P or IL13 R130Q//IL4RA Q551R were significant predictors of the decrease of forced expiratory volume and forced vital capacity (P ≤ .006). Genotype GG of TNFAG308A was associated with bronchial hyperresponsiveness in the whole population and in nonatopic individuals (90.63% vs 9.38%; odds ratio, 3.78; 95% confidence interval, 1.10-12.83). TNFA GA and IL5 CC and TNFA GA and IL1A CC were 2 epistatic predictors of exhaled nitrogen monoxide decrease during follow-up (P = .02 and P = .004, respectively). The association with TNFA GA and IL1A CC was the most significant in nonatopic bakers (P < .001). CONCLUSION: We evidenced a predicting influence of IL13/IL4RA and TNFA in the early exposure to allergens and irritants that precedes occupational asthma. The significance of the associations in the absence of atopy suggests an influence of the genetics predictors related to inflammatory pathways

Omics technologies in allergy and asthma research: An EAACI position paper.

Allergic diseases and asthma are heterogenous chronic inflammatory conditions with several distinct complex endotypes. Both environmental and genetic factors can influence the development and progression of allergy. Complex pathogenetic pathways observed in allergic disorders present a challenge in patient management and successful targeted treatment strategies. The increasing availability of high-throughput omics technologies, such as genomics, epigenomics, transcriptomics, proteomics, and metabolomics allows studying biochemical systems and pathophysiological processes underlying allergic responses. Additionally, omics techniques present clinical applicability by functional identification and validation of biomarkers. Therefore, finding molecules or patterns characteristic for distinct immune-inflammatory endotypes, can subsequently influence its development, progression, and treatment. There is a great potential to further increase the effectiveness of single omics approaches by integrating them with other omics, and nonomics data. Systems biology aims to simultaneously and longitudinally understand multiple layers of a complex and multifactorial disease, such as allergy, or asthma by integrating several, separated data sets and generating a complete molecular profile of the condition. With the use of sophisticated biostatistics and machine learning techniques, these approaches provide in-depth insight into individual biological systems and will allow efficient and customized healthcare approaches, called precision medicine. In this EAACI Position Paper, the Task Force "Omics technologies in allergic research" broadly reviewed current advances and applicability of omics techniques in allergic diseases and asthma research, with a focus on methodology and data analysis, aiming to provide researchers (basic and clinical) with a desk reference in the field. The potential of omics strategies in understanding disease pathophysiology and key tools to reach unmet needs in allergy precision medicine, such as successful patients' stratification, accurate disease prognosis, and prediction of treatment efficacy and successful prevention measures are highlighted

TVI- Arquitectura y Construcción - AR313 - 202102

Descripción: El curso TVI-Arquitectura y construcción introduce al estudiante en el conocimiento de las necesidades constructivas del proyecto arquitectónico y en la aplicación de los sistema estructurales; en la coordinación de sistemas estructurales para hacer posible que los sótanos de estacionamiento calcen sobre plantas de desarrollo habitacional, que los ductos de instalaciones eléctricas y sanitarias tengan continuidad, etc. Se diseñan pequeños edificios de oficinas, fábricas, centros comerciales, clínicas, complejos deportivos, etc. Propósito: Desarrollar propuestas arquitectónicas cuya concepción involucre la necesidad de pensar en sistemas estructurales adecuados, un correcto dimensionamiento para las necesidades materiales del proyecto (tales como estacionamiento, traslado de muebles, y seguridad) La construcción implica decidir una lógica estructural, por el comportamiento del material, y la expresión arquitectónica en coherencia con el tema ¿organización y funcionamiento- y el lugar. La asignatura contribuye al desarrollo de las competencias específicas de la carrera: Diseño Fundamentado, que corresponde a los criterios NAAB PC2, PC3, PC8, PC5, SC3, SC5, así como, Técnica y Construcción que corresponde a los criterios NAAB SC1, SC4, SC6; ambas en el nivel de logro 2. Tiene como requisito la asignatura de AR309 TV - Arquitectura y Medio Ambient

April 18th - 22nd, 2022, Córdoba, Argentina

Del 18 al 22 de abril de 2022 se llevó a cabo el XI Encuentro FoF en el Auditorio “Mirta Mosconi” del Observatorio de Córdoba. Fue la primera edición híbrida de este evento anual. Se han cubierto siete áreas de la astronomía: instrumentación y herramientas, sistemas planetarios, el sol y la física solar, astrofísica estelar, astronomía galáctica, astronomía extragaláctica y cosmología y gravitación. La reunión registró 177 participantes individuales, entre los cuales 88 fueron presenciales mientras que el resto participó de forma remota. En cuanto a la distribución de género de los participantes, el 57 por ciento eran hombres. Esta edición incluyó 12 conferencias magistrales (50-50% hombres-mujeres), 38 charlas breves aportadas (55-45% hombres-mujeres), 17 e-posters (65-35% hombres-mujeres), 7 talleres/prácticas sesiones y 2 mesas redondas. Todas las actividades han sido grabadas y los videos publicados en YouTube. En este cuadernillo incluimos los resúmenes de las charlas y e-posters presentados en el XI encuentro FoF.From 18 to 22 April 2022, the XI edition of the FoF meeting took place at the "Mirta Mosconi" Auditorium of the Córdoba’s Observatory. It was the first hybrid edition of this annual event. Seven areas of astronomy have been covered: Instrumentation and Tools, Planetary Systems, the Sun and Heliophysics, Stellar Astrophysics, Galactic Astronomy, Extragalactic Astronomy, and Cosmology & Gravity. The meeting registered 177 individual participants, among which 88 were in-person attendees while the remaining participated remotely. Regarding the gender distribution of participants, 57 per cent were male. This edition included 12 keynote addresses (50-50% male-female), 38 contributed short talks (55-45% male-female), 17 e-posters (65-35% male-female), 7 workshop/hands-on sessions, and 2 round table discussion sessions. All the activities have been recorded, and the videos published on YouTube. In this booklet, we include the abstracts of talks and e-posters presented at the XI FoF meeting.List of Abstracts – Talks: Chemical Abundances in Planetary Nebulae: Collisionally Excited Lines vs. Recombination Lines / M. Peña Cárdenas -- Automated classification of eclipsing binary systems in the VVV Survey / V. Daza Perilla -- Strong non-dipolar magnetic fields in millisecond pulsars? / J. Pelle -- Formation and Evolution of central stars of Planetary Nebulae / M. Miller Bertolami -- Exploration of magnetic activity indices in M dwarfs / C. Oviedo -- Plasma Correction in the “Cosine Relation” for Pulsar Pulse Profile / G. Briozzo -- Regolith ejection on the asteroid Didymos due to its fast rotation / N. Trógolo -- Orbital evolution of circumbinary planets due to creep tides / F. Zoppetti -- The physical and chemical signatures of young protostars and planet-forming disks / E. Artur de la Villarmois -- The host galaxies of binary compact objects across cosmic time / M.C. Artale -- Gravastars in f(R,L) gravity / C. Vieira Gomes -- The integrated Sachs-Wolfe effect in 4D Einstein-Gauss-Bonnet gravity / M. Ghodsi Yengejeh -- Wiener filter for CMB maps using Neural Networks / M. B. Costanza -- NumCosmo halo tools: application to cluster cosmology and cluster mass estimation / M. Penna-Lima -- Giant HII Regions and HII Galaxies as tracers of the Hubble expansion and its use in cosmology / D. Fernandez-Arenas -- Cosmology with baryons: modelling the cosmic matter distribution for Large-Scale Structure analyses / G. Aricò -- On dynamo theories for cosmological magnetic fields / M. Rubio -- Universal renormalization procedure for higher curvature AdS gravity in up to 5 dimensions / I. Araya Quezada -- Clues on the formation of giant low surface brightness galaxies / G. Galaz -- Low Surface Brightness Galaxes in the IllustrisTNG Simulation / L. Peréz-Montaño -- 2D Surface Brightness Modelling of Large Galaxies: Photometry, Structural Parameters and Black Hole Scaling Relations / E. Ríos-López -- Formation of Ultra-Diffuse galaxies in different environments / J. Benavides-Blanco -- Influence of environment on the AGN-starburst connection in small galaxy systems / F. Duplancic -- AGN & Voids. The role of active objects in cosmic voids / M. L. Ceccarelli -- Spin alignment around Illustris voids / F. Dávila Kurbán -- Fermionic dark matter halos from a maximum entropy principle / C. Argüelles -- Pairwise velocities in the strongly nonlinear regime of large-scale structures / J. Garcia-Farieta -- Modelling the formation of the GD-1 stellar stream inside a host with a fermionic dark matter core-halo distribution / M. F. Mestre -- On the influence of halo mass accretion history on galaxy properties and assembly bias / A. Montero Dorta -- EMPIRE: A new semi-empirical model for the Galaxy-Halo connection / A. Rodriguez-Puebla -- Dark-matter-deficient galaxies in the Illustris-TNG simulations / E. Tau -- Spiral galaxies with ring structures / S. Alonso -- Bar properties in dwarf barred galaxies from Virgo / V. Cuomo -- MaNGA/SDSS-IV: Archaeological reconstruction of the radial and global growth of galaxies / V. Ávila-Reese -- Gas shocks around galaxy clusters / A. Rost -- A deep near-infrared view of the Ophiuchus galaxy cluster / G. Coldwell -- Kinematics of the Local Group gas and galaxies in the Hestia simulations / L. Biaus -- The physical origin and impact of stellar-gas misalignments in galaxies from the CIELO simulation / C. Casanueva -- Nearby galaxies – insights into galaxy evolution / K. Menéndez-Delmestre -- New and upcoming astronomical instrumentation: opportunities for collaboration between Latin American astronomers / T. Goncalves -- Chemical evolution of galaxies / P. Tissera -- On the Magellanic Clouds stellar clusters characterization from their integrated spectra / F. Simondi Romero -- The dynamics of the Milky Way and the Large Magellanic Cloud / N. Garavito Camargo -- Star clusters study in the inner region of the Small Magellanic Cloud / B. De Bortoli -- The internal structure of clusters in the Magellanic Clouds / J. Rodríguez -- Machine learning for membership determination in open clusters / P. Hasan -- CAPOS: Distance, reddening and global metallicity determination of Bulge Globular Clusters / S. Villanova -- A statistical study of the compressible energy cascade rate in the solar wind: MAVEN and PSP observations / M. Brodiano -- Large amplitude oscillations in solar filaments / M. Cécere -- Pseudostreamer influence on flux rope evolution / A. Sahade ; List of Posters: Analysis of the eclipsing times variations of an evolved binary / M. Ramos -- The effect of galaxy orbits on the outer regions of clusters:connections with the splashback radius / A. De Almeida -- Low Surface Brightness Galaxies in IllustrisTNG / L. Peréz-Montaño -- Age determination of 3 star clusters belonging to the Magellanic Clouds / M. Tapia Reina -- Is a 4U 0114+65 a wind-accreting magnetar? a glimpse of NuSTAR and NICER / E. Saavedra -- Galaxy pairs in S-PLUS DR2 / C. Cerdosino -- Kinematics of the Local Group gas and galaxies in the Hestia simulations / L. Biaus -- Ultralight Dark Matter: A very short review / M. Díaz Araque -- Galaxy rotation curve fitting using state-of-the-art machine learning tools / S. Collazo -- Chemical signatures of planetary formation and evolution in the WASP-160 binary system / E. Jofré -- A determination of the local Hubble constant using Giant HII Regions and HII Galaxies / D. Fernández-Arenas -- Early-type dwarf galaxies in low-density environments: the case of CGCG014-074 / N. Guevara -- Black Holes Shadows in Konoplya-Stuchlik-Zhidenko metrics / G. Briozzo -- Skylight: a new code for general relativistic ray tracing and radiative transport in arbitrary spacetimes / J. Pelle -- Low-Frequency Detection of Diffuse Radio Emission from Low-mass PSZ Clusters / S. Salunkhe -- Study of Stellar Populations Properties in Simulated Galaxies / A. Cornejo Cárdenas -- The Integrated Sachs-Wolfe Effect in 4D Einstein-Gauss-Bonnet Gravity / M. Ghodsi Yengejeh.Daza Perilla, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Astronomía Teórica y Experimental; Argentina.Trógolo, Nair. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina.Zoppetti, Federico. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina.Benavides Blanco, José. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina.Benavides Blanco, José. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Astronomía Teórica y Experimental; Argentina.Ceccarelli, María Laura. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina.Ceccarelli, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Astronomía Teórica y Experimental; Argentina.Dávila Kurbán, Federico. Conicet. Instituto de Astronomía Teórica y Experimental; Argentina.Simondi Romero, Federico Oscar. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina.Cécere, Mariana. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; ArgentinaCécere, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Astronomía Teórica y Experimental; Argentina.Sahade, Abril. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina.Sahade, Abril. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Astronomía Teórica y Experimental; Argentina.Ramos, Matías. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina.Tapia Reina, Martina. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina.Jofré, Emiliano. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina

Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Background: Additional safe and efficacious vaccines are needed to control the COVID-19 pandemic. We aimed to analyse the efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate. Methods: HERALD is a randomised, observer-blinded, placebo-controlled, phase 2b/3 clinical trial conducted in 47 centres in ten countries in Europe and Latin America. By use of an interactive web response system and stratification by country and age group (18–60 years and ≥61 years), adults with no history of virologically confirmed COVID-19 were randomly assigned (1:1) to receive intramuscularly either two 0·6 mL doses of CVnCoV containing 12 μg of mRNA or two 0·6 mL doses of 0·9% NaCl (placebo) on days 1 and 29. The primary efficacy endpoint was the occurrence of a first episode of virologically confirmed symptomatic COVID-19 of any severity and caused by any strain from 15 days after the second dose. For the primary endpoint, the trial was considered successful if the lower limit of the CI was greater than 30%. Key secondary endpoints were the occurrence of a first episode of virologically confirmed moderate-to-severe COVID-19, severe COVID-19, and COVID-19 of any severity by age group. Primary safety outcomes were solicited local and systemic adverse events within 7 days after each dose and unsolicited adverse events within 28 days after each dose in phase 2b participants, and serious adverse events and adverse events of special interest up to 1 year after the second dose in phase 2b and phase 3 participants. Here, we report data up to June 18, 2021. The study is registered at ClinicalTrials.gov, NCT04652102, and EudraCT, 2020–003998–22, and is ongoing. Findings: Between Dec 11, 2020, and April 12, 2021, 39 680 participants were enrolled and randomly assigned to receive either CVnCoV (n=19 846) or placebo (n=19 834), of whom 19 783 received at least one dose of CVnCoV and 19 746 received at least one dose of placebo. After a mean observation period of 48·2 days (SE 0·2), 83 cases of COVID-19 occurred in the CVnCoV group (n=12 851) in 1735·29 person-years and 145 cases occurred in the placebo group (n=12 211) in 1569·87 person-years, resulting in an overall vaccine efficacy against symptomatic COVID-19 of 48·2% (95·826% CI 31·0–61·4; p=0·016). Vaccine efficacy against moderate-to-severe COVID-19 was 70·7% (95% CI 42·5–86·1; CVnCoV 12 cases in 1735·29 person-years, placebo 37 cases in 1569·87 person-years). In participants aged 18–60 years, vaccine efficacy against symptomatic disease was 52·5% (95% CI 36·2–64·8; CVnCoV 71 cases in 1591·47 person-years, placebo, 136 cases in 1449·23 person-years). Too few cases occurred in participants aged 61 years or older (CVnCoV 12, placebo nine) to allow meaningful assessment of vaccine efficacy. Solicited adverse events, which were mostly systemic, were more common in CVnCoV recipients (1933 [96·5%] of 2003) than in placebo recipients (1344 [67·9%] of 1978), with 542 (27·1%) CVnCoV recipients and 61 (3·1%) placebo recipients reporting grade 3 solicited adverse events. The most frequently reported local reaction after any dose in the CVnCoV group was injection-site pain (1678 [83·6%] of 2007), with 22 grade 3 reactions, and the most frequently reported systematic reactions were fatigue (1603 [80·0%] of 2003) and headache (1541 [76·9%] of 2003). 82 (0·4%) of 19 783 CVnCoV recipients reported 100 serious adverse events and 66 (0·3%) of 19 746 placebo recipients reported 76 serious adverse events. Eight serious adverse events in five CVnCoV recipients and two serious adverse events in two placebo recipients were considered vaccination-related. None of the fatal serious adverse events reported (eight in the CVnCoV group and six in the placebo group) were considered to be related to study vaccination. Adverse events of special interest were reported for 38 (0·2%) participants in the CVnCoV group and 31 (0·2%) participants in the placebo group. These events were considered to be related to the trial vaccine for 14 (<0·1%) participants in the CVnCoV group and for five (<0·1%) participants in the placebo group. Interpretation: CVnCoV was efficacious in the prevention of COVID-19 of any severity and had an acceptable safety profile. Taking into account the changing environment, including the emergence of SARS-CoV-2 variants, and timelines for further development, the decision has been made to cease activities on the CVnCoV candidate and to focus efforts on the development of next-generation vaccine candidates. Funding: German Federal Ministry of Education and Research and CureVac

30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries.

BACKGROUND There are data on the safety of cancer surgery and the efficacy of preventive strategies on the prevention of postoperative symptomatic COVID-19 in these patients. But there is little such data for any elective surgery. The main objectives of this study were to examine the safety of bariatric surgery (BS) during the coronavirus disease 2019 (COVID-19) pandemic and to determine the efficacy of perioperative COVID-19 protective strategies on postoperative symptomatic COVID-19 rates. METHODS We conducted an international cohort study to determine all-cause and COVID-19-specific 30-day morbidity and mortality of BS performed between 01/05/2020 and 31/10/2020. RESULTS Four hundred ninety-nine surgeons from 185 centres in 42 countries provided data on 7704 patients. Elective primary BS (n = 7084) was associated with a 30-day morbidity of 6.76% (n = 479) and a 30-day mortality of 0.14% (n = 10). Emergency BS, revisional BS, insulin-treated type 2 diabetes, and untreated obstructive sleep apnoea were associated with increased complications on multivariable analysis. Forty-three patients developed symptomatic COVID-19 postoperatively, with a higher risk in non-whites. Preoperative self-isolation, preoperative testing for SARS-CoV-2, and surgery in institutions not concurrently treating COVID-19 patients did not reduce the incidence of postoperative COVID-19. Postoperative symptomatic COVID-19 was more likely if the surgery was performed during a COVID-19 peak in that country. CONCLUSIONS BS can be performed safely during the COVID-19 pandemic with appropriate perioperative protocols. There was no relationship between preoperative testing for COVID-19 and self-isolation with symptomatic postoperative COVID-19. The risk of postoperative COVID-19 risk was greater in non-whites or if BS was performed during a local peak