1,044 research outputs found
Alien Registration- Cormier, Joseph F. (Van Buren, Aroostook County)
https://digitalmaine.com/alien_docs/33145/thumbnail.jp
Perinatal maternal antibiotic exposure augments lung injury in offspring in experimental bronchopulmonary dysplasia
Copyright © 2020 the American Physiological Society. During the newborn period, intestinal commensal bacteria influence pulmonary mucosal immunology via the gut-lung axis. Epidemiological studies have linked perinatal antibiotic exposure in human newborns to an increased risk for bronchopulmonary dysplasia, but whether this effect is mediated by the gut-lung axis is unknown. To explore antibiotic disruption of the newborn gut-lung axis, we studied how perinatal maternal antibiotic exposure influenced lung injury in a hyperoxia-based mouse model of bronchopulmonary dysplasia. We report that disruption of intestinal commensal colonization during the perinatal period promotes a more severe bronchopulmonary dysplasia phenotype characterized by increased mortality and pulmonary fibrosis. Mechanistically, metagenomic shifts were associated with decreased IL-22 expression in bronchoalveolar lavage and were independent of hyperoxia-induced inflammasome activation. Collectively, these results demonstrate a previously unrecognized influence of the gut-lung axis during the development of neonatal lung injury, which could be leveraged to ameliorate the most severe and persistent pulmonary complication of preterm birth
Wastewater Sequencing Reveals Community and Variant Dynamics of the Collective Human Virome
Wastewater is a discarded human by-product, but its analysis may help us understand the health of populations. Epidemiologists first analyzed wastewater to track outbreaks of poliovirus decades ago, but so-called wastewater-based epidemiology was reinvigorated to monitor SARS-CoV-2 levels while bypassing the difficulties and pit falls of individual testing. Current approaches overlook the activity of most human viruses and preclude a deeper understanding of human virome community dynamics. Here, we conduct a comprehensive sequencing-based analysis of 363 longitudinal wastewater samples from ten distinct sites in two major cities. Critical to detection is the use of a viral probe capture set targeting thousands of viral species or variants. Over 450 distinct pathogenic viruses from 28 viral families are observed, most of which have never been detected in such samples. Sequencing reads of established pathogens and emerging viruses correlate to clinical data sets of SARS-CoV-2, influenza virus, and monkeypox viruses, outlining the public health utility of this approach. Viral communities are tightly organized by space and time. Finally, the most abundant human viruses yield sequence variant information consistent with regional spread and evolution. We reveal the viral landscape of human wastewater and its potential to improve our understanding of outbreaks, transmission, and its effects on overall population health
Studying Parton Energy Loss in Heavy-Ion Collisions via Direct-Photon and Charged-Particle Azimuthal Correlations
Charged-particle spectra associated with direct photon () and
are measured in + and Au+Au collisions at center-of-mass energy
GeV with the STAR detector at RHIC. A hower-shape
analysis is used to partially discriminate between and .
Assuming no associated charged particles in the direction (near
side) and small contribution from fragmentation photons (), the
associated charged-particle yields opposite to (away side) are
extracted. At mid-rapidity () in central Au+Au collisions,
charged-particle yields associated with and at high
transverse momentum ( GeV/) are suppressed by a factor
of 3-5 compared with + collisions. The observed suppression of the
associated charged particles, in the kinematic range and GeV/, is similar for and , and
independent of the energy within uncertainties. These
measurements indicate that the parton energy loss, in the covered kinematic
range, is insensitive to the parton path length.Comment: submitted to Phys. Rev. Lett, 6 pages, 4 figure
Measurements of meson production in relativistic heavy-ion collisions at RHIC
We present results for the measurement of meson production via its
charged kaon decay channel in Au+Au collisions at
, 130, and 200 GeV, and in and +Au collisions
at GeV from the STAR experiment at the BNL Relativistic
Heavy Ion Collider (RHIC). The midrapidity () meson transverse
momentum () spectra in central Au+Au collisions are found to be well
described by a single exponential distribution. On the other hand, the
spectra from , +Au and peripheral Au+Au collisions show power-law tails
at intermediate and high and are described better by Levy
distributions. The constant yield ratio vs beam species, collision
centrality and colliding energy is in contradiction with expectations from
models having kaon coalescence as the dominant mechanism for production
at RHIC. The yield ratio as a function of is consistent
with a model based on the recombination of thermal quarks up to GeV/, but disagrees at higher transverse momenta. The measured nuclear
modification factor, , for the meson increases above unity at
intermediate , similar to that for pions and protons, while is
suppressed due to the energy loss effect in central Au+Au collisions. Number of
constituent quark scaling of both and for the meson
with respect to other hadrons in Au+Au collisions at =200 GeV
at intermediate is observed. These observations support quark
coalescence as being the dominant mechanism of hadronization in the
intermediate region at RHIC.Comment: 22 pages, 21 figures, 4 table
Observation of charge-dependent azimuthal correlations and possible local strong parity violation in heavy ion collisions
Parity-odd domains, corresponding to non-trivial topological solutions of the
QCD vacuum, might be created during relativistic heavy-ion collisions. These
domains are predicted to lead to charge separation of quarks along the orbital
momentum of the system created in non-central collisions. To study this effect,
we investigate a three particle mixed harmonics azimuthal correlator which is a
\P-even observable, but directly sensitive to the charge separation effect. We
report measurements of this observable using the STAR detector in Au+Au and
Cu+Cu collisions at =200 and 62~GeV. The results are presented
as a function of collision centrality, particle separation in rapidity, and
particle transverse momentum. A signal consistent with several of the
theoretical expectations is detected in all four data sets. We compare our
results to the predictions of existing event generators, and discuss in detail
possible contributions from other effects that are not related to parity
violation.Comment: 17 pages, 14 figures, as accepted for publication in Physical Review
C
Growth of Long Range Forward-Backward Multiplicity Correlations with Centrality in Au+Au Collisions at = 200 GeV
Forward-backward multiplicity correlation strengths have been measured with
the STAR detector for Au+Au and collisions at =
200 GeV. Strong short and long range correlations (LRC) are seen in central
Au+Au collisions. The magnitude of these correlations decrease with decreasing
centrality until only short range correlations are observed in peripheral Au+Au
collisions. Both the Dual Parton Model (DPM) and the Color Glass Condensate
(CGC) predict the existence of the long range correlations. In the DPM the
fluctuation in the number of elementary (parton) inelastic collisions produces
the LRC. In the CGC longitudinal color flux tubes generate the LRC. The data is
in qualitative agreement with the predictions from the DPM and indicates the
presence of multiple parton interactions.Comment: 6 pages, 3 figures The abstract has been slightly modifie
Systematic Measurements of Identified Particle Spectra in pp, d+Au and Au+Au Collisions from STAR
Identified charged particle spectra of , , and
\pbar at mid-rapidity () measured by the \dedx method in the
STAR-TPC are reported for and d+Au collisions at \snn = 200 GeV and for
Au+Au collisions at 62.4 GeV, 130 GeV, and 200 GeV. ... [Shortened for arXiv
list. Full abstract in manuscript.]Comment: 58 pages, 46 figures, 37 table
Hadronic resonance production in +Au collisions at = 200 GeV at RHIC
We present the first measurements of the , (892),
(1232), (1385), and (1520) resonances in +Au
collisions at = 200 GeV, reconstructed via their hadronic
decay channels using the STAR detector at RHIC. The masses and widths of these
resonances are studied as a function of transverse momentum (). We observe
that the resonance spectra follow a generalized scaling law with the transverse
mass (). The of , , and . The , ,
, , and ratios in
+Au collisions are compared to the measurements in minimum bias
interactions, where we observe that both measurements are comparable. The
nuclear modification factors () of the , , and
scale with the number of binary collisions () for 1.2 GeV/.Comment: STAR Collaboration. Submitted to PR
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