Determinants of Neonatal Mortality Rates in the U.S.: A Reduced Form Model

The aim of this paper is to contribute to an understanding of the determinants of differences in race-specific neonatal mortality rates among large counties of the U.S. in 1977. After estimating cross-sectional regressions, we apply their coefficients to national trends in the exogenous variables to "explain" the rapid decline in neonatal mortality since 1964. The regressions and the extrapolations point to the importance of abortion availability, neonatal intensive care availability, females schooling levels, and to a lesser extent Medicaid, BCHS projects, and WIC in trends in black neonatal mortality between 1964 and 1977. They also underscore the importance of schooling, neonatal intensive care, abortion, Medicaid, WIC, and to a lesser extent poverty and organized family planning clinics in trends in white neonatal mortality in those years. A particularly striking finding is that the increase in abortion availability is the single most important factor in the reduction in the black neonatal mortality rate. Not only does the growth in abortion dominate other program measures, but it also dominates trends in schooling, poverty,female employment, and physician availability. The actual reduction due to abortion amounts to 1.2 deaths per thousand live births or 10 percent of the observed decline.

Demographic Analysis of Birthweight-Specific Neonatal Mortality

This paper explores the determinants of birthweight-specific neonatal mortality rates across States in the U.S. in 1980. We are able to explore the interactions between the determinants and birthweight because of the new data available through the National Infant Mortality Surveillance (NIMS). The NIMS links birth and death certificates for each state, resulting in a data base with race-specific neonatal mortality rates by birthweight, and other characteristics. Using a reduced-form model, we find abortion and neonatal intensive care availability to be the most important determinants of overall neonatal mortality. For whites, the two factors are of approximately equal importance in determining neonatal mortality. For blacks, abortion availability has twice the impact of neonatal inexpensive care. Moreover, our results suggest that neonatal mortality rates could be lowered by policies that reduce the inequality in these health resources across states.

Roles and Responsibilities of Family Home Caregivers for Elderly People in Qatar: Experiences and Challenges

The family, as a social institution in Qatar, is the main care provider for its older adult members. In this paper we examine what caregivers do – their work practices – and the different roles and responsibilities that home caregivers perform when providing care for elderly persons in Qatar. The findings of this study were based from a larger study using qualitative descriptive design. This article demonstrates the work practices and main challenges that caregivers face while taking care of their elderly. We argue that a main source of stress for caregivers is the lack of formal services and supports geared towards individuals caring for their ageing loved ones; addressing this service gap would alleviate some of the demands associated with caregiving. The paper will present exemplars of caregivers taking care of their elderly relative. These exemplars are used to support the analysis which is clustered around identified related themes. The main findings regarding the challenges that caregivers face include: feelings of responsibility; dependency on caregiver; emotional care; social planning; problem solving; and environmental quality. All of the themes impacted the health of the caregivers and led to stress and burden on the life of the caregiver

CAUGHT BETWEEN A ROCK AND A HARD MINERAL ENCRUSTATION: LONG-LIVED AQUATIC INSECTS ACCUMULATE CALCIUM CARBONATE DEPOSITS IN A MONTANE DESERT STREAM

Aquatic ecosystems overlying regions of limestone bedrock can feature active deposition of calcium carbonate in the form of travertine or tufa. Although most travertine deposits form a cement-like layer on stream substrates, mineral deposits can also form on benthic invertebrates. However, little is known about which taxa may be prone to calcium carbonate encrustation and which life history traits may make taxa more susceptible to becoming encrusted. Here we report the presence of calcium carbonate deposits on live insects collected from a montane stream in the Madrean Sky Islands (Huachuca Mountains) of Arizona between 2011 and 2013. Life history differences are examined between taxa with and without travertine deposits. Thirteen genera of aquatic insects were found with calcium carbonate deposits on the exoskeleton as well as 22 other genera, also encountered in the study stream, that have not previously been found with such deposits. Taxa with calcium carbonate encrustation had significantly longer-lived aquatic stages than those without encrustation. Furthermore, encrustation presence did not differ among aerial dispersal modes. These results suggest that the extent of calcium carbonate deposition on aquatic insects is primarily related to the length of time they are in the stream. Since mineral encrustation may reduce predation pressure and mobility, changes in patterns of travertine formation in these systems may have profound effects on ecological interactions. Los ecosistemas dulceacuícolas ubicados en regiones de roca caliza pueden contener depósitos de carbonato de calcio en forma de travertino o tufa. Aunque muchos depósitos de travertino se encuentran como una capa o manto de cemento sobre el fondo del arroyo, los depósitos también pueden formarse sobre los invertebrados bentónicos. Sin embargo, poco se sabe acerca de las especies que son propensas a los depósitos de travertino, o acerca de las características de estas especies que influyen en tal proceso. En este manuscrito reportamos la presencia de depósitos de travertino en insectos vivos y recolectados en un arroyo montañoso en el Archipiélago Madrense de Arizona durante 2011–2013 y examinamos las diferencias en las historias de vida entre taxones con o sin depósitos de travertino. Encontramos trece géneros de insectos acuáticos con travertino sobre el exoesqueleto y vientedos géneros sin travertino. Los taxones con travertino tienen una fase acuática significativamente más larga que los taxones sin travertino. Además, la presencia de travertino no difirió entre especies con distintas maneras de dispersión aérea. Estos resultados sugieren que las diferencias en los depósitos de travertino en insectos acuáticos ocurren principalmente a causa de la duración del período de vida acuática del insecto. Aunque los depósitos de travertino pueden reducir la presión por depredación y movilidad, cambios en los patrones de formación de travertino en estos sistemas pueden afectar profundamente las interacciones ecológicas

Roles and Responsibilities of Family Home Caregivers for Elderly People in Qatar: Experiences and Challenges

The family, as a social institution in Qatar, is the main care provider for its older adult members. In this paper we examine what caregivers do – their work practices – and the different roles and responsibilities that home caregivers perform when providing care for elderly persons in Qatar. The findings of this study were based from a larger study using qualitative descriptive design. This article demonstrates the work practices and main challenges that caregivers face while taking care of their elderly. We argue that a main source of stress for caregivers is the lack of formal services and supports geared towards individuals caring for their ageing loved ones; addressing this service gap would alleviate some of the demands associated with caregiving. The paper will present exemplars of caregivers taking care of their elderly relative. These exemplars are used to support the analysis which is clustered around identified related themes. The main findings regarding the challenges that caregivers face include: feelings of responsibility; dependency on caregiver; emotional care; social planning; problem solving; and environmental quality. All of the themes impacted the health of the caregivers and led to stress and burden on the life of the caregiver

HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID Patients

The inability of patients with CVID to mount specific antibody responses to pathogens has raised concerns on the risk and severity of SARS-CoV-2 infection, but there might be a role for protective T cells in these patients. SARS-CoV-2 reactive T cells have been reported for SARS-CoV-2 unexposed healthy individuals. Until now, there is no data on T cell immunity to SARS-CoV-2 infection in CVID. This study aimed to evaluate reactive T cells to human endemic corona viruses (HCoV) and to study pre-existing SARS-CoV-2 reactive T cells in unexposed CVID patients. We evaluated SARS-CoV-2- and HCoV-229E and -OC43 reactive T cells in response to seven peptide pools, including spike and nucleocapsid (NCAP) proteins, in 11 unexposed CVID, 12 unexposed and 11 post COVID-19 healthy controls (HC). We further characterized reactive T cells by IFNγ, TNFα and IL-2 profiles. SARS-CoV-2 spike-reactive CD4+ T cells were detected in 7 of 11 unexposed CVID patients, albeit with fewer multifunctional (IFNγ/TNFα/IL-2) cells than unexposed HC. CVID patients had no SARS-CoV-2 NCAP reactive CD4+ T cells and less reactive CD8+ cells compared to unexposed HC. We observed a correlation between T cell reactivity against spike of SARS-CoV-2 and HCoVs in unexposed, but not post COVID-19 HC, suggesting cross-reactivity. T cell responses in post COVID-19 HC could be distinguished from unexposed HC by higher frequencies of triple-positive NCAP reactive CD4+ T cells. Taken together, SARS-CoV-2 reactive T cells are detectable in unexposed CVID patients albeit with lower recognition frequencies and polyfunctional potential. Frequencies of triple-functional reactive CD4+ cells might provide a marker to distinguish HCoV cross-reactive from SARS-CoV-2 specific T cell responses. Our data provides evidence, that anti-viral T cell immunity is not relevantly impaired in most CVID patients

Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells

The SARS-CoV-2 pandemic has so far claimed over three and a half million lives worldwide. Though the SARS-CoV-2 mediated disease COVID-19 has first been characterized by an infection of the upper airways and the lung, recent evidence suggests a complex disease including gastrointestinal symptoms. Even if a direct viral tropism of intestinal cells has recently been demonstrated, it remains unclear, whether gastrointestinal symptoms are caused by direct infection of the gastrointestinal tract by SARS-CoV-2 or whether they are a consequence of a systemic immune activation and subsequent modulation of the mucosal immune system. To better understand the cause of intestinal symptoms we analyzed biopsies of the small intestine from SARS-CoV-2 infected individuals. Applying qRT-PCR and immunohistochemistry, we detected SARS-CoV-2 RNA and nucleocapsid protein in duodenal mucosa. In addition, applying imaging mass cytometry and immunohistochemistry, we identified histomorphological changes of the epithelium, which were characterized by an accumulation of activated intraepithelial CD8(+) T cells as well as epithelial apoptosis and subsequent regenerative proliferation in the small intestine of COVID-19 patients. In summary, our findings indicate that intraepithelial CD8(+) T cells are activated upon infection of intestinal epithelial cells with SARS-CoV-2, providing one possible explanation for gastrointestinal symptoms associated with COVID-19

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitination of BECN1, thus promoting its proteasomal degradation. SKP2 activity is regulated by phosphorylation in a hetero-complex involving FKBP51, PHLPP, AKT1, and BECN1. Genetic or pharmacological inhibition of SKP2 decreases BECN1 ubiquitination, decreases BECN1 degradation and enhances autophagic flux. Middle East respiratory syndrome coronavirus (MERS-CoV) multiplication results in reduced BECN1 levels and blocks the fusion of autophagosomes and lysosomes. Inhibitors of SKP2 not only enhance autophagy but also reduce the replication of MERS-CoV up to 28,000-fold. The SKP2-BECN1 link constitutes a promising target for host-directed antiviral drugs and possibly other autophagy-sensitive conditions

TU Tau B: The Peculiar 'Eclipse' of a possible proto-Barium Giant

TU Tau (= HD 38218 = HIP 27135) is a binary system consisting of a C-N carbon star primary and an A-type secondary. We report on new photometry and spectroscopy which tracked the recent disappearance of the A-star secondary. The dimming of the A-star was gradual and irregular, with one or more brief brightenings, implying the presence of nonhomogeneities in the carbon star outflow. We also present evidence that the A-star is actively accreting s-process enriched material from the carbon star and suggest that it will therefore eventually evolve into a Barium giant. This is an important system as well because the A-type star can serve as a probe of the outer atmosphere of the carbon star.Comment: 9 pages, 9 figures, 4 tables, a number of amateur observatories made significant contributions to this research. Paper accepted for publication in The Astronomical Journa