Utopia and Contemporary Human Society: A Model for Sustainable Continuance

Sir Thomas More’s Utopia outlines a bustling, blissful society in which all individuals live equitably, happily, and comfortably. Utopia, which literally means “no-place,” simply does not exist. However, More provides Utopia as a progressive template through which analogous contemporary social and economic structure may be assessed. Juxtaposing contemporary society with Utopia, a relatively superior or perfect state, illuminates some factors inhibiting modern society from otherwise ascending to the state and functionality of a Utopia

Extreme set-up and run-up on steep cliffs (Banneg Island, France)

International audienceno abstrac

Champs de repères 2D non orthogonaux

National audience

Frame Fields for CAD models

International audienceGiven a triangulated surface, a unit length tangent vector field can be used to orient entities located on the surface, such as glyphs or strokes. When these entities are invariant under a π/2 rotation (squares, or curvature hatching), the orientation can be represented by a frame field i.e. four orthogonal tangent unit vectors at each point of the surface. The generation of such fields is a key component of recent quad meshing algorithms based on global parameterization, as it defines the orientation of the final facets. State-of-the-art methods are able to generate smooth frame fields subject to some hard constraints (direction and topology) or smooth constraints (matching the curvature direction). When we have a surface triangular mesh, and a vector defined on each facet, we can't directly know if all the vectors are colinear. We first have to define the (so called) parallel transport of every edge to compare the vectors on a common plan. When dealing with CAD models, the field must be aligned with feature edges. A problem occurs when there is a low angle corner formed by two colliding feature edges. Our solution not only defines the parallel transport to obtain smoothed frame fields on a surface triangular mesh, it also redefines the parallel transport wherever there is a low angle corner, to smooth a frame field as if these corners' angles were π/2

Designing 2D and 3D Non-Orthogonal Frame Fields

International audienceWe present a method for direction field design on surface and volumetric meshes supporting non-orthogonality. Our approach is a generalization of the representation of 3D cross fields in spherical harmonic basis. As such it induces a geometrically meaningful measure of smoothness, allows orthogonality control by a simple parameter and enables orientation constraints of a single direction. To the best of our knowledge this is the first work to propose non-orthogonal 3D frame field design. We demonstrate the applicability of our method to generate anisotropic quadrangular and hexahedral meshes which are particularly useful for remeshing CAD models

COVID-19: a fatal case of acute liver failure associated with SARS-CoV-2 infection in pre-existing liver cirrhosis

Background: The detection of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is challenging, particularly in post-mortem human tissues. However, there is increasing evidence for viral SARS-CoV-2 manifestation in non-respiratory tissues. In this context, it is a current matter of debate, whether SARS-CoV-2 shows hepatotropism. Case presentation: Here, we report a case of an 88-year-old women with massive SARS-CoV-2 viremia, severe jaundice and clinical signs of an acute hepatitis, who died within a few days from an acute liver failure without showing any clinical signs of pneumonia. Autopsy revealed a severe chronic and acute liver damage with bile duct infestation by SARS-CoV-2 that was accompanied by higher expressions of angiotensin-converting enzyme-2 (ACE2), Cathepsin L and transmembrane serine protease 2 (TMPRSS2). Conclusion: Our findings indicate an enhanced biliary susceptibility to viral infection with SARS-CoV-2, that might have resulted from pre-existing severe liver damage. Furthermore, our findings emphasize the differential diagnosis of coronavirus disease 2019 (COVID-19)-associated liver failure in the clinical setting of an inexplicable jaundice

TU Tau B: The Peculiar 'Eclipse' of a possible proto-Barium Giant

TU Tau (= HD 38218 = HIP 27135) is a binary system consisting of a C-N carbon star primary and an A-type secondary. We report on new photometry and spectroscopy which tracked the recent disappearance of the A-star secondary. The dimming of the A-star was gradual and irregular, with one or more brief brightenings, implying the presence of nonhomogeneities in the carbon star outflow. We also present evidence that the A-star is actively accreting s-process enriched material from the carbon star and suggest that it will therefore eventually evolve into a Barium giant. This is an important system as well because the A-type star can serve as a probe of the outer atmosphere of the carbon star.Comment: 9 pages, 9 figures, 4 tables, a number of amateur observatories made significant contributions to this research. Paper accepted for publication in The Astronomical Journa

Causes of death and comorbidities in hospitalized patients with COVID-19

Infection by the new corona virus strain SARS-CoV-2 and its related syndrome COVID-19 has been associated with more than two million deaths worldwide. Patients of higher age and with preexisting chronic health conditions are at an increased risk of fatal disease outcome. However, detailed information on causes of death and the contribution of pre-existing health conditions to death yet is missing, which can be reliably established by autopsy only. We performed full body autopsies on 26 patients that had died after SARS-CoV-2 infection and COVID-19 at the Charite University Hospital Berlin, Germany, or at associated teaching hospitals. We systematically evaluated causes of death and pre-existing health conditions. Additionally, clinical records and death certificates were evaluated. We report findings on causes of death and comorbidities of 26 decedents that had clinically presented with severe COVID-19. We found that septic shock and multi organ failure was the most common immediate cause of death, often due to suppurative pulmonary infection. Respiratory failure due to diffuse alveolar damage presented as immediate cause of death in fewer cases. Several comorbidities, such as hypertension, ischemic heart disease, and obesity were present in the vast majority of patients. Our findings reveal that causes of death were directly related to COVID-19 in the majority of decedents, while they appear not to be an immediate result of preexisting health conditions and comorbidities. We therefore suggest that the majority of patients had died of COVID-19 with only contributory implications of preexisting health conditions to the mechanism of death

Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study.

OBJECTIVES: Dexamethasone has become the standard of care for severe coronavirus disease 2019 (COVID-19), but its virological impact is poorly understood. The objectives of this work were to characterize the kinetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) concentration in the upper respiratory tract (URT) and the antibody response in patients with (D+) and without (D-) dexamethasone treatment. METHODS: Data and biosamples from hospitalized patients with severe COVID-19, enrolled between 4th March and 11th December 2020 in a prospective observational study, were analysed. SARS-CoV-2 virus concentration in serial URT samples was measured using RT-PCR. SARS-CoV-2-specific immunoglobulins A and G (IgA and IgG) were measured in serum samples using S1-ELISA. RESULTS: We compared 101 immunocompetent patients who received dexamethasone (according to the inclusion criteria and dosage determined in the RECOVERY trial) to 93 immunocompetent patients with comparable disease severity from the first months of the pandemic, who had not been treated with dexamethasone or other glucocorticoids. We found no inter-group differences in virus concentration kinetics, duration of presence of viral loads >106 viral copies/mL (D+ median 17 days (IQR 13-24), D- 19 days (IQR 13-29)), or time from symptom onset until seroconversion (IgA: D+ median 11.5 days (IQR 11-12), D- 14 days (IQR 11.5-15.75); IgG: D+ 13 days (IQR 12-14.5), D- 12 days (IQR 11-15)). CONCLUSION: Dexamethasone does not appear to lead to a change in virus clearance or a delay in antibody response in immunocompetent patients hospitalized with severe COVID-19