Shaping The Future: Developing Principles for Policy Recommendations for Responsible Innovation in Virtual Worlds

As Extended Reality (XR) technologies continue to evolve at a rapid pace, they hold the promise of transforming the way we interact both with digital information and the physical world. Whilst Augmented Reality (AR), Virtual Reality (VR), and Mixed Reality (MR) technologies offer unbridled opportunities for social connections, productivity, and play, these rapid technological advancements also pose critical challenges to ethics, privacy, accessibility, and safety. At present, there is little policy documentation that directly addresses the novel affordances posed by XR technologies, leading to a ‘policy void’ in this space. Having clear and effective policy frameworks prior to the widespread adoption of technology encourages and enables responsible and ethical innovation of XR technologies. This workshop is therefore dedicated to developing forward-thinking principles to guide policy recommendations that address potential future vulnerabilities posed by the widespread adoption of XR technologies whilst simultaneously encouraging the responsible innovation of new advancements within XR. To ensure these policy recommendations promote responsible innovation, the workshop will assemble multidisciplinary academics, industry developers and international policymakers. Our goal is to ensure that all perspectives are considered such that we can collaboratively chart a responsible and sustainable course for the XR landscape

Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018

Publisher Copyright: © 2022, The Author(s).Background: Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is critical for effective geographic and epidemiological targeting of prevention and treatment interventions. Age- and sex-specific HIV prevalence estimates are widely available at the national level, and region-wide local estimates were recently published for adults overall. We add further dimensionality to previous analyses by estimating HIV prevalence at local scales, stratified into sex-specific 5-year age groups for adults ages 15–59 years across SSA. Methods: We analyzed data from 91 seroprevalence surveys and sentinel surveillance among antenatal care clinic (ANC) attendees using model-based geostatistical methods to produce estimates of HIV prevalence across 43 countries in SSA, from years 2000 to 2018, at a 5 × 5-km resolution and presented among second administrative level (typically districts or counties) units. Results: We found substantial variation in HIV prevalence across localities, ages, and sexes that have been masked in earlier analyses. Within-country variation in prevalence in 2018 was a median 3.5 times greater across ages and sexes, compared to for all adults combined. We note large within-district prevalence differences between age groups: for men, 50% of districts displayed at least a 14-fold difference between age groups with the highest and lowest prevalence, and at least a 9-fold difference for women. Prevalence trends also varied over time; between 2000 and 2018, 70% of all districts saw a reduction in prevalence greater than five percentage points in at least one sex and age group. Meanwhile, over 30% of all districts saw at least a five percentage point prevalence increase in one or more sex and age group. Conclusions: As the HIV epidemic persists and evolves in SSA, geographic and demographic shifts in prevention and treatment efforts are necessary. These estimates offer epidemiologically informative detail to better guide more targeted interventions, vital for combating HIV in SSA.Peer reviewe

Neutron-proton diffraction scattering and neutron total cross-secions up to 200-GeV

The authors propose to use the 0{sup o} neutral beam planned for Experimental Area 2 to measure differential cross sections for np elastic scattering in the diffraction region over the energy range of from 40 to 200 GeV and also total cross sections for neutrons on protons, deuterons, and other nuclei over the same energy range. The proposed experiments would use techniques previously developed by the authors in similar experiments at the Bevatron and the AGS. Most of the apparatus already exists. The two experiments could be run in the same beam, either simultaneously or sequentially. The experiments are simple and place very modest demands on accelerator performance

Randomized, Controlled Trial Evaluating a Baby Wash Product on Skin Barrier Function in Healthy, Term Neonates

Objectives To examine the hypothesis that the use of a wash product formulated for newborn (<1 month of age) bathing is not inferior (no worse) to bathing with water only. Design Assessor‐blinded, randomized, controlled, noninferiority trial. Setting A teaching hospital in the Northwest of England and in participants’ homes. Participants Three‐hundred‐and‐seven healthy, term infants recruited within 48 hours of birth. Method We compared bathing with a wash product (n = 159) to bathing with water alone (n = 148). The primary outcome was transepidermal water loss (TEWL) at 14 days postbirth; the predefined difference deemed to be unimportant was 1.2. Secondary outcomes comprised changes in stratum corneum hydration, skin surface pH, clinical observations of the skin, and maternal views. Results Complete TEWL data were obtained for 242 (78.8%) infants. Wash was noninferior to water alone in terms of TEWL (intention‐to‐treat analysis: 95% confidence interval [CI] for difference [wash–water, adjusted for family history of eczema, neonate state, and baseline] −1.24, 1.07; per protocol analysis: 95% CI −1.42, 1.09). No significant differences were found in secondary outcomes. Conclusion We were unable to detect any differences between the newborn wash product and water. These findings provide reassurance to parents who choose to use the test newborn wash product or other technically equivalent cleansers and provide the evidence for health care professionals to support parental choice

ASSOCIATION BETWEEN SKIN BARRIER DEVELOPMENT AND EARLY-ONSET ATOPIC DERMATITIS: A LONGITUDINAL BIRTH COHORT STUDY

A diagnosis of atopic dermatitis (AD) is common during infancy; however, it is unclear whether differential skin barrier development defines this period and signals disease onset in predisposed individuals. A longitudinal observational cohort study (NCT03143504) assessed the feasibility of remote skin testing from birth to monitor skin barrier maturation and model association with an AD diagnosis by 12-months of age. Biophysical testing and infrared spectroscopy were conducted at the maternity ward and family home. Tape stripping collected samples for desquamatory protease and Natural Moisturising factor (NMF) analysis. The four common European Filaggrin (FLG) risk alleles were screened. A total of 128 infants completed the study with 20% developing mild disease. Significant changes in permeability barrier function, desquamatory protease activity and molecular composition assessed spectroscopically were observed longitudinally, but only subtle evidence of differential skin barrier development was noted between infant subgroups. Common FLG risk alleles were strongly associated with early onset disease and conferred a significant reduction in NMF and water content by four weeks of age. Accounting for a family history of atopy, these parameters alongside a greater lipid/protein ratio and reduced chymotrypsin-like activity at birth were associated with AD. Measured in ambient conditions, transepidermal water loss did not signal disease risk at any stage. Skin barrier dysfunction lacked an acquired modality but was considered proportional to cohort severity and suggests that a portfolio of tests used in a community setting, has the potential to improve current AD risk evaluations from birth

Neutron-nucleus total cross sections at 5.7 GeV/c

The neutron total cross sections for He, Be, C, Al, Fe, Cu, Cd, W, Pb and U have been measured to an accuracy of 2% at 5.7 +/- 0.6 GeV/c. The total cross section versus atomic weight data was fit to an absorbing uniform grey sphere optical model. The best fit parameters are R = aoA1/3 where ao = 1.27 +/- 0.01 fm, and a nucleon mean free path in nuclear matter of 3.0 +/- 0.2 fm. The energy dependence of the nucleon-nucleus total cross sections is discussed in terms of the nucleon-nucleon total cross sections and a screening terms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32800/1/0000173.pd

Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study.

In this study, Vitamin D supplementation results in improved clinical severity of atopic dermatitis and increased skin surface LL-37 levels, analyzed by a novel, non-invasive method. Vitamin D supplementation could be a therapeutic option in AD

Neutron-proton and neutron-deuteron total cross sections at 4.0 and 5.7 GeV/c

The np and nd total cross sections have been measured directly with a neutron beam with momenta of 4.0 +/- 0.6 and 5.7 +/- 0.6 GeV/c. The data are compared with the previous nucleon-nucleon and nucleon-deuteron results, and the deuteron screening term was also evaluated. The measured total cross section are 43.1 +/- 0.6 and 80.3 +/- 1.9 mb at 4.0 GeV/c and 42 +/- 0.6 and 77.8 +/- 1.3 mb at 5.7 GeV/c.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32799/1/0000172.pd