Postoperative SBRT in the treatment of early-stage oropharyngeal and oral cavity cancers with high-risk margins: A dosimetric comparison of volumetric modulated arc therapy with or without non-coplanar arcs and acute toxicity outcomes from the STEREOPOSTOP GORTEC 2017–03 phase 2 trial

International audienceThe STEREO POSTOP GORTEC 2017-03 phase 2 trial (NCT03401840) evaluates postoperative stereotactic body radiotherapy (SBRT) in case of high-risk margins for pT1-T2/N0 oropharyngeal and oral cavity tumors. The present ancillary study aimed to compare the dosimetric impact of adding non-coplanar arcs to the volumetric modulated arc therapy (VMAT) technique and to evaluate acute toxicities on the first patients included in this trial

Radiation dosimetry of [ 131 I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment

International audienceDosimetry for melanoma-targeted radionuclide therapy (TRT) with [131 I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de Bourgogne) using SPECT-CT imaging and ex vivo measurements

Practical and technical key challenges in head and neck adaptive radiotherapy: The GORTEC point of view

International audienceAnatomical variations occur during head and neck (H&N) radiotherapy (RT) treatment. These variations may result in underdosage to the target volume or overdosage to the organ at risk. Replanning during the treatment course can be triggered to overcome this issue. Due to technological, methodological and clinical evolutions, tools for adaptive RT (ART) are becoming increasingly sophisticated. The aim of this paper is to give an overview of the key steps of an H&N ART workflow and tools from the point of view of a group of French-speaking medical physicists and physicians (from GORTEC). Focuses are made on image registration, segmentation, estimation of the delivered dose of the day, workflow and quality assurance for an implementation of H&N offline and online ART. Practical recommendations are given to assist physicians and medical physicists in a clinical workflow

Mean activity concentration estimated from 15 cm diameter circular Regions of Interest (ROIs) on 15 consecutive slices and accuracy.

<p>Data acquired on the 4 PET systems used in 2D mode. Activity concentration in images and in phantom expressed in kBq/mL. Standard deviation (SD), accuracy and maximum deviation are in %.</p

Central profile on a transverse slice of phantoms.

<p>Data are normalized to the maximum value intensity of the profile. No abnormality was seen.</p

Mean activity concentration estimated from 15 cm diameter circular Regions of Interest (ROIs) on 15 consecutive slices and accuracy.

<p>Data acquired on the 8 PET systems used in 3D mode. Activity concentration in images and in phantom expressed in kBq/mL. Standard deviation (SD), accuracy and maximum deviation are in %.</p

Observed artefacts on images acquired on uniform phantom.

<p>Display scale is [0; 100%]. A: no artefacts (site 9), B: LOR-RAMLA concentric ring artefacts (site 6), C: FBP concentric ring artefacts (site 4).</p

Dose calibrator reproducibility and accuracy results.

<p>Repeated measurements of certified standard source (⁶⁸Ge) on the dose calibrators of 11 sites. Standard source activity was calculated by applying decay calculation between the calibration date and the measurements date. Measurements expressed in MBq. Standard deviation (SD) and accuracy are in %.</p