Data mining for software engineering and humans in the loop

The field of data mining for software engineering has been growing over the last decade. This field is concerned with the use of data mining to provide useful insights into how to improve software engineering processes and software itself, supporting decision-making. For that, data produced by software engineering processes and products during and after software development are used. Despite promising results, there is frequently a lack of discussion on the role of software engineering practitioners amidst the data mining approaches. This makes adoption of data mining by software engineering practitioners difficult. Moreover, the fact that experts’ knowledge is frequently ignored by data mining approaches, together with the lack of transparency of such approaches, can hinder the acceptability of data mining by software engineering practitioners. To overcome these problems, this position paper provides a discussion of the role of software engineering experts when adopting data mining approaches. It also argues that this role can be extended to increase experts’ involvement in the process of building data mining models. We believe that such extended involvement is not only likely to increase software engineers’ acceptability of the resulting models, but also improve the models themselves. We also provide some recommendations aimed at increasing the success of experts involvement and model acceptability

Image-Enhanced Endoscopy with I-scan Technology for the Evaluation of Duodenal Villous Patterns.

BACKGROUND: I-scan technology is the newly developed endoscopic tool that works in real time and utilizes a digital contrast method to enhance endoscopic image. AIMS: We performed a feasibility study aimed to determine the diagnostic accuracy of i-scan technology for the evaluation of duodenal villous patterns, having histology as the reference standard. METHODS: In this prospective, single center, open study, patients undergoing upper endoscopy for an histological evaluation of duodenal mucosa were enrolled. All patients underwent upper endoscopy using high resolution view in association with i-scan technology. During endoscopy, duodenal villous patterns were evaluated and classified as normal, partial villous atrophy, or marked villous atrophy. Results were then compared with histology. RESULTS: One hundred fifteen subjects were recruited in this study. The endoscopist was able to find marked villous atrophy of the duodenum in 12 subjects, partial villous atrophy in 25, and normal villi in the remaining 78 individuals. The i-scan system was demonstrated to have great accuracy (100 %) in the detection of marked villous atrophy patterns. I-scan technology showed quite lower accuracy in determining partial villous atrophy or normal villous patterns (respectively, 90 % for both items). CONCLUSIONS: Image-enhancing endoscopic technology allows a clear visualization of villous patterns in the duodenum. By switching from the standard to the i-scan view, it is possible to optimize the accuracy of endoscopy in recognizing villous alteration in subjects undergoing endoscopic evaluation

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice

Contains fulltext : 109613.pdf (publisher's version ) (Open Access)BACKGROUND: By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the functional decline associated with aging is still under debate. METHODS: Young (4 M) and old (21 M) male C57BL/6J mice were fed a control low-fat (10E%) or a high-fat diet (45E%) for 2 weeks. During the intervention gross energy intake and energy excretion in the feces were measured. After sacrifice the small and large intestine were isolated and the small intestine was divided in three equal parts. Swiss rolls were prepared of each of the isolated segments for histological analysis and the luminal content was isolated to examine alterations in the microflora with 16S rRNA Q-PCR. Furthermore, mucosal scrapings were isolated from each segment to determine differential gene expression by microarray analysis and global DNA methylation by pyrosequencing. RESULTS: Digestible energy intake was similar between the two age groups on both the control and the high-fat diet. Microarray analysis on RNA from intestinal scrapings showed no marked changes in expression of genes involved in metabolic processes. Decreased expression of Cubilin was observed in the intestine of 21-month-old mice, which might contribute to aging-induced vitamin B12 deficiency. Furthermore, microarray data analysis revealed enhanced expression of a large number of genes involved in immune response and inflammation in the colon, but not in the small intestine of the 21-month-old mice. Aging-induced global hypomethylation was observed in the colon and the distal part of the small intestine, but not in the first two sections of the small intestine. CONCLUSION: In 21-month old mice the most pronounced effects of aging were observed in the colon, whereas very few changes were observed in the small intestine

The Dynamic Universal Creativity Process

In this chapter we introduce the Dynamic Universal Creativity Process (DUCP), defined as the active ensemble of all creativity episodes in the evolution of our cosmos. It is shown how this construct descends naturally through a shift in the leading perspective in creativity studies: from a focus on static creative achievements to the consideration of dynamic processes, which even transcend their agents. Four mechanisms for the dynamic extension in time and space of creativity episodes are presented: continued exploration, concatenation, estimation, and exaptation. The concepts of wide-sense and strict-sense creativity are introduced to allow the consideration of four layers of existence in the DUCP: material, biological, psycho-social, and artificial. The theoretical and practical implications of these definitions are discussed, also in view of contributing to the mending of the cultural fracture between science and the arts, under the flag of creativity studies. A description of the creativity mechanisms characterizing the material, biological, psycho-social, and artificial layers is provided, highlighting intra- and inter-layer concatenation potential and achievements. Among other concepts, complex systems, biological evolution, bipedalism, neoteny, individual and social mind-based behaviour, as well as artificial intelligence, all find an integrated place in the framework of creativity studies, under the DUCP umbrella. Implications on educational systems of the future are drafted in the final discussion