602 research outputs found
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Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved the treatment of RA, patients often inquire about dietary interventions to improve RA symptoms, as they perceive pain and/or swelling after the consumption or avoidance of certain foods. There is evidence that some foods have pro- or anti-inflammatory effects mediated by diet-related metabolites. In addition, recent literature has shown a link between diet-related metabolites and microbiome changes, since the gut microbiome is involved in the metabolism of some dietary ingredients. But diet and the gut microbiome are not the only factors linked to circulating pro- and anti-inflammatory metabolites. Other factors including smoking, associated comorbidities, and therapeutic drugs might also modify the circulating metabolomic profile and play a role in RA pathogenesis. This article summarizes what is known about circulating pro- and anti-inflammatory metabolites in RA. It also emphasizes factors that might be involved in their circulating concentrations and diet-related metabolites with a beneficial effect in RA
An analytical model for Loc/ID mappings caches
Concerns regarding the scalability of the interdomain routing have encouraged researchers to start elaborating a more robust Internet architecture. While consensus on the exact form of the solution is yet to be found, the need for a semantic decoupling of a node's location and identity is generally accepted as a promising way forward. However, this typically requires the use of caches that store temporal bindings between the two namespaces, to avoid hampering router packet forwarding speeds. In this article, we propose a methodology for an analytical analysis of cache performance that relies on the working-set theory. We first identify the conditions that network traffic must comply with for the theory to be applicable and then develop a model that predicts average cache miss rates relying on easily measurable traffic parameters. We validate the result by emulation, using real packet traces collected at the egress points of a campus and an academic network. To prove its versatility, we extend the model to consider cache polluting user traffic and observe that simple, low intensity attacks drastically reduce performance, whereby manufacturers should either overprovision router memory or implement more complex cache eviction policies.Peer ReviewedPostprint (author's final draft
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Design of an anti-inflammatory diet (ITIS diet) for patients with rheumatoid arthritis.
Background:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved treatment of RA, patients with RA often inquire about dietary interventions to improve RA symptoms, as they perceive rapid changes in their symptoms after consumption of certain foods. There is evidence that some ingredients have pro- or anti-inflammatory effects. In addition, recent literature has shown a link between diet and microbiome changes. Both diet and the gut microbiome are linked to circulating metabolites that may modulate inflammation. However, evidence of the effects of an anti-inflammatory and probiotic-rich diet in patients with RA is scarce. There is also a need for biological data to support its anti-inflammatory effects. Methods:The main goal of this study is to delineate the design process for a diet tailored to our RA population. To achieve this goal, we collected information on diet, supplements, cooking methods, and intake of different ingredients for each patient. Different groups were interviewed, and their feedback was assessed to design a diet that incorporates suggested anti-inflammatory ingredients in a manner that was easy for patients to adopt based on their lifestyles and backgrounds. Results:We designed a diet that includes a high intake of potential anti-inflammatory ingredients. Feedback from highly motivated patients was critical in constructing an anti-inflammatory diet (ITIS diet) with elevated adherence. Conclusion:In order to tailor our diet, we surveyed our patients on several different parameters. We obtained important feedback on how feasible our ITIS diet is for RA patients. Using this feedback, we made minor improvements and finalized the design of the ITIS diet. This diet is being used in an on-going pilot study to determine their anti-inflammatory effect in pain and joint swelling in RA patients. Trial registration:Not applicable
On the scalability of LISP and advanced overlaid services
In just four decades the Internet has gone from a lab experiment to a worldwide, business critical infrastructure that caters to the communication needs of almost a half of the Earth's population. With these figures on its side, arguing against the Internet's scalability would seem rather unwise. However, the Internet's organic growth is far from finished and, as billions of new devices are expected to be joined in the not so distant future, scalability, or lack thereof, is commonly believed to be the Internet's biggest problem.
While consensus on the exact form of the solution is yet to be found, the need for a semantic decoupling of a node's location and identity, often called a location/identity separation, is generally accepted as a promising way forward. Typically, this requires the introduction of new network elements that provide the binding of the two names-paces and caches that avoid hampering router packet forwarding speeds. But due to this increased complexity the solution's scalability is itself questioned.
This dissertation evaluates the suitability of using the Locator/ID Separation Protocol (LISP), one of the most successful proposals to follow the location/identity separation guideline, as a solution to the Internet's scalability problem. However, because the deployment of any new architecture depends not only on solving the incumbent's technical problems but also on the added value that it brings, our approach follows two lines. In the first part of the thesis, we develop the analytical tools to evaluate LISP's control plane scalability while in the second we show that the required control/data plane separation provides important benefits that could drive LISP's adoption.
As a first step to evaluating LISP's scalability, we propose a methodology for an analytical analysis of cache performance that relies on the working-set theory to estimate traffic locality of reference. One of our main contribution is that we identify the conditions network traffic must comply with for the theory to be applicable and then use the result to develop a model that predicts average cache miss rates. Furthermore, we study the model's suitability for long term cache provisioning and assess the cache's vulnerability in front of malicious users through an extension that accounts for cache polluting traffic. As a last step, we investigate the main sources of locality and their impact on the asymptotic scalability of the LISP cache. An important finding here is that destination popularity distribution can accurately describe cache performance, independent of the much harder to model short term correlations. Under a small set of assumptions, this result finally enables us to characterize asymptotic scalability with respect to the amount of prefixes (Internet growth) and users (growth of the LISP site). We validate the models and discuss the accuracy of our assumptions using several one-day-long packet traces collected at the egress points of a campus and an academic network.
To show the added benefits that could drive LISP's adoption, in the second part of the thesis we investigate the possibilities of performing inter-domain multicast and improving intra-domain routing. Although the idea of using overlaid services to improve underlay performance is not new, this dissertation argues that LISP offers the right tools to reliably and easily implement such services due to its reliance on network instead of application layer support. In particular, we present and extensively evaluate Lcast, a network-layer single-source multicast framework designed to merge the robustness and efficiency of IP multicast with the configurability and low deployment cost of application-layer overlays. Additionally, we describe and evaluate LISP-MPS, an architecture capable of exploiting LISP to minimize intra-domain routing tables and ensure, among other, support for multi protocol switching and virtual networks.En menos de cuatro décadas Internet ha evolucionado desde un experimento de laboratorio hasta una infraestructura de alcance mundial, de importancia crÃtica para negocios y que atiende a las necesidades de casi un tercio de los habitantes del planeta. Con estos números, es difÃcil tratar de negar la necesidad de escalabilidad de Internet. Sin embargo, el crecimiento orgánico de Internet está aún lejos de finalizar ya que se espera que mil millones de dispositivos nuevos se conecten en el futuro cercano. Asà pues, la falta de escalabilidad es el mayor problema al que se enfrenta Internet hoy en dÃa. Aunque la solución definitiva al problema está aún por definir, la necesidad de desacoplar semánticamente la localización e identidad de un nodo, a menudo llamada locator/identifier separation, es generalmente aceptada como un camino prometedor a seguir. Sin embargo, esto requiere la introducción de nuevos dispositivos en la red que unan los dos espacios de nombres disjuntos resultantes y de cachés que almacenen los enlaces temporales entre ellos con el fin de aumentar la velocidad de transmisión de los enrutadores. A raÃz de esta complejidad añadida, la escalabilidad de la solución en si misma es también cuestionada. Este trabajo evalúa la idoneidad de utilizar Locator/ID Separation Protocol (LISP), una de las propuestas más exitosas que siguen la pauta locator/identity separation, como una solución para la escalabilidad de la Internet. Con tal fin, desarrollamos las herramientas analÃticas para evaluar la escalabilidad del plano de control de LISP pero también para mostrar que la separación de los planos de control y datos proporciona un importante valor añadido que podrÃa impulsar la adopción de LISP. Como primer paso para evaluar la escalabilidad de LISP, proponemos una metodologÃa para un estudio analÃtico del rendimiento de la caché que se basa en la teorÃa del working-set para estimar la localidad de referencias. Identificamos las condiciones que el tráfico de red debe cumplir para que la teorÃa sea aplicable y luego desarrollamos un modelo que predice las tasas medias de fallos de caché con respecto a parámetros de tráfico fácilmente medibles. Por otra parte, para demostrar su versatilidad y para evaluar la vulnerabilidad de la caché frente a usuarios malintencionados, extendemos el modelo para considerar el rendimiento frente a tráfico generado por usuarios maliciosos. Como último paso, investigamos como usar la popularidad de los destinos para estimar el rendimiento de la caché, independientemente de las correlaciones a corto plazo. Bajo un pequeño conjunto de hipótesis conseguimos caracterizar la escalabilidad con respecto a la cantidad de prefijos (el crecimiento de Internet) y los usuarios (crecimiento del sitio LISP). Validamos los modelos y discutimos la exactitud de nuestras suposiciones utilizando varias trazas de paquetes reales. Para mostrar los beneficios adicionales que podrÃan impulsar la adopción de LISP, también investigamos las posibilidades de realizar multidifusión inter-dominio y la mejora del enrutamiento dentro del dominio. Aunque la idea de utilizar servicios superpuestos para mejorar el rendimiento de la capa subyacente no es nueva, esta tesis sostiene que LISP ofrece las herramientas adecuadas para poner en práctica de forma fiable y fácilmente este tipo de servicios debido a que LISP actúa en la capa de red y no en la capa de aplicación. En particular, presentamos y evaluamos extensamente Lcast, un marco de multidifusión con una sola fuente diseñado para combinar la robustez y eficiencia de la multidifusión IP con la capacidad de configuración y bajo coste de implementación de una capa superpuesta a nivel de aplicación. Además, describimos y evaluamos LISP-MPS, una arquitectura capaz de explotar LISP para minimizar las tablas de enrutamiento intra-dominio y garantizar, entre otras, soporte para conmutación multi-protocolo y redes virtuales
Actividades vivenciales para producción de textos narrativos en estudiante de quinto grado de educación básica regular, Ayacucho 2019
La investigación que se presenta se desarrolló teniendo como finalidad determinar la
influencia de las actividades vivenciales en la producción de textos narrativos en los
estudiantes de V ciclo de Educación Básica Regular de institución educativa 38127-UGEL
Cangallo 2019. Es una investigación desarrollada desde un enfoque cuantitativo, de tipo
experimental y diseño de investigación pre experimental. Para la recopilación de datos se
hizo uso de una rúbrica el mismo que fue sometido a una prueba de validez y confiabilidad,
siendo el resultado muy positivo, cuyos datos fueron sistematizados para hallar la
correspondiente prueba de hipótesis. El estadÃgrafo utilizado en la presente investigación fue
Wilcoxon para determinar la diferencia existente entre el pre test y el post test, con un nivel
de significancia del 5% (0,05). Los resultados obtenidos mediante el estadÃgrafo Wilcoxon,
nos muestra que las actividades vivenciales influyen significativamente en la producción de
textos narrativos en estudiantes de V ciclo de Educación Básica Regular de la institución
educativa 38127-UGEL Cangallo 2019 (p= 0,000<0,05
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