Anterior thigh composition measured using ultrasound imaging to quantify relative thickness of muscle and non-contractile tissue: a potential biomarker for musculoskeletal health

This study aimed to use ultrasound imaging to provide objective data on the effects of ageing and gender on relative thickness of quadriceps muscle and non-contractile tissue thickness (subcutaneous fat, SF, combined with perimuscular fascia). In 136 healthy males and females (aged 18-90 years n=63 aged 18-35 years; n=73 aged 65-90). Images of the anterior thigh (dominant) were taken in relaxed supine using B-mode ultrasound imaging. Thickness of muscle, SF and perimuscular fascia were measured, and percentage thickness of total anterior thigh thickness calculated. Independent t-tests compared groups. Correlation between tissue thickness and BMI was examined using Pearson’s coefficient. Muscle thickness was: 39±8mm in young males, 29±6mm in females, 25±4mm in older males and 20±5mm in females. Percentage muscle to thigh thickness was greater in young participants (p=0.001). Percentage SF and fascia was 17±6% in young and 26±8% in older males, 32±7% in young and 44±7% in older females. BMI was similar for age and correlated moderately with non-contractile tissue (r=0.54; p<0.001) and poorly with muscle (r=-0.01; p=0.93). In conclusion, this novel application of ultrasound imaging as a simple and rapid means of assessing thigh composition (relative thickness of muscle and non-contractile tissue) may help inform health status, e.g. in older people at risk of frailty and loss of mobility, and aid monitoring effects of weight loss or gain, deconditioning and exercise

The relationship between agency, communion, and neural processes associated with conforming to social influence

Social influence is ubiquitous in our daily lives, influencing our opinions, beliefs, and behaviors. Individual differences may determine who is most likely to conform to the opinions of others. More specifically, individual differences in interdependent and independent self-construal determine an individual's sensitivity to and focus on their social surroundings. Relatedly, society traditionally ascribes and prescribes different levels of agency (independence) and communion (interdependence) to men and women. Here, we examined how individual differences in self-construal, and their congruence with gender expectations, influence how people process and respond to social feedback. Results from independent behavioral and neuroimaging samples show that a stronger interdependent self-construal was associated with increased likelihood of conformity, whereas an independent self-construal was not. Further, neuroimaging data suggests that the relationship between brain activity and conformity is moderated by the congruence of gender stereotypes and self-construal. Specifically, stereotypically congruent women (with stronger interdependence) and men (with stronger independence) showed increased activity in mentalizing regions (and value regions in men) when conforming. Stereotypically incongruent women (with stronger independence) and men (with stronger interdependence) showed decreased mentalizing activity when conforming. These results shed light on underlying (neuro)psychological mechanisms that are associated with conformity among different groups

Potential and current distribution in strongly anisotropic Bi(2)Sr(2) CaCu(2)O(8) single crystals at current breakdown

Experiments on potential differences in the low-temperature vortex solid phase of monocrystalline platelets of superconducting Bi(2)Sr(2)CaCu(2)O(8) (BSCCO) subjected to currents driven either through an "ab" surface or from one such surface to another show evidence of a resistive/nonresistive front moving progressively out from the current contacts as the current increases. The depth of the resistive region has been measured by a novel in-depth voltage probe contact. The position of the front associated with an injection point appears to depend only on the current magnitude and not on its withdrawal point. It is argued that enhanced nonresistive superconducting anisotropy limits current penetration to less than the London length and results in a flat rectangular resistive region with simultaneous "ab" and "c" current breakdown which moves progressively out from the injection point with increasing current. Measurements in "ab" or "c" configurations are seen to give the same information, involving both ab-plane and c-axis conduction properties.Comment: 9 pages, 13 figures, typo error corrected, last section was refine

Critical-point scaling function for the specific heat of a Ginzburg-Landau superconductor

If the zero-field transition in high temperature superconductors such as YBa_2Cu_3O_7-\delta is a critical point in the universality class of the 3-dimensional XY model, then the general theory of critical phenomena predicts the existence of a critical region in which thermodynamic functions have a characteristic scaling form. We report the first attempt to calculate the universal scaling function associated with the specific heat, for which experimental data have become available in recent years. Scaling behaviour is extracted from a renormalization-group analysis, and the 1/N expansion is adopted as a means of approximation. The estimated scaling function is qualitatively similar to that observed experimentally, and also to the lowest-Landau-level scaling function used by some authors to provide an alternative interpretation of the same data. Unfortunately, the 1/N expansion is not sufficiently reliable at small values of N for a quantitative fit to be feasible.Comment: 20 pages; 4 figure

Deterministic and stochastic descriptions of gene expression dynamics

A key goal of systems biology is the predictive mathematical description of gene regulatory circuits. Different approaches are used such as deterministic and stochastic models, models that describe cell growth and division explicitly or implicitly etc. Here we consider simple systems of unregulated (constitutive) gene expression and compare different mathematical descriptions systematically to obtain insight into the errors that are introduced by various common approximations such as describing cell growth and division by an effective protein degradation term. In particular, we show that the population average of protein content of a cell exhibits a subtle dependence on the dynamics of growth and division, the specific model for volume growth and the age structure of the population. Nevertheless, the error made by models with implicit cell growth and division is quite small. Furthermore, we compare various models that are partially stochastic to investigate the impact of different sources of (intrinsic) noise. This comparison indicates that different sources of noise (protein synthesis, partitioning in cell division) contribute comparable amounts of noise if protein synthesis is not or only weakly bursty. If protein synthesis is very bursty, the burstiness is the dominant noise source, independent of other details of the model. Finally, we discuss two sources of extrinsic noise: cell-to-cell variations in protein content due to cells being at different stages in the division cycles, which we show to be small (for the protein concentration and, surprisingly, also for the protein copy number per cell) and fluctuations in the growth rate, which can have a significant impact.Comment: 23 pages, 5 figures; Journal of Statistical physics (2012

Determination of the Gamow-Teller Quenching Factor from Charge Exchange Reactions on 90Zr

Double differential cross sections between 0-12 degrees were measured for the 90Zr(n,p) reaction at 293 MeV over a wide excitation energy range of 0-70 MeV. A multipole decomposition technique was applied to the present data as well as the previously obtained 90Zr(p,n) data to extract the Gamow-Teller (GT) component from the continuum. The GT quenching factor Q was derived by using the obtained total GT strengths. The result is Q=0.88+/-0.06 not including an overall normalization uncertainty in the GT unit cross section of 16%.Comment: 11 papes, 4 figures, submitted to Physics Letters B (accepted), gzipped tar file, changed content

The self-consistent bounce: an improved nucleation rate

We generalize the standard computation of homogeneous nucleation theory at zero temperature to a scenario in which the bubble shape is determined self-consistently with its quantum fluctuations. Studying two scalar models in 1+1 dimensions, we find the self-consistent bounce by employing a two-particle irreducible (2PI) effective action in imaginary time at the level of the Hartree approximation. We thus obtain an effective single bounce action which determines the rate exponent. We use collective coordinates to account for the translational invariance and the growth instability of the bubble and finally present a new nucleation rate prefactor. We compare the results with those obtained using the standard 1-loop approximation and show that the self-consistent rate can differ by several orders of magnitude.Comment: 28 pages, revtex, 7 eps figure