321 research outputs found
Bi-directional association between depression and HF: An electronic health records-based cohort study.
To determine whether a bi-directional relationship exists between depression and HF within a single population of individuals receiving primary care services, using longitudinal electronic health records (EHRs).
This retrospective cohort study utilized EHRs for adults who received primary care services within a large healthcare system in 2006. Validated EHR-based algorithms identified 10,649 people with depression (depression cohort) and 5,911 people with HF (HF cohort) between January 1, 2006 and December 31, 2018. Each person with depression or HF was matched 1:1 with an unaffected referent on age, sex, and outpatient service use. Each cohort (with their matched referents) was followed up electronically to identify newly diagnosed HF (in the depression cohort) and depression (in the HF cohort) that occurred after the index diagnosis of depression or HF, respectively. The risks of these outcomes were compared (vs. referents) using marginal Cox proportional hazard models adjusted for 16 comorbid chronic conditions.
2,024 occurrences of newly diagnosed HF were observed in the depression cohort and 944 occurrences of newly diagnosed depression were observed in the HF cohort over approximately 4-6 years of follow-up. People with depression had significantly increased risk for developing newly diagnosed HF (HR 2.08, 95% CI 1.89-2.28) and people with HF had a significantly increased risk of newly diagnosed depression (HR 1.34, 95% CI 1.17-1.54) after adjusting for all 16 comorbid chronic conditions.
These results provide evidence of a bi-directional relationship between depression and HF independently of age, sex, and multimorbidity from chronic illnesses
Anomalous Pseudoscalar-Photon Vertex In and Out of Equilibrium
The anomalous pseudoscalar-photon vertex is studied in real time in and out
of equilibrium in a constituent quark model. The goal is to understand the
in-medium modifications of this vertex, exploring the possibility of enhanced
isospin breaking by electromagnetic effects as well as the formation of neutral
pion condensates in a rapid chiral phase transition in peripheral,
ultrarelativistic heavy-ion collisions. In equilibrium the effective vertex is
afflicted by infrared and collinear singularities that require hard thermal
loop (HTL) and width corrections of the quark propagator. The resummed
effective equilibrium vertex vanishes near the chiral transition in the chiral
limit. In a strongly out of equilibrium chiral phase transition we find that
the chiral condensate drastically modifies the quark propagators and the
effective vertex. The ensuing dynamics for the neutral pion results in a
potential enhancement of isospin breaking and the formation of
condensates. While the anomaly equation and the axial Ward identity are not
modified by the medium in or out of equilibrium, the effective real-time
pseudoscalar-photon vertex is sensitive to low energy physics.Comment: Revised version to appear in Phys. Rev. D. 42 pages, 4 figures, uses
Revte
Five blood pressure loci identified by an updated genome-wide linkage scan: meta-analysis of the Family Blood Pressure Program.
BACKGROUND: A preliminary genome-wide linkage analysis of blood pressure in the Family Blood Pressure Program (FBPP) was reported previously. We harnessed the power and ethnic diversity of the final pooled FBPP dataset to identify novel loci for blood pressure thereby enhancing localization of genes containing less common variants with large effects on blood pressure levels and hypertension.
METHODS: We performed one overall and 4 race-specific meta-analyses of genome-wide blood pressure linkage scans using data on 4,226 African-American, 2,154 Asian, 4,229 Caucasian, and 2,435 Mexican-American participants (total N = 13,044). Variance components models were fit to measured (raw) blood pressure levels and two types of antihypertensive medication adjusted blood pressure phenotypes within each of 10 subgroups defined by race and network. A modified Fisher's method was used to combine the P values for each linkage marker across the 10 subgroups.
RESULTS: Five quantitative trait loci (QTLs) were detected on chromosomes 6p22.3, 8q23.1, 20q13.12, 21q21.1, and 21q21.3 based on significant linkage evidence (defined by logarithm of odds (lod) score â„3) in at least one meta-analysis and lod scores â„1 in at least 2 subgroups defined by network and race. The chromosome 8q23.1 locus was supported by Asian-, Caucasian-, and Mexican-American-specific meta-analyses.
CONCLUSIONS: The new QTLs reported justify new candidate gene studies. They may help support results from genome-wide association studies (GWAS) that fall in these QTL regions but fail to achieve the genome-wide significance
Statistical Properties of the Linear Sigma Model
The statistical equilibrium properties of the linear sigma model are studied,
with a view towards characterizing the field configurations employed as initial
conditions for numerical simulations of the formation of disoriented chiral
condensates in high-energy nuclear collisions. The field is decomposed into its
spatial average (the order parameter) and the fluctuations (the quasi-
particles) and enclosed in a rectangular box with periodic boundary conditions.
The quantized quasi-particle modes are described approximately by Klein-Gordon
dispersion relations containing an effective mass that depends on both the
temperature and the magnitude of the order parameter. The thermal fluctuations
are instrumental in shaping the effective potential governing the order
parameter, and the evolution of its statistical distribution with temperature
is discussed, as is the behavior of the associated effective masses. As the
system is cooled the field fluctuations subside, causing a smooth change from
the high-temperature phase in which chiral symmetry is approximately restored
towards the normal phase. Of practical interest is the fact that the
equilibrium field configurations can be sampled in a simple manner, thus
providing a convenient means for specifying the initial conditions in dynamical
simulations of the non-equilibrium relaxation of the chiral field. The
corresponding correlation function is briefly considered and used to calculate
the spectral strength of radiated pions. Finally, by propagating samples of
initial configurations by the exact equation of motion, it has been ascertained
that the treatment is sufficiently accurate to be of practical utility.Comment: 42 pages total, incl 18 figs using pstricks ([email protected]
Grain Surface Models and Data for Astrochemistry
AbstractThe cross-disciplinary field of astrochemistry exists to understand the formation, destruction, and survival of molecules in astrophysical environments. Molecules in space are synthesized via a large variety of gas-phase reactions, and reactions on dust-grain surfaces, where the surface acts as a catalyst. A broad consensus has been reached in the astrochemistry community on how to suitably treat gas-phase processes in models, and also on how to present the necessary reaction data in databases; however, no such consensus has yet been reached for grain-surface processes. A team of âŒ25 experts covering observational, laboratory and theoretical (astro)chemistry met in summer of 2014 at the Lorentz Center in Leiden with the aim to provide solutions for this problem and to review the current state-of-the-art of grain surface models, both in terms of technical implementation into models as well as the most up-to-date information available from experiments and chemical computations. This review builds on the results of this workshop and gives an outlook for future directions
Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV
We report the results of a study of color coherence effects in ppbar
collisions based on data collected by the D0 detector during the 1994-1995 run
of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8
TeV. Initial-to-final state color interference effects are studied by examining
particle distribution patterns in events with a W boson and at least one jet.
The data are compared to Monte Carlo simulations with different color coherence
implementations and to an analytic modified-leading-logarithm perturbative
calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters
A multi-center study on the attitudes of Malaysian emergency health care staff towards allowing family presence during resuscitation of adult patients
BACKGROUND
The practice of allowing family members to witness on-going active resuscitation has been gaining ground in many developed countries since it was first introduced in the early 1990s. In many Asian countries, the acceptability of this practice has not been well studied.
AIM
We conducted a multi-center questionnaire study to determine the attitudes of health care professionals in Malaysia towards family presence to witness ongoing medical procedures during resuscitation.
METHODS
Using a bilingual questionnaire (in Malay and English language), we asked our respondents about their attitudes towards allowing family presence (FP) as well as their actual experience of requests from families to be allowed to witness resuscitations. Multiple logistic regression was used to analyze the association between the many variables and a positive attitude towards FP.
RESULTS
Out of 300 health care professionals who received forms, 270 responded (a 90% response rate). Generally only 15.8% of our respondents agreed to allow relatives to witness resuscitations, although more than twice the number (38.5%) agreed that relatives do have a right to be around during resuscitation. Health care providers are significantly more likely to allow FP if the procedures are perceived as likely to be successful (e.g., intravenous cannulation and blood taking as compared to chest tube insertion). Doctors were more than twice as likely as paramedics to agree to FP (p-value = 0.002). This is probably due to the Malaysian work culture in our health care systems in which paramedics usually adopt a 'follow-the-leader' attitude in their daily practice.
CONCLUSION
The concept of allowing FP is not well accepted among our Malaysian health care providers
Search for electroweak production of single top quarks in collisions.
We present a search for electroweak production of single top quarks in the electron+jets and muon+jets decay channels. The measurements use ~90 pb^-1 of data from Run 1 of the Fermilab Tevatron collider, collected at 1.8 TeV with the DZero detector between 1992 and 1995. We use events that include a tagging muon, implying the presence of a b jet, to set an upper limit at the 95% confidence level on the cross section for the s-channel process ppbar->tb+X of 39 pb. The upper limit for the t-channel process ppbar->tqb+X is 58 pb. (arXiv
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