Effect of organic, low-input and conventional production systems on pesticide and growth regulator residues in wheat, potato and cabbage

The Nafferton factorial systems comparison (NFSC) experiments facilitate the investigation of effects of, and interaction between, three production system components - a) rotational position, b) fertility and c) crop protection management - in organic, conventional and low-input crop management systems. This paper presents first results on pesticide and growth regulator residues observed over a period of two years. Residues were only detected for three (Chlormequat, Chlorothalonil and Aldicarb) of the 28 pesticides used in the experiments. As expected, residue levels were affected by the crop protection practices, but significant effects of fertility management practices were also detected. This indicates that the human health risks associated with pesticide residues may increase in low input systems which attempt to reduce the environmental impact of conventional farming systems by switching to organic matter based fertilisation regimes

Two Session Cognitive Bias Modification Training; Exercise Interpretation Bias

Cognitive bias modification is the direct manipulation of a target bias by extensive exposure to task contingencies that encourage predetermined patterns of processing selectivity1,2. Forty-eight participants from a general population sample recruited for a two-part study investigating the effect of two sessions of exercise orientated Positive CBM-I Training, in comparison to a Neutral Pseudo Training condition. Baseline, post session one and post session two self-report measures of Anxiety, Depression and Stress were collected. Measures of interpretation bias were collected at baseline and post session two, both with and without cognitive load. Results suggest that for individuals undergoing two sessions of Positive CBM-I Training over a fortnight had significantly decreased Trait Anxiety scores, relative to the Pseudo Neutral Training condition. The findings hold promise for the Cognitive Bias Modification paradigm for decreasing symptoms of Anxiety

Human papillomavirus vaccination acceptance and hesitancy in South Africa: Research and policy agenda

Cervical cancer is responsible for one-quarter of a million deaths per year  worldwide. In South Africa (SA), cervical cancer is the leading cause of  cancer deaths among women aged 15 - 44 years. Human papillomavirus  (HPV) vaccines provide a safe and highly effective means to reduce the burden of cervical cancer. The World Health Organization initiated a plan for the elimination of cervical cancer; the programme’s success relies on the introduction and high uptake of HPV vaccines globally. SA introduced a school-based HPV vaccination programme in 2014, but uptake is not as high as expected. Suboptimal HPV vaccination coverage may result from various factors, including vaccine hesitancy. Vaccine-hesitant parents may delay or refuse HPV vaccination for their daughters. Tailored interventions are needed to address this. However, knowledge regarding vaccine  hesitancy and policies to address this hesitancy in SA are currently limited. While SA has taken commendable steps in cervical cancer prevention by implementing and financing the HPV vaccination programme, it is  imperative that there are clear policies in place to help strengthen the programme. These policies need to clarify areas of uncertainty that may lead to mistrust, and pre-empt factors that will cause hesitancy. Equally important is that local research should be conducted to better understand HPV vaccination hesitancy and other determinants of uptake to further inform and shape national policies

Comparing semi-analytic particle tagging and hydrodynamical simulations of the Milky Way's stellar halo

Particle tagging is an efficient, but approximate, technique for using cosmological N-body simulations to model the phase-space evolution of the stellar populations predicted, for example, by a semi-analytic model of galaxy formation. We test the technique developed by Cooper et al. (which we call STINGS here) by comparing particle tags with stars in a smooth particle hydrodynamic (SPH) simulation. We focus on the spherically averaged density profile of stars accreted from satellite galaxies in a Milky Way (MW)-like system. The stellar profile in the SPH simulation can be recovered accurately by tagging dark matter (DM) particles in the same simulation according to a prescription based on the rank order of particle binding energy. Applying the same prescription to an N-body version of this simulation produces a density profile differing from that of the SPH simulation by ≲10 per cent on average between 1 and 200 kpc. This confirms that particle tagging can provide a faithful and robust approximation to a self-consistent hydrodynamical simulation in this regime (in contradiction to previous claims in the literature). We find only one systematic effect, likely due to the collisionless approximation, namely that massive satellites in the SPH simulation are disrupted somewhat earlier than their collisionless counterparts. In most cases, this makes remarkably little difference to the spherically averaged distribution of their stellar debris. We conclude that, for galaxy formation models that do not predict strong baryonic effects on the present-day DM distribution of MW-like galaxies or their satellites, differences in stellar halo predictions associated with the treatment of star formation and feedback are much more important than those associated with the dynamical limitations of collisionless particle tagging

Raman scattering studies of spin, charge, and lattice dynamics in Ca_{2-x}Sr_{x}RuO_{4} (0 =< x < 0.2)

We use Raman scattering to study spin, charge, and lattice dynamics in various phases of Ca_{2-x}Sr_{x}RuO_{4}. With increasing substitution of Ca by Sr in the range 0 =< x < 0.2, we observe (1) evidence for an increase of the electron-phonon interaction strength, (2) an increased temperature-dependence of the two-magnon energy and linewidth in the antiferromagnetic insulating phase, and (3) evidence for charge gap development, and hysteresis associated with the structural phase change, both of which are indicative of a first-order metal-insulator transition (T_{MI}) and a coexistence of metallic and insulating components for T < T_{MI}

Bound state solutions of the Dirac-Rosen-Morse potential with spin and pseudospin symmetry

The energy spectra and the corresponding two- component spinor wavefunctions of the Dirac equation for the Rosen-Morse potential with spin and pseudospin symmetry are obtained. The $s-$wave ($\kappa = 0$ state) solutions for this problem are obtained by using the basic concept of the supersymmetric quantum mechanics approach and function analysis (standard approach) in the calculations. Under the spin symmetry and pseudospin symmetry, the energy equation and the corresponding two-component spinor wavefunctions for this potential and other special types of this potential are obtained. Extension of this result to $\kappa \neq 0$ state is suggested.Comment: 18 page

Galactic stellar haloes in the CDM model

We present six simulations of galactic stellar haloes formed by the tidal disruption of accreted dwarf galaxies in a fully cosmological setting. Our model is based on the Aquarius project, a suite of high-resolution N-body simulations of individual dark matter haloes. We tag subsets of particles in these simulations with stellar populations predicted by the galform semi-analytic model. Our method self-consistently tracks the dynamical evolution and disruption of satellites from high redshift. The luminosity function (LF) and structural properties of surviving satellites, which agree well with observations, suggest that this technique is appropriate. We find that accreted stellar haloes are assembled between 1 < z < 7 from less than five significant progenitors. These progenitors are old, metal-rich satellites with stellar masses similar to the brightest Milky Way dwarf spheroidals (107–108 M⊙). In contrast to previous stellar halo simulations, we find that several of these major contributors survive as self-bound systems to the present day. Both the number of these significant progenitors and their infall times are inherently stochastic. This results in great diversity among our stellar haloes, which amplifies small differences between the formation histories of their dark halo hosts. The masses (∼ 108–109 M⊙) and density/surface-brightness profiles of the stellar haloes (from 10 to 100 kpc) are consistent with expectations from the Milky Way and M31. Each halo has a complex structure, consisting of well-mixed components, tidal streams, shells and other subcomponents. This structure is not adequately described by smooth models. The central regions (<10 kpc) of our haloes are highly prolate (c/a∼ 0.3), although we find one example of a massive accreted thick disc. Metallicity gradients in our haloes are typically significant only where the halo is built from a small number of satellites. We contrast the ages and metallicities of halo stars with surviving satellites, finding broad agreement with recent observations

Single stranded fully Modified-Phosphorothioate oligonucleotides can induce structured nuclear inclusions, alter nuclear protein localization and disturb the transcriptome In Vitro

Oligonucleotides and nucleic acid analogues that alter gene expression are now showing therapeutic promise in human disease. Whilst the modification of synthetic nucleic acids to protect against nuclease degradation and to influence drug function is common practice, such modifications may also confer unexpected physicochemical and biological properties. Gapmer mixed-modified and DNA oligonucleotides on a phosphorothioate backbone can bind non-specifically to intracellular proteins to form a variety of toxic inclusions, driven by the phosphorothioate linkages, but also influenced by the oligonucleotide sequence. Recently, the non-antisense or other off-target effects of 2′ O- fully modified phosphorothioate linkage oligonucleotides are becoming better understood. Here, we report chemistry-specific effects of oligonucleotides composed of modified or unmodified bases, with phosphorothioate linkages, on subnuclear organelles and show altered distribution of nuclear proteins, the appearance of highly stable and strikingly structured nuclear inclusions, and disturbed RNA processing in primary human fibroblasts and other cultured cells. Phosphodiester, phosphorodiamidate morpholino oligomers, and annealed complimentary phosphorothioate oligomer duplexes elicited no such consequences. Disruption of subnuclear structures and proteins elicit severe phenotypic disturbances, revealed by transcriptomic analysis of transfected fibroblasts exhibiting such disruption. Our data add to the growing body of evidence of off-target effects of some phosphorothioate nucleic acid drugs in primary cells and suggest alternative approaches to mitigate these effects

(1+1)-Dirac particle with position-dependent mass in complexified Lorentz scalar interactions: effectively PT-symmetric

The effect of the built-in supersymmetric quantum mechanical language on the spectrum of the (1+1)-Dirac equation, with position-dependent mass (PDM) and complexified Lorentz scalar interactions, is re-emphasized. The signature of the "quasi-parity" on the Dirac particles' spectra is also studied. A Dirac particle with PDM and complexified scalar interactions of the form S(z)=S(x-ib) (an inversely linear plus linear, leading to a PT-symmetric oscillator model), and S(x)=S_{r}(x)+iS_{i}(x) (a PT-symmetric Scarf II model) are considered. Moreover, a first-order intertwining differential operator and an $\eta$-weak-pseudo-Hermiticity generator are presented and a complexified PT-symmetric periodic-type model is used as an illustrative example.Comment: 11 pages, no figures, revise

Supersymmetric solutions of PT-/non-PT-symmetric and non-Hermitian Screened Coulomb potential via Hamiltonian hierarchy inspired variational method

The supersymmetric solutions of PT-symmetric and Hermitian/non-Hermitian forms of quantum systems are obtained by solving the Schrodinger equation for the Exponential-Cosine Screened Coulomb potential. The Hamiltonian hierarchy inspired variational method is used to obtain the approximate energy eigenvalues and corresponding wave functions.Comment: 13 page