Solvent free model for self-assembling fluid bilayer membranes: Stabilization of the fluid phase based on broad attractive tail potentials

We present a simple and highly adaptable method for simulating coarse-grained lipid membranes without explicit solvent. Lipids are represented by one head-bead and two tail-beads, with the interaction between tails being of key importance in stabilizing the fluid phase. Two such tail-tail potentials were tested, with the important feature in both cases being a variable range of attraction. We examined phase diagrams of this range versus temperature for both functional forms of the tail-tail attraction and found that a certain threshold attractive width was required to stabilize the fluid phase. Within the fluid phase region we find that material properties such as area per lipid, orientational order, diffusion constant, inter-leaflet flip-flop rate and bilayer stiffness all depend strongly and monotonically on the attractive width. For three particular values of the potential width we investigate the transition between gel and fluid phases via heating or cooling and find that this transition is discontinuous with considerable hysteresis. We also investigated the stretching of a bilayer to eventually form a pore and found excellent agreement with a recently published analytic theory.Comment: 14 pages 12 figure

Does Migration Make You Happy?:A Longitudinal Study of Internal Migration and Subjective Well-Being

The authors acknowledge financial support from the Economic and Social Research Council (ESRC) (RES-625-28-0001). This project is part of the ESRC Centre for Population Change (CPC). Financial support from the Marie Curie programme under the European Union's Seventh Framework Programme (FP/2007-2013) / Career Integration Grant n. PCIG10-GA-2011-303728 (CIG Grant NBHCHOICE, Neighbourhood choice, neighbourhood sorting, and neighbourhood effects).The majority of quantitative studies on the consequences of internal migration focus almost exclusively on the labour-market outcomes and the material well-being of migrants. We investigate whether individuals who migrate within the UK become happier after the move than they were before, and whether the effect is permanent or transient. Using life-satisfaction responses from twelve waves of the British Household Panel Survey and employing a fixed-effects model, we derive a temporal pattern of migrants’ subjective well-being around the time of the migration event. Our findings make an original contribution by revealing that, on average, migration is preceded by a period when individuals experience a significant decline in happiness for a variety of reasons, including changes in personal living arrangements. Migration itself causes a boost in happiness, and brings people back to their initial levels. The research contributes, therefore, to advancing an understanding of migration in relation to set-point theory. Perhaps surprisingly, long-distance migrants are at least as happy as short-distance migrants despite the higher social and psychological costs involved. The findings of this paper add to the pressure to retheorize migration within a conceptual framework that accounts for social well-being from a life-course perspective.PostprintPeer reviewe

Long‐Wavelength Sinuosity of Linear Dunes on Earth and Titan and the Effect of Underlying Topography

AbstractOn both Earth and Titan, some linear dunefields are characterized by curvilinear patterning atypical of the regularity and straightness of typical longitudinal dunefields. We use remotely sensed imagery and an automated dune crestline detection algorithm to analyze the controls on spatial patterning. Here it is shown that topography can influence the patterning, as dune alignments bend to deflect downslope under the influence of gravity. The effect is pronounced in a terrestrial dunefield (the Great Sandy desert, Australia) where substantial topography underlies, but is absent where the dunefield is underlain by subdued relief (southwestern Kalahari). This knowledge allows the inference of subtle topographic changes underlying dunefields from dunefield patterning, where other sources of elevation data may be absent. This methodology is explored using the Belet Sand Sea of Titan, where likely areas of topographic change at resolutions finer than those currently available from radar altimetry are inferred.</jats:p

The economic and innovation contribution of universities: a regional perspective

Universities and other higher education institutions (HEIs) have come to be regarded as key sources of knowledge utilisable in the pursuit of economic growth. Although there have been numerous studies assessing the economic and innovation impact of HEIs, there has been little systematic analysis of differences in the relative contribution of HEIs across regions. This paper provides an exploration of some of these differences in the context of the UK’s regions. Significant differences are found in the wealth generated by universities according to regional location and type of institution. Universities in more competitive regions are generally more productive than those located in less competitive regions. Also, traditional universities are generally more productive than their newer counterparts, with university productivity positively related to knowledge commercialisation capabilities. Weaker regions tend to be more dependent on their universities for income and innovation, but often these universities under-perform in comparison to counterpart institutions in more competitive regions. It is argued that uncompetitive regions lack the additional knowledge infrastructure, besides universities, that are more commonly a feature of more competitive regions

Magnetic susceptibility, exchange interactions and spin-wave spectra in the local spin density approximation

Starting from exact expression for the dynamical spin susceptibility in the time-dependent density functional theory a controversial issue about exchange interaction parameters and spin-wave excitation spectra of itinerant electron ferromagnets is reconsidered. It is shown that the original expressions for exchange integrals based on the magnetic force theorem (J. Phys. F14 L125 (1984)) are optimal for the calculations of the magnon spectrum whereas static response function is better described by the ``renormalized'' magnetic force theorem by P. Bruno (Phys. Rev. Lett. 90, 087205 (2003)). This conclusion is confirmed by the {\it ab initio} calculations for Fe and Ni.Comment: 12 pages, 2 figures, submitted to JPC

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30–40-fold increased risk of high-grade serous extra-uterine Müllerian cancers (HGSEMC), otherwise referred to as ‘ovarian carcinomas’, which frequently develop from fimbrial cells but not from the proximal portion of the fallopian tube. Here we compare the DNA methylome of the fimbrial and proximal ends of the fallopian tube in BRCA1/2 mutation carriers and non-carriers. We show that the number of CpGs displaying significant differences in methylation levels between fimbrial and proximal fallopian tube segments are threefold higher in BRCA mutation carriers than in controls, correlating with overexpression of activation-induced deaminase in their fimbrial epithelium. The differentially methylated CpGs accurately discriminate HGSEMCs from non-serous subtypes. Epigenetic reprogramming is an early pre-malignant event integral to BRCA1/2 mutation-driven carcinogenesis. Our findings may provide a basis for cancer-preventative strategies

On the Lack of Correlation Between [OIII]/[OII] and Lyman-Continuum Escape Fraction

We present the first results of our pilot study of 8 photometrically selected Lyman continuum (LyC) emitting galaxy candidates from the COSMOS field and focus on their optical emission line ratios. Observations were performed in the H and K bands using the Multi-Object Spectrometer for Infra-Red Exploration (MOSFIRE) instrument at the Keck Observatory, targeting the [OII], H$\beta$, and [OIII] emission lines. We find that photometrically selected LyC emitting galaxy candidates have high ionization parameters, based on their high [OIII]/[OII] ratios (O32), with an average ratio for our sample of 2.5$\pm$0.2. Preliminary results of our companion Low Resolution Imaging Spectrometer (LRIS) observations, targeting LyC and Ly$\alpha$, show that those galaxies with the largest O32 are typically found to also be Ly$\alpha$ emitters. High O32 galaxies are also found to have tentative non-zero LyC escape fractions ($f_{esc}(LyC)$) based on $u$ band photometric detections. These results are consistent with samples of highly ionized galaxies, including confirmed LyC emitting galaxies from the literature. We also perform a detailed comparison between the observed emission line ratios and simulated line ratios from density bounded H$_{\textrm{II}}$ regions modeled using the photoionization code MAPPINGS V. Estimates of $f_{esc}(LyC)$ for our sample fall in the range from 0.0-0.23 and suggest possible tension with published correlations between O32 and $f_{esc}(LyC)$, adding weight to dichotomy of arguments in the literature. We highlight the possible effects of clumpy geometry and mergers that may account for such tension.Comment: 21 pages, 11 figures, 3 tables, accepted for publication in MNRA

Metabolic profile and in vitro embryo production of primiparous canchim cows kept in areas of intensive grazing or silvipastoral.

In regions with a tropical climate, shading may determine greater animal comfort (Garcia et al, 2011), impacting on productivity.Edição dos Proceedings of the 32nd Annual Meeting of the Brazilian Embryo Technology Society (SBTE)

Corporate Social Responsibility and Islamic Financial Institutions (IFIs): Management Perceptions from IFIs in Bahrain

Islamic finance is gaining greater attention in the finance industry, and this paper analyses how Islamic financial institutions (IFIs) are responding to the welfare needs of society. Using interview data with managers and content analysis of the disclosures, this study attempts to understand management perceptions of corporate social responsibility (CSR) in IFIs. A thorough understanding of CSR by managers, as evident in the interviews, has not been translated fully into practice. The partial use of IFIs’ potential role in social welfare would add further challenges in the era of financialisation