Observation of magnetization reversal and negative magnetization in a double perovskite compound Sr2YbRuO6

Detailed magnetic properties of the compound Sr2YbRuO6 are presented here. The compound belongs to the family of double perovskites forming a monoclinic structure. Magnetization meas-urements reveal clear evidence for two components of magnetic ordering aligned opposite to each other, leading to a magnetization reversal, compensation temperature (T* = 34 K) and neg-ative magnetization at low temperatures and low magnetic fields. Heat capacity measurements corroborate the presence of two components in the magnetic ordering and a noticeable third anomaly at low temperatures (~15 K) which cannot be attributed the Schottky effect. The calcu-lated magnetic entropy is substantially lower than that expected for the ground states of the or-dered moments of Ru5+ and Yb3+, indicating the presence of large crystal field effects and/ or in-complete magnetic ordering and/or magnetic frustrations well above the magnetic ordering. An attempt is made to explain the magnetization reversal within the frameworks of available models.Comment: 15 pages text, 6 figures Journal-ref: J.Phys.:Condens.Matter 20(2008)23520

FLI1+ cells transcriptional analysis reveals LMO2-PRDM16 axis in angiogenesis

A network of molecular factors drives the development, differentiation, and maintenance of endothelial cells. Friend leukemia integration 1 transcription factor (FLI1) is a bona fide marker of endothelial cells during early development. In zebrafish Tg(fli1:EGFP)(y1), we identified two endothelial cell populations, high-fli1(+) and low-fli1(+), by the intensity of green fluorescent protein signal. By comparing RNA-sequencing analysis of non-fli1 expressing cells (fli1(−)) with these two (fli1(+)) cell populations, we identified several up-regulated genes, not previously recognized as important, during endothelial development. Compared with fli1(−) and low-fli1(+) cells, high-fli1(+) cells showed up-regulated expression of the zinc finger transcription factor PRDI-BF1 and RIZ homology domain containing 16 (prdm16). Prdm16 knockdown (KD) by morpholino in the zebrafish larva was associated with impaired angiogenesis and increased number of low-fli1(+) cells at the expense of high-fli1(+) cells. In addition, PRDM16 KD in endothelial cells derived from human-induced pluripotent stem cells impaired their differentiation and migration in vitro. Moreover, zebrafish mutants (mut) with loss of function for the oncogene LIM domain only 2 (lmo2) also showed reduced prdm16 gene expression combined with impaired angiogenesis. Prdm16 expression was reduced further in endothelial (CD31(+)) cells compared with CD31(−) cells isolated from lmo2-mutants (lmo2-mut) embryos. Chromatin immunoprecipitation–PCR demonstrated that Lmo2 binds to the promoter and directly regulates the transcription of prdm16. This work unveils a mechanism by which prdm16 expression is activated in endothelial cells by Lmo2 and highlights a possible therapeutic pathway by which to modulate endothelial cell growth and repair

Implications of Global Peak Population for Canada\u27s Future

In “Imagining Canada’s Future” the Social Science and Humanities Research Council (SSHRC) engaged various stakeholders to help establish six Future Challenge Areas. This report elaborates on the capacity of the Canadian research community with regard to the Future Challenge Area on “What might the implications of global peak population be for Canada?” It provides answers to sub-questions associated with this theme, namely: (1) What do we need to understand in order to effectively nurture the next generations? (2) What might Canadian families look like in five, 10, and 20 years, and how might they measure their well-being? (3) Life cycle issues are challenging society, in Canada and around the world. What are the future implications of state regulation from cradle to grave? (4) What effect will global migration have on our cities of the future? (5) How could changing demographics and migration affect rural and remote communities—such as in the North, including the Arctic? (6) What are the potential impacts of global peak population with respect to Canada’s energy and resource consumption and climate change

High-Redshift Metals. II. Probing Reionization Galaxies with Low-Ionization Absorption Lines at Redshift Six

We present a survey for low-ionization metal absorption line systems towards 17 QSOs at redshifts z_em=5.8-6.4. Nine of our objects were observed at high resolution with either Keck/HIRES or Magellan/MIKE, and the remainder at moderate resolution with Keck/ESI. The survey spans 5.3 < z_abs < 6.4 and has a pathlength interval \Delta X=39.5, or \Delta z=8.0. In total we detect ten systems, five of which are new discoveries. The line-of-sight number density is consistent with the combined number density at z~3 of DLAs and sub-DLAs, which comprise the main population of low-ionization systems at lower redshifts. This apparent lack of evolution may occur because low ionization systems are hosted by lower-mass halos at higher redshifts, or because the mean cross section of low-ionization gas at a given halo mass increases with redshift due to the higher densities and lower ionizing background. The roughly constant number density notably contrasts with the sharp decline at z > 5.3 in the number density of highly-ionized systems traced by C IV. The low-ionization systems at z~6 span a similar range of velocity widths as lower-redshift sub-DLAs but have significantly weaker lines at a given width. This implies that the mass-metallicity relation of the host galaxies evolves towards lower metallicities at higher redshifts. These systems lack strong Si IV and C IV, which are common among lower-redshift DLAs and sub-DLAs. This is consistent, however, with a similar decrease in the metallicity of the low- and high-ionization phases, and does not necessarily indicate a lack of nearby, highly-ionized gas. The high number density of low-ionization systems at z~6 suggests that we may be detecting galaxies below the current limits of i-dropout and Ly-alpha emission galaxy surveys. These systems may therefore be the first direct probes of the `typical' galaxies responsible for hydrogen reionization.Comment: 15 pages, 15 figures, submitted to Ap

The role of venture capitalists in the regional innovation ecosystem : a comparison of networking patterns between private and publicly backed venture capital funds

This paper empirically examines the development of social networks among venture capitalists and other professionals of the regional innovation ecosystem. Using an online survey of venture capitalists, the article considers their networking behaviour, focusing particularly on the distinction between those employed by private and those employed by publicly backed venture capital funds, and on the composition and spatial search of their networks. It investigates whether the frequency of interaction between venture capitalists and other members of the innovation ecosystem is associated with the nature of the venture capital funds. The paper provides the first detailed investigation of the relationship between different types of venture capitalists and other players of the innovation ecosystem such as universities incubators, research institutes, and business support organisations. The results show that there are distinctive differences within the two seemingly similar professional groups (private and public venture capitalists), and public dependence of the venture capital fund is strongly and significantly associated with higher volumes of interactions. The more publicly dependent a fund is, the more it interacts with other players of the innovation system. This finding has important implications for both academics and practitioners and suggests that publicly backed funds have a wider role to play in mobilising the different players of the regional innovation ecosystem

A metric for predicting binaural speech intelligibility in stationary noise and competing speech maskers

One criterion in the design of binaural sound scenes in audio production is the extent to which the intended speech message is correctly understood. Object-based audio broadcasting systems have permitted sound editors to gain more access to the metadata (e.g., intensity and location) of each sound source, providing better control over speech intelligibility. The current study describes and evaluates a binaural distortion-weighted glimpse proportion metric -- BiDWGP -- which is motivated by better-ear glimpsing and binaural masking level differences. BiDWGP predicts intelligibility from two alternative input forms: either binaural recordings or monophonic recordings from each sound source along with their locations. Two listening experiments were performed with stationary noise and competing speech, one in the presence of a single masker, the other with multiple maskers, for a variety of spatial configurations. Overall, BiDWGP with both input forms predicts listener keyword scores with correlations of 0.95 and 0.91 for single- and multi-masker conditions, respectively. When considering masker type separately, correlations rise to 0.95 and above for both types of maskers. Predictions using the two input forms are very similar, suggesting that BiDWGP can be applied to the design of sound scenes where only individual sound sources and their locations are available

A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection.

BACKGROUND: Trachoma, an infectious disease of the conjunctiva caused by Chlamydia trachomatis, is an important global cause of blindness. A dysregulated extracellular matrix (ECM) proteolysis during the processes of tissue repair following infection and inflammation are thought to play a key role in the development of fibrotic sequelae of infection, which ultimately leads to blindness. Expression and activity of matrix metalloproteinase 9 (MMP-9), a major effector of ECM turnover, is up-regulated in the inflamed conjunctiva of trachoma subjects. Genetic variation within the MMP9 gene affects in vitro MMP9 expression levels, enzymatic activity and susceptibility to various inflammatory and fibrotic conditions. METHODS: We genotyped 651 case-control pairs from trachoma endemic villages in The Gambia for coding single nucleotide polymorphisms (SNPs) in the MMP9 gene using the high-throughput Sequenom system. Single marker and haplotype conditional logistic regression (CLR) analysis for disease association was performed. RESULTS: The Q279R mutation located in exon 6 of MMP9 was found to be associated with lower risk for severe disease sequelae of ocular Chlamydia trachomatis infection. This mutation, which leads to a nonsynonymous amino-acid change within the active site of the enzyme may reduce MMP-9-induced degradation of the structural components of the ECM during inflammatory episodes in trachoma and its associated fibrosis. CONCLUSION: This work supports the hypothesis that MMP-9 has a role in the pathogenesis of blinding trachoma

Explaining the effects of an intervention designed to promote evidence-based diabetes care : a theory-based process evaluation of a pragmatic cluster randomised controlled trial

Background The results of randomised controlled trials can be usefully illuminated by studies of the processes by which they achieve their effects. The Theory of Planned Behaviour (TPB) offers a framework for conducting such studies. This study used TPB to explore the observed effects in a pragmatic cluster randomised controlled trial of a structured recall and prompting intervention to increase evidence-based diabetes care that was conducted in three Primary Care Trusts in England. Methods All general practitioners and nurses in practices involved in the trial were sent a postal questionnaire at the end of the intervention period, based on the TPB (predictor variables: attitude; subjective norm; perceived behavioural control, or PBC). It focussed on three clinical behaviours recommended in diabetes care: measuring blood pressure; inspecting feet; and prescribing statins. Multivariate analyses of variance and multiple regression analyses were used to explore changes in cognitions and thereby better understand trial effects. Results Fifty-nine general medical practitioners and 53 practice nurses (intervention: n = 55, 41.98% of trial participants; control: n = 57, 38.26% of trial participants) completed the questionnaire. There were no differences between groups in mean scores for attitudes, subjective norms, PBC or intentions. Control group clinicians had 'normatively-driven' intentions (i.e., related to subjective norm scores), whereas intervention group clinicians had 'attitudinally-driven' intentions (i.e., related to attitude scores) for foot inspection and statin prescription. After controlling for effects of the three predictor variables, this group difference was significant for foot inspection behaviour (trial group × attitude interaction, beta = 0.72, p < 0.05; trial group × subjective norm interaction, beta = -0.65, p < 0.05). Conclusion Attitudinally-driven intentions are proposed to be more consistently translated into action than normatively-driven intentions. This proposition was supported by the findings, thus offering an interpretation of the trial effects. This analytic approach demonstrates the potential of the TPB to explain trial effects in terms of different relationships between variables rather than differences in mean scores. This study illustrates the use of theory-based process evaluation to uncover processes underlying change in implementation trials.European Union ReBEQI projec

Use or Abuse? A Qualitative Study of Emergency Physicians' Views on Use of Observation Stays at Three Hospitals in the United States and England.

STUDY OBJECTIVE: Accumulating evidence has shown increasing use of observation stays for patients presenting to emergency departments and requiring diagnostic evaluation or time-limited treatment plans, but critics suggest that this expansion arises from hospitals' concerns to maximize revenue and shifts costs to patients. Perspectives of physicians making decisions to admit, observe, or discharge have been absent from the debate. We examine the views of emergency physicians in the United States and England on observation stays, and what influences their decisions to use observation services. METHODS: We undertook in-depth, qualitative interviews with a purposive sample of physicians in 3 hospitals across the 2 countries and analyzed these using an approach based on the constant-comparison method. Limitations include the number of sites, whose characteristics are not generalizable to all institutions, and the reliance on self-reported interview accounts. RESULTS: Physicians used observation status for the specific presentations for which it is well evidenced but acknowledged administrative and financial considerations in their decisionmaking. They also highlighted an important role for observation not described in the literature: as a "safe space," relatively immune from the administrative gaze, where diagnostic uncertainties, sociomedical problems, and medicolegal challenges could be contained. CONCLUSION: Observation status increases the options available to admitting physicians in a way that they valued for its potential benefits to patient safety and quality of care, but some of these have been neglected in the literature to date. Reform to observation status should address these important but previously unacknowledged functions