2,986 research outputs found
On Three-Dimensional Space Groups
An entirely new and independent enumeration of the crystallographic space
groups is given, based on obtaining the groups as fibrations over the plane
crystallographic groups, when this is possible. For the 35 ``irreducible''
groups for which it is not, an independent method is used that has the
advantage of elucidating their subgroup relationships. Each space group is
given a short ``fibrifold name'' which, much like the orbifold names for
two-dimensional groups, while being only specified up to isotopy, contains
enough information to allow the construction of the group from the name.Comment: 26 pages, 8 figure
Radio Observations of the Hubble Deep Field South region: I. Survey Description and Initial Results
This paper is the first of a series describing the results of the Australia
Telescope Hubble Deep Field South (ATHDFS) radio survey. The survey was
conducted at four wavelengths - 20, 11, 6, and 3 cm, over a 4-year period, and
achieves an rms sensitivity of about 10 microJy at each wavelength. We describe
the observations and data reduction processes, and present data on radio
sources close to the centre of the HDF-S. We discuss in detail the properties
of a subset of these sources. The sources include both starburst galaxies and
galaxies powered by an active galactic nucleus, and range in redshift from 0.1
to 2.2. Some of them are characterised by unusually high radio-to-optical
luminosities, presumably caused by dust extinction.Comment: Accepted by AJ. 32 pages, 4 tables, 3 figures. PDF with
full-resolution figures is on
http://www.atnf.csiro.au/people/rnorris/N197.pd
Enhanced Gauge Groups in N=4 Topological Amplitudes and Lorentzian Borcherds Algebras
We continue our study of algebraic properties of N=4 topological amplitudes
in heterotic string theory compactified on T^2, initiated in arXiv:1102.1821.
In this work we evaluate a particular one-loop amplitude for any enhanced gauge
group h \subset e_8 + e_8, i.e. for arbitrary choice of Wilson line moduli. We
show that a certain analytic part of the result has an infinite product
representation, where the product is taken over the positive roots of a
Lorentzian Kac-Moody algebra g^{++}. The latter is obtained through double
extension of the complement g= (e_8 + e_8)/h. The infinite product is
automorphic with respect to a finite index subgroup of the full T-duality group
SO(2,18;Z) and, through the philosophy of Borcherds-Gritsenko-Nikulin, this
defines the denominator formula of a generalized Kac-Moody algebra G(g^{++}),
which is an 'automorphic correction' of g^{++}. We explicitly give the root
multiplicities of G(g^{++}) for a number of examples.Comment: 33 pages, 3 figure
Generalized Relativistic Meson Wave Function
We study the most general, relativistic, constituent meson
wave function within a new covariant framework. We find that by including a
tensor wave function component, a pure valence quark model is now capable of
reproducing not only all static pion data (, )
but also the distribution amplitude, form factor , and structure
functions. Further, our generalized spin wave function provides a much better
detailed description of meson properties than models using a simple
relativistic extension of the nonrelativistic wave function.Comment: 17 pages, REXTeX 3.0 file, (uuencoded postscript files of 8 figures
appended
Spontaneous and deliberate future thinking: A dual process account
© 2019 Springer Nature.This is the final published version of an article published in Psychological Research, licensed under a Creative Commons Attri-bution 4.0 International License. Available online at: https://doi.org/10.1007/s00426-019-01262-7.In this article, we address an apparent paradox in the literature on mental time travel and mind-wandering: How is it possible that future thinking is both constructive, yet often experienced as occurring spontaneously? We identify and describe two âroutesâ whereby episodic future thoughts are brought to consciousness, with each of the âroutesâ being associated with separable cognitive processes and functions. Voluntary future thinking relies on controlled, deliberate and slow cognitive processing. The other, termed involuntary or spontaneous future thinking, relies on automatic processes that allows âfully-fledgedâ episodic future thoughts to freely come to mind, often triggered by internal or external cues. To unravel the paradox, we propose that the majority of spontaneous future thoughts are âpre-madeâ (i.e., each spontaneous future thought is a re-iteration of a previously constructed future event), and therefore based on simple, well-understood, memory processes. We also propose that the pre-made hypothesis explains why spontaneous future thoughts occur rapidly, are similar to involuntary memories, and predominantly about upcoming tasks and goals. We also raise the possibility that spontaneous future thinking is the default mode of imagining the future. This dual process approach complements and extends standard theoretical approaches that emphasise constructive simulation, and outlines novel opportunities for researchers examining voluntary and spontaneous forms of future thinking.Peer reviewe
Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes
Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function. A new group of genomes sharing substantial nucleotide sequences constitute Cluster J. The six mycobacteriophages forming Cluster J are morphologically members of the Siphoviridae, but have unusually long genomes ranging from 106.3 to 117 kbp. Reconstruction of the capsid by cryo-electron microscopy of mycobacteriophage BAKA reveals an icosahedral structure with a triangulation number of 13. All six phages are temperate and homoimmune, and prophage establishment involves integration into a tRNA-Leu gene not previously identified as a mycobacterial attB site for phage integration. The Cluster J genomes provide two examples of intron splicing within the virion structural genes, one in a major capsid subunit gene, and one in a tail gene. These genomes also contain numerous freestanding HNH homing endonuclease, and comparative analysis reveals how these could contribute to genome mosaicism. The unusual Cluster J genomes provide new insights into phage genome architecture, gene function, capsid structure, gene mobility, intron splicing, and evolution
Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial.
BACKGROUND: Ventilator-acquired pneumonia (VAP) is a common reason for antimicrobial therapy in the intensive care unit (ICU). Biomarker-based diagnostics could improve antimicrobial stewardship through rapid exclusion of VAP. Bronchoalveloar lavage (BAL) fluid biomarkers have previously been shown to allow the exclusion of VAP with high confidence. METHODS/DESIGN: This is a prospective, multi-centre, randomised, controlled trial to determine whether a rapid biomarker-based exclusion of VAP results in fewer antibiotics and improved antimicrobial management. Patients with clinically suspected VAP undergo BAL, and VAP is confirmed by growth of a potential pathogen atâ[â„]â10(4) colony-forming units per millilitre (CFU/ml). Patients are randomised 1:1, to either a 'biomarker-guided recommendation on antibiotics' in which BAL fluid is tested for IL-1ÎČ and IL-8 in addition to routine microbiology testing, or to 'routine use of antibiotics' in which BAL undergoes routine microbiology testing only. Clinical teams are blinded to intervention until 6Â hours after randomisation, when biomarker results are reported to the clinician. The primary outcome is a change in the frequency distribution of antibiotic-free days (AFD) in the 7Â days following BAL. Secondary outcome measures include antibiotic use at 14 and 28Â days; ventilator-free days; 28-day mortality and ICU mortality; sequential organ failure assessment (SOFA) at days 3, 7 and 14; duration of stay in critical care and the hospital; antibiotic-associated infections; and antibiotic-resistant pathogen cultures up to hospital discharge, death or 56Â days. A healthcare-resource-utilisation analysis will be calculated from the duration of critical care and hospital stay. In addition, safety data will be collected with respect to performing BAL. A sample size of 210 will be required to detect a clinically significant shift in the distribution of AFD towards more patients having fewer antibiotics and therefore more AFD. DISCUSSION: This trial will test whether a rapid biomarker-based exclusion of VAP results in rapid discontinuation of antibiotics and therefore improves antibiotic management in patients with suspected VAP. TRIAL REGISTRATION: ISRCTN65937227 . Registered on 22 August 2013. ClinicalTrials.gov, NCT01972425 . Registered on 24 October 2013
Insights into a viral motor : the structure of the HK97 packaging termination assembly
Double-stranded DNA viruses utilise machinery, made of terminase proteins, to package viral DNA into the capsid. For cos bacteriophage, a defined signal, recognised by small terminase, flanks each genome unit. Here we present the first structural data for a cos virus DNA packaging motor, assembled from the bacteriophage HK97 terminase proteins, procapsids encompassing the portal protein, and DNA containing a cos site. The cryo-EM structure is consistent with the packaging termination state adopted after DNA cleavage, with DNA density within the large terminase assembly ending abruptly at the portal protein entrance. Retention of the large terminase complex after cleavage of the short DNA substrate suggests that motor dissociation from the capsid requires headful pressure, in common with pac viruses. Interestingly, the clip domain of the 12-subunit portal protein does not adhere to C12 symmetry, indicating asymmetry induced by binding of the large terminase/DNA. The motor assembly is also highly asymmetric, showing a ring of 5 large terminase monomers, tilted against the portal. Variable degrees of extension between N- and C-terminal domains of individual subunits suggest a mechanism of DNA translocation driven by inter-domain contraction and relaxation
Yukawa couplings in intersecting D-brane models
We compute the Yukawa couplings among chiral fields in toroidal Type II
compactifications with wrapping D6-branes intersecting at angles. Those models
can yield realistic standard model spectrum living at the intersections. The
Yukawa couplings depend both on the Kahler and open string moduli but not on
the complex structure. They arise from worldsheet instanton corrections and are
found to be given by products of complex Jacobi theta functions with
characteristics. The Yukawa couplings for a particular intersecting brane
configuration yielding the chiral spectrum of the MSSM are computed as an
example. We also show how our methods can be extended to compute Yukawa
couplings on certain classes of elliptically fibered CY manifolds which are
mirror to complex cones over del Pezzo surfaces. We find that the Yukawa
couplings in intersecting D6-brane models have a mathematical interpretation in
the context of homological mirror symmetry. In particular, the computation of
such Yukawa couplings is related to the construction of Fukaya's category in a
generic symplectic manifold.Comment: 47 pages, using JHEP3.cls, 11 figures. Typos and other minor
corrections. References adde
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