110 research outputs found

    Studi greci e latini per Giuseppina Matino

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    [Italiano]: Il volume raccoglie ventinove studi greci e latini dedicati all’illustre grecista Giuseppina Matino da partecipanti alla Sezione di Scienze dell’Antichità del Dipartimento di Studi Umanistici dell’Università degli Studi di Napoli Federico II. I saggi spaziano dalla lingua e letteratura greca alla lingua e letteratura latina, alla filologia classica, alla papirologia, alla letteratura latina umanistica, alla filologia bizantina e alla ricezione dei classici. Questa ampia gamma di temi rispecchia i molteplici campi di studio coltivati nella Sezione di Scienze dell’Antichità, della quale Giuseppina Matino è stata Responsabile negli anni più recenti della sua carriera accademica. /[English]: This volume contains twenty-nine essays on Greek and Latin texts, presented to the renowned Hellenist Giuseppina Matino by members of the ‘Sciences of Antiquity’ Unit at the Department of Humanities of the University Federico II in Naples. The papers range from Greek language and literature to Latin language and literature, classical philology, papyrology, humanistic Latin literature, Byzantine philology, and classical reception. Such a variety of subjects reflects the multiple research fields that are being pursued at the ‘Sciences of Antiquity’ Unit, of which Giuseppina Matino has been in charge during the latest years of her academic career

    Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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    Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

    Per l'edizione dei Libri Medicinali di Aezio Amideno, I

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    Studio sulla tradizione manoscritta dell'Enciclopedia medica di Aezio Amiden

    Rec. a L. Viscido, Lessico zoologico nelle Variae di Cassiodoro

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    Recensione di un'opera lessicografica sulle Variae di Cassiodor
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