Les incantatifs

S’agissant des actes de langage participant à la construction de la réalité sociale, les philosophes contemporains se sont restreints aux déclarations. Nous avançons qu’il existe une autre catégorie qui contribue à la fabrique et au maintien des faits sociaux : celle des incantatifs, actes de langage dont le but est l’expression et la génération d’émotions collectives, et qui contribuent ainsi à la création et au maintien des communautés

As sagas de Harald e de Egil : o governo do rei na Noruega

Monografia (graduação)—Universidade de Brasília, Instituto de Ciências Humanas, Departamento de História, 2014.O processo que culminou com a reunião dos diferentes povos que compõem a atual Noruega, sob um único rei, é visto como consolidado a partir do final do século IX e início do X. Para a historiografia, esse processo inicia-se e conclui-se com Harald Hårfagre, após uma sucessão de combates e conquistas. Embora se perceba a existência de um poder superior, ou central, este existe apenas na condição de ser reconhecido pelo povo, que se baseia na sua tradição para validá-lo. A análise dos elementos-chave que compunham a história de Harald através das sagas permite compreender de que forma o poder do monarca e a construção de seu reino eram representados. Apesar de a historiografia moderna rejeitar completamente as sagas como retratos da realidade, as mesmas possuem significado e valor historiográficos. São produto da cultura oral de uma sociedade e ao se entender a importância da narrativa como memória coletiva, as sagas se transformam em documentos que registram os valores positivos e negativos que justificam e legitimam o poder. _______________________________________________________________________________ ABSTRACTThe process that led to the gathering of the different peoples that form present-day Norway, under a sole king, is seen as consolidated from the end of the ninth and early tenth centuries. For historiography, this process begins and ends with Harald Hårfagre, after a succession of battles and conquests. Although it is possible to read a superior power, or a central one, it exists solely under the condition of its recognition by the people, which validates it based on its own traditions. The analysis of key elements that compose the story of Harald through the sagas allows us understanding of how the power of the monarch and the building of his kingdom were represented. Although modern historiography completely rejects the sagas as depictions of reality, they do have historiographical meaning and value. They are products of the oral culture of a society and by understanding the importance of this narrative as collective memory, the sagas become documents that record the positive and negative values that justify and legitimise power

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator

Dos efeitos do terror

Tradução de Josemar Machado de Oliveira. Esse texto de Benjamin Constant apareceu em maio de 1797 na reedição Das Reações Políticas

Das reações políticas

Tradução de Josemar Machado de Oliveira

Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Cote d\u27Ivoire

BackgroundA single co-administered dose of ivermectin (IVM) plus diethylcarbamazine (DEC) plus albendazole (ALB), or triple-drug therapy, was recently found to be more effective for clearing microfilariae (Mf) than standard DEC plus ALB currently used for mass drug administration programs for lymphatic filariasis (LF) outside of sub-Saharan Africa. Triple-drug therapy has not been previously tested in LF-uninfected individuals from Africa. This study evaluated the pharmacokinetics (PK), safety, and efficacy of triple-drug therapy in people with and without Wuchereria bancrofti infection in West Africa.MethodsIn this open-label cohort study, treatment-naïve microfilaremic (>50 mf/mL, n = 32) and uninfected (circulating filarial antigen negative, n = 24) adults residing in Agboville district, Côte d’Ivoire, were treated with a single dose of IVM plus DEC plus ALB, and evaluated for adverse events (AEs) until 7 days post treatment. Drug levels were assessed by liquid chromatography and mass spectrometry. Persons responsible for assessing AEs were blinded to participants’ infection status.FindingsThere was no difference in AUC0-inf or Cmax between LF-infected and uninfected participants (P>0.05 for all comparisons). All subjects experienced mild AEs; 28% and 25% of infected and uninfected participants experienced grade 2 AEs, respectively. There were no severe or serious adverse events. Only fever (16 of 32 versus 4 of 24, PConclusionsModerate to heavy W. bancrofti infection did not affect PK parameters for IVM, DEC or ALB following a single co-administered dose of these drugs compared to uninfected individuals. The drugs were well tolerated. This study confirmed the efficacy of the triple-drug therapy for clearing W. bancrofti Mf and has added important information to support the use of this regimen in LF elimination programs in areas of Africa without co-endemic onchocerciasis or loiasis.Trial registrationClinicalTrials.gov NCT02845713.</div