Aspects of the archaeology of the castle in the north of England C 1066-1216

This thesis is an examination of the archaeological, historical and landscape contexts of the Norman castle in the northern counties of Cumberland, Durham, Lancashire, Northumberland, Westmorland and the Ridings of Yorkshire. The assumption at the heart of this study is that castles are social institutions, arenas in which repetitive social actions, such as administration, are undertaken. Castles are also arenas where other forms of social interaction, such as warfare or sieges, were staged. These social actions, and the spaces in which they happened, structure and are structured by the ideas and concepts of lordship and actively employ castles in a meaningful way. It is demonstrated in this study that both architectural and landscape forms are actively employed in meaningful ways. What is emphasised and argued throughout this study is that evidence traditionally employed to provide chronological data, documentary evidence or architectural features, actually provide social information. This study also shows that the concept of lordship changes and develops over the late eleventh and twelfth centuries. These changes have consequences for the landscape context of sites where there are changing, developing relationships between settlements, whether newly founded or pre-existing, over time. The general conclusions reached in this study are that castles must be examined as social institutions rather than in isolation as architecture or simply as arenas where historical events took place

Investigation of the Effects of Image Signal-to-Noise Ratio on TSPO PET Quantification of Neuroinflammation

Neuroinflammation may be imaged using positron emission tomography (PET) and the tracer [11C]-PK11195. Accurate and precise quantification of 18 kilodalton Translocator Protein (TSPO) binding parameters in the brain has proven difficult with this tracer, due to an unfavourable combination of low target concentration in tissue, low brain uptake of the tracer and relatively high non-specific binding, all of which leads to higher levels of relative image noise. To address these limitations, research into new radioligands for the TSPO, with higher brain uptake and lower non-specific binding relative to [11C]-PK11195, is being conducted world-wide. However, factors other than radioligand properties are known to influence signal-to-noise ratio in quantitative PET studies, including the scanner sensitivity, image reconstruction algorithms and data analysis methodology. The aim of this thesis was to investigate and validate computational tools for predicting image noise in dynamic TSPO PET studies, and to employ those tools to investigate the factors that affect image SNR and reliability of TSPO quantification in the human brain. The feasibility of performing multiple (n≥40) independent Monte Carlo simulations for each dynamic [11C]-PK11195 frame- with realistic modelling of the radioactivity source, attenuation and PET tomograph geometries- was investigated. A Beowulf-type high performance computer cluster, constructed from commodity components, was found to be well suited to this task. Timing tests on a single desktop computer system indicated that a computer cluster capable of simulating an hour-long dynamic [11C]-PK11195 PET scan, with 40 independent repeats, and with a total simulation time of less than 6 weeks, could be constructed for less than 10,000 Australian dollars. A computer cluster containing 44 computing cores was therefore assembled, and a peak simulation rate of 2.84x105 photon pairs per second was achieved using the GEANT4 Application for Tomographic Emission (GATE) Monte Carlo simulation software. A simulated PET tomograph was developed in GATE that closely modelled the performance characteristics of several real-world clinical PET systems in terms of spatial resolution, sensitivity, scatter fraction and counting rate performance. The simulated PET system was validated using adaptations of the National Electrical Manufacturers Association (NEMA) quality assurance procedures within GATE. Image noise in dynamic TSPO PET scans was estimated by performing n=40 independent Monte Carlo simulations of an hour-long [11C]-PK11195 scan, and of an hour- long dynamic scan for a hypothetical TSPO ligand with double the brain activity concentration of [11C]-PK11195. From these data an analytical noise model was developed that allowed image noise to be predicted for any combination of brain tissue activity concentration and scan duration. The noise model was validated for the purpose of determining the precision of kinetic parameter estimates for TSPO PET. An investigation was made into the effects of activity concentration in tissue, radionuclide half-life, injected dose and compartmental model complexity on the reproducibility of kinetic parameters. Injecting 555 MBq of carbon-11 labelled TSPO tracer produced similar binding parameter precision to 185 MBq of fluorine-18, and a moderate (20%) reduction in precision was observed for the reduced carbon-11 dose of 370 MBq. Results indicated that a factor of 2 increase in frame count level (relative to [11C]-PK11195, and due for example to higher ligand uptake, injected dose or absolute scanner sensitivity) is required to obtain reliable binding parameter estimates for small regions of interest when fitting a two-tissue compartment, four-parameter compartmental model. However, compartmental model complexity had a similarly large effect, with the reduction of model complexity from the two-tissue compartment, four-parameter to a one-tissue compartment, two-parameter model producing a 78% reduction in coefficient of variation of the binding parameter estimates at each tissue activity level and region size studied. In summary, this thesis describes the development and validation of Monte Carlo methods for estimating image noise in dynamic TSPO PET scans, and analytical methods for predicting relative image noise for a wide range of tissue activity concentration and acquisition durations. The findings of this research suggest that a broader consideration of the kinetic properties of novel TSPO radioligands, with a view to selection of ligands that are potentially amenable to analysis with a simple one-tissue compartment model, is at least as important as efforts directed towards reducing image noise, such as higher brain uptake, in the search for the next generation of TSPO PET tracers

MAGIC-2D simulations of high efficiency hollow beam klystrons

Results from MAGIC-2D simulations of hollow beam, 800 MHz klystrons, with efficiencies on the order of 85% are presented. Such tubes employ the core oscillation method of electron bunching, which allows for most electrons in the beam to be contained within the bunch at the output cavity. By moving towards hollow beam geometries, the bunch at the output cavity presents a favourable phase and spatial profile for energy extraction, and thus, the overall tube efficiency can be maximised

Numerical design of high efficiency klystrons using core oscillation bunching

1-D and 2-D numerical simulations of 800 MHz klystrons with efficiencies approaching 90% are presented. While traditional klystrons employ monotonic electron bunching along their lengths, the core oscillation method allows for an improved bunch shape at the output cavity, facilitating maximum energy extraction. The core oscillation bunching scheme proves an attractive method for attaining high efficiency operation in klystrons, which can be used to reduce the power consumption of future particle accelerators

Raman microscopic studies of PVD deposited hard ceramic coatings.

PVD hard ceramic coatings grown via the combined cathodic arc/unbalance magnetron deposition process were studied using Raman microscopy. Characteristic spectra from binary, multicomponent, multilayered and superlattice coatings were acquired to gain knowledge of the solid-state physics associated with Raman scattering from polycrystalline PVD coatings and to compile a comprehensive spectral database. Defect-induced first order scattering mechanisms were observed which gave rise to two pronounced groups of bands related to the acoustical (150-300cm[-1]) and optical (400-750cm[-1]) parts of the phonon spectrum. Evidence was gathered to support the theory that the optic modes were mainly due to the vibrations of the lighter elements and the acoustic modes due to the vibrations of the heavier elements within the lattice.A study into the deformation and disordering on the Raman spectral bands of PVD coatings was performed. TiAIN and TiZrN coatings were intentionally damaged via scratching methods. These scratches were then analysed by Raman mapping, both across and along, and a detailed spectral interpretation performed. Band broadening occurred which was related to "phonon relaxation mechanisms" as a direct result of the breaking up of coating grains resulting in a larger proportion of grain boundaries per-unit-volume. A direct correlation of the amount of damage with band width was observed. Band shifts were also found to occur which were due to the stresses caused by the scratching process. These shifts were found to be the largest at the edges of scratches. The Raman mapping of "droplets", a defect inherent to PVD deposition processes, found that higher compressive stresses and large amounts of disorder occurred for coating growth onto droplets.Strategies designed to evaluate the ability of Raman microscopy to monitor the extent of real wear on cutting tools were evaluated. The removal of a coating layer and subsequent detection of a base layer proved successful. This was then expanded to real wear situations in which tools were monitored after 3,6,12,64,120 and 130 minutes-in-cut. A PCA chemometrics model able to distinguish between component layers and oxides was developed.Raman microscopy was found to provide structural and compositional information on oxide scales formed on the surfaces of heat-treated coatings. Wear debris, generated as a consequence of sliding wear tests on various coatings, was also found to be primarily oxide products. The comparison of the oxide types within the debris to those formed on the surface of the same coating statically oxidised, facilitated a contact temperature during sliding to be estimated.Raman microscopy, owing to the piezo-spectroscopic effect, is sensitive to stress levels. The application of Raman microscopy for the determination of residual compressive stresses within PVD coatings was evaluated. TiAlN/VN superlattice coatings with engineered stresses ranging -3 to -11.3 GPa were deposited onto SS and HSS substrates. Subsequent Raman measurements found a correlation coefficient of 0.996 between Raman band position and stress (determined via XRD methods). In addition, there was also a similar correlation coefficient observed between hardness and Raman shift (cm-1). The application of mechanical stresses on a TiAlCrN coating via a stress rig was investigated and tensile and compressive shifts were observed

Initial validation of a novel method of presurgical language localization through functional connectivity (fcMRI)

OBJECTIVE: Neurosurgery is potentially curative in chronic epilepsy but can only be offered to patients if the surgical risk to language is known. Clinical functional magnetic resonance imaging (fMRI) is an ideal, noninvasive method for localizing language cortex yet remains to be validated for this purpose. We have recently presented a novel method for localizing language cortex. Here we present a preliminary evaluation of this method’s validity. We hypothesized language regions identified using this novel method would demonstrate stronger functional connectivity than randomly generated set of proximal networks. METHOD: fMRI data were collected from sixteen temporal lobe patients (12 left) being evaluated for epilepsy surgery at UCLA (mean age 38.9 [sd 11.4]; 6 female; per Wada 14 left language dominant, 1 right, 1 mixed). Language maps were generated using a recently standardized method relying on a conjunction of language tasks (e.g., visual object naming; auditory naming; reading) to identify known language regions (Broca’s area; inferior and superior Wernicke’s Areas; Angular gyrus; Basal Temporal Language Area; Exner’s Area; and Supplementary Speech Area). With activations defined as network nodes, mean network connectivity was compared via permutation tests with alternate (i) fully random and (ii) proximal random networks. Mean network connectivity was determined in independently-acquired motor fMRI datasets (9 foot, 16 hand, 14 tongue). FINDINGS: 77% (30/39) of clinician-derived language networks exhibited mean connectivity greater than fully random networks (p\u3c0.05). Similarly, 69% (27/39) of clinician-derived language networks exhibited mean connectivity greater than proximal random networks (p\u3c0.05). Further analysis of networks not passing the permutation test suggests that low connectivity of non-valid networks may be driven not by low connectivity across all nodes, but by individual nodes that may not actually possess membership within the network. CONCLUSIONS: This study provides preliminary validity for a novel, clinician-based approach to mapping language cortex pre-surgery. This complements our recent work showing this method is reliable, and supports a proposed study comparing fMRI language maps using this technique with the results of direct stimulation mapping

Insights from geodynamo simulations into long-term geomagnetic field behaviour

Detailed knowledge of the long-term spatial configuration and temporal variability of the geomagnetic field is lacking because of insufficient data for times prior to 10 ka. We use realisations from suitable numerical simulations to investigate three important questions about stability of the geodynamo process: is the present field representative of the past field; does a time-averaged field actually exist; and, supposing it exists, how long is needed to define such a field. Numerical geodynamo simulations are initially selected to meet existing criteria for morphological similarity to the observed magnetic field. A further criterion is introduced to evaluate similarity of long-term temporal variations. Allowing for reasonable uncertainties in the observations, observed and synthetic axial dipole moment frequency spectra for time series of order a million years in length should be fit by the same power law model. This leads us to identify diffusion time as the appropriate time scaling for such comparisons. In almost all simulations, intervals considered to have good morphological agreement between synthetic and observed field are shorter than those of poor agreement. The time needed to obtain a converged estimate of the time-averaged field was found to be comparable to the length of the simulation, even in non-reversing models, suggesting that periods of stable polarity spanning many magnetic diffusion times are needed to obtain robust estimates of the mean dipole field. Long term field variations are almost entirely attributable to the axial dipole; nonzonal components converge to long-term average values on relatively short timescales (15-20 kyr). In all simulations, the time-averaged spatial power spectrum is characterised by a zigzag pattern as a function of spherical harmonic degree, with relatively higher power in odd degrees than in even degrees. We suggest that long-term spatial characteristics of the observed field may emerge on averaging times that are within reach for the next generation of global time-varying paleomagnetic field models.

Revitalizing the South End - The Gateway for Downtown Springfield

This studio report explores a service learning strategy in the context of the Graduate Urban Design Studio taught in the Department of Landscape Architecture and Regional Planning at the University of Massachusetts Amherst. The primary goal of this project is to design the South End as the future gateway for downtown Springfield that will help to transform it into a vibrant urban community. Green design strategies, improvement of services and businesses for residents and the employees of local businesses, and new housing opportunities will enhance the vibrancy, resilience, and quality of life of this disadvantaged urban community. Revitalizing the South End - The Gateway for Downtown Springfield proposes improved parks, boulevards and Main Street as a mixed-use spine that will improve the neighborhood in a physical, cultural, and social sense. Six sustainable learning and planning principles have emerged from this studio: 1. Green infrastructure - Green streets as networks and structural framework 2. Sustainable urban form – Mixed use and pedestrian friendly neighborhoods 3. Community-building art - Expression of place and peopl