Advancing Program Symmetry for US-Canada Investment in Cross-Border Transportation

Reviewing the 17 years since the enactment of NAFTA, the U.S. and Canada have undertaken many initiatives to improve cross-border connections. While the range of issues that receive dedicated treatment is broad, this article focuses on crossborder transportation. Since NAFTA, both countries have set up multi-year federal investment programs for cross-border transportation – the U.S. Coordinated Border Infrastructure Program (CBI) in 1998 and the Canadian Border Infrastructure Fund (BIF) in 2002. In 2000, the U.S. Department of Transportation (USDOT) and Transport Canada (TC) signed a memorandum of cooperation (MOC) on transportation issues which led to the creation of the U.S.-Canada Transportation Border Working Group (TBWG)

Advancing U.S.-Canada Border Transportation Planning and Programming

Since NAFTA, the United States and Canada have initiated programs to address cross-border transportation and anticipated increases in North American trade and travel. In 1999, The United States, through its multi-year transportation authorization act, began the Coordinated Border Infrastructure Program (CBI). This program, focused on border transportation investments, also established federal support for regional, binational planning coalitions. In 2000, U.S. Secretary of Transportation Rodney Slater and Canadian Minister of Transportation David Collenette signed a memorandum of cooperation to collaborate on transportation issues of mutual interest. This quickly led to the formation of the U.S.-Canada Transportation Border Working Group (TBWG) in the same year. In 2002, the Canadian federal government unveiled the Border Infrastructure Fund (BIF)

Evaluation of Commercial Pre-Inspection Pilot Test - Blaine, WA

U.S. Customs and Border Protection (USCBP) is pilot-testing the operation of a commercial primary inspection booth on Canadian soil. The pilot test is occurring at the Pacific Highway port-of-entry in Blaine, WA. In past years, the Border Policy Research Institute (BPRI) has partnered with the Whatcom Council of Governments (WCOG) to collect extensive datasets at Pacific Highway, including metrics such as the average dwell-time of a truck at a primary booth and the average wait-time in the queue

Long-term observations of pteropod phenology along the Western Antarctic Peninsula

Shifts in phenology – annually occurring life history events – have been observed among many marine organisms due to global warming. We examined if phenological changes in the pteropod (pelagic snail) Limacina helicina antarctica have occurred along the Western Antarctic Peninsula, one of the most intensely warming regions on Earth, which would have important implications for regional food web dynamics. Pteropod shell diameters were analyzed from samples collected in the Palmer Antarctica Long-Term Ecological Research (PAL LTER) program year-round sediment trap from 2004 to 2018. There was considerable interannual variability in the time of appearance of a new pteropod cohort, which ranged from day of year 22–255, but no long-term, directional change. Mean L. h. antarctica growth rate for the time series was 0.009 mm day−1 and there was no significant long-term change in growth rate. This study represents the first in the Southern Ocean to illustrate that pteropods actively grow throughout the winter season. Sea ice was the dominant driver of pteropod phenology, with earlier sea ice retreat the year prior, lower winter sea surface temperature (SST) the year prior, and higher primary productivity in the same year leading to earlier pteropod time of appearance. Similarly, more open water with higher autumn SST, both the year prior, and elevated chlorophyll a the same year, promoted faster pteropod growth. These results indicate that while pteropods are responsive to considerable environmental variability, their phenology has remained relatively stable. The identified responses of pteropod phenology to environmental shifts are key for determining future effects of climate change on biogeochemical cycling and plankton trophic interactions in the region

International mobility & trade corridor project (IMTC) 2008 Passenger Intercept Survey Final Report

The 2008 survey is intended to serve as a complement to the 2000 survey, supporting the investigation of changes in behavior over time

Vibrational Spectroscopy for Pathology from Biochemical Analysis to Diagnostic Tool

Cervical cancer is the second most common cancer in women worldwide with 80% of cases arising in the developing world. The mortality associated with cervical cancer can be reduced if this disease is detected at the early stages of development or at the pre-malignant state (cervical intra-epithelial neoplasia, CIN). The aim of this study was to investigate the potential of Raman spectroscopy as a diagnostic tool to detect biochemical changes accompanying cervical cancer progression. Raman spectra were acquired from proteins, nucleic acids, lipids and carbohydrates in order to gain an insight into the biochemical composition of cells and tissues. Spectra were also obtained from histological samples of normal, CIN and invasive carcinoma tissue from 40 patients. Multivariate analysis of the spectra was carried out to develop a classification model to discriminate normal from abnormal tissue. The results show that Raman spectroscopy displays a high sensitivity to biochemical changes in tissue during disease progression resulting in an exceptional prediction accuracy when discriminating between normal cervical tissue, invasive carcinoma and cervical intra-epithelial neoplasia (CIN). Raman spectroscopy shows enormous clinical potential as a rapid non invasive diagnostic tool for cervical and other cancers

Caught in the Act: Strong, Active Ram Pressure Stripping in Virgo Cluster Spiral NGC 4330

We present a multi-wavelength study of NGC 4330, a highly-inclined spiral galaxy in the Virgo Cluster which is a clear example of strong, ongoing ICM-ISM ram pressure stripping. The HI has been removed from well within the undisturbed old stellar disk, to 50% - 65% of R_25. Multi-wavelength data (WIYN BVR and H-alpha, VLA 21-cm HI and radio continuum, and GALEX NUV and FUV) reveal several one-sided extraplanar features likely caused by ram pressure at an intermediate disk-wind angle. At the leading edge of the interaction, the H-alpha and dust extinction curve sharply out of the disk in a remarkable and distinctive "upturn" feature that may be generally useful as a diagnostic indicator of active ram pressure. On the trailing side, the ISM is stretched out in a long tail which contains 10% of the galaxy's total HI emission, 6 - 9% of its NUV-FUV emission, but only 2% of the H-alpha. The centroid of the HI tail is downwind of the UV/H-alpha tail, suggesting that the ICM wind has shifted most of the ISM downwind over the course of the past 10 - 300 Myr. Along the major axis, the disk is highly asymmetric in the UV, but more symmetric in H-alpha and HI, also implying recent changes in the distributions of gas and star formation. The UV-optical colors indicate very different star formation histories for the leading and trailing sides of the galaxy. On the leading side, a strong gradient in the UV-optical colors of the gas-stripped disk suggests that it has taken 200-400 Myr to strip the gas from a radius of >8 to 5 kpc, but on the trailing side there is no age gradient. All our data suggest a scenario in which NGC 4330 is falling into cluster center for first time and has experienced a significant increase in ram pressure over the last 200-400 Myr.Comment: AJ accepted; 22 pages, 25 figures, version with full-resolution figures available at http://www.astro.yale.edu/abramso

The Action of Bax and Bcl-2 on T Cell Selection

T cell development and selection in the thymus are shaped by the induction of apoptosis. However, a direct role in T cell development and selection for any of the molecules known to regulate apoptosis has remained controversial. We have studied the effect of bax and bcl-2 transgenes in recombination activation gene 1–deficient (RAG-1−/−) mice transgenic for the major histocompatibility complex class I–restricted F5 T cell receptor. Overexpression of a bax transgene in the thymus seriously impairs the production of mature T cells, whereas bcl-2 overexpression greatly promotes it. The effect of bax and bcl-2 overexpression on antigen-induced negative selection was studied using fetal thymic organ cultures. This analysis showed that Bcl-2 strongly inhibits negative selection, whereas Bax does not affect it. Our data directly show that Bcl-2 family members have specific roles in T cell selection and also lend support to the hypothesis that Bax and Bcl-2 can antagonize each other's action in a certain apoptosis pathway while in another they can be functionally nonreciprocal