Improving Access to Trails and Green Space: Brightwood Neighborhood, Springfield, Massachusetts

Accessibility has been an issue with the Connecticut River Walk and Bikeway (River Walk) since its completion in 2003. Our project focuses on designing better connections between this Springfield, MA rail trail and the local environmental justice communities it is meant to serve. As a team of four undergraduate design students, we have spent three months conducting a comprehensive research study on the trail. Ultimately, we will be turning over our research to the Appalachian Mountain Club which intends to use it for reference in their efforts to secure funding for improving River Walk access in the city of Springfield. As part of an undergraduate design studio class under the instruction of Professor Michael DiPasquale, our team conducted extensive research on the Connecticut River Walk and Bikeway. Looking through the lens of equity, we identified a cogent lack of access to this rail trail from the Brightwood neighborhood, to which it runs parallel. Similar environmental justice issues in Springfield have been studied by UMass students in the past, such as “Making Connections — Envisioning Springfield’s North End,” and Healthy Place-Making: Revitalizing Springfield’s Medical District, completed in graduate urban design studios in 2009 and 2019, respectively. Our work this semester builds upon these previous studies, while also delineating itself through our focus on the River Walk specifically. Our study consists of four parts: research, community engagement, design solutions, and deliverables. Much like a traditional planning project, these objectives were completed in a partially chronological fashion. Our approach consisted of overlaps between each component — as much as our research informed our engagement, what we learned from our engagement also informed our research, and so on. With the ultimate goal of providing the Appalachian Mountain Club with a wealth of information supporting the need for funding for improvements to the Connecticut River Walk and Bikeway, our team combined the results of our research, engagement, and design into this document: our deliverable for the project

Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020-2030

Human biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission’s Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing internal and aggregate exposure in different target populations; 2) assessing exposure to chemicals across life stages; (3) assessing combined exposure to multiple chemicals (mixtures); (4) bridging regulatory silos on aggregate exposure; and (5) enhancing the effectiveness of risk management measures. In this strategy paper we propose a vision and a strategy for the use of HBM in chemical regulations and public health policy in Europe and beyond. We outline six strategic objectives and a roadmap to further strengthen HBM approaches and increase their implementation in the regulatory risk assessment of chemicals to enhance our understanding of exposure and health impacts, enabling timely and targeted policy interventions and risk management. These strategic objectives are: 1) further development of sampling strategies and sample preparation; 2) further development of chemical-analytical HBM methods; 3) improving harmonisation throughout the HBM research life cycle; 4) further development of quality control / quality assurance throughout the HBM research life cycle; 5) obtain sustained funding and reinforcement by legislation; and 6) extend target-specific communication with scientists, policymakers, citizens and other stakeholders. HBM approaches are essential in risk assessment to address scientific, regulatory and societal challenges. HBM requires full and strong support from the scientific and regulatory domain to reach its full potential in public and occupational health assessment and in regulatory decision-making.info:eu-repo/semantics/publishedVersio

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured rodent and human islets, and in vivo rodent models. Here, we examined the mechanistic consequences of glucotoxic and lipotoxic conditions on human islets in vivo and developed and/or used 3 complementary models that allowed comparison of the effects of hyperglycemic and/or insulin-resistant metabolic stress conditions on human and mouse islets, which responded quite differently to these challenges. Hyperglycemia and/or insulin resistance impaired insulin secretion only from human islets in vivo. In human grafts, chronic insulin resistance decreased antioxidant enzyme expression and increased superoxide and amyloid formation. In human islet grafts, expression of transcription factors NKX6.1 and MAFB was decreased by chronic insulin resistance, but only MAFB decreased under chronic hyperglycemia. Knockdown of NKX6.1 or MAFB expression in a human β cell line recapitulated the insulin secretion defect seen in vivo. Contrary to rodent islet studies, neither insulin resistance nor hyperglycemia led to human β cell proliferation or apoptosis. These results demonstrate profound differences in how excess glucose or lipid influence mouse and human insulin secretion and β cell activity and show that reduced expression of key islet-enriched transcription factors is an important mediator of glucotoxicity and lipotoxicity