The Ursinus Weekly, December 11, 1950

Jeckely calls for resistance to communism • Sheeder talks at Trinity • Juniors choose 1952 Ruby heads • Chaplain to conduct communion • Y group discusses Atlantic Union plan • Red Cross unit plays host to area chapters • Snow Ball opens Fall social season • Students, faculty give blood to Red Cross • Three seniors admitted to dramatic honor frat • Former Ursinus coach dies in auto accident • Over 200 combine to present annual Messiah production • Only memories and souvenirs remain of seniors\u27 colorful formal dance • Warren W. Walters is the official engineer, the man-on-the-spot when trouble arises • French Club holds annual Xmas party • Nachrichten Deutschen Verein • Mack re-elected • Frosberg announces jobs open to grads • Commercialized Christmas forms basis of writer\u27s satire on holiday theme • Storm plays havoc on Ursinus campus • Library has tea • Bears win second 67-38 over Temple Pharmacy • Matmen work out for coming season • Grizzlies whip Crusaders 102-71 as records fall: Bears\u27 fiery attack breaks team mark after absorbing setback by Lycoming • Girls elect Keyser basketball captain • Hooper elected as 1951 hockey captain • Derago leads district scoring; Seibel fourth • Banquet, dance to top pre-holiday festivities • Chess team wins • Thirty couples enjoy reopening of Cafe Pigalle on Saturday • Y conducts Xmas vespers • German Club fetes • Duryea holds tea • Sophs pick committee to decorate at banquet • Lit reading to be held Tuesday • Glessner addresses guildhttps://digitalcommons.ursinus.edu/weekly/1555/thumbnail.jp

The Ursinus Weekly, November 20, 1950

14th Messiah will be given December 7th • Fifteen seniors honored with listing in annual publication of Who\u27s Who • WSSF drive kindles much campus activity • Thespians to give psychological mystery, Angel Street, December first and second • May Day petition deadline is Tuesday • Bloodmobile coming to Collegeville December 7 • Ruby group pictures to be taken after Thanksgiving • MSGA to seek vote on dorm amendment • Jones reads poems of Eliot to Tuesday night audience • Gillespie\u27s orchestra to furnish music for December 8 Sunnybrook senior ball • Editorial: Spirit of Thanksgiving; Dorm government: Its meaning; Counsel for the councils • Frosberg has three-fold job • Herbsleb discusses international law before local IRC • Freshmen women elect Jen Price chairman of decoration committee • Library work in progress • Undergrads invited to join competition in contract bridge • Dart tourney • Como concert postponed • Chess Club wins • Herbsleb addresses pre-legal society • Belles edged 2-1 by Owlette squad • Chestnut Hill falls to Snell\u27s Belles 5-0 • Jayvee coeds triumph over Chestnut Hill 2-0 • Diplomats win 2-0 over Bear booters • Dragons 5-1 victors over soccer squad • Plan student bowling • Grizzlies tie Susquehanna in grid season finale, 6-6https://digitalcommons.ursinus.edu/weekly/1553/thumbnail.jp

The Ursinus Weekly, February 26, 1951

Senior musical to revive era of flapper, prohibition • IRC to discuss U.S. foreign policy • Food council conducts review of situation here • Big top chosen theme of freshman dance, March 2 • Book review given • Quartet sings to bank cashier, endorses faulty check vocally • Time features successful industrialist, E. D. Bransome, former student here • Play books in Library • 1936 Ursinus graduate attains USAF honors • Campus March of dimes nets $34 total; Maples heads list • Board discloses interest in armed service units • Audience to enter mood of Tuesday\u27s suspenseful drama • Summer students asked to sign up • 29 delegates attend Philadelphia debate • Hess enumerates ways of using law training • WAA abandons plans for annual minstrel show; To sell socks • FTA considers courses • Editorial: An Ursinus community chest? • Reflections on mealtime • Weekly asks: What do you think of having an ROTC unit at a church-related college? • Canine King Henry lounges on campus, carries schedule of dog-ology, barking • Dr. J. H. A. Bomberger, first Ursinus president, led college through difficulties of early years • Juniata, too, has mystery balls • Campus agents promote local sale of cigarettes • Glenwood Memorial recalls dim past, puzzles over current popular usage • George Gay, Ursinus immortal, had brilliant grid career • Bucknell Bisons trounce matmen 29-5 as Helfferich posts lone win for locals • Battling Bruins rebound to edge Dragons 74-70 • Bryn Mawr bests swimmers, 19-18 • Belles post second victory of season • Bears rout cadets 85-71 as league race tightens • Brodbeck I clinches tie in intramurals • Y activities to center around Wednesday night fireside chats • Lintner heads Red Cross • 3 French Club members attend dinner in Philadelphia church • Dr. Allan Rice to address Lions on Atlantic Union • Juniors name committee heads • Dolman reads humorous work on Education of Hyman Kaplanhttps://digitalcommons.ursinus.edu/weekly/1560/thumbnail.jp

The Ursinus Weekly, December 4, 1950

Gillespie to play at Friday night senior formal • Men students cast 107-71 vote against dorm amendment • Music organizations to present Messiah in Bomberger chapel Thursday night • Y Commissions to meet; PAC plans Xmas party • Response to WSSF is disappointing; Receipts total $350 • Critic hails Angel Street as vehicle for superb thespian dramatic acting • Hungarian to address Tuesday night Forum • Twelve to become Rosicrucians • Yule traditions dominate ensuing campus activities • Bloodmobile to be at Trinity church Thursday morning • 26 are accepted by local chapter of Pi Gamma Mu • Cafe Pigalle to return to gym Saturday night • Mary MacPherson chosen May Queen; Marge Paynter named pageant manager • Editorial: Dynamic force • WSGA notes • Delta Pi Sigma welcomes ten off-campus men • English Club admits members • Revived rec center attracts many • 45 future teachers approach termination of tribulation • IRC hears attorney speak on problems of western nations • Ruby schedules photos, pushes subscriptions • Pigskin parade • Bears top textile 64-50 in court season inaugural • Six close careers on soccer squad • Derr deadlocks Albright 6-6 • Four senior girls play hockey finale • Grid player scans all-state selections • Ursinus grid aggregation suffers loss of twelve graduating upper classmen • Penn triumphs 3-1 over Ursinus girls • Reid Watson became football manager when injury benched former grid star • Messiah reputation stems from mastery of simple techniques • Eight teams compete in debate tournament • Chess team loses • Kershner does dialect in fourth lit readinghttps://digitalcommons.ursinus.edu/weekly/1554/thumbnail.jp

The Lantern Vol. 31, No. 1, December 1963

• Today\u27s Memory • The Realization • Life Fire • Come Sleep • The Ends Meet • Dawn of Darkness • Closed and Done: With Apologies to No One • A Search • Concern • Obvious Oblivion • Love\u27s Ashes • Silence • To My Dentist • Snow • Wisdom • Look Up • Nepenthe • With Apologies to Charles Schulz • Autumn and You • What is Optimism? • Agnostic? • Potpourri of Beinghttps://digitalcommons.ursinus.edu/lantern/1085/thumbnail.jp

The Ursinus Weekly, May 11, 1964

New Lost City Ramblers to perform Friday: Agency sponsors blue grass group • Bombers bombed by MSGA, faculty reviewing • UC scholar wins St. Andrews scholarship • Survey supports APO projects • Loved you Conrad : Spring festival succeeds with new program • Bible fellowship • Two classes elect officers today • Pi Nu Epsilon inducts members • Ursinus Circle • Obituary • Editorial: Attention administration • Mr. Pennypacker stages a remarkable performance: Robbins, Sinclair, Auchincloss and Matusow star in production • Spring hits UC campus with sun, fun and studies • Next President: Johnson • Letter to the Editor • Ursinus thinclads retain MAC crown: Cooper wins two, Dunn ties 440 record; Gladstone, Robart, Walter, relay take 1st • Softballers win; Season undefeated • Batsmen even for week: Defeated Drexel, split with Haverford and lost to LaSalle • Tennis loses 3rd; Bryn Mawr takes 4 • Lacrosse wins 4th; Swamp E-burg 13-3 • MAC summary • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/3110/thumbnail.jp

Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response

There is an unmet need for interventions with better compliance that prevent the adverse effects of sex steroid deficiency on the musculoskeletal system. We identified a blueberry cultivar (Montgomerym [Mont]) that added to the diet protects female mice from musculoskeletal loss and body weight changes induced by ovariectomy. Mont, but not other blueberries, increased the endogenous antioxidant response by bypassing the traditional antioxidant transcription factor Nrf2 and without activating estrogen receptor canonical signaling. Remarkably, Mont did not protect the male skeleton from androgen-induced bone loss. Moreover, Mont increased the variety of bacterial communities in the gut microbiome (α-diversity) more in female than in male mice; shifted the phylogenetic relatedness of bacterial communities (β-diversity) further in females than males; and increased the prevalence of the taxon Ruminococcus1 in females but not males. Therefore, this nonpharmacologic intervention (i) protects from estrogen but not androgen deficiency; (ii) preserves bone, skeletal muscle, and body composition; (iii) elicits antioxidant defense responses independently of classical antioxidant/estrogenic signaling; and (iv) increases gut microbiome diversity toward a healthier signature. These findings highlight the impact of nutrition on musculoskeletal and gut microbiome homeostasis and support the precision medicine principle of tailoring dietary interventions to patient individualities, like sex.Fil: Sato, Amy Y.. University of Arkansas for Medical Sciences; Estados Unidos. Indiana University. School of Medicine; Estados UnidosFil: Pellegrini, Gretel Gisela. Indiana University. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Cregor, Meloney. University of Arkansas for Medical Sciences; Estados Unidos. Indiana University. School of Medicine; Estados UnidosFil: McAndrews, Kevin. Indiana University. School of Medicine; Estados UnidosFil: Choi, Roy B. Indiana University. School of Medicine; Estados UnidosFil: Maiz, Maria. Purdue University; Estados UnidosFil: Johnson, Olivia. Indiana University. School of Medicine; Estados UnidosFil: McCabe, Linda D.. Purdue University; Estados UnidosFil: McCabe, George P.. Purdue University; Estados UnidosFil: Ferruzzi, Mario G.. North Carolina State University; Estados UnidosFil: Lila, Mary Ann. North Carolina State University; Estados UnidosFil: Peacock, Munro. Indiana University. School of Medicine; Estados UnidosFil: Burr, David B.. Indiana University. School of Medicine; Estados UnidosFil: Nakatsu, Cindy H.. Purdue University; Estados UnidosFil: Weaver, Connie M.. Purdue University; Estados UnidosFil: Bellido, Teresita. University of Arkansas for Medical Sciences; Estados Unidos. Indiana University. School of Medicine; Estados Unido

Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.

OBJECTIVE: The aim of this study was to search for genes/variants that modify the effect of LRRK2 mutations in terms of penetrance and age-at-onset of Parkinson's disease. METHODS: We performed the first genomewide association study of penetrance and age-at-onset of Parkinson's disease in LRRK2 mutation carriers (776 cases and 1,103 non-cases at their last evaluation). Cox proportional hazard models and linear mixed models were used to identify modifiers of penetrance and age-at-onset of LRRK2 mutations, respectively. We also investigated whether a polygenic risk score derived from a published genomewide association study of Parkinson's disease was able to explain variability in penetrance and age-at-onset in LRRK2 mutation carriers. RESULTS: A variant located in the intronic region of CORO1C on chromosome 12 (rs77395454; p value = 2.5E-08, beta = 1.27, SE = 0.23, risk allele: C) met genomewide significance for the penetrance model. Co-immunoprecipitation analyses of LRRK2 and CORO1C supported an interaction between these 2 proteins. A region on chromosome 3, within a previously reported linkage peak for Parkinson's disease susceptibility, showed suggestive associations in both models (penetrance top variant: p value = 1.1E-07; age-at-onset top variant: p value = 9.3E-07). A polygenic risk score derived from publicly available Parkinson's disease summary statistics was a significant predictor of penetrance, but not of age-at-onset. INTERPRETATION: This study suggests that variants within or near CORO1C may modify the penetrance of LRRK2 mutations. In addition, common Parkinson's disease associated variants collectively increase the penetrance of LRRK2 mutations. ANN NEUROL 2021;90:82-94

A human breast cell model of pre-invasive to invasive transition

A crucial step in human breast cancer progression is the acquisition of invasiveness. There is a distinct lack of human cell culture models to study the transition from pre-invasive to invasive phenotype as it may occur 'spontaneously' in vivo. To delineate molecular alterations important for this transition, we isolated human breast epithelial cell lines that showed partial loss of tissue polarity in three-dimensional reconstituted-basement membrane cultures. These cells remained non-invasive; however, unlike their non-malignant counterparts, they exhibited a high propensity to acquire invasiveness through basement membrane in culture. The genomic aberrations and gene expression profiles of the cells in this model showed a high degree of similarity to primary breast tumor profiles. The xenograft tumors formed by the cell lines in three different microenvironments in nude mice displayed metaplastic phenotypes, including squamous and basal characteristics, with invasive cells exhibiting features of higher grade tumors. To find functionally significant changes in transition from pre-invasive to invasive phenotype, we performed attribute profile clustering analysis on the list of genes differentially expressed between pre-invasive and invasive cells. We found integral membrane proteins, transcription factors, kinases, transport molecules, and chemokines to be highly represented. In addition, expression of matrix metalloproteinases MMP-9,-13,-15,-17 was up regulated in the invasive cells. Using siRNA based approaches, we found these MMPs to be required for the invasive phenotype. This model provides a new tool for dissection of mechanisms by which pre-invasive breast cells could acquire invasiveness in a metaplastic context