A Biography of Richard Dennis (1770-1845)

Richard Dennis, son of John Dennis and Mary Jacque (maiden name), was born in the state of New Jersey in 1770. During Richard\u27s lifetime he made his way south into the state of Georgia where he established himself within Savannah as a merchant. By 1800 Dennis was fully active in the local business society and town government. If duty called then.Richard Dennis answered because, not only was he a successful merchant but Dennis was appointed commander of the local Savannah militia. Dennis had fruitful ten year period in Savannah until for one reason and another he evacuated the city. Sources support the idea that Dennis ventured into states such as Pennsylvania and Kentucky. Whatever his reason was for leaving he did in fact continue his career as a merchant. On 8 November 1845, after three marriages and the births of three children, Richard Dennis died in the state of Kentucky.https://digitalcommons.georgiasouthern.edu/sav-bios-lane/1059/thumbnail.jp

The Social Influence Qualities of Social Network Sites: A Qualitative and Experimental Investigation

While social network sites (SNS) are a popular form of new media, the literature has not investigated the social influence of these internet sites. Using a mixed method approach of qualitative interviews and a laboratory experiment, this study tests a process model predicting the effects of communication processes and technology on social influence. This model suggested that SNSs may be more effective at social influence than face-to-face communication. A qualitative study was performed to determine whether the hypotheses were plausible whereby it was suggested that SNSs may influence other individuals and SNSs might be a more effective at influencing individuals when compared to other methods of communication. Qualitative results illustrate that social network sites have several strengths over traditional communications mediums and that they can be used to effectively influence others. The results of the experiment found that face-to-face communication was more effective than social network sites at influencing individuals. The data implies that sharing more ideas, when combined with slower communication medium such as SNSs, can actually result in less social influence. However, Facebook participants overwhelmingly felt that they needed more time to complete tasks. Thus, it is not yet possible to reject the theory that SNSs have the potential to be more influential than face-to-face communication

Correlation between fracture surface morphology and toughness in Zr-based bulk metallic glasses

Fracture surfaces of Zr-based bulk metallic glasses of various compositions tested in the as-cast and annealed conditions were analyzed using scanning electron microscopy. The tougher samples have shown highly jagged patterns at the beginning stage of crack propagation, and the length and roughness of this jagged pattern correlate well with the measured fracture toughness values. These jagged patterns, the main source of energy dissipation in the sample, are attributed to the formation of shear bands inside the sample. This observation provides strong evidence of significant “plastic zone” screening at the crack tip

Savoring mediates the effect of nature on positive affect

The more time people spend in nature, the happier they feel. But how consistent is this link, and what mechanisms might account for this beneficial effect of nature on wellbeing? The aim of the present study was to test one potential mechanism linking nature to wellbeing—the ability to savor experiences. Participants (N = 60, 70% female, aged 18 to 34, university students) were randomly assigned to take a daily 20-minute walk in a natural or urban environment for seven consecutive days. Each night, they completed a daily diary report about their experiences that day, including the amount and types of their savoring during the walk (i.e., absorption and intensification of experiences), savoring after the walk (i.e., expression of gratitude and sharing their experiences with others) all adapted from the Ways of Savoring Checklist (Bryant & Veroff, 2007), and their daily feelings of positive affect (PA) and negative affect (NA), adapted from the affective circumplex (Barrett & Russell, 1998). Path analyses using multi-level structural equation modeling (MSEM) found that the composite measure of daily savoring significantly mediated the effect of nature on PA, controlling for NA and physical activity. Daily exposure to nature contributed to greater daily savoring, which predicted higher daily PA. Additional analyses showed that absorption and intensification of experiences in nature and sharing nature experiences with others were the key components of savoring, which may help to explain why people feel happier as a result of spending time in nature

Advanced Atomic Force Microscopy for BioMaterials Research

Optical microscopy uses the interactions between light and materials to provide images of the microscopic world. It is widely employed in science to study the behavior and properties of microscopic organisms and cells. Atomic force microscopy (AFM) is a technique for obtaining images of the surfaces of materials at the atomic to micrometer scales. AFM operates by rastering an ultra-sharp needle across a sample surface and recording the height of the needle at each position. While AFM can provide atomic resolution images of the contours (topography) of a surface, it can also perform extremely sensitive measurements of surface mechanical properties. By fabricating custom AFM probes, the mechanical properties of specific locations of living cells can be studied and manipulated. In addition, high-speed imaging of biological materials can provide images of changes to cellular surfaces in response to chemical or electrical signals. This poster will present examples and applications of advanced AFM capabilities for research in biomaterials available in the Boise State University Surface Science Laboratory

Concordance and Mutation

We provide a framework for studying the interplay between concordance and positive mutation and identify some of the basic structures relating the two. The fundamental result in understanding knot concordance is the structure theorem proved by Levine: for n>1 there is an isomorphism phi from the concordance group C_n of knotted (2n-1)-spheres in S^{2n+1} to an algebraically defined group G_{+-}; furthermore, G__{+-} is isomorphic to the infinite direct sum Z^infty direct sum Z_2^infty direct sum Z_4^infty. It was a startling consequence of the work of Casson and Gordon that in the classical case the kernel of phi on C_1 is infinitely generated. Beyond this, little has been discovered about the pair (C_1,phi). In this paper we present a new approach to studying C_1 by introducing a group, M, defined as the quotient of the set of knots by the equivalence relation generated by concordance and positive mutation, with group operation induced by connected sum. We prove there is a factorization of phi, C_1-->M-->G_-. Our main result is that both maps have infinitely generated kernels. Among geometric constructions on classical knots, the most subtle is positive mutation. Positive mutants are indistinguishable using classical abelian knot invariants as well as by such modern invariants as the Jones, Homfly or Kauffman polynomials. Distinguishing positive mutants up to concordance is a far more difficult problem; only one example has been known until now. The results in this paper provide, among other results, the first infinite families of knots that are distinct from their positive mutants, even up to concordance.Comment: Published in Geometry and Topology at http://www.maths.warwick.ac.uk/gt/GTVol5/paper26.abs.htm

Outcomes after angiography with sodium bicarbonate and acetylcysteine

Background: Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy. Methods: Using a 2-by-2 factorial design, we randomly assigned 5177 patients at high risk for renal complications who were scheduled for angiography to receive intravenous 1.26% sodium bicarbonate or intravenous 0.9% sodium chloride and 5 days of oral acetylcysteine or oral placebo; of these patients, 4993 were included in the modified intention-to-treat analysis. The primary end point was a composite of death, the need for dialysis, or a persistent increase of at least 50% from baseline in the serum creatinine level at 90 days. Contrast-associated acute kidney injury was a secondary end point. Results: The sponsor stopped the trial after a prespecified interim analysis. There was no interaction between sodium bicarbonate and acetylcysteine with respect to the primary end point (P=0.33). The primary end point occurred in 110 of 2511 patients (4.4%) in the sodium bicarbonate group as compared with 116 of 2482 (4.7%) in the sodium chloride group (odds ratio, 0.93; 95% confidence interval [CI], 0.72 to 1.22; P=0.62) and in 114 of 2495 patients (4.6%) in the acetylcysteine group as compared with 112 of 2498 (4.5%) in the placebo group (odds ratio, 1.02; 95% CI, 0.78 to 1.33; P=0.88). There were no significant between-group differences in the rates of contrast-associated acute kidney injury. Conclusions: Among patients at high risk for renal complications who were undergoing angiography, there was no benefit of intravenous sodium bicarbonate over intravenous sodium chloride or of oral acetylcysteine over placebo for the prevention of death, need for dialysis, or persistent decline in kidney function at 90 days or for the prevention of contrast-associated acute kidney injury. (Funded by the U.S. Department of Veterans Affairs Office of Research and Development and the National Health and Medical Research Council of Australia; PRESERVE ClinicalTrials.gov number, NCT01467466.

Structure-activity relationships of the N-terminus of calcitonin gene-related peptide:key roles of alanine-5 and threonine-6 in receptor activation

Background and purpose - The N-terminus of calcitonin gene-related peptide (CGRP) is important for receptor activation, especially the disulphide-bonded ring (residues 1-7). However, the roles of individual amino acids within this region have not been examined and so the molecular determinants of agonism are unknown. This study has examined the role of residues 1, 3-6 and 8-9, excluding Cys-2 and Cys-7. Experimental approach - CGRP derivatives were substituted with either cysteine or alanine; further residues were introduced at position 6. Their affinity was measured by radioligand binding and their efficacy by measuring cAMP production in SK-N-MC cells and ß-arrestin 2 translocation in CHO-K1 cells at the CGRP receptor. Key results - Substitution of Ala-5 by cysteine reduced affinity 270-fold and reduced efficacy for production of cAMP in SK-N-MCs. Potency at ß-arrestin translocation was reduced by 9-fold. Substitution of Thr-6 by cysteine destroyed all measurable efficacy of both cAMP and ß-arrestin responses; substitution with either alanine or serine impaired potency. Substitutions at positions 1, 4, 8 and 9 resulted in approximately 10-fold reductions in potency at both responses. Similar observations were made at a second CGRP-activated receptor, the AMY1(a) receptor. Conclusions and implications - Ala-5 and Thr-6 are key determinants of agonist activity for CGRP. Ala-5 is also very important for receptor binding. Residues outside of the 1-7 ring also contribute to agonist activity

A Retrospective Real-World Study of the Effectiveness and Tolerability of Tildrakizumab in UK Adults with Moderate-to-Severe Chronic Plaque Psoriasis

INTRODUCTION: As with most medicines historically, clinicians prescribing tildrakizumab have relied on information derived from registration studies undertaken in a prospective controlled clinical trial setting. More recently, clinicians, policymakers, and commissioners increasingly rely on real-world data to inform both policy and practice. METHODS: A retrospective real-world data study was undertaken at four specialist dermatology departments in the United Kingdom. All adult patients treated with tildrakizumab for moderate-to-severe plaque psoriasis were included, with data being collected for 122 patients. RESULTS: Psoriatic patients on tildrakizumab tended to be overweight (median body mass index of 32 (range 19–59) (n = 61); 26/68 (38%)  120 kg). The study population had high levels of comorbidities (83/116, 72%), multiple special sites (39/117, 33%), and histories of biological treatments (81/100, 81%). Most patients (61/80, 76%) initiated on tildrakizumab were switched from another biological treatment. Tildrakizumab was effective, with 91/122 (75%) patients remaining on treatment for the duration of the study—a median of 12 months per patient (range 1–29 months)—and achieving a change in median Psoriasis Area and Severity Index (PASI) from 12 to 0.35 and in Dermatology Life Quality Index (DLQI) from 20 to 0. The response rate was 57/66 (86%) when tildrakizumab was used as the first- or second-line biologic compared to 19/31 (61%) when used as the third- to seventh-line. Thirty-three (78.6%) patients over 90 kg of weight received the 200-mg dose of tildrakizumab. All but one (n = 8) patient with body weight over 120 kg maintained response over time. There was one treatment discontinuation; a patient who had a local sensitivity reaction. CONCLUSIONS: In UK clinical practice, tildrakizumab was well tolerated and effective at doses of 100 mg or 200 mg in a range of patient phenotypes

Predicting the consumption of foods low in saturated fats among people diagnosed with Type 2 diabetes and cardiovascular disease: the role of planning in the theory of planned behaviour

The present study tested the utility of an extended version of the theory of planned behaviour that included a measure of planning, in the prediction of eating foods low in saturated fats among adults diagnosed with Type 2 diabetes and/or cardiovascular disease Participants (N = 184) completed questionnaires assessing standard theory of planned behaviour measures (attitude, subjective norm, and perceived behavioural control) and the additional volitional variable of planning in relation to eating foods low in saturated fats Self-report consumption of foods low insaturated fats was assessed 1 month later In partial support of the theory of planned behaviour, results indicated that attitude and subjective norm predicted intentions to eat foods low in saturated fats and intentions and perceived behavioural control predicted the consumption of foods low in saturated fats As an additional variable, planning predicted the consumption of foods low in saturated fats directly and also mediated the intention-behaviour and perceived behavioural control-behaviour relationships, suggesting an important role for planning as a post-intentional construct determining healthy eating choices. Suggestions are offered for interventions designed to improve adherence to healthy eating recommendations for people diagnosed with these chronic conditions with a specific emphasis on the steps and activities that are required to promote a healthier lifestyle. (C) 2010 Elsevier Ltd. All rights reserve