Mechanisms of Hsp90 regulation

Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in the activation of disparate client proteins. This implicates Hsp90 in diverse biological processes that require a variety of co-ordinated regulatory mechanisms to control its activity. Perhaps the most important regulator is heat shock factor 1 (HSF1), which is primarily responsible for upregulating Hsp90 by binding heat shock elements (HSEs) within Hsp90 promoters. HSF1 is itself subject to a variety of regulatory processes and can directly respond to stress. HSF1 also interacts with a variety of transcriptional factors that help integrate biological signals, which in turn regulate Hsp90 appropriately. Because of the diverse clientele of Hsp90 a whole variety of co-chaperones also regulate its activity and some are directly responsible for delivery of client protein. Consequently, co-chaperones themselves, like Hsp90, are also subject to regulatory mechanisms such as post translational modification. This review, looks at the many different levels by which Hsp90 activity is ultimately regulated

Bluegrass music, identity, and place in the 1960s-1970s

Since the early 1960s, Bluegrass has been classified as characteristic of Appalachia and Appalachian identity by popular writers and scholars of the region. By the 1970s, Bluegrass became a global phenomenon, with internationally distributed genre-centric publications, mail-order music, and events across America. This paper will explore ways in which Bluegrass is Appalachian and how it came to be so closely linked to Appalachian identity in the 1960s-1970s. In addition to briefly reviewing the history of bluegrass with a focus on geography and identity, this poster will present original research on primary sources. I provide a content analysis of two periodicals, Bluegrass Unlimited and Muleskinner News, and map events listed in the publications. I expect to find that Bluegrass—including music performed by artists considered “of” or “in” Appalachia—was enjoyed all across the United States and overseas. This research expands our notions of the Bluegrass genre and queries its associations with regional identity