Application of the operator product expansion to the short distance behavior of nuclear potentials

We investigate the short distance behavior of nucleon-nucleon (NN) potentials defined through Bethe-Salpeter wave functions, by perturbatively calculating anomalous dimensions of 6-quark operators in QCD. Thanks to the asymptotic freedom of QCD, 1-loop computations give certain exact results for the potentials in the zero distance limit. In particular the functional form of the S-state central NN potential at short distance $r$ is predicted to be a little weaker than $r^{-2}$. On the other hand, due to the intriguing character of the anomalous dimension spectrum, perturbative considerations alone can not determine whether this potential is repulsive or attractive at short distances. A crude estimation suggests that the force at short distance is repulsive, as found numerically in lattice QCD. A similar behavior is found for the tensor potential.Comment: 40 pages, no figure

Southern Ocean albedo, inter-hemispheric energy transports and the double ITCZ: global impacts of biases in a coupled model

A causal link has been invoked between inter-hemispheric albedo, cross-equatorial energy transport and the double-IntertropicalConvergence Zone (ITCZ) bias in climate models. Southern Ocean cloud biases are a major determinant of inter-hemispheric albedo biases in many models, including HadGEM2-ES, a fully coupled model with a dynamical ocean. In this study, targeted albedo corrections are applied to explore the dynamical response to artificially reducing these biases. The Southern Hemisphere jet increases in strength in response to the increased tropical-extratropical temperature gradient, with increased energy transport into the mid-latitudes in the atmosphere, but no improvement is observed in the double-ITCZ bias or atmospheric cross-equatorial energy transport. The majority of the adjustment in energy transport in the tropics is achieved in the ocean, with the response further limited to the Pacific Ocean. As a result, the frequently argued teleconnection between the Southern Ocean and tropical precipitation biases is muted. Further experiments in which tropical longwave biases are also reduced do not yield improvement in the representation of the tropical atmosphere. These results suggest that the dramatic improvements in tropical precipitation that have been shown in previous studies may be a function of the lack of dynamical ocean and/or the simplified hemispheric albedo bias corrections applied in that work. It further suggests that efforts to correct the double ITCZ problem in coupled models that focus on large-scale energetic controls will prove fruitless without improvements in the representation of atmospheric processes.MKH, MC and JMH were supported by the Natural Environment Research Council/Department for International Development via the Future Climates for Africa (FCFA) funded project ’Improving Model Processes for African Climate’ (IMPALA, NE/M017265/1). JMH and AJ were supported by the Joint UK DECC/Defra Met Office Hadley Centre Climate Programme (GA01101)

Transition from oil & gas drilling fluids to geothermal drilling fluids

The harsh downhole conditions encountered in geothermal wells, specifically the high temperatures (HT) together with the toughness of the rock found in many geothermal formations, makes the drilling operation challenging. Drilling in such environments requires specialised drilling fluid formulations that have high thermal stability, good rheological properties, excellent lubricity and low formation damage. Given the wealth of experience in drilling wells in the oil industry, it is tempting to assume that the design of geothermal drilling fluids would be straightforward. However, is this the case? In this literature review, we have attempted to answer the question: “to what degree can developments in oil and gas drilling fluids be transferred to drilling fluids for geothermal wells?” To keep the scope of the review manageable, we have focused on two key aspects of drilling fluid design: rate of penetration (ROP) and HT fluid stability (and maintenance of the desired rheological properties of the fluid at high temperatures). The review has allowed the identification of gaps in both fundamental understanding and in existing technology. Rate of penetration is improved using low viscosity and low-density fluids, and we recommend that foams and aphron systems should be investigated to achieve this (depending on the application pressure). It should be noted, however, that such systems to date have only been studied at relatively low temperatures and the challenge of increasing the thermal stability of the formulation components needs to be addressed. Highly thermally stable polymer systems exist but these are both expensive and not widely available. A systematic study of the impact of copolymer molecular architecture on hydrolytic thermal stability is recommended. A promising solution to both maintaining good rheological properties at high temperature and providing fluid loss control is the use of particulates, especially those in the nano-size range. Additionally, nanocomposite systems show promise in this area and should be investigated. Particle stabilized foams and aphrons are a particularly interesting solution and we recommend that these are studied. It is also recommended to investigate the effect of drilling fluid on long term geothermal well performance

One- and two-photon activated phototoxicity of conjugated porphyrin dimers with high two-photon absorption cross sections

Two-photon excited photodynamic therapy (PDT) has the potential to provide a highly targeted treatment for neoplastic diseases, as excitation can be pin-pointed to small volumes at the laser focus. In addition, two-photon PDT offers deeper penetration into mammalian tissue due to the longer wavelength of irradiation. Here we report the one-photon and two-photon excited PDT results for a collection of conjugated porphyrin dimers with high two-photon absorption cross sections. These dimers demonstrate high one-photon PDT efficacy against a human ovarian adenocarcinoma cell line (SK-OV-3) and exhibit no significant dark-toxicity at concentrations of up to 20 microM. Their one-photon excited PDT efficiencies, following irradiation at 657 nm, approach that of Visudyne, a drug used clinically for PDT. We investigated and optimised the effect of the photosensitizer concentration, incubation time and the light dose on the PDT efficacy of these dimers. These studies led to the selection of P2C2-NMeI as the most effective porphyrin dimer. We have demonstrated that P2C2-NMeI undergoes a two-photon activated process following excitation at 920 nm (3.6-6.8 mW, 300 fs, 90 MHz) and compared it to Visudyne. We conclude that the in vitro two-photon PDT efficacy of P2C2-NMeI is about twice that of Visudyne. This result highlights the potential of this series of porphyrin dimers for two-photon PDT

Mid-Upper Arm Circumference based Nutrition Programming: evidence for a new approach in regions with high burden of Acute Malnutrition

In therapeutic feeding programs (TFP), mid-upper arm circumference (MUAC) shows advantages over weight-for-height Z score (WHZ) and is recommended by the World Health Organization (WHO) as an independent criterion for screening children 6-59 months old. Here we report outcomes and treatment response from a TFP using MUAC ≤118 mm or oedema as sole admission criteria for severe acute malnutrition (SAM)

Vacuum Ambiguity in de Sitter Space at Strong Coupling

It is well known that in the weak coupling regime, quantum field theories in de Sitter space do not have a unique vacuum, but a class of vacua parametrized by a complex parameter $\alpha$, i.e., the so-called $\alpha$-vacua. In this article, using gauge/gravity duality, we calculate the symmetric two-point function of strongly coupled ${\cal N}=4$ supersymmetric Yang-Mills theory on $dS_3$. We find that there is a class of de Sitter invariant vacua, parametrized by a set of complex parameters $\{\alpha_{\nu}\}$.Comment: 17 pages in JHEP style, references adde

Challenges and Opportunities: What Can We Learn from Patients Living with Chronic Musculoskeletal Conditions, Health Professionals and Carers about the Concept of Health Literacy Using Qualitative Methods of Inquiry?

The field of health literacy continues to evolve and concern public health researchers and yet remains a largely overlooked concept elsewhere in the healthcare system. We conducted focus group discussions in England UK, about the concept of health literacy with older patients with chronic musculoskeletal conditions (mean age = 73.4 years), carers and health professionals. Our research posed methodological, intellectual and practical challenges. Gaps in conceptualisation and expectations were revealed, reiterating deficiencies in predominant models for understanding health literacy and methodological shortcomings of using focus groups in qualitative research for this topic. Building on this unique insight into what the concept of health literacy meant to participants, we present analysis of our findings on factors perceived to foster and inhibit health literacy and on the issue of responsibility in health literacy. Patients saw health literacy as a result of an inconsistent interactive process and the implications as wide ranging; healthcare professionals had more heterogeneous views. All focus group discussants agreed that health literacy most benefited from good inter-personal communication and partnership. By proposing a needs-based approach to health literacy we offer an alternative way of conceptualising health literacy to help improve the health of older people with chronic conditions

In Vivo Gene Delivery to Lymph Node Stromal Cells Leads to Transgene-specific CD8+ T Cell Anergy in Mice

Lymph node stromal cells play a role in self-tolerance by presenting tissue antigens to T cells. Yet, immunomodulatory properties of lymphoid tissue stroma, particularly toward CD4+ T cells, remain insufficiently characterized by lack of tools to target antigens for presentation by stromal cells. A lentiviral vector was therefore designed for antigen delivery to MHC class II(+) cells of nonhematopoietic origin. Following intravenous vector delivery, the transgene was detected in lymph node gp38+ stromal cells which were CD45- MHCII+ and partly positive for CD86 and CTLA4 or B7-H4. The transgene was not detected in classical dendritic cells of lymph nodes or spleen. Transgene-specific CD4+ and CD8+ T cell responses were primed and regulatory T cells were also induced but effector T cell response did not develop, even after a peptide boost. Antigen-specific CD8+ T cells were not cytolytic in vivo. Thus, expressing a neo-antigen in MHC-II+ lymph node stroma seems to trigger blunt CD4 T cell responses leading to antigen-specific CD8+ T cell anergy. These results open up new perspectives to further characterize lymph node stromal cell functional properties and to develop gene transfer protocols targeting lymph node stroma to induce peripheral tolerance

Characterisation of Antibody Interactions with the G Protein of Vesicular Stomatitis Virus Indiana Strain and Other Vesiculovirus G Proteins

Vesicular stomatitis virus Indiana strain G protein (VSVind.G) is the most commonly used envelope glycoprotein to pseudotype lentiviral vectors (LV) for experimental and clinical applications. Recently, G proteins derived from other vesiculoviruses (VesG), for example Cocal virus, have been proposed as alternative LV envelopes with possible advantages compared to VSVind.G. Well-characterised antibodies that recognise VesG will be useful for vesiculovirus research, development of G protein-containing advanced therapy medicinal products (ATMPs), and deployment of VSVind-based vaccine vectors. Here we show that one commercially available monoclonal antibody, 8G5F11, binds to and neutralises G proteins from three strains of VSV as well as Cocal, and Maraba viruses, whereas the other commercially available monoclonal anti-VSVind.G antibody, IE9F9, binds to and neutralises only VSVind.G. Using a combination of G protein chimeras and site-directed mutations, we mapped the binding epitopes of IE9F9 and 8G5F11 on VSVind.G. IE9F9 binds close to the receptor binding site and competes with soluble low-density lipoprotein receptor (LDLR) for binding to VSVind.G, explaining its mechanism of neutralisation. In contrast, 8G5F11 binds close to a region known to undergo conformational changes when the G protein moves to its post-fusion structure, and we propose that 8G5F11 cross-neutralises VesGs by inhibiting this.IMPORTANCE VSVind.G is currently regarded as the gold-standard envelope to pseudotype lentiviral vectors. However, recently other G proteins derived from vesiculoviruses have been proposed as alternative envelopes. Here, we investigated two commercially available anti-VSVind.G monoclonal antibodies for their ability to cross-react with other vesiculovirus G proteins, and identified the epitopes they recognise, and explored their neutralisation activity. We have identified 8G5F11, for the first time, as a cross-neutralising antibody against several vesiculovirus G proteins. Furthermore, we elucidated the two different neutralisation mechanisms employed by these two monoclonal antibodies. Understanding how cross-neutralising antibodies interact with other G proteins may be of interest in the context of host-pathogen interaction and co-evolution as well as providing the opportunity to modify the G proteins and improve G protein-containing medicinal products and vaccine vectors

Análisis del impacto de las publicaciones sobre PYMES en revistas latinoamericanas. Parte 1: Primera Parte

oai:ojs.rmlconsultores.com:article/1From a search of the literature related to Small and Medium sized Enterprises (SMEs) in the Network of Scientific Journals from Latin America and the Caribbean, Spain and Portugal (REDALYC) were determined 149 articles related to the topic in 8 countries and international organizations referenced in that network. The most important journals for the subject and also from the analysis of the keywords presented in the abstract, the relevant thematics for the publications about SMEs were found. Utilizing Perish (Harzing, 2007) the literature on SMEs referenced in Google Scholar and h indicator was determined. Of the 1000 articles founded 215 had an h index > = 1 indicator and 75% of the articles referenced even they appear in Google Scholar, have not a real impact (h = 0). The methodology allows to recommend a simple form that can be incorporated in the Academic Master Programs for determining for a thesis topic, those articles published an indexed in scientific journals and with a real impact for the topic.Se determinaron a partir de una búsqueda de las publicaciones relacionadas con la Pequeña y Mediana Empresa (PYMES) en la Red de Revistas Cientí­ficas de América Latina y el Caribe, España y Portugal (REDALYC), 149 artí­culos relacionados con el tema en revistas de 8 paí­ses y de Organismos Internacionales referenciados en la misma.  Se determinó igualmente las revistas más importantes para el tema en cuestión y a partir del análisis de las palabras claves presentadas en el resumen, las sub temáticas que más se analizan en cuanto a PYMES para las revista indexadas en la red mencionada. Se empleó la herramienta Perish (Harzing, 2007) para el análisis de las publicaciones sobre la temática PYMES referenciadas en el Google Académico y su indicador h. De los 1000 artí­culos encontrados 215 tienen un indicador h >= 1 y el 75 % de los artí­culos aunque aparezcan referenciados en el Google Académico, no han tenido un impacto real (h=0). La metodologí­a empleada permite recomendar una forma simple que puede incorporarse en los Programas Académicos de Maestrí­a y que permite determinar para un tema de Tesis, aquellos artí­culos publicados en revistas indexadas y con mayor impacto para la misma.Se determinaron a partir de una búsqueda de las publicaciones relacionadas con la Pequeña y Mediana Empresa (PYMES) en la Red de Revistas Cientí­ficas de América Latina y el Caribe, España y Portugal (REDALYC), 149 artí­culos relacionados con el tema en revistas de 8 paí­ses y de Organismos Internacionales referenciados en la misma.  Se determinó igualmente las revistas más importantes para el tema en cuestión y a partir del análisis de las palabras claves presentadas en el resumen, las sub temáticas que más se analizan en cuanto a PYMES para las revista indexadas en la red mencionada. Se empleó la herramienta Perish (Harzing, 2007) para el análisis de las publicaciones sobre la temática PYMES referenciadas en el Google Académico y su indicador h. De los 1000 artí­culos encontrados 215 tienen un indicador h >= 1 y el 75 % de los artí­culos aunque aparezcan referenciados en el Google Académico, no han tenido un impacto real (h=0). La metodologí­a empleada permite recomendar una forma simple que puede incorporarse en los Programas Académicos de Maestrí­a y que permite determinar para un tema de Tesis, aquellos artí­culos publicados en revistas indexadas y con mayor impacto para la misma