Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study

Aims/hypothesis: Many SNPs have been associated with glycaemic traits and type 2 diabetes, but their joint effects on glycaemic traits and the underlying mechanisms leading to hyperglycaemia over time are largely unknown. We aimed to investigate the association of six genetic risk scores (GRSs) with changes in plasma glucose, insulin sensitivity, insulin secretion and incident type 2 diabetes in the prospective METabolic Syndrome In Men (METSIM) study. Methods: We generated weighted GRSs for fasting plasma glucose ([FPG] GRSFPG, 35 SNPs), 2 h plasma glucose ([2hPG] GRS2hPG, 9 SNPs), insulin secretion (GRSIS, 17 SNPs), insulin resistance (GRSIR, 9 SNPs) and BMI (GRSBMI, 95 SNPs) and a non-weighted GRS for type 2 diabetes (GRST2D, 76 SNPs) in up to 8749 non-diabetic Finnish men. Linear regression was used to test associations of the GRSs with changes in glycaemic traits over time. Results: GRST2D, GRSFPG and GRSIS were associated with an increase in FPG, GRST2D with an increase in glucose AUC and a decrease in insulin secretion, and GRS2hPG with an increase in 2hPG during the follow-up (p < 0.0017 for all models). GRST2D, GRSFPG and GRSIS were associated with incident type 2 diabetes (p < 0.008 for all models). GRSBMI and GRSIR were not significantly associated with any changes in glycaemic traits. Conclusions/interpretation: In the METSIM follow-up study, GRST2D, GRSFPG and GRSIS were associated with the worsening of FPG and an increase in incident type 2 diabetes. GRST2D was additionally associated with a decrease in insulin secretion, and GRS2hPG with an increase in 2hPG

First lattice QCD estimate of the g_{D^* D pi} coupling

We present the results of the first lattice QCD study of the strong coupling g_{D^* D pi}. From our simulations in the quenched approximation, we obtain g_{D^* D pi} = 18.8 +/- 2.3^{+1.1}_{-2.0} and hat(g)_c = 0.67 +/- 0.08^{+0.04}_{-0.06}. Whereas previous theoretical studies gave different predictions, our result favours a large value for hat(g)_c. It agrees very well with the recent experimental value by CLEO. hat(g) varies very little with the heavy mass and we find in the infinite mass limit hat(g)_infinity = 0.69(18).Comment: 24 pages, 7 figures; references added, corrected typos, Comments added about the continuum limi

Scaling critical behavior of superconductors at zero magnetic field

We consider the scaling behavior in the critical domain of superconductors at zero external magnetic field. The first part of the paper is concerned with the Ginzburg-Landau model in the zero magnetic field Meissner phase. We discuss the scaling behavior of the superfluid density and we give an alternative proof of Josephson's relation for a charged superfluid. This proof is obtained as a consequence of an exact renormalization group equation for the photon mass. We obtain Josephson's relation directly in the form $\rho_{s}\sim t^{\nu}$, that is, we do not need to assume that the hyperscaling relation holds. Next, we give an interpretation of a recent experiment performed in thin films of $YBa_{2}Cu_{3}O_{7-\delta}$. We argue that the measured mean field like behavior of the penetration depth exponent $\nu'$ is possibly associated with a non-trivial critical behavior and we predict the exponents $\nu=1$ and $\alpha=-1$ for the correlation lenght and specific heat, respectively. In the second part of the paper we discuss the scaling behavior in the continuum dual Ginzburg-Landau model. After reviewing lattice duality in the Ginzburg-Landau model, we discuss the continuum dual version by considering a family of scalings characterized by a parameter $\zeta$ introduced such that $m_{h,0}^2\sim t^{\zeta}$, where $m_{h,0}$ is the bare mass of the magnetic induction field. We discuss the difficulties in identifying the renormalized magnetic induction mass with the photon mass. We show that the only way to have a critical regime with $\nu'=\nu\approx 2/3$ is having $\zeta\approx 4/3$, that is, with $m_{h,0}$ having the scaling behavior of the renormalized photon mass.Comment: RevTex, 15 pages, no figures; the subsection III-C has been removed due to a mistak

ESTIMATING GENOME-WIDE COPY NUMBER USING ALLELE SPECIFIC MIXTURE MODELS

Genomic changes such as copy number alterations are thought to be one of the major underlying causes of human phenotypic variation among normal and disease subjects [23,11,25,26,5,4,7,18]. These include chromosomal regions with so-called copy number alterations: instead of the expected two copies, a section of the chromosome for a particular individual may have zero copies (homozygous deletion), one copy (hemizygous deletions), or more than two copies (amplifications). The canonical example is Down syndrome which is caused by an extra copy of chromosome 21. Identification of such abnormalities in smaller regions has been of great interest, because it is believed to be an underlying cause of cancer. More than one decade ago comparative genomic hybridization (CGH)technology was developed to detect copy number changes in a high-throughput fashion. However, this technology only provides a 10 MB resolution which limits the ability to detect copy number alterations spanning small regions. It is widely believed that a copy number alteration as small as one base can have significant downstream effects, thus microarray manufacturers have developed technologies that provide much higher resolution. Unfortunately, strong probe effects and variation introduced by sample preparation procedures have made single-point copy number estimates too imprecise to be useful. CGH arrays use a two-color hybridization, usually comparing a sample of interest to a reference sample, which to some degree removes the probe effect. However, the resolution is not nearly high enough to provide single-point copy number estimates. Various groups have proposed statistical procedures that pool data from neighboring locations to successfully improve precision. However, these procedure need to average across relatively large regions to work effectively thus greatly reducing the resolution. Recently, regression-type models that account for probe-effect have been proposed and appear to improve accuracy as well as precision. In this paper, we propose a mixture model solution specifically designed for single-point estimation, that provides various advantages over the existing methodology. We use a 314 sample database, constructed with public datasets, to motivate and fit models for the conditional distribution of the observed intensities given allele specific copy numbers. With the estimated models in place we can compute posterior probabilities that provide a useful prediction rule as well as a confidence measure for each call. Software to implement this procedure will be available in the Bioconductor oligo packagehttp://www.bioconductor.org)

Solutions of a particle with fractional δ\delta-potential in a fractional dimensional space

A Fourier transformation in a fractional dimensional space of order \la (0<\la\leq 1) is defined to solve the Schr\"odinger equation with Riesz fractional derivatives of order \a. This new method is applied for a particle in a fractional $\delta$-potential well defined by V(x) =- \gamma\delta^{\la}(x), where $\gamma>0$ and \delta^{\la}(x) is the fractional Dirac delta function. A complete solutions for the energy values and the wave functions are obtained in terms of the Fox H-functions. It is demonstrated that the eigen solutions are exist if 0< \la<\a. The results for \la= 1 and \a=2 are in exact agreement with those presented in the standard quantum mechanics

Measurement of Rb in e+e- Collisions at 182 - 209 GeV

Measurements of Rb, the ratio of the bbbar cross-section to the qqbar cross- section in e+e- collisions, are presented. The data were collected by the OPAL experiment at LEP at centre-of-mass energies between 182 GeV and 209 GeV. Lepton, lifetime and event shape information is used to tag events containing b quarks with high efficiency. The data are compatible with the Standard Model expectation. The mean ratio of the eight measurements reported here to the Standard Model prediction is 1.055+-0.031+-0.037, where the first error is statistical and the second systematic.Comment: 21 pages, 5 figures, Submitted to Phys. Letts

Measurement of the B0 Lifetime and Oscillation Frequency using B0->D*+l-v decays

The lifetime and oscillation frequency of the B0 meson has been measured using B0->D*+l-v decays recorded on the Z0 peak with the OPAL detector at LEP. The D*+ -> D0pi+ decays were reconstructed using an inclusive technique and the production flavour of the B0 mesons was determined using a combination of tags from the rest of the event. The results t_B0 = 1.541 +- 0.028 +- 0.023 ps, Dm_d = 0.497 +- 0.024 +- 0.025 ps-1 were obtained, where in each case the first error is statistical and the second systematic.Comment: 17 pages, 4 figures, submitted to Phys. Lett.

Limit cycles in uniform isochronous centers of discontinuous differential systems with four zones

We apply the averaging theory of first order for discontinuous differential systems to study the bifurcation of limit cycles from the periodic orbits of the uniform isochronous center of the differential systems ẋ = -y+x, y = x + xy, and ẋ = -y + xy, y = x + xy, when they are perturbed inside the class of all discontinuous quadratic and cubic polynomials differential systems with four zones separately by the axes of coordinates, respectively. Using averaging theory of first order the maximum number of limit cycles that we can obtain is twice the maximum number of limit cycles obtained in a previous work for discontinuous quadratic differential systems perturbing the same uniform isochronous quadratic center at origin perturbed with two zones separately by a straight line, and 5 more limit cycles than those achieved in a prior result for discontinuous cubic differential systems with the same uniform isochronous cubic center at the origin perturbed with two zones separately by a straight line. Comparing our results with those obtained perturbing the mentioned centers by the continuous quadratic and cubic differential systems we obtain 8 and 9 more limit cycles respectively