Estrategias de marketing político. El merchandising del Partido Socialista Obrero Español y Podemos

Esta investigación se centra en el estudio del "marketing político", un fenómeno vinculado a las estrategias del marketing comercial. A lo largo de los años, ha ido evolucionando y desarrollando nuevas técnicas y herramientas con el fin de llegar al electorado y conseguir su apoyo y voto. Este trabajo focaliza en el merchandising político, un área que no ha sido prácticamente estudiada en España y con escasas investigaciones a nivel internacional. De manera concreta, analiza los productos de merchandising electoral del Partido Socialista Obrero Español y Podemos, que son los dos únicos partidos en España que cuentan con tienda web de sus productos.Departamento de Historia Moderna, Contemporánea y de América, Periodismo y Comunicación Audiovisual y PublicidadGrado en Periodism

Los simuladores de negocios como alternativa del desarrollo de las competencias de los estudiantes de la Universidad Técnica de Cotopaxi, de la carrera de ingeniería comercial, periodo 2013, 2014

This research was conducted in order to develop a teaching guide Business Simulation Game Simul @ will help meet critical aspects of creating and managing a business project in the students of the Technical University of Cotopaxi Career Commercial Engineering This project will provide students with access to new technologies generating common situations that entrepreneurs and business day in order to contribute to their academic process face….La presente investigación se realizó con la finalidad de elaborar una guía didáctica del Juego de Simulación Empresarial Simul@ que ayudará a conocer aspectos críticos de la creación y gestión de un proyecto empresarial en los estudiantes de la Universidad Técnica de Cotopaxi de la Carrera de Ingeniería Comercial, este proyecto proporcionará a los estudiantes el acceso a nuevas tecnologías generando situaciones habituales a las que se enfrentan emprendedores y empresarios día a día con el propósito de contribuir en su proceso académico…

Arrendamiento Financiero y su Incidencia en la situación financiera de la empresa de SERVICIOS SALUBRIDAD SANEAMIENTO AMBIENTAL Y SERVICIOS S.A.C. en el Año 2015

El siguiente trabajo de investigación llamado “arrendamiento financiero y su incidencia en la situación financiera” en la empresa SALUBRIDAD SANEAMIENTO AMBIENTAL Y SERVICIOS SAC, Pueblo Libre ,2017 al considerar esta alternativa de financiamiento la empresa puede adquirir sus activos fijos mediante leasing y mejorar la productividad de la empresa Ssays SAC, reducir las obligaciones financieras a corto plazo, contar con mayor liquidez. Al optar por esta fuente de financiamiento la empresa cuenta con diversos beneficios como: la depreciación acelerada del activo esto permite la recuperación de la inversión realizada, renovación de los activos sin la necesidad de desembolsos de dinero líquido, utilización del IGV como crédito fiscal, etc. Al utilizar el leasing trajo ventajas para la empresa tanto en lo económico, financiero, y tributario esto permitió ser más competitivos y generar mayores ingresos en el futuro.The present research work called “Financial Leasing and its impact on the financial situation” about SALUBRIDAD SANEAMIENTO AMBIENTAL Y SERVICIOS S.A.C.’S Company display the financial leasing like a financial choice where the factory can buy fixed assets and improve its productivity, reduce its short-time debt and has more liquidity. When company chooses financial leasing like a financial source could access the following benefits: recover the investment through accelerated depreciation of the asset, renewal of assets without liquid money payment, use taxes like fiscal credit, etc. Use financial leasing on the company brings economic, financial and tax benefits. This allows the company be competitive and produce more income on the future.Trabajo de investigació

Arrendamiento Financiero y su Incidencia en la situación financiera de la empresa de SERVICIOS SALUBRIDAD SANEAMIENTO AMBIENTAL Y SERVICIOS S.A.C. en el Año 2015

El siguiente trabajo de investigación llamado “arrendamiento financiero y su incidencia en la situación financiera” en la empresa SALUBRIDAD SANEAMIENTO AMBIENTAL Y SERVICIOS SAC, Pueblo Libre ,2017 al considerar esta alternativa de financiamiento la empresa puede adquirir sus activos fijos mediante leasing y mejorar la productividad de la empresa Ssays SAC, reducir las obligaciones financieras a corto plazo, contar con mayor liquidez. Al optar por esta fuente de financiamiento la empresa cuenta con diversos beneficios como: la depreciación acelerada del activo esto permite la recuperación de la inversión realizada, renovación de los activos sin la necesidad de desembolsos de dinero líquido, utilización del IGV como crédito fiscal, etc. Al utilizar el leasing trajo ventajas para la empresa tanto en lo económico, financiero, y tributario esto permitió ser más competitivos y generar mayores ingresos en el futuro.The present research work called “Financial Leasing and its impact on the financial situation” about SALUBRIDAD SANEAMIENTO AMBIENTAL Y SERVICIOS S.A.C.’S Company display the financial leasing like a financial choice where the factory can buy fixed assets and improve its productivity, reduce its short-time debt and has more liquidity. When company chooses financial leasing like a financial source could access the following benefits: recover the investment through accelerated depreciation of the asset, renewal of assets without liquid money payment, use taxes like fiscal credit, etc. Use financial leasing on the company brings economic, financial and tax benefits. This allows the company be competitive and produce more income on the future.Trabajo de investigació

Primeros hallazgos de Aedes (Stegomyia) albopictus (Skuse, 1894) en la provincia de Valencia, España

Enmarcado dentro del proyecto “Vigilancia entomológica en aero- puertos y puertos frente a vectores importados de enfermedades infecciosas exóticas, y vigilancia de potenciales vectores autócto- nos de dichas enfermedades”, en septiembre de 2013 se detecta por primera vez la presencia de Aedes albopictus (Diptera, Culici- dae) en la provincia de Valencia en las localidades costeras de Sueca, Cullera y Gandía, gracias a la utilización de trampas de ovi- posición

Elearning, Communication and Open-data: Massive Mobile, Ubiquitous and Open Learning

ABSTRACT: In MOOCs, learning analytics have to be addressed to the various types of learners that participate. This deliverable describes indicators that enable both teachers and learner to monitor the progress and performance as well as identify whether there are learners at risk of dropping out. How these indicators should be computed and displayed to end users by means of dashboards is also explained. Furthermore a proposal based on xAPI statements for storing relevant data and events is provided

Infection-specific PET imaging with 18F-fluorodeoxysorbitol and 2-[18F]F-ρ-aminobenzoic acid: An extended diagnostic tool for bacterial and fungal diseases

IntroductionSuspected infectious diseases located in difficult-to-access sites can be challenging due to the need for invasive procedures to isolate the etiological agent. Positron emission tomography (PET) is a non-invasive imaging technology that can help locate the infection site. The most widely used radiotracer for PET imaging (2-deoxy-2[18F] fluoro-D-glucose: [18F]FDG) shows uptake in both infected and sterile inflammation. Therefore, there is a need to develop new radiotracers able to specifically detect microorganisms.MethodsWe tested two specific radiotracers: 2-deoxy-2-[18F]-fluoro-D-sorbitol ([18F]FDS) and 2-[18F]F-ρ-aminobenzoic acid ([18F]FPABA), and also developed a simplified alternative of the latter for automated synthesis. Clinical and reference isolates of bacterial and yeast species (19 different strains in all) were tested in vitro and in an experimental mouse model of myositis infection.Results and discussionNon-lactose fermenters (Pseudomonas aeruginosa and Stenotrophomonas maltophilia) were unable to take up [18F]FDG in vitro. [18F]FDS PET was able to visualize Enterobacterales myositis infection (i.e., Escherichia coli) and to differentiate between yeasts with differential assimilation of sorbitol (i.e., Candida albicans vs. Candida glabrata). All bacteria and yeasts tested were detected in vitro by [18F]FPABA. Furthermore, [18F]FPABA was able to distinguish between inflammation and infection in the myositis mouse model (E. coli and Staphylococcus aureus) and could be used as a probe for a wide variety of bacterial and fungal species

Effect of high-volume insecticide spraying on sand fly vectors in household gardens in Spain

This study investigated the efficacy of high-volume spraying with the adulticide α-cypermethrin alone and in combination with the larvicide diflubenzuron on the density of sand flies in gardens of three detached households in periurban areas in southeast Spain. Treatments were applied four times between June and August 2016, and four nearby sites, two households and two non-urbanized sites, were untreated controls. The number of sand flies collected between May and October 2016 using sticky interception and light attraction traps, was 4446 specimens. Species identified morphologically included Sergentomyia minuta (n = 2101; 48%), Phlebotomus perniciosus (n = 1922; 44%), Phlebotomus papatasi (n = 173; 4%), Phlebotomus sergenti (n = 161; 4%) and Phlebotomus ariasi (n = 36; 1%). Sand flies were detected in both treated and untreated sites. The proportion of positive sticky traps and the median (range) density of sand flies in positive traps were 61% traps and 7 (2-172) sand flies/m2 /day in untreated sites, and 43% traps and 4 (1-56) sand flies/m2 /day in treated sites (p < 0.05). Similarly, for light traps, it was 96% traps and 30 (3-168) flies/trap/day, and 83% traps and 3 (1-12) sand flies/trap/day, respectively (p < 0.05). However, sand fly density followed a comparable seasonal pattern in untreated and treated sites and did not consistently decrease following insecticide applications. These results were confirmed with mixed negative binomial modelling of sand fly density adjusted for time since application, month, environmental setting and site. The limited efficacy of the treatments, added to their cost, the impact of insecticides on non-target organisms and human health, and the risk of development of insecticide resistance, should dissuade similar outdoor applications to control sand fly vector populations in residential areas.Open Access funding was provided, thanks to the CRUE-CSIC UM agreement with Wiley.The study was funded by the Spanish Ministry of Science and Innovation (Grant number: AGL2013-46981-R) and received support from VectorNet, a European network for sharing data on the geographic distribution of arthropod vectors, transmitting human and animal disease agents funded by the European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC). CMH held a PhD grant from the University of Murcia (Contrato predoctoral FPU). EB, MO, CMH, JR and SV were beneficiaries of a COST TD1303 short scientific mission grant to develop sand fly sampling and identification techniques. CMH is now supported by Margarita Salas Postdoctoral Grant in University of Murcia from the Program of Requalification of the Spanish University System (Spanish Ministry of Universities), founded by the European Union—NextGenerationEU.Peer reviewe

Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature

Primary Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of SS is complex with environmental triggers and genetic factors involved. By conducting an integrated multi-omics study, we confirmed a vast coordinated hypomethylation and overexpression effects in IFN-related genes, what is known as the IFN signature. Stratified and conditional analyses suggest a strong interaction between SS-associated HLA genetic variation and the presence of Anti-Ro/SSA autoantibodies in driving the IFN epigenetic signature and determining SS. We report a novel epigenetic signature characterized by increased DNA methylation levels in a large number of genes enriched in pathways such as collagen metabolism and extracellular matrix organization. We identified potential new genetic variants associated with SS that might mediate their risk by altering DNA methylation or gene expression patterns, as well as disease-interacting genetic variants that exhibit regulatory function only in the SS population. Our study sheds new light on the interaction between genetics, autoantibody profiles, DNA methylation and gene expression in SS, and contributes to elucidate the genetic architecture of gene regulation in an autoimmune population