Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project

Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. Results: The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation. Conclusion: This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

[Prehabilitation, therapeutic innovation]

The concept of prehabilitation emerged in the United States in the 1940s to maintain the performance of American soldiers notably through good nutrition and sport. It was then a question of optimising the patient's health status in a pre-treatment situation and reducing surgical stress. The specific collaborative programme Proadapt, comprising multiprofessional expertise, was put in place for elderly patients in 2016

Cercospora beticola toxins. Part VI : preliminary studies of protonation and complexation equilibria

International audienc

Prédiction de l’entrée en travail sous 24 heures en cas de rupture des membranes à terme

International audienc

Journée clermontoise sur l'imprécision et l'incertitude en fusion d'information : théories et applications

International audienceThis document deals with the uncertainty and the imprecision in data fusion. In a first part, we present papers providing with I. Bloch and D. Dubois, concerning their speech. In a second part, we present a report of the two workshops and the synthesis cards of the taking up applicationsLa prise en compte de l'incertitude et de l'imprécision dans des problèmes de fusion d'informations, généralement effectuée dans le cadre de la théorie de l'évidence ou de la théorie des possibilités, apparaît comme une problématique transversale et qui est susceptible de toucher un vaste champ d'applications. C'est pour cette raison que plusieurs laboratoires clermontois ont organisé, le mercredi 16 juin 1999, une journée d'échange entre les spécialistes des théories de l'incertain et les chercheurs utilisant ces théories dans des applications concrètes. Ce document se présente en deux parties. Dans la première, nous avons regroupé un certain nombre de publications fournies par I. Bloch et D. Dubois, en rapport avec l'intervention qu'ils ont effectuée. Dans la deuxième partie, nous présentons un compte rendu des deux tables rondes et des fiches de synthèse reprenant les applications abordées