Moinho Joinville: força motriz para reapropriação do território

TCC (graduação) - Universidade Federal de Santa Catarina. Centro Tecnológico. ArquiteturaTCC sem resumo

Multidisciplinary applications of tree-ring analysis in Newfoundland and Labrador

Article from the Irish Journal of Newfoundland and Labrador Research ‘Ktaqamkuk Across The Water Thar Muir’ which was originally published in 2009 by the Centre for Newfoundland and Labrador Studies

Magnetic ordering in the pyrochlore Ho₂CrSbO₇ determined from neutron diffraction, and the magnetic properties of other RE₂CrSbO₇ phases (RE=Y, Tb, Dy, Er)

AbstractThe magnetic structure of the pyrochlore Ho2CrSbO7, which orders magnetically below 13K, has been studied using neutron powder diffraction. Ho2CrSbO7 is found to form an “ordered spin-ice structure” where the magnetic moments are constrained along the 111 axes, but with a ferromagnetic moment in one direction. The Cr3+ ions order ferromagnetically and this is thought to lift the degeneracy of the x, y and z directions in the cubic structure causing the ferromagnetic component from the Ho3+ ions to align. The pyrochlores RE2CrSbO7 where RE=Y, Tb, Dy and Er have also been prepared and studied using SQUID magnetometry

Hydro-morphodynamics 2D modelling using a discontinuous Galerkin discretisation

The development of morphodynamic models to simulate sediment transport accurately is a challenging process that is becoming ever more important because of our increasing exploitation of the coastal zone, as well as sea-level rise and the potential increase in strength and frequency of storms due to a changing climate. Morphodynamic models are highly complex given the non-linear and coupled nature of the sediment transport problem. Here we implement a new depth-averaged coupled hydrodynamic and sediment transport model within the coastal ocean model Thetis, built using the code generating framework Firedrake which facilitates code flexibility and optimisation benefits. To the best of our knowledge, this represents the first full morphodynamic model including both bedload and suspended sediment transport which uses a discontinuous Galerkin based finite element discretisation. We implement new functionalities within Thetis extending its existing capacity to model scalar transport to modelling suspended sediment transport, incorporating within Thetis options to model bedload transport and bedlevel changes. We apply our model to problems with non-cohesive sediment and account for effects of gravity and helical flow by adding slope gradient terms and parametrising secondary currents. For validation purposes and in demonstrating model capability, we present results from test cases of a migrating trench and a meandering channel comparing against experimental data and the widely-used model Telemac-Mascaret

The multidimensional comprehension of Chagas disease. Contributions, approaches, challenges and opportunities from and beyond the Information, Education and Communication (IEC) field

Chagas is a complex, multidimensional phenomenon in which political, economic, environmental, biomedical, epidemiological, psychological, and sociocultural factors intersect. Nonetheless, the hegemonic conceptualisation has long envisioned Chagas as primarily a biomedical question, while ignoring or downplaying the other dimensions, and this limited view has reinforced the disease?s long neglect. Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness, increased case detection and follow-up, improved adherence to care, and integrated participation of various actors from multiple action levels. Information, Education, and Communication (IEC) initiatives have great potential for impact in the implementation of multidimensional programs of prevention and control successfully customised to the diverse and complex contexts where Chagas disease persists.Instituto de Física de Líquidos y Sistemas Biológico

European Portuguese Adaptation of Glasgow Content of Thoughts Inventory (GCTI): Psychometric Characterization in Higher Education Students

Persistent cognitive activity is an important factor in disturbing sleep-onset both during bedtime and when attempting to get back to sleep after nocturnal awakenings. One of the most specific self-report measures designed to assess this feature is the Glasgow Content of Thoughts Inventory (GCTI). In this study, we investigated the preliminary psychometric properties of GCTI in a large sample of higher education European Portuguese students (N = 2995). Our results suggest that there is evidence of good internal consistency (α = 0.93) and validity indicators. Moreover, we found an interpretable factorial structure comprising 5 correlated factors that needs to be confirmed in future studies. The European Portuguese version of the GCTI appears to be a reliable and valid instrument for measurement of sleep-onset disturbing cognitions

The multidimensional comprehension of chagas disease. Contributions, approaches, challenges and opportunities from and beyond the information, education and communication field

Chagas is a complex, multidimensional phenomenon in which political, economic, environmental, biomedical, epidemiological, psychological, and sociocultural factors intersect. Nonetheless, the hegemonic conceptualisation has long envisioned Chagas as primarily a biomedical question, while ignoring or downplaying the other dimensions, and this limited view has reinforced the disease’s long neglect. Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness, increased case detection and follow-up, improved adherence to care, and integrated participation of various actors from multiple action levels. Information, Education, and Communication (IEC) initiatives have great potential for impact in the implementation of multidimensional programs of prevention and control successfully customised to the diverse and complex contexts where Chagas disease persists.Fil: Sanmartino, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Forsyth, Colin J.. No especifíca;Fil: Avaria, Andrea. Universidad Autónoma de Chile; ChileFil: Velarde Rodriguez, Mar. Universidad de Basilea; SuizaFil: Gómez I Prat, Jordi. 6hospital Universitari Vall Dhebron; EspañaFil: Albajar Viñas, Pedro. Organización Mundial de la Salud; Suiz

T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium.

The regulation of mucosal immune function is critical to host protection from enteric pathogens but is incompletely understood. The nervous system and the neurotransmitter acetylcholine play an integral part in host defense against enteric bacterial pathogens. Here we report that acetylcholine producing-T-cells, as a non-neuronal source of ACh, were recruited to the colon during infection with the mouse pathogen Citrobacter rodentium. These ChAT+ T-cells did not exclusively belong to one Th subset and were able to produce IFNγ, IL-17A and IL-22. To interrogate the possible protective effect of acetylcholine released from these cells during enteric infection, T-cells were rendered deficient in their ability to produce acetylcholine through a conditional gene knockout approach. Significantly increased C. rodentium burden was observed in the colon from conditional KO (cKO) compared to WT mice at 10 days post-infection. This increased bacterial burden in cKO mice was associated with increased expression of the cytokines IL-1β, IL-6, and TNFα, but without significant changes in T-cell and ILC associated IL-17A, IL-22, and IFNγ, or epithelial expression of antimicrobial peptides, compared to WT mice. Despite the increased expression of pro-inflammatory cytokines during C. rodentium infection, inducible nitric oxide synthase (Nos2) expression was significantly reduced in intestinal epithelial cells of ChAT T-cell cKO mice 10 days post-infection. Additionally, a cholinergic agonist enhanced IFNγ-induced Nos2 expression in intestinal epithelial cell in vitro. These findings demonstrated that acetylcholine, produced by specialized T-cells that are recruited during C. rodentium infection, are a key mediator in host-microbe interactions and mucosal defenses

Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in rats

Rationale: Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired accumbens DA transmission reallocate their behavior away from food-reinforced activities that have high response requirements, and instead select less-effortful types of food-seeking behavior. Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related processes, emerging evidence also implicates adenosine A2A receptors. Objective: The present work was undertaken to test the hypothesis that accumbens A2A receptor stimulation would produce effects similar to those produced by DA depletion or antagonism. Methods: Three experiments assessed the effects of the adenosine A2A agonist CGS 21680 on performance of a concurrent choice task (lever pressing for preferred food vs. intake of less preferred chow) that is known to be sensitive to DA antagonists and accumbens DA depletions. Results: Systemic injections of CGS 21680 reduced lever pressing but did not increase feeding. In contrast, bilateral infusions of the adenosine A2A receptor agonist CGS 21680 (6.0- 24.0 ng) into the nucleus accumbens decreased lever pressing for the preferred food, but substantially increased consumption of the less preferred chow. Injections of CGS 21680 into a control site dorsal to the accumbens were ineffective. Conclusions: Taken together, these results are consistent with the hypothesis that local stimulation of adenosine A2A receptors in nucleus accumbens produces behavioral effects similar to those induced by accumbens DA depletions. Accumbens adenosine A2A receptors appear to be a component of the brain circuitry regulating effort-related choice behavio