Bargaining Equilibrium in a Non-Stationary Environment

No abstract.

Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest

The neural crest, a transient population of migratory cells, forms the craniofacial skeleton and peripheral nervous system, among other derivatives in vertebrate embryos. The transcriptional repressor Snail2 is thought to be crucial for the epithelial-to-mesenchymal transition (EMT) that promotes neural crest delamination from the neural tube; however, little is known about its downstream targets. To this end, we depleted avian Snail2 in the premigratory neural crest using morpholino antisense oligonucleotides and examined effects on potential targets by quantitative PCR. Several dorsal neural tube genes were upregulated by alleviating Snail2 repression; moreover, the cell adhesion molecule cadherin6B was derepressed within 30 minutes of blocking Snail2 translation. Examination of the chick cadherin6B genomic sequence reveals that the regulatory region contains three pairs of clustered E boxes, representing putative Snail2 binding sites. Furthermore, in vivo and in vitro biochemical analyses demonstrate that Snail2 directly binds to these sites and regulates cadherin6B transcription. These results are the first to describe a direct target of Snail2 repression in vivo and in the context of the EMT that characterizes neural crest developmen

Method of fabricating a twisted composite superconductor

A method of producing a twisted, stabilized wire or tube superconductor which can be used to wind electromagnets, armatures, rotors, field windings for motors and generators, and other magnetic devices which use a solenoid, toroidal, or other type winding is reported. At least one groove is formed along the length of a wire substrate which is then twisted into a helix and a layer of intermetallic superconducting material is formed in the groove. This layer can be formed by depositing the desired intermetallic compound into the groove or by diffusing one component of the superconductor into the groove formed in a substrate composed of the other component. The superconductor prepared by this method comprises a non-superconductor wire twisted into the shape of a helix, having at least one groove containing a layer of superconductor material along the length of the wire

New twisted intermetallic compound superconductor: A concept

Method for processing Nb3Sn and other intermetallic compound superconductors produces a twisted, stabilized wire or tube which can be used to wind electromagnetics, armatures, rotors, and field windings for motors and generators as well as other magnetic devices

Effects of Foreground Contamination on the Cosmic Microwave Background Anisotropy Measured by MAP

We study the effects of diffuse Galactic, far-infrared extragalactic source, and radio point source emission on the cosmic microwave background (CMB) anisotropy data anticipated from the MAP experiment. We focus on the correlation function and genus statistics measured from mock MAP foreground-contaminated CMB anisotropy maps generated in a spatially-flat cosmological constant dominated cosmological model. Analyses of the simulated MAP data at 90 GHz (0.3 deg FWHM resolution smoothed) show that foreground effects on the correlation function are small compared with cosmic variance. However, the Galactic emission, even just from the region with |b| > 20 deg, significantly affects the topology of CMB anisotropy, causing a negative genus shift non-Gaussianity signal. Given the expected level of cosmic variance, this effect can be effectively reduced by subtracting existing Galactic foreground emission models from the observed data. IRAS and DIRBE far-infrared extragalactic sources have little effect on the CMB anisotropy. Radio point sources raise the amplitude of the correlation function considerably on scales below 0.5 deg. Removal of bright radio sources above a 5 \sigma detection limit effectively eliminates this effect. Radio sources also result in a positive genus curve asymmetry (significant at 2 \sigma) on 0.5 deg scales. Accurate radio point source data is essential for an unambiguous detection of CMB anisotropy non-Gaussianity on these scales. Non-Gaussianity of cosmological origin can be detected from the foreground-subtracted CMB anisotropy map at the 2 \sigma level if the measured genus shift parameter |\Delta\nu| >= 0.02 (0.04) or if the measured genus asymmetry parameter |\Delta g| >= 0.03 (0.08) on a 0.3 (1.0) deg FWHM scale.Comment: 26 pages, 7 figures, Accepted for Publication in Astrophysical Journal (Some sentences and figures modified

The Low Column Density Lyman-alpha Forest

We develop an analytical method based on the lognormal approximation to compute the column density distribution of the Lyman-alpha forest in the low column density limit. We compute the column density distributions for six different cosmological models and found that the standard, COBE-normalized CDM model cannot fit the observations of the Lyman-alpha forest at z=3. The amplitude of the fluctuations in that model has to be lowered by a factor of almost 3 to match observations. However, the currently viable cosmological models like the lightly tilted COBE-normalized CDM+Lambda model, the CHDM model with 20% neutrinos, and the low-amplitude Standard CDM model are all in agreement with observations, to within the accuracy of our approximation, for the value of the cosmological baryon density at or higher than the old Standard Bing Bang Nucleosynthesis value of 0.0125 for the currently favored value of the ionizing radiation intensity. With the low value for the baryon density inferred by Hogan & Rugers (1996), the models can only marginally match observations.Comment: three postscript figures included, submitted to ApJ

Gamma rays from ultracompact primordial dark matter minihalos

Ultracompact minihalos have recently been proposed as a new class of dark matter structure. These minihalos would be produced by phase transitions in the early Universe or features in the inflaton potential, and constitute non-baryonic massive compact halo objects (MACHOs) today. We examine the prospect of detecting ultracompact minihalos in gamma-rays if dark matter consists of self-annihilating particles. We compute present-day fluxes from minihalos produced in the electron-positron annihilation epoch, and the QCD and electroweak phase transitions in the early Universe. Even at a distance of 100 pc, minihalos produced during the electron-positron annihilation epoch should be eminently detectable today, either by the Fermi satellite, current Air Cherenkov telescopes, or even in archival EGRET data. Within ~1 pc, minihalos formed in the QCD phase transition would have similar predicted fluxes to the dwarf spheroidal galaxies targeted by current indirect dark matter searches, so might also be detectable by present or upcoming experiments.Comment: 5 pages, 3 figures. Minor update to match published version of erratu

Nonlinear stochastic biasing from the formation epoch distribution of dark halos

We propose a physical model for nonlinear stochastic biasing of one-point statistics resulting from the formation epoch distribution of dark halos. In contrast to previous works on the basis of extensive numerical simulations, our model provides for the first time an analytic expression for the joint probability function. Specifically we derive the joint probability function of halo and mass density contrasts from the extended Press-Schechter theory. Since this function is derived in the framework of the standard gravitational instability theory assuming the random-Gaussianity of the primordial density field alone, we expect that the basic features of the nonlinear and stochastic biasing predicted from our model are fairly generic. As representative examples, we compute the various biasing parameters in cold dark matter models as a function of a redshift and a smoothing length. Our major findings are (1) the biasing of the variance evolves strongly as redshift while its scale-dependence is generally weak and a simple linear biasing model provides a reasonable approximation roughly at R\simgt 2(1+z)\himpc, and (2) the stochasticity exhibits moderate scale-dependence especially on R\simlt 20\himpc, but is almost independent of $z$. Comparison with the previous numerical simulations shows good agreement with the above behavior, indicating that the nonlinear and stochastic nature of the halo biasing is essentially understood by taking account of the distribution of the halo mass and the formation epoch.Comment: 34 pages, 11 figures, ApJ (2000) in pres