3,111 research outputs found
Confinement Effects on Carbon Dioxide Methanation: A Novel Mechanism for Abiotic Methane Formation
An important scientific debate focuses on the possibility of abiotic synthesis of hydrocarbons during oceanic crust-seawater interactions. While on-site measurements near hydrothermal vents support this possibility, laboratory studies have provided data that are in some cases contradictory. At conditions relevant for sub-surface environments it has been shown that classic thermodynamics favour the production of CO2 from CH4, while abiotic methane synthesis would require the opposite. However, confinement effects are known to alter reaction equilibria. This report shows that indeed thermodynamic equilibrium can be shifted towards methane production, suggesting that thermal hydrocarbon synthesis near hydrothermal vents and deeper in the magma-hydrothermal system is possible. We report reactive ensemble Monte Carlo simulations for the CO2 methanation reaction. We compare the predicted equilibrium composition in the bulk gaseous phase to that expected in the presence of confinement. In the bulk phase we obtain excellent agreement with classic thermodynamic expectations. When the reactants can exchange between bulk and a confined phase our results show strong dependency of the reaction equilibrium conversions, [Formula: see text], on nanopore size, nanopore chemistry, and nanopore morphology. Some physical conditions that could shift significantly the equilibrium composition of the reactive system with respect to bulk observations are discussed
How the asymmetry of internal potential influences the shape of I-V characteristic of nanochannels
Ion transport in biological and synthetic nanochannels is characterized by
such phenomena as ion current fluctuations, rectification, and pumping.
Recently, it has been shown that the nanofabricated synthetic pores could be
considered as analogous to biological channels with respect to their transport
characteristics \cite{Apel, Siwy}. The ion current rectification is analyzed.
Ion transport through cylindrical nanopores is described by the Smoluchowski
equation. The model is considering the symmetric nanopore with asymmetric
charge distribution. In this model, the current rectification in asymmetrically
charged nanochannels shows a diode-like shape of characteristic. It is
shown that this feature may be induced by the coupling between the degree of
asymmetry and the depth of internal electric potential well. The role of
concentration gradient is discussed
Antimicrobial resistance in Mycoplasma genitalium sampled from the British general population
Background:
Mycoplasma genitalium is a common sexually transmitted infection. Treatment guidelines focus on those with symptoms and sexual contacts, generally with regimens including doxycycline and/or azithromycin as first-line and moxifloxacin as second-line treatment. We investigated the prevalence of antimicrobial resistance (AMR)-conferring mutations in M. genitalium among the sexually-active British general population. /
Methods: The third national survey of sexual attitudes and lifestyles (Natsal-3) is a probability sample survey of 15 162 men and women aged 16–74 years in Britain conducted during 2010–12. Urine test results for M. genitalium were available for 4507 participants aged 16–44 years reporting >1 lifetime sexual partner. In this study, we sequenced regions of the 23S rRNA and parC genes to detect known genotypic determinants for resistance to macrolides and fluoroquinolones respectively. /
Results: 94% (66/70) of specimens were re-confirmed as M. genitalium positive, with successful sequencing in 85% (56/66) for 23S rRNA and 92% (61/66) for parC genes. Mutations in 23S rRNA gene (position A2058/A2059) were detected in 16.1% (95%CI: 8.6% to 27.8%) and in parC (encoding ParC D87N/D87Y) in 3.3% (0.9%–11.2%). Macrolide resistance was more likely in participants reporting STI diagnoses (past 5 years) (44.4% (18.9%–73.3%) vs 10.6% (4.6%–22.6%); p=0.029) or sexual health clinic attendance (past year) (43.8% (23.1%–66.8%) vs 5.0% (1.4%–16.5%); p=0.001). All 11 participants with AMR-conferring mutations had attended sexual health clinics (past 5 years), but none reported recent symptoms. /
Conclusions This study highlights challenges in M. genitalium management and control. Macrolide resistance was present in one in six specimens from the general population in 2010–2012, but no participants with AMR M. genitalium reported symptoms. Given anticipated increases in diagnostic testing, new strategies including novel antimicrobials, AMR-guided therapy, and surveillance of AMR and treatment failure are recommended
Phonons and specific heat of linear dense phases of atoms physisorbed in the grooves of carbon nanotube bundles
The vibrational properties (phonons) of a one-dimensional periodic phase of
atoms physisorbed in the external groove of the carbon nanotube bundle are
studied. Analytical expressions for the phonon dispersion relations are
derived. The derived expressions are applied to Xe, Kr and Ar adsorbates. The
specific heat pertaining to dense phases of these adsorbates is calculated.Comment: 4 PS figure
Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs
The reference annotations made for a genome sequence provide the framework
for all subsequent analyses of the genome. Correct annotation is particularly
important when interpreting the results of RNA-seq experiments where short
sequence reads are mapped against the genome and assigned to genes according to
the annotation. Inconsistencies in annotations between the reference and the
experimental system can lead to incorrect interpretation of the effect on RNA
expression of an experimental treatment or mutation in the system under study.
Until recently, the genome-wide annotation of 3-prime untranslated regions
received less attention than coding regions and the delineation of intron/exon
boundaries. In this paper, data produced for samples in Human, Chicken and A.
thaliana by the novel single-molecule, strand-specific, Direct RNA Sequencing
technology from Helicos Biosciences which locates 3-prime polyadenylation sites
to within +/- 2 nt, were combined with archival EST and RNA-Seq data. Nine
examples are illustrated where this combination of data allowed: (1) gene and
3-prime UTR re-annotation (including extension of one 3-prime UTR by 5.9 kb);
(2) disentangling of gene expression in complex regions; (3) clearer
interpretation of small RNA expression and (4) identification of novel genes.
While the specific examples displayed here may become obsolete as genome
sequences and their annotations are refined, the principles laid out in this
paper will be of general use both to those annotating genomes and those seeking
to interpret existing publically available annotations in the context of their
own experimental dataComment: 44 pages, 9 figure
Host galaxies of long gamma-ray bursts in the Millennium Simulation
(abridged) In this work, we investigate the nature of the host galaxies of
long Gamma-Ray bursts (LGRBs) using a galaxy catalogue constructed from the
Millennium Simulation. We developed an LGRB synthetic model based on the
hypothesis that these events originate at the end of the life of massive stars
following the collapsar model, with the possibility of including a constraint
on the metallicity of the progenitor star. A complete observability pipeline
was designed to calculate a probability estimation for a galaxy to be
observationally identified as a host for LGRBs detected by present
observational facilities. This new tool allows us to build an observable host
galaxy catalogue which is required to reproduce the current stellar mass
distribution of observed hosts. This observability pipeline predicts that the
minimum mass for the progenitor stars should be ~75 solar masses in order to be
able to reproduce BATSE observations. Systems in our observable catalogue are
able to reproduce the observed properties of host galaxies, namely stellar
masses, colours, luminosity, star formation activity and metallicities as a
function of redshift. At z>2, our model predicts that the observable host
galaxies would be very similar to the global galaxy population. We found that
~88 per cent of the observable host galaxies with mean gas metallicity lower
than 0.6 solar have stellar masses in the range 10^8.5-10^10.3 solar masses in
excellent agreement with observations. Interestingly, in our model observable
host galaxies remain mainly within this mass range regardless of redshift,
since lower stellar mass systems would have a low probability of being observed
while more massive ones would be too metal-rich. Observable host galaxies are
predicted to preferentially inhabit dark matter haloes in the range
10^11-10^11.5 solar masses, with a weak dependence on redshift.Comment: 11 pages, 10 figures, accepted for publication in MNRA
Variability selected high-redshift quasars on SDSS Stripe 82
The SDSS-III BOSS Quasar survey will attempt to observe z>2.15 quasars at a
density of at least 15 per square degree to yield the first measurement of the
Baryon Acoustic Oscillations in the Ly-alpha forest. To help reaching this
goal, we have developed a method to identify quasars based on their variability
in the u g r i z optical bands. The method has been applied to the selection of
quasar targets in the SDSS region known as Stripe 82 (the Southern equatorial
stripe), where numerous photometric observations are available over a 10-year
baseline. This area was observed by BOSS during September and October 2010.
Only 8% of the objects selected via variability are not quasars, while 90% of
the previously identified high-redshift quasar population is recovered. The
method allows for a significant increase in the z>2.15 quasar density over
previous strategies based on optical (ugriz) colors, achieving a density of
24.0 deg^{-2} on average down to g~22 over the 220 deg^2 area of Stripe 82. We
applied this method to simulated data from the Palomar Transient Factory and
from Pan-STARRS, and showed that even with data that have sparser time sampling
than what is available in Stripe 82, including variability in future quasar
selection strategies would lead to increased target selection efficiency in the
z>2.15 redshift range. We also found that Broad Absorption Line quasars are
preferentially present in a variability than in a color selection.Comment: 14 pages, 21 figures, accepted for publication in A&
Searching for Exoplanets Using a Microresonator Astrocomb
Detection of weak radial velocity shifts of host stars induced by orbiting
planets is an important technique for discovering and characterizing planets
beyond our solar system. Optical frequency combs enable calibration of stellar
radial velocity shifts at levels required for detection of Earth analogs. A new
chip-based device, the Kerr soliton microcomb, has properties ideal for
ubiquitous application outside the lab and even in future space-borne
instruments. Moreover, microcomb spectra are ideally suited for astronomical
spectrograph calibration and eliminate filtering steps required by conventional
mode-locked-laser frequency combs. Here, for the calibration of astronomical
spectrographs, we demonstrate an atomic/molecular line-referenced,
near-infrared soliton microcomb. Efforts to search for the known exoplanet HD
187123b were conducted at the Keck-II telescope as a first in-the-field
demonstration of microcombs
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