Sharing Your Scholarly Work Through Open Access Publishing

Open access publishing is often presented as a monolith, but there are a variety of approaches to making your work available open access. Defined by Peter Suber as “digital, online, free of charge, and free of most copyright and licensing restrictions,” open access initiatives and models have emerged since the movement gained momentum at the beginning of the twenty-first century (Open Access, 2012, 4). Participants will explore open access publishing to better understand its principles and practices. Facilitators will share campus resources to support a variety of open access publishing models, including institutional funding for open access publishing charges, green open access via deposit in the institutional repository (ISU ReD), and transformative agreements offered by Milner Library. Finally, participants will engage in a discussion focused on ways to increase engagement with and impact of their scholarly work via open access. This workshop is designed for early career faculty members in their first four years at Illinois State, although others engaged in scholarly work at ISU are welcome

Continuing Professional Development with Cooperative Learning in a Professional Learning Group

Cooperative learning is a dynamic pedagogical model that can teach varied content to a diverse range of students. Students work together in small, structured heterogeneous groups to complete tasks. The purpose of this paper is to explore teachers’ experiences with Cooperative Learning during a school-based research project. This research was also designed to gain a greater understanding of Continuing Professional Development within a Professional Learning Group that has the potential to enhance the quality of a physical education (PE) program with non-PE specialist elementary teachers. This research suggests that the implementation of Cooperative Learning or any innovative models-based practice in schools is enhanced by continuing Professional Development. Teachers’ implementation of Cooperative Learning was assisted by teachers in this study by being part of a Professional Learning Group to help them reflect, identify, and start to overcome some of the obstacles that arise when implementing a new pedagogical model

An Alternative Method: Using Novels in Mathematics to Teach the Concepts

This paper explains a research project conducted exploring the effectiveness of using the novel, The Number Devil, to teach math concepts. The effectiveness was measured by if students met the standards, if students understood the concepts, and if students enjoyed the method of instruction. The reason for conducting this research was to look at new ways of teaching mathematics due to the thought that many students dislike and do not understand math. Using novels could prove to be an effective way to vary the instruction and teach difficult concepts. To complete this research, I taught a class the math concepts explored within the novel The Number Devil. Using the data gathered, I found that engagement leads to understanding, using context or relevancy are important to learning, fragmented learning fails, and no single method of instruction works for every student. Future research of this topic could be conducted in looking at The Number Devil in parts separated by math concept or in using a different book or novel in a math class to more effectively teach the concepts

Soils of the Central Nebraska Loess Hills and Central Loess Plains

Understanding soil systems that characterize a region is critical to natural resource management. However, the knowledge gained through intensive study of local soil systems, which takes place annually as part of collegiate soil judging contests, is often poorly preserved for future use. In this study, field descriptions and laboratory data for 16 soil profiles described for the 2019 Region 5 Soil Judging Contest were used to characterize the soil system of the Central Nebraska Loess Hills and Central Loess Plains. Three landscape components of this soil system were analyzed: the loess uplands and rainwater basins, the transitional zone, and bottomlands. Rainwater basins exhibit increasing clay, clay films, and melanization compared to surrounding uplands. The transitional zone between the upland and bottomlands exhibits fining and aging of parent material with increasing elevation, resulting in increased prevalence of clay films, lower pH relative to parent material, and melanization. The bottomlands exhibited subtle variations in texture of the alluvium resulting in differences in expression of melanization, effervescence, pH, and redoximorphic features. Patterns observed within this soil system are well explained by existing pedogenic theories and demonstrate the unique interplay between soil-forming factors characteristic of this region of the Great Plains

Protease-sensitive synthetic prions

Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc). Frequently, PrP(Sc) is protease-resistant but protease-sensitive (s) prions have been isolated in humans and other animals. We report here that protease-sensitive, synthetic prions were generated in vitro during polymerization of recombinant (rec) PrP into amyloid fibers. In 22 independent experiments, recPrP amyloid preparations, but not recPrP monomers or oligomers, transmitted disease to transgenic mice (n = 164), denoted Tg9949 mice, that overexpress N-terminally truncated PrP. Tg9949 control mice (n = 174) did not spontaneously generate prions although they were prone to late-onset spontaneous neurological dysfunction. When synthetic prion isolates from infected Tg9949 mice were serially transmitted in the same line of mice, they exhibited sPrP(Sc) and caused neurodegeneration. Interestingly, these protease-sensitive prions did not shorten the life span of Tg9949 mice despite causing extensive neurodegeneration. We inoculated three synthetic prion isolates into Tg4053 mice that overexpress full-length PrP; Tg4053 mice are not prone to developing spontaneous neurological dysfunction. The synthetic prion isolates caused disease in 600-750 days in Tg4053 mice, which exhibited sPrP(Sc). These novel synthetic prions demonstrate that conformational changes in wild-type PrP can produce mouse prions composed exclusively of sPrP(Sc)

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented opportunity to glean new insights into telomere biology on a previously unimaginable scale. To this end, a number of approaches for estimating telomere length from whole-genome sequencing data have been proposed. Here we present Telomerecat, a novel approach to the estimation of telomere length. Previous methods have been dependent on the number of telomeres present in a cell being known, which may be problematic when analysing aneuploid cancer data and non-human samples. Telomerecat is designed to be agnostic to the number of telomeres present, making it suited for the purpose of estimating telomere length in cancer studies. Telomerecat also accounts for interstitial telomeric reads and presents a novel approach to dealing with sequencing errors. We show that Telomerecat performs well at telomere length estimation when compared to leading experimental and computational methods. Furthermore, we show that it detects expected patterns in longitudinal data, repeated measurements, and cross-species comparisons. We also apply the method to a cancer cell data, uncovering an interesting relationship with the underlying telomerase genotype

Achievement of the planetary defense investigations of the Double Asteroid Redirection Test (DART) mission

NASA's Double Asteroid Redirection Test (DART) mission was the first to demonstrate asteroid deflection, and the mission's Level 1 requirements guided its planetary defense investigations. Here, we summarize DART's achievement of those requirements. On 2022 September 26, the DART spacecraft impacted Dimorphos, the secondary member of the Didymos near-Earth asteroid binary system, demonstrating an autonomously navigated kinetic impact into an asteroid with limited prior knowledge for planetary defense. Months of subsequent Earth-based observations showed that the binary orbital period was changed by –33.24 minutes, with two independent analysis methods each reporting a 1σ uncertainty of 1.4 s. Dynamical models determined that the momentum enhancement factor, β, resulting from DART's kinetic impact test is between 2.4 and 4.9, depending on the mass of Dimorphos, which remains the largest source of uncertainty. Over five dozen telescopes across the globe and in space, along with the Light Italian CubeSat for Imaging of Asteroids, have contributed to DART's investigations. These combined investigations have addressed topics related to the ejecta, dynamics, impact event, and properties of both asteroids in the binary system. A year following DART's successful impact into Dimorphos, the mission has achieved its planetary defense requirements, although work to further understand DART's kinetic impact test and the Didymos system will continue. In particular, ESA's Hera mission is planned to perform extensive measurements in 2027 during its rendezvous with the Didymos–Dimorphos system, building on DART to advance our knowledge and continue the ongoing international collaboration for planetary defense

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility

Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper

Letter from Rachel Colby to John Muir, undated

Dear Mr. Muir […] changed the date of our evening from Dec 31 to Wednesday, Dec 29th. I hope you can come on the 29th just the same. Cordially, R V Colby […] […] Monda