Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report

We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

DAMAV project for vineyard disease detection by UAV imagery

AgrosupBAPGEAPSIDAMAV project for vineyard disease detection by UAV imagery . CIRG-AgEng 2016, International Conférence on Agricultural Engineering, Automation, Environment and Food Safet

DAMAV project for vineyard disease detection by UAV imagery

AgrosupBAPGEAPSIDAMAV project for vineyard disease detection by UAV imagery . CIRG-AgEng 2016, International Conférence on Agricultural Engineering, Automation, Environment and Food Safet

DAMAV project for vineyard disease detection by UAV imagery

AgrosupBAPGEAPSIDAMAV project for vineyard disease detection by UAV imagery . CIRG-AgEng 2016, International Conférence on Agricultural Engineering, Automation, Environment and Food Safet

Multispectral band selection for imaging sensor design for vineyard disease detection: case of Flavescence Dorée

Agrosup EA GEAPSI DOCTInternational audienceDisease detection and control is thus one of the main objectives of vineyard research in France. Monitoring diseases manually is fastidious and time consuming, so current research aims to develop an automatic detection of vineyard diseases. This project explored the use of a high-resolution multi-spectral camera embedded on a UAV (Unmanned Aerial Vehicle) to identify the infected zones in a field. In-field spectrometry studies were performed to identify the best spectral bands for the sensor design. The best models were found to be the function of the grapevine variety considered and the 520-600-650-690-730-750-800 nm bands were found to be the most efficient for all types of grapevines, with an overall classification accuracy of more than 94%

Texture, Color and Frequential Proxy-Detection Image Processing for Crop Characterization in a Context of Precision Agriculture

The concept of precision agriculture consists to spatially manage crop management practices according to in-field variability. This concept is principally dedicated to variable-rate application of inputs such as nitrogen, seeds and phytosanitary products, allowing for a better yield management and reduction on the use of pesticides, herbicides … In this general context, the development of ICT techniques has allowed relevant progresses for Leaf Area Index (LAI) (Richardson et al., 2009), crop density (Saeys et al., 2009), stress (Zygielbaum et al., 2009) … Most of the tools used for Precision Farming utilizes optical and/or imaging sensors and dedicated treatments, in real time or not, and eventually combined to 3D plant growth modeling or disease development (Fournier et al., 2003 ; Robert et al., 2008). To evaluate yields or to better define the appropriated periods for the spraying or fertilizer input, to detect crop, weeds, diseases …, the remote sensing imaging devices are often used to complete or replace embedded sensors onboard the agricultural machinery (Aparicio et al., 2000). Even if these tools provide sufficient accurate information, they get some drawbacks compared to “proxy-detection” optical sensors: resolution, easy-to-use tools, accessibility, cost, temporality, precision of the measurement … The use of specific image acquisition systems coupled to reliable image processing should allow for a reduction of working time, a lower work hardness and a reduction of the bias of the measurement according to the operator, or a better spatial sampling due to the rapidity of the image acquisition (instead of the use of remote sensing). The early evaluation of yield could allow farmers, for example, to adjust cultivation practices (e.g., last nitrogen (N) input), to organize harvest and storage logistics. The optimization of late N application could lead to significant improvements for the environment, one of the most important concerns that precision agriculture aims to address. We propose in this chapter to explore the proxy-detection domain by focusing first on the development of robust image acquisition systems, and secondly on the use of image processing for different applications tied on one hand to wheat crop characterization, such as the detection and counting of wheat ears per m² (in a context of yield prediction) and the weed detection, and on the other hand to the evolution of seed development/germination performance of chicory achenes. Results of the different processing are presented in the last part just before a conclusion

Acetate-Free Biofiltration Versus Online Acetate-Free Hemodiafiltration in Patients at High Risk of Hemodialysis Intolerance

International audienceIntradialytic hypotension (IDH) is one of the most frequent and worrying issues in chronic hemodialysis. Systolic blood pressure (BP) <90 mm Hg has the strongest association with mortality in patients receiving chronic kidney replacement therapy (CKRT). IDH results from the combination of excessive ultrafiltration rate, membrane bio-incompatibility, and inappropriate hemodynamic response (heart rate and contractility, vascular tone). Modulation of the dialysate composition can improve tolerance, but standard bicarbonate dialysis remains associated with frequent IDH in patients at high risk. Online high-volume hemodiafiltration (HDF) was proposed to improve hemodynamic tolerance but was also associated with IDH in a subset of patients