Initiation, discontinuation, and restarting HIV pre-exposure prophylaxis: ongoing implementation strategies

When used appropriately, pre-exposure prophylaxis (PrEP) substantially reduces the risk of HIV acquisition. Early implementation outcomes often suggest poor PrEP adherence and persistence; however, this intervention is time-limited and the need for PrEP fluctuates as risk behaviours change. In this Viewpoint we examine the current guidelines and early programmatic outcomes after starting, stopping, and restarting PrEP, and we review the implications of PrEP in relation to HIV testing algorithms. Guidelines suggest to discontinue PrEP when a person is no longer at risk for HIV, but effectively implementing this strategy requires support tools to make the decision of stopping and restarting PrEP that considers the complex relationship between risk perceptions and risk behaviours. Safely discontinuing PrEP also requires greater understanding of the daily dosing duration that is needed to protect the person after their last HIV exposure. Additionally, clear strategies are needed to re-engage a person as their HIV exposure risk changes over time

QCD Sum Rules and Applications to Nuclear Physics

Applications of QCD sum-rule methods to the physics of nuclei are reviewed, with an emphasis on calculations of baryon self-energies in infinite nuclear matter. The sum-rule approach relates spectral properties of hadrons propagating in the finite-density medium, such as optical potentials for quasinucleons, to matrix elements of QCD composite operators (condensates). The vacuum formalism for QCD sum rules is generalized to finite density, and the strategy and implementation of the approach is discussed. Predictions for baryon self-energies are compared to those suggested by relativistic nuclear physics phenomenology. Sum rules for vector mesons in dense nuclear matter are also considered.Comment: 92 pages, ReVTeX, 9 figures can be obtained upon request (to Xuemin Jin

Compressibility and Electronic Structure of MgB2 up to 8 GPa

The lattice parameters of MgB2 up to pressures of 8 GPa were determined using high-resolution x-ray powder diffraction in a diamond anvil cell. The bulk modulus, B0, was determined to be 151 +-5 GPa. Both experimental and first-principles calculations indicate nearly isotropic mechanical behavior under pressure. This small anisotropy is in contrast to the 2 dimensional nature of the boron pi states. The pressure dependence of the density of states at the Fermi level and a reasonable value for the average phonon frequency account within the context of BCS theory for the reduction of Tc under pressure.Comment: REVTeX file. 4 pages, 4 figure

QCD phase transitions from relativistic hadron models

The models of translationally invariant infinite nuclear matter in the relativistic mean field models are very interesting and simple, since the nucleon can connect only to a constant vector and scalar meson field. Can one connect these to the complicated phase transitions of QCD ? For an affirmative answer to this question, one must consider models where the coupling constants to the scalar and vector fields must depend on density in a non-linear way, since as such the models are not explicitly chirally invariant. Once this is ensured, indeed one can derive a quark condensate indirectly from the energy density of nuclear matter which goes to zero at large density and temperature. The change to zero condensate indicates a smooth phase transition.Comment: 12 pages latex file, 1 table, 12 Postscript figures. To appear in Zeit. f. Phys.

Pre-main-sequence population in NGC 1893 region

In this paper we continued our efforts to understand the star formation scenario in and around the young cluster NGC 1893. We used a sample of the young stellar sources (YSOs) identified on the basis of multiwavelength data (optical, near-infrared (NIR), mid-infrared (MIR) and X-ray) to study the nature of YSOs associated with the region. The identified YSOs show an age spread of ~ 5 Myr. The YSOs located near the nebulae at the periphery of the cluster are relatively younger in comparison to those located within the cluster region. The present results are in accordance with those obtained by us in previous studies. Other main results from the present study are: 1) the fraction of disk bearing stars increases towards the periphery of the cluster; 2) there is an evidence supporting the notion that the mechanisms for disk dispersal operate less efficiently for low-mass stars; 3) the sample of Class II sources is found to be relatively older in comparison to that of Class III sources. A comparison of various properties of YSOs in the NGC 1893 region with those in the Tr 37/ IC 1396 region is also discussed.Comment: Accepted for publication in New Astronom

Electronic localization at mesoscopic length scales: different definitions of localization and contact effects in a heuristic DNA model

In this work we investigate the electronic transport along model DNA molecules using an effective tight-binding approach that includes the backbone on site energies. The localization length and participation number are examined as a function of system size, energy dependence, and the contact coupling between the leads and the DNA molecule. On one hand, the transition from an diffusive regime to a localized regime for short systems is identified, suggesting the necessity of a further length scale revealing the system borders sensibility. On the other hand, we show that the lenght localization and participation number, do not depended of system size and contact coupling in the thermodynamic limit. Finally we discuss possible length dependent origins for the large discrepancies among experimental results for the electronic transport in DNA sample

Erasmus Language students in a British University – a case study

Students’ assessment of their academic experience is actively sought by Higher Education institutions, as evidenced in the National Student Survey introduced in 2005. Erasmus students, despite their growing numbers, tend to be excluded from these satisfaction surveys, even though they, too, are primary customers of a University. This study aims to present results from bespoke questionnaires and semi-structured interviews with a sample of Erasmus students studying languages in a British University. These methods allow us insight into the experience of these students and their assessment as a primary customer, with a focus on language learning and teaching, university facilities and student support. It investigates to what extent these factors influence their levels of satisfaction and what costs of adaptation if any, they encounter. Although excellent levels of satisfaction were found, some costs affect their experience. They relate to difficulties in adapting to a learning methodology based on a low number of hours and independent learning and to a guidance and support system seen as too stifling. The results portray this cohort’s British University as a well-equipped and well-meaning but ultimately overbearing institution, which may indicate that minimising costs can eliminate some sources of dissatisfaction

MSSM Higgs sector CP violation at photon colliders: Revisited

We present a comprehensive analysis on the MSSM Higgs sector CP violation at photon colliders including the chargino contributions as well as the contributions of other charged particles. The chargino loop contributions can be important for the would-be CP odd Higgs production at photon colliders. Polarization asymmetries are indispensable in determining the CP properties of neutral Higgs bosons.Comment: 24 pages, 40 figure